1
40
47
-
Text
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URL Address
<a href="http://doi.org/10.1001/archpedi.158.10.977" target="_blank" rel="noreferrer noopener">http://doi.org/10.1001/archpedi.158.10.977</a>
Pages
977–981
Issue
10
Volume
158
Dublin Core
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Title
A name given to the resource
Effect of a standardized pharyngitis treatment protocol on use of antibiotics in a pediatric emergency department.
Publisher
An entity responsible for making the resource available
Archives of Pediatrics & Adolescent Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-10
Subject
The topic of the resource
*Emergency Service; *Practice Guidelines as Topic; Adolescent; Adult; Anti-Bacterial Agents/*therapeutic use; Child; Cohort Studies; Dose-Response Relationship; Drug; Drug Administration Schedule; Evidence-Based Medicine; Female; Follow-Up Studies; Hospital; Hospitals; Humans; Male; Pediatric; Pharyngitis/*drug therapy/*microbiology; Preschool; Streptococcal Infections/*drug therapy/microbiology; Treatment Outcome
Creator
An entity primarily responsible for making the resource
Diaz Maria Carmen G; Symons Nadine; Ramundo Maria L; Christopher Norman C
Description
An account of the resource
BACKGROUND: Pharyngitis is a common complaint in pediatric patients. If clinical parameters are used alone, bacterial pathogens will be wrongly implicated in many cases. A nonstandardized approach to the treatment of children with pharyngitis in an emergency department setting may lead to inappropriate empirical therapy, contribute to increased bacterial resistance, and result in adverse events related to the treatment provided. OBJECTIVE: To implement evidence-based guidelines for the diagnosis and treatment of children with pharyngitis in an emergency department setting and thereby influence practices of prescribing antibiotics. DESIGN AND METHODS: An evidence-based guideline for the evaluation and treatment of patients with pharyngitis was developed and implemented in our emergency department. Preintervention and postintervention patient cohorts were identified by a search of the emergency department's clinical repository. A medical record review was performed using a standardized data abstraction form (history and examination data, diagnostic testing, and therapy provided). Treatment decisions were judged as appropriate if the diagnosis of pharyngitis caused by group A beta-hemolytic streptococci was based on confirmatory microbiological testing rather than on the history and physical examination findings alone. RESULTS: We included 443 patients for study (219 preintervention and 224 postintervention). In the preintervention group, 97 (44%) of 214 received appropriate treatment. In the postintervention group, 204 (91%) of 224 received appropriate treatment. CONCLUSION: An evidence-based clinical guideline can influence and improve practices of prescribing antibiotics by pediatric emergency physicians in a teaching hospital setting.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1001/archpedi.158.10.977" target="_blank" rel="noreferrer noopener">10.1001/archpedi.158.10.977</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Emergency Service
*Practice Guidelines as Topic
2004
Adolescent
Adult
Akron Children's Hospital
Anti-Bacterial Agents/*therapeutic use
Archives of pediatrics & adolescent medicine
Child
Christopher Norman C
Cohort Studies
Department of Emergency Medicine
Department of Pediatrics
Diaz Maria Carmen G
Dose-Response Relationship
Drug
Drug Administration Schedule
Evidence-Based Medicine
Female
Follow-Up Studies
Hospital
Hospitals
Humans
Male
NEOMED College of Medicine
Pediatric
Pharyngitis/*drug therapy/*microbiology
Preschool
Ramundo Maria L
Streptococcal Infections/*drug therapy/microbiology
Symons Nadine
Treatment Outcome
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/01.pec.0000106237.72265.bb" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.pec.0000106237.72265.bb</a>
Pages
12–16
Issue
1
Volume
20
Dublin Core
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Title
A name given to the resource
The educational experience of pediatric emergency medicine fellows in the use and application of procedural sedation/analgesia.
Publisher
An entity responsible for making the resource available
Pediatric emergency care
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-01
Subject
The topic of the resource
*Fellowships and Scholarships; Analgesia/*methods; Analgesics/administration & dosage/*therapeutic use; Anesthesiology/*education; Clinical Competence/standards; Conscious Sedation/*methods; Curriculum/standards; Data Collection; Emergency Medicine/*education; Emergency Service; Hospital; Humans; Hypnotics and Sedatives/administration & dosage/*therapeutic use; Pediatrics/*education; Teaching/statistics & numerical data
Creator
An entity primarily responsible for making the resource
Pollauf Laura A; Lutes R Esther; Ramundo Maria L; Christopher Norman C
Description
An account of the resource
OBJECTIVES: The purpose of this study is to describe the clinical and educational experience provided to the pediatric emergency medicine (PEM) fellows in procedural sedation/analgesia during their course of training. METHODS: A nonanonymous survey was completed by the program director of each Accreditation Council for Graduate Medical Education (ACGME)-accredited PEM fellowship program listed in the 2001 to 2002 Graduate Medical Education Directory. Information relating to program demographics, agents available for use in the emergency department (ED), and the educational opportunities offered to trainees was sought. RESULTS: Each of the 32 ACGME-accredited programs completed the survey. Thirty programs report using procedural sedation and analgesia (PSA) to facilitate the completion of nonpainful and 32 programs to facilitate the completion of painful procedures in the ED. Twenty-nine programs (92%) permit their fellows to provide PSA independently after meeting credentialing criteria at their institution. Formal didactic sessions, direct supervision of procedures, and dedicated journal clubs were the 3 most frequently cited educational methods reported. The educational method chosen was not predicted by the ED type, the size of the training program, or by the volume of patients evaluated in the ED. Twelve program directors report their belief that a minimum number of procedures should be completed prior to completion of the training program. CONCLUSION: There is wide variation in the educational methods used by PEM fellowship training programs in procedural sedation/analgesia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.pec.0000106237.72265.bb" target="_blank" rel="noreferrer noopener">10.1097/01.pec.0000106237.72265.bb</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fellowships and Scholarships
2004
Akron Children's Hospital
Analgesia/*methods
Analgesics/administration & dosage/*therapeutic use
Anesthesiology/*education
Christopher Norman C
Clinical Competence/standards
Conscious Sedation/*methods
Curriculum/standards
Data Collection
Department of Emergency Medicine
Department of Pediatrics
Emergency Medicine/*education
Emergency Service
Hospital
Humans
Hypnotics and Sedatives/administration & dosage/*therapeutic use
Lutes R Esther
NEOMED College of Medicine
Pediatric emergency care
Pediatrics/*education
Pollauf Laura A
Ramundo Maria L
Teaching/statistics & numerical data
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/01.pec.0000150987.19228.c8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.pec.0000150987.19228.c8</a>
Pages
35–37
Issue
1
Volume
21
Dublin Core
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Title
A name given to the resource
A thyroglossal duct cyst causing apnea and cyanosis in a neonate.
Publisher
An entity responsible for making the resource available
Pediatric emergency care
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
Airway Obstruction/etiology/therapy; Apnea/*etiology/therapy; Cyanosis/*etiology/therapy; Humans; Infant; Intratracheal; Intubation; Male; Newborn; Thyroglossal Cyst/*complications/*congenital
Creator
An entity primarily responsible for making the resource
Diaz Maria Carmen G; Stormorken Anne; Christopher Norman C
Description
An account of the resource
This is a case of a 3-week-old male who presented to the emergency department with intermittent apnea and cyanosis. While in the emergency department, he had respiratory compromise with stress and required intubation. Further evaluation confirmed the diagnosis of a thyroglossal duct cyst. Congenital lesions causing extrinsic airway compression should be considered in all neonates with apnea, cyanosis, and respiratory compromise. Knowledge of pediatric airway anatomy and physiology is important in all cases where obstructive apnea is suspected.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/01.pec.0000150987.19228.c8" target="_blank" rel="noreferrer noopener">10.1097/01.pec.0000150987.19228.c8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Airway Obstruction/etiology/therapy
Akron Children's Hospital
Apnea/*etiology/therapy
Christopher Norman C
Cyanosis/*etiology/therapy
Department of Emergency Medicine
Department of Pediatrics
Diaz Maria Carmen G
Humans
Infant
Intratracheal
Intubation
Male
NEOMED College of Medicine
Newborn
Pediatric emergency care
Stormorken Anne
Thyroglossal Cyst/*complications/*congenital
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1136/jmedgenet-2018-105800" target="_blank" rel="noreferrer noopener">http://doi.org/10.1136/jmedgenet-2018-105800</a>
Pages
123–130
Issue
3
Volume
56
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics; Department of Integrative Medical Sciences
Affiliated Hospital
Akron Children's Hospital
Dublin Core
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Title
A name given to the resource
Diagnosis of 'possible' mitochondrial disease: an existential crisis.
Publisher
An entity responsible for making the resource available
Journal of medical genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
clinical genetics; diagnosis; evidence based practice; metabolic disorders
Creator
An entity primarily responsible for making the resource
Parikh Sumit; Karaa Amel; Goldstein Amy; Bertini Enrico Silvio; Chinnery Patrick F; Christodoulou John; Cohen Bruce H; Davis Ryan L; Falk Marni J; Fratter Carl; Horvath Rita; Koenig Mary Kay; Mancuso Michaelangelo; McCormack Shana; McCormick Elizabeth M; McFarland Robert; Nesbitt Victoria; Schiff Manuel; Steele Hannah; Stockler Silvia; Sue Carolyn; Tarnopolsky Mark; Thorburn David R; Vockley Jerry; Rahman Shamima
Description
An account of the resource
Primary genetic mitochondrial diseases are often difficult to diagnose, and the term 'possible' mitochondrial disease is used frequently by clinicians when such a diagnosis is suspected. There are now many known phenocopies of mitochondrial disease. Advances in genomic testing have shown that some patients with a clinical phenotype and biochemical abnormalities suggesting mitochondrial disease may have other genetic disorders. In instances when a genetic diagnosis cannot be confirmed, a diagnosis of 'possible' mitochondrial disease may result in harm to patients and their families, creating anxiety, delaying appropriate diagnosis and leading to inappropriate management or care. A categorisation of 'diagnosis uncertain', together with a specific description of the metabolic or genetic abnormalities identified, is preferred when a mitochondrial disease cannot be genetically confirmed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/jmedgenet-2018-105800" target="_blank" rel="noreferrer noopener">10.1136/jmedgenet-2018-105800</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Akron Children's Hospital
Bertini Enrico Silvio
Chinnery Patrick F
Christodoulou John
clinical genetics
Cohen Bruce H
Davis Ryan L
Department of Integrative Medical Sciences
Department of Pediatrics
Diagnosis
evidence based practice
Falk Marni J
Fratter Carl
Goldstein Amy
Horvath Rita
Journal of medical genetics
Karaa Amel
Koenig Mary Kay
Mancuso Michaelangelo
McCormack Shana
McCormick Elizabeth M
McFarland Robert
metabolic disorders
NEOMED College of Medicine
Nesbitt Victoria
Parikh Sumit
Rahman Shamima
Schiff Manuel
Steele Hannah
Stockler Silvia
Sue Carolyn
Tarnopolsky Mark
Thorburn David R
Vockley Jerry
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/0009922806291013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/0009922806291013</a>
Pages
628–632
Issue
7
Volume
45
Dublin Core
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Title
A name given to the resource
Ethyl vinyl chloride vapocoolant spray fails to decrease pain associated with intravenous cannulation in children.
Publisher
An entity responsible for making the resource available
Clinical pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-09
Subject
The topic of the resource
Adolescent; Catheterization; Central Venous/*adverse effects; Child; Emergency Medical Services; Ethyl Chloride/administration & dosage/*therapeutic use; Female; Humans; Male; Pain/*prevention & control; Placebos; Treatment Failure; Vinyl Chloride
Creator
An entity primarily responsible for making the resource
Costello Mary; Ramundo Maria; Christopher Norman C; Powell Keith R
Description
An account of the resource
The purpose of the study was to determine the effect of ethyl vinyl chloride vapocoolant spray on pain reported by children undergoing intravenous cannulation. A randomized, double-blinded, placebo-controlled trial was conducted on eligible children between the ages of 9 and 18 years seen in a pediatric emergency department and requiring intravenous cannulation. Informed consent was obtained, and children were randomized to receive ethyl vinyl chloride spray, isopropyl alcohol spray, or no spray (control group). Patient demographics and information pertaining to each intravenous cannulation were recorded. Children indicated the degree of pain associated with intravenous cannulation on a 100-mm visual analog scale (VAS) compared to a baseline pain score of "zero." Statistical analysis was performed by using Stata version 7. One hundred twenty-seven subjects were enrolled: 37 received ethyl vinyl chloride vapocoolant spray, 48 received isopropyl alcohol spray (placebo), and 42 received no pretreatment. Mean VAS scores for pain experienced during cannulation were 34, 33, and 31 mL for each group, respectively. Ethyl vinyl chloride vapocoolant spray failed to measurably reduce pain associated with intravenous cannulation when compared to those pretreated with isopropyl alcohol spray or receiving no intervention.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/0009922806291013" target="_blank" rel="noreferrer noopener">10.1177/0009922806291013</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Adolescent
Akron Children's Hospital
Catheterization
Central Venous/*adverse effects
Child
Christopher Norman C
Clinical pediatrics
Costello Mary
Department of Emergency Medicine
Department of Pediatrics
Emergency Medical Services
Ethyl Chloride/administration & dosage/*therapeutic use
Female
Humans
Male
NEOMED College of Medicine
Pain/*prevention & control
Placebos
Powell Keith R
Ramundo Maria
Treatment Failure
Vinyl Chloride
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1197/j.aem.2005.11.085" target="_blank" rel="noreferrer noopener">http://doi.org/10.1197/j.aem.2005.11.085</a>
Pages
537–542
Issue
5
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Screening for adolescent depression in a pediatric emergency department.
Publisher
An entity responsible for making the resource available
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-05
Subject
The topic of the resource
*Adolescent Behavior; Adolescent; Adult; Age Distribution; Comorbidity; Cross-Sectional Studies; Depression/classification/*diagnosis/*epidemiology; Emergency Service; Female; Hospital/*statistics & numerical data; Hospitalization/statistics & numerical data; Humans; Logistic Models; Male; Mass Screening/*instrumentation/*statistics & numerical data; Ohio/epidemiology; Patient Participation/statistics & numerical data; Pediatrics/*statistics & numerical data; Prevalence; Psychiatric Status Rating Scales; Transportation of Patients/statistics & numerical data; Wounds and Injuries/epidemiology
Creator
An entity primarily responsible for making the resource
Scott Emily Gale; Luxmore Brett; Alexander Heather; Fenn Robin L; Christopher Norman C
Description
An account of the resource
OBJECTIVES: To describe the prevalence of depressive symptoms in adolescents presenting to the emergency department (ED) and to describe their demographics and outcomes compared with adolescents endorsing low levels of depressive symptoms. METHODS: The Beck Depression Inventory-2nd edition (BDI-II) was used to screen all patients 13-19 years of age who presented to the ED during the period of study. The BDI-II is a 21-item self-report instrument used to measure the presence and severity of depressive symptoms in adolescents and adults. Demographics and clinical outcomes of screening-program participants were abstracted by chart review. Patients were categorized into one of four severity categories (minimal, mild, moderate, or severe) and one of three presenting complaint categories (medical, trauma, mental health). RESULTS: Four hundred eighty-seven patients were approached, and 351(72%) completed the screening protocol. Participants endorsed minimal (n = 192, 55%), mild (n = 52, 15%), moderate (n = 41, 11%), or severe depressive symptoms (n = 66, 19%). Those with moderate or severe depressive symptoms were more likely to be hospitalized. Of patients completing the BDI-II, 72% with psychiatric, 12% with traumatic, and 19% with medical chief complaints endorsed either moderate or severe depressive symptoms. CONCLUSIONS: Depressive symptoms are prevalent in this screening sample, regardless of presenting complaint. A substantial proportion of patients with nonpsychiatric chief complaints endorsed moderate or severe depressive symptoms. A screening program might allow earlier identification and referral of patients at risk for depression.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1197/j.aem.2005.11.085" target="_blank" rel="noreferrer noopener">10.1197/j.aem.2005.11.085</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Adolescent Behavior
2006
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
Adolescent
Adult
Age Distribution
Akron Children's Hospital
Alexander Heather
Christopher Norman C
Comorbidity
Cross-Sectional Studies
Department of Emergency Medicine
Department of Pediatrics
Depression/classification/*diagnosis/*epidemiology
Emergency Service
Female
Fenn Robin L
Hospital/*statistics & numerical data
Hospitalization/statistics & numerical data
Humans
Logistic Models
Luxmore Brett
Male
Mass Screening/*instrumentation/*statistics & numerical data
NEOMED College of Medicine
Ohio/epidemiology
Patient Participation/statistics & numerical data
Pediatrics/*statistics & numerical data
Prevalence
Psychiatric Status Rating Scales
Scott Emily Gale
Transportation of Patients/statistics & numerical data
Wounds and Injuries/epidemiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/jpepsy/jsq113" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/jpepsy/jsq113</a>
Pages
806–815
Issue
7
Volume
36
Dublin Core
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Title
A name given to the resource
The Impact of Caregiver Distress on the Longitudinal Development of Child Acute Post-traumatic Stress Disorder Symptoms in Pediatric Injury Victims.
Publisher
An entity responsible for making the resource available
Journal of Pediatric Psychology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
ANALYSIS of variance; CHILD health services; CHILDREN'S injuries; POST-traumatic stress disorder in children; PSYCHOLOGY; STRUCTURAL equation modeling; VARIATION in child development
Creator
An entity primarily responsible for making the resource
Ostrowski Sarah A; Ciesla Jeffrey A; Lee Timothy J; Irish Leah; Christopher Norman C; Delahanty Douglas L
Description
An account of the resource
Objective The present study prospectively examined the development of child PTSD symptoms (PTSS) and the impact of caregiver PTSS on child PTSS following injury. Methods One hundred and eighteen ED patients and their caregivers were interviewed in-hospital and 2- and 6-weeks posttrauma. Structural equation modeling and hierarchical linear regressions examined the development of PTSS. Results A model combining child and caregiver 2-week PTSS into one latent family PTSS variable provided the best fit to the data. Child in-hospital avoidance symptoms predicted higher levels of 2-week family PTSS. Two-week family PTSS predicted child 6-week PTSS. Post hoc analyses revealed an interaction between in-hospital caregiver avoidance symptoms and child reexperiencing symptoms in predicting 6-week child PTSS. Conclusions Results highlight the dynamic development of child PTSS. Different symptom clusters may be related to higher PTSS at differing times posttrauma and may inform the development of time-sensitive methods of assessment and intervention for injury victims. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/jpepsy/jsq113" target="_blank" rel="noreferrer noopener">10.1093/jpepsy/jsq113</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Akron Children's Hospital
Analysis of Variance
CHILD health services
CHILDREN'S injuries
Christopher Norman C
Ciesla Jeffrey A
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
Irish Leah
Journal of Pediatric Psychology
Lee Timothy J
NEOMED College of Medicine
Ostrowski Sarah A
POST-traumatic stress disorder in children
Psychology
STRUCTURAL equation modeling
VARIATION in child development
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jts.20517" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jts.20517</a>
Pages
282–287
Issue
2
Volume
23
Dublin Core
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Title
A name given to the resource
The efficacy of early propranolol administration at reducing PTSD symptoms in pediatric injury patients: A pilot study.
Publisher
An entity responsible for making the resource available
Journal of Traumatic Stress
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-04
Subject
The topic of the resource
TREATMENT of post-traumatic stress disorder; STRESS (Psychology); GENDER differences (Psychology); CHILDREN'S injuries; BLIND experiment; PHARMACOLOGY; PLACEBOS (Medicine); PROPRANOLOL
Creator
An entity primarily responsible for making the resource
Nugent Nicole R; Christopher Norman C; Crow John P; Browne Lorin; Ostrowski Sarah; Delahanty Douglas L
Description
An account of the resource
Initial research supports the use of propranolol to prevent posttraumatic stress disorder (PTSD); research has not examined pharmacological prevention for children. Twenty-nine injury patients (ages 10–18 years old) at risk for PTSD were randomized to a double-blind 10-day trial of propranolol or placebo initiated within 12 hours postadmission. Six-week PTSD symptoms and heart rate were assessed. Although intent-to-treat analyses revealed no group differences, findings supported a significant interaction between gender and treatment in medication-adherent participants, ΔR2 = .21. Whereas girls receiving propranolol reported more PTSD symptoms relative to girls receiving placebo, ΔR2 = .44, boys receiving propranolol showed a nonsignificant trend toward fewer PTSD symptoms than boys receiving placebo, ΔR2 = .32. Findings inform gender differences regarding pharmacological PTSD prevention in youth. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jts.20517" target="_blank" rel="noreferrer noopener">10.1002/jts.20517</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Akron Children's Hospital
BLIND experiment
Browne Lorin
CHILDREN'S injuries
Christopher Norman C
Crow John P
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
GENDER differences (Psychology)
Journal of Traumatic Stress
NEOMED College of Medicine
Nugent Nicole R
Ostrowski Sarah
pharmacology
PLACEBOS (Medicine)
Propranolol
STRESS (Psychology)
TREATMENT of post-traumatic stress disorder
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1542/peds.2008-2427" target="_blank" rel="noreferrer noopener">http://doi.org/10.1542/peds.2008-2427</a>
Pages
888–894
Issue
3
Volume
124
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pediatric Urolithiasis: Clinical Predictors in the Emergency Department.
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
LOGISTIC regression analysis; CHILDREN'S hospitals; BLADDER stones; DISEASE risk factors; HEMATURIA in children; PEDIATRIC diagnosis; TOMOGRAPHY; URINALYSIS; URINARY calculi – Diagnosis
Creator
An entity primarily responsible for making the resource
Persaud Andre C; Stevenson Michelle D; McMahon Daniel R; Christopher Norman C
Description
An account of the resource
OBJECTIVE: The objective of this study was to identify factors that predict the presence of urolithiasis detected with unenhanced computed tomography (UCT) in children. METHODS: A retrospective study of all subjects \textless21 years of age who presented to the emergency department at Akron Children's Hospital and underwent UCT of the abdomen between January 2002 and December 2005 was performed. Demographic, clinical, diagnostic, treatment, and disposition data were abstracted by using a standardized form. Univariate and logistic regression analyses of factors associated with urolithiasis were performed. RESULTS: A total of 339 eligible patients were identified, with 110 cases of urolithiasis detected with UCT for 95 individual patients. The mean age of the study patients was 14.4 years; 72 patients (66%) were female. In 17 cases (15%) of urolithiasis, initial urinalysis results were negative for blood. Fifty-seven stones (51.8%) were ureteral, 26(23.6%) were renal, and 4 (3.6%) were in the bladder. Among children who did not have a stone identified through UCT, 23 cases (10%) of potentially significant, alternative diagnoses were identified. A history of urolithiasis, a history of nausea and vomiting, the presence of flank pain on examination, and \textgreater2 red blood cells per high-power field in urine microscopy were positively associated with urolithiasis. A history of fever or dysuria and costovertebral angle tenderness on physical examination were inversely associated with urolithiasis on UCT scans. CONCLUSIONS: UCT plays an important role in the diagnostic evaluation of children with flank pain. Approximately 15% of children with urolithiasis do not have hematuria. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/peds.2008-2427" target="_blank" rel="noreferrer noopener">10.1542/peds.2008-2427</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Akron Children's Hospital
BLADDER stones
CHILDREN'S hospitals
Christopher Norman C
Department of Emergency Medicine
Department of Pediatrics
DISEASE risk factors
HEMATURIA in children
LOGISTIC regression analysis
McMahon Daniel R
NEOMED College of Medicine
PEDIATRIC diagnosis
Pediatrics
Persaud Andre C
Stevenson Michelle D
Tomography
Urinalysis
URINARY calculi – Diagnosis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jts.20286" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jts.20286</a>
Pages
677–687
Issue
5
Volume
20
Dublin Core
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Title
A name given to the resource
Acute child and mother psychophysiological responses and subsequent PTSD symptoms following a child's traumatic event.
Publisher
An entity responsible for making the resource available
Journal of Traumatic Stress
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-10
Subject
The topic of the resource
MENTAL depression; POST-traumatic stress disorder; RESEARCH; STATISTICAL sampling; HYDROCORTISONE; CHILDREN; MOTHERS; TRAUMA centers; URINE
Creator
An entity primarily responsible for making the resource
Ostrowski Sarah A; Christopher Norman C; van Dulmen Manfred HM; Delahanty Douglas L
Description
An account of the resource
This study examined the relationship between acute cortisol responses to trauma and subsequent PTSD symptoms (PTSS) in children and their biological mothers. Urinary cortisol levels were assessed in 54 children aged 8–18 upon admission to a level-1 trauma center. Six weeks posttrauma, 15-hour urine samples were collected from children and their mothers. Depression and PTSS were assessed at 6 weeks (N = 44) and 7 months (N = 38) posttrauma. Higher child in-hospital cortisol significantly predicted 6-week child PTSS. This was true only for boys at 7 months. In mothers, lower 6-week cortisol levels significantly predicted 7-month PTSS. Results extend findings of differing directions of acute hormonal predictors of PTSS in adults versus children to a sample of genetically related individuals. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.1002/jts.20286" target="_blank" rel="noreferrer noopener">10.1002/jts.20286</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Akron Children's Hospital
Children
Christopher Norman C
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
Hydrocortisone
Journal of Traumatic Stress
MENTAL depression
Mothers
NEOMED College of Medicine
Ostrowski Sarah A
POST-traumatic stress disorder
Research
STATISTICAL sampling
Trauma Centers
Urine
van Dulmen Manfred HM
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/jpepsy/jsl005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/jpepsy/jsl005</a>
Pages
309–318
Issue
3
Volume
32
Dublin Core
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Title
A name given to the resource
Parental Posttraumatic Stress Symptoms as a Moderator of Child's Acute Biological Response and Subsequent Posttraumatic Stress Symptoms in Pediatric Injury Patients.
Publisher
An entity responsible for making the resource available
Journal of Pediatric Psychology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-04
Subject
The topic of the resource
POST-traumatic stress disorder; STRESS (Psychology); CHILDREN; NEUROSES; PARENTS
Creator
An entity primarily responsible for making the resource
Nugent Nicole R; Ostrowski Sarah; Christopher Norman C; Delahanty Douglas L
Description
An account of the resource
Objective To examine how parental responses following pediatric injury may influence their child's posttraumatic stress symptoms (PTSS). Methods Heart rate (HR) from 82 pediatric injury patients was measured during emergency medical services (EMSs) transport and following hospital admission. Twelve-hour urinary cortisol levels were assessed upon admission. Child PTSS and parental PTSS and general distress were assessed 6 weeks and 6 months after trauma. Results Six-week parental PTSS predicted 6-month child PTSS even after controlling for demographics and general parent distress (ΔR² = .08, p = .03). Parental PTSS moderated the relationship between (a) child cortisol levels and 6-month child PTSS (ΔR² = .08, p = .03) and between (b) hospital HR and 6-month child PTSS (ΔR² = .09, p = .03). Conclusion The present findings suggest that parental response to trauma may interact with child acute physiological responses to predict persistent child PTSS. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/jpepsy/jsl005" target="_blank" rel="noreferrer noopener">10.1093/jpepsy/jsl005</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Akron Children's Hospital
Children
Christopher Norman C
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
Journal of Pediatric Psychology
NEOMED College of Medicine
NEUROSES
Nugent Nicole R
Ostrowski Sarah
Parents
POST-traumatic stress disorder
STRESS (Psychology)
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/jpepsy/jsl003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/jpepsy/jsl003</a>
Pages
338–342
Issue
3
Volume
32
Dublin Core
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Title
A name given to the resource
Brief Report: The Impact of Maternal Posttraumatic Stress Disorder Symptoms and Child Gender on Risk for Persistent Posttraumatic Stress Disorder Symptoms in Child Trauma Victims.
Publisher
An entity responsible for making the resource available
Journal of Pediatric Psychology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-04
Subject
The topic of the resource
POST-traumatic stress disorder; STRESS (Psychology); CHILDREN; NEUROSES; TRAUMATIC neuroses
Creator
An entity primarily responsible for making the resource
Ostrowski Sarah A; Christopher Norman C; Delahanty Douglas L
Description
An account of the resource
Objective To longitudinally examine the impact of maternal posttraumatic stress disorder symptoms (PTSS) on child adjustment following a child's traumatic injury, focusing on child gender differences. Methods Forty-one child traumatic injury victims aged 8-18 years and their biological mothers were interviewed over two follow-ups (6 weeks and 7 months). Children were administered the Clinician-Administered Posttraumatic Stress Disorder (PTSD) Scale for Children and Adolescents (CAPS-CA), whereas mothers completed the CAPS. Results Six weeks post trauma, maternal PTSS were significantly related to PTSS in boys but not in girls. However, at 7 months, maternal PTSS were strongly related to child PTSS in both boys and girls. Significant 6-week maternal distress-child gender interactions suggested that maternal PTSS, especially avoidance, predicted greater 7-month PTSS but that this was primarily because of a significant relationship in females. Conclusions Maternal distress was found to negatively impact subsequent child adjustment, particularly in females. These results underscore the importance of considering family-centered interventions for child PTSD, especially in girls. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/jpepsy/jsl003" target="_blank" rel="noreferrer noopener">10.1093/jpepsy/jsl003</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Akron Children's Hospital
Children
Christopher Norman C
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
Journal of Pediatric Psychology
NEOMED College of Medicine
NEUROSES
Ostrowski Sarah A
POST-traumatic stress disorder
STRESS (Psychology)
TRAUMATIC neuroses
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1469-7610.2006.01648.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1469-7610.2006.01648.x</a>
Pages
919–926
Issue
9
Volume
47
Dublin Core
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Title
A name given to the resource
Emergency medical service and in-hospital vital signs as predictors of subsequent PTSD symptom severity in pediatric injury patients.
Publisher
An entity responsible for making the resource available
Journal of Child Psychology & Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-09
Subject
The topic of the resource
POST-traumatic stress disorder; CARDIOVASCULAR diseases; HEART beat; JUVENILE diseases; MEDICAL emergencies; PEDIATRIC trauma centers
Creator
An entity primarily responsible for making the resource
Nugent Nicole R; Christopher Norman C; Delahanty Douglas L
Description
An account of the resource
Background: The present study investigated the extent to which heart rate (HR) levels soon after a traumatic event predicted posttraumatic stress disorder (PTSD) symptom severity assessed 6 weeks and 6 months later in child trauma victims. Methods: Participants consisted of 82 children (56 boys, 26 girls) aged 8–18 who were admitted to a Midwestern trauma center. HR data were recorded from emergency medical services (EMS) records, upon admission to the emergency department (ED), for the first 20 minutes following admission, and upon discharge. Subsequent PTSD and depressive symptoms were assessed 6-weeks and 6-months post-trauma. Results: HR recorded during EMS transport was significantly correlated with PTSD symptoms at 6 weeks ( r = .42) and at 6 months ( r = .35). After removing the variance associated with demographic variables and depressive symptoms, HR during EMS transport and averaged over the first 20 minutes following admission significantly predicted 6-week PTSD symptoms. The first recorded EMS HR measure significantly predicted 6-month PTSD symptoms. HR averaged over the first 20 minutes of EMS transport and averaged over the first 20 minutes following admission marginally predicted 6-month PTSD symptoms ( ps = .051 and .079, respectively). Conclusions: The present findings suggest that physiological arousal soon after a traumatic event may be associated with increased risk for the development of PTSD symptoms in child trauma victims. These findings provide preliminary support for the use of acute cardiovascular levels as markers of child trauma victims at higher risk of developing symptoms of PTSD. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1469-7610.2006.01648.x" target="_blank" rel="noreferrer noopener">10.1111/j.1469-7610.2006.01648.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Akron Children's Hospital
CARDIOVASCULAR diseases
Christopher Norman C
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
HEART beat
Journal of Child Psychology & Psychiatry
JUVENILE diseases
MEDICAL emergencies
NEOMED College of Medicine
Nugent Nicole R
PEDIATRIC trauma centers
POST-traumatic stress disorder
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jts.20130" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jts.20130</a>
Pages
349–359
Issue
3
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Initial physiological responses and perceived hyperarousal predict subsequent emotional numbing in pediatric injury patients.
Publisher
An entity responsible for making the resource available
Journal of Traumatic Stress
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-06
Subject
The topic of the resource
AVOIDANCE (Psychology); POST-traumatic stress disorder; HOSPITAL emergency services; CHILDREN'S injuries; URINE; HEART beat; CHILDREN'S accidents; DEPRESSION in children; EMOTIONS (Psychology)
Creator
An entity primarily responsible for making the resource
Nugent Nicole R; Christopher Norman C; Delahanty Douglas L
Description
An account of the resource
The present study tested the hypothesis that acute posttraumatic hyperarousal would lead to the development of emotional numbing (EN) symptoms in a pediatric injury population. Eighty-two youths aged 8–18 years were recruited from the emergency department of a Midwestern children's hospital. Heart rate was recorded from emergency medical services reports and a 12-hour urine collection was initiated upon admission. Six weeks and 6 months later, depression and PTSD symptoms were assessed. Initial heart rate and urinary cortisol levels predicted 6-week and 6-month EN after controlling for concurrent depression, avoidance, and reexperiencing symptoms and 6-week hyperarousal symptoms. These findings provide empirical support for prior hypotheses concerning the development of PTSD symptoms over time. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jts.20130" target="_blank" rel="noreferrer noopener">10.1002/jts.20130</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Akron Children's Hospital
Avoidance (Psychology)
CHILDREN'S accidents
CHILDREN'S injuries
Christopher Norman C
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
DEPRESSION in children
EMOTIONS (Psychology)
HEART beat
HOSPITAL emergency services
Journal of Traumatic Stress
NEOMED College of Medicine
Nugent Nicole R
POST-traumatic stress disorder
Urine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1542/peds.2005-1100" target="_blank" rel="noreferrer noopener">http://doi.org/10.1542/peds.2005-1100</a>
Pages
1162–1168
Issue
4
Volume
117
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evaluation of Nonpharmacologic Methods of Pain and Anxiety Management for Laceration Repair in the Pediatric Emergency Department.
Publisher
An entity responsible for making the resource available
Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
PAIN management; CHILDREN; LETTERS to the editor; ANXIETY in children; DISTRACTION (Psychology); PAIN in children; PEDIATRIC emergency services
Creator
An entity primarily responsible for making the resource
Sinha Madhumita; Christopher Norman C; Fenn Robin; Reeves Laurie
Description
An account of the resource
BACKGROUND. Nonpharmacologic interventions, such as distraction, have been shown to be powerful adjuncts in reducing pain and anxiety in children with both acute and chronic painful conditions. There are no controlled studies evaluating these interventions as adjuncts to facilitate completion of painful procedures in the pediatric emergency department (ED). OBJECTIVE. We assessed the effectiveness of distraction techniques in reducing the sensory and affective components of pain among pediatric patients undergoing laceration repair in the ED. METHODS. Eligible children between 6 and 18 years of age (N = 240) presenting to the ED for laceration repair were randomly assigned to an intervention or control arm. Those assigned to the intervention arm were given a choice of age-appropriate distracters during laceration repair. Quantitative measures of pain intensity, situational anxiety, and pain distress (as perceived by the parent) were assessed by using the 7-point Facial Pain Scale, State Trait Anxiety Inventory for Children, and a visual analog scale, respectively, before and after laceration repair. The State Trait Anxiety Inventory for Children was performed in children ≥10 years of age. RESULTS. There was no difference in mean change in Facial Pain Scale scores between the control and the intervention groups in children \textless10 years of age. Multivariate analysis in this same age group showed that the intervention was independently associated with a reduction in pain distress as perceived by parents based on the mean change in visual analog scale scores. In older children, the intervention was independently associated with reduction in situational anxiety but not in pain intensity or in parental perception of pain distress. CONCLUSIONS. The use of distraction techniques is effective in reducing situational anxiety in older children and lowering parental perception of pain distress in younger children. This technique may have a role in improving the quality of management of procedural pain in a pediatric ED setting. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1542/peds.2005-1100" target="_blank" rel="noreferrer noopener">10.1542/peds.2005-1100</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Akron Children's Hospital
ANXIETY in children
Children
Christopher Norman C
Department of Emergency Medicine
Department of Pediatrics
DISTRACTION (Psychology)
Fenn Robin
LETTERS to the editor
NEOMED College of Medicine
PAIN in children
Pain Management
PEDIATRIC emergency services
Pediatrics
Reeves Laurie
Sinha Madhumita
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/1359104511406487" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/1359104511406487</a>
Pages
485–497
Issue
4
Volume
16
Dublin Core
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Title
A name given to the resource
The influence of family environment on dissociation in pediatric injury patients.
Publisher
An entity responsible for making the resource available
Clinical Child Psychology & Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-10
Subject
The topic of the resource
Female; Male; Ohio; Socioeconomic Factors; Child; Prospective Studies; Income; Self Report; Confidence Intervals; Family; Social Environment; Human; Semi-Structured Interview; Questionnaires; Chi Square Test; Descriptive Research; Descriptive Statistics; Funding Source; Scales; Correlational Studies; Data Analysis Software; Pretest-Posttest Design; Checklists; Adolescence; Pearson's Correlation Coefficient; Retrospective Design; Analysis of Covariance; Child Development; Bivariate Statistics; Severity of Illness Indices; Family Relations; Family Coping; Interview Guides; Parametric Statistics; Parenting Education; Patient-Family Relations; Dissociative Disorders – Risk Factors; Accidents – Adverse Effects; Wounds and Injuries – Complications
Creator
An entity primarily responsible for making the resource
Nugent Nicole R; Sledjeski Eve M; Christopher Norman C; Delahanty Douglas L
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/1359104511406487" target="_blank" rel="noreferrer noopener">10.1177/1359104511406487</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Accidents – Adverse Effects
Adolescence
Akron Children's Hospital
Analysis of Covariance
Bivariate Statistics
Checklists
Chi Square Test
Child
Child Development
Christopher Norman C
Clinical Child Psychology & Psychiatry
Confidence Intervals
Correlational Studies
Data Analysis Software
Delahanty Douglas L
Department of Emergency Medicine
Department of Pediatrics
Descriptive Research
Descriptive Statistics
Dissociative Disorders – Risk Factors
Family
Family Coping
Family Relations
Female
Funding Source
Human
Income
Interview Guides
Male
NEOMED College of Medicine
Nugent Nicole R
Ohio
Parametric Statistics
Parenting Education
Patient-Family Relations
Pearson's Correlation Coefficient
Pretest-Posttest Design
Prospective Studies
Questionnaires
Retrospective Design
Scales
Self Report
Semi-Structured Interview
Severity of Illness Indices
Sledjeski Eve M
Social Environment
Socioeconomic Factors
Wounds and Injuries – Complications
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1136/jmedgenet-2018-105800" target="_blank" rel="noreferrer noopener">http://doi.org/10.1136/jmedgenet-2018-105800</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
123-130
Issue
3
Volume
56
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics; Department of Integrative Medical Sciences
Affiliated Hospital
Akron Children's Hospital
Dublin Core
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Title
A name given to the resource
Diagnosis of 'possible' mitochondrial disease: an existential crisis.
Publisher
An entity responsible for making the resource available
Journal of medical genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
clinical genetics; diagnosis; evidence based practice; metabolic disorders
Creator
An entity primarily responsible for making the resource
Parikh Sumit; Karaa Amel; Goldstein Amy; Bertini Enrico Silvio; Chinnery Patrick F; Christodoulou John; Cohen Bruce H; Davis Ryan L; Falk Marni J; Fratter Carl; Horvath Rita; Koenig Mary Kay; Mancuso Michaelangelo; McCormack Shana; McCormick Elizabeth M; McFarland Robert; Nesbitt Victoria; Schiff Manuel; Steele Hannah; Stockler Silvia; Sue Carolyn; Tarnopolsky Mark; Thorburn David R; Vockley Jerry; Rahman Shamima
Description
An account of the resource
Primary genetic mitochondrial diseases are often difficult to diagnose, and the term 'possible' mitochondrial disease is used frequently by clinicians when such a diagnosis is suspected. There are now many known phenocopies of mitochondrial disease. Advances in genomic testing have shown that some patients with a clinical phenotype and biochemical abnormalities suggesting mitochondrial disease may have other genetic disorders. In instances when a genetic diagnosis cannot be confirmed, a diagnosis of 'possible' mitochondrial disease may result in harm to patients and their families, creating anxiety, delaying appropriate diagnosis and leading to inappropriate management or care. A categorisation of 'diagnosis uncertain', together with a specific description of the metabolic or genetic abnormalities identified, is preferred when a mitochondrial disease cannot be genetically confirmed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/jmedgenet-2018-105800" target="_blank" rel="noreferrer noopener">10.1136/jmedgenet-2018-105800</a>
2019
Akron Children's Hospital
Bertini Enrico Silvio
Chinnery Patrick F
Christodoulou John
clinical genetics
Cohen Bruce H
Davis Ryan L
Department of Integrative Medical Sciences
Department of Pediatrics
Diagnosis
evidence based practice
Falk Marni J
Fratter Carl
Goldstein Amy
Horvath Rita
Journal of medical genetics
Karaa Amel
Koenig Mary Kay
Mancuso Michaelangelo
McCormack Shana
McCormick Elizabeth M
McFarland Robert
metabolic disorders
NEOMED College of Medicine
Nesbitt Victoria
Parikh Sumit
Rahman Shamima
Schiff Manuel
Steele Hannah
Stockler Silvia
Sue Carolyn
Tarnopolsky Mark
Thorburn David R
Vockley Jerry
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00240-019-01133-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00240-019-01133-1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adolescents with urinary stones have elevated urine levels of inflammatory mediators
Publisher
An entity responsible for making the resource available
Urolithiasis
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-04
Subject
The topic of the resource
Biomarker; Cytokine; Innate immunity; Interleukin
Creator
An entity primarily responsible for making the resource
Kusumi Kirsten; Ketz John; Saxena Vijay; Spencer John David; Safadi Fayez; Schwaderer Andrew
Description
An account of the resource
Urinary stones are increasing in children, primarily during adolescence. Although urinary stones are often viewed in the context of intermittent stone events, increasing evidence indicates that stones are a metabolic process associated with chronic kidney disease and cardiovascular disease. These aforementioned stone-associated conditions may have pediatric origins. To compare urine inflammatory markers in otherwise healthy stone forming children versus matched controls. Urine samples were collected from 12 adolescents with urinary stones along with 15 controls. The levels of 30 urine cytokines were measured using a Mesoscale 30-Plex Human Cytokine panel and normalized to urine creatinine levels. Macrophage inflammatory protein 1β and interleukin 13 levels were significantly elevated in the urine of the stone forming adolescents compared to controls. Interleukin 17A was elevated in the urine of controls. This study indicates that urine levels of cytokines involved in chronic inflammation and fibrosis are elevated in urinary stone formers as early as adolescence. Because stone formers are at risk for chronic kidney disease, macrophage inflammatory protein 1β and interleukin 13 represent investigative targets.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00240-019-01133-1" target="_blank" rel="noreferrer noopener">10.1007/s00240-019-01133-1</a>
2019
Biomarker
Cytokine
Department of Pediatrics
Innate immunity
Interleukin
June 2019 Update
Ketz John
Kusumi Kirsten
NEOMED College of Medicine
Safadi Fayez
Saxena Vijay
Schwaderer Andrew
Spencer John David
urolithiasis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3928/19382359-20190219-02" target="_blank" rel="noreferrer noopener">http://doi.org/10.3928/19382359-20190219-02</a>
Pages
E121–E127
Issue
3
Volume
48
ISSN
0090-4481
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Title
A name given to the resource
Exercise-Induced Dyspnea in Children and Adolescents: Differential Diagnosis
Publisher
An entity responsible for making the resource available
Pediatric Annals
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-03
Subject
The topic of the resource
Pediatrics; adults; asthma; induced bronchoconstriction; hyperventilation; vocal-cord dysfunction
Creator
An entity primarily responsible for making the resource
Bhatia R; Abu-Hasan M; Weinberger M
Description
An account of the resource
Exercise-induced dyspnea in children and adolescents can occur for many reasons. Although asthma is the common cause, failure to prevent exercise-induced asthma by pretreatment with a bronchodilator, such as albuterol, indicates that other etiologies should be considered. Other causes of exercise-induced dyspnea include exercise-induced vocal cord dysfunction, exercise-induced laryngomalacia, exercise-induced hyperventilation, chest wall restrictive abnormalities, cardiac causes, and normal physiologic limitation. When exercise-induced dyspnea is not from asthma, cardiopulmonary exercise testing with reproduction of the patient's dyspnea is the means to identify the other causes. Cardiopulmonary exercise testing monitors oxygen use, carbon-dioxide production, end-tidal pCO(2) (partial pressure of carbon dioxide), and electrocardiogram. Additional components to testing are measurement of blood pH and pCO(2) when symptoms are reproduced, and selective flexible laryngoscopy when upper airway obstruction is observed to specifically identify vocal cord dysfunction or laryngomalacia. This approach is a highly effective means to identify exercise-induced dyspnea that is not caused by asthma.
Identifier
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<a href="http://doi.org/10.3928/19382359-20190219-02" target="_blank" rel="noreferrer noopener">10.3928/19382359-20190219-02</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2019
Abu-Hasan M
adults
asthma
Bhatia R
Department of Pediatrics
hyperventilation
induced bronchoconstriction
June 2019 Update
NEOMED College of Medicine
Pediatric Annals
Pediatrics
vocal-cord dysfunction
Weinberger M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1136/annrheumdis-2019-216040" target="_blank" rel="noreferrer noopener">http://doi.org/10.1136/annrheumdis-2019-216040</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1722-1731
Issue
12
Volume
78
ISSN
1468-2060
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Title
A name given to the resource
Emergent high fatality lung disease in systemic juvenile arthritis
Publisher
An entity responsible for making the resource available
Annals Of The Rheumatic Diseases
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-12
Subject
The topic of the resource
treatment; inflammation; adult onset still's disease; DMARDs (biologic); juvenile idiopathic arthritis
Creator
An entity primarily responsible for making the resource
Saper Vivian E; Chen Guangbo; Deutsch Gail H; Guillerman R Paul; Birgmeier Johannes; Jagadeesh Karthik; Canna Scott; Schulert Grant; Deterding Robin; Xu Jianpeng; Leung Ann N; Bouzoubaa Layla; Abulaban Khalid; Baszis Kevin; Behrens Edward M; Birmingham James; Casey Alicia; Cidon Michal; Cron Randy Q; De Aliva; De Benedetti Fabrizio; Ferguson Ian; Fishman Martha P; Goodman Steven I; Graham T Brent; Grom Alexei A; Haines Kathleen; Hazen Melissa; Henderson Lauren A; Ho Assunta; Ibarra Maria; Inman Christi J; Jerath Rita; Khawaja Khulood; Kingsbury Daniel J; Klein-Gitelman Marisa; Lai Khanh; Lapidus Sivia; Lin Clara; Lin Jenny; Liptzin Deborah R; Milojevic Diana; Mombourquette Joy; Onel Karen; Ozen Seza; Perez Maria; Phillippi Kathryn; Prahalad Sampath; Radhakrishna Suhas; Reinhardt Adam; Riskalla Mona; Rosenwasser Natalie; Roth Johannes; Schneider Rayfel; Schonenberg-Meinema Dieneke; Shenoi Susan; Smith Judith A; Sönmez Hafize Emine; Stoll Matthew L; Towe Christopher; Vargas Sara O; Vehe Richard K; Young Lisa R; Yang Jacqueline; Desai Tushar; Balise Raymond; Lu Ying; Tian Lu; Bejerano Gill; Davis Mark M; Khatri Purvesh; Mellins Elizabeth D; Childhood Arthritis and Rheumatology Research Alliance Registry Investigators
Description
An account of the resource
OBJECTIVE: To investigate the characteristics and risk factors of a novel parenchymal lung disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). METHODS: In a multicentre retrospective study, 61 cases were investigated using physician-reported clinical information and centralised analyses of radiological, pathological and genetic data. RESULTS: LD was associated with distinctive features, including acute erythematous clubbing and a high frequency of anaphylactic reactions to the interleukin (IL)-6 inhibitor, tocilizumab. Serum ferritin elevation and/or significant lymphopaenia preceded LD detection. The most prevalent chest CT pattern was septal thickening, involving the periphery of multiple lobes ± ground-glass opacities. The predominant pathology (23 of 36) was pulmonary alveolar proteinosis and/or endogenous lipoid pneumonia (PAP/ELP), with atypical features including regional involvement and concomitant vascular changes. Apparent severe delayed drug hypersensitivity occurred in some cases. The 5-year survival was 42%. Whole exome sequencing (20 of 61) did not identify a novel monogenic defect or likely causal PAP-related or macrophage activation syndrome (MAS)-related mutations. Trisomy 21 and young sJIA onset increased LD risk. Exposure to IL-1 and IL-6 inhibitors (46 of 61) was associated with multiple LD features. By several indicators, severity of sJIA was comparable in drug-exposed subjects and published sJIA cohorts. MAS at sJIA onset was increased in the drug-exposed, but was not associated with LD features. CONCLUSIONS: A rare, life-threatening lung disease in sJIA is defined by a constellation of unusual clinical characteristics. The pathology, a PAP/ELP variant, suggests macrophage dysfunction. Inhibitor exposure may promote LD, independent of sJIA severity, in a small subset of treated patients. Treatment/prevention strategies are needed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1136/annrheumdis-2019-216040" target="_blank" rel="noreferrer noopener">10.1136/annrheumdis-2019-216040</a>
PMID: 31562126
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Abulaban Khalid
adult onset still's disease
Akron Children's Hospital
Annals of the rheumatic diseases
Balise Raymond
Baszis Kevin
Behrens Edward M
Bejerano Gill
Birgmeier Johannes
Birmingham James
Bouzoubaa Layla
Canna Scott
Casey Alicia
Chen Guangbo
Childhood Arthritis and Rheumatology Research Alliance Registry Investigators
Cidon Michal
Cron Randy Q
Davis Mark M
De Aliva
De Benedetti Fabrizio
Department of Pediatrics
Desai Tushar
Deterding Robin
Deutsch Gail H
DMARDs (biologic)
Ferguson Ian
Fishman Martha P
Goodman Steven I
Graham T Brent
Grom Alexei A
Guillerman R Paul
Haines Kathleen
Hazen Melissa
Henderson Lauren A
Ho Assunta
Ibarra Maria
Inflammation
Inman Christi J
Jagadeesh Karthik
Jerath Rita
Journal Article
juvenile idiopathic arthritis
Khatri Purvesh
Khawaja Khulood
Kingsbury Daniel J
Klein-Gitelman Marisa
Lai Khanh
Lapidus Sivia
Leung Ann N
Lin Clara
Lin Jenny
Liptzin Deborah R
Lu Ying
Mellins Elizabeth D
Milojevic Diana
Mombourquette Joy
NEOMED College of Medicine
November 2019 Update
Onel Karen
Ozen Seza
Perez Maria
Phillippi Kathryn
Prahalad Sampath
Radhakrishna Suhas
Reinhardt Adam
Riskalla Mona
Rosenwasser Natalie
Roth Johannes
Saper Vivian E
Schneider Rayfel
Schonenberg-Meinema Dieneke
Schulert Grant
Shenoi Susan
Smith Judith A
Sönmez Hafize Emine
Stoll Matthew L
Tian Lu
Towe Christopher
Treatment
Vargas Sara O
Vehe Richard K
Xu Jianpeng
Yang Jacqueline
Young Lisa R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/head.13681" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/head.13681</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1871-1873
Issue
10
Volume
59
ISSN
1526-4610
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pediatric Migraine Action Plan (PedMAP)
Publisher
An entity responsible for making the resource available
Headache
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-11
Creator
An entity primarily responsible for making the resource
Turner Scott B; Rende Elizabeth K; Pezzuto Tara; Weaver Samantha; Henderlong-Kropp Annmarie; Greene Kaitlin A; Bicknese Alma R; Dilts Jennifer J; Gautreaux Jennifer; Victorio M Cristina C; Strauss Lauren D; Lagman-Bartolome Ana Marissa; Szperka Christina L; Yonker Marcy; Hershey Andrew D; Gelfand Amy A
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/head.13681" target="_blank" rel="noreferrer noopener">10.1111/head.13681</a>
PMID: 31710105
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Akron Children's Hospital
Bicknese Alma R
Department of Pediatrics
Dilts Jennifer J
Gautreaux Jennifer
Gelfand Amy A
Greene Kaitlin A
Headache
Henderlong-Kropp Annmarie
Hershey Andrew D
Journal Article
Lagman-Bartolome Ana Marissa
NEOMED College of Medicine
November 2019 Update
Pezzuto Tara
Rende Elizabeth K
Strauss Lauren D
Szperka Christina L
Turner Scott B
Victorio M Cristina C
Weaver Samantha
Yonker Marcy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/978-3-030-12771-8_46" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/978-3-030-12771-8_46</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
151
ISSN
3-030-12771-0
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ugh
Publisher
An entity responsible for making the resource available
Health Disparities : Weaving A New Understanding Through Case Narratives
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019
Subject
The topic of the resource
Pediatrics; Mental health; Medicine; Social Work; Medicine & Public Health; Health Psychology; Medical Sociology; Premedical Education; Family support
Creator
An entity primarily responsible for making the resource
Sladjana Courson
Description
An account of the resource
Ugh. I am ashamed to say that is the first word that comes to my mind when I see Jake’s name on my schedule for the day. He is 10 and he has been my patient since he was born. He has an 8-year-old sister Annie and a 5-year-old brother Jimmy. They usually all come in together with their mother even if only one of them has an appointment that day.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/978-3-030-12771-8_46" target="_blank" rel="noreferrer noopener">10.1007/978-3-030-12771-8_46</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Akron Children's Hospital
Department of Pediatrics
Family support
Health Disparities : Weaving A New Understanding Through Case Narratives
Health Psychology
Journal Article
Medical Sociology
Medicine
Medicine & Public Health
Mental Health
NEOMED College of Medicine
November 2019 Update
Pediatrics
Premedical Education
Sladjana Courson
Social Work
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/neuonc/noz175.767" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/neuonc/noz175.767</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S57-S58
Issue
4, SI
Volume
66
ISSN
1545-5009
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1093/neuonc/noz175.767" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1093/neuonc/noz175.767</a>
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chemotherapy Strategies for Young Children Newly-Diagnosed with Medulloblastoma up to the Era of Molecular Profiling - A Comparative Outcomes Analysis
Publisher
An entity responsible for making the resource available
Pediatric Blood & Cancer
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-12
Creator
An entity primarily responsible for making the resource
Finlay J; Mynarek M; Dhall G; Lafay-Cousin L; Mazewski C M; Ashley D; Cohen B H; von Bueren A O; Gerber N; Leary S; Geyer J R; Tait D; Gajjar A; Rutkowski S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/neuonc/noz175.767" target="_blank" rel="noreferrer noopener">10.1093/neuonc/noz175.767</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2019
Akron Children's Hospital
Ashley D
Cohen B H
Department of Integrative Medical Sciences
Department of Pediatrics
Dhall G
Finlay J
Gajjar A
Gerber N
Geyer J R
Journal Article
Lafay-Cousin L
Leary S
Mazewski C M
Mynarek M
NEOMED College of Medicine
November 2019 Update
Pediatric blood & cancer
Rutkowski S
Tait D
von Bueren A O
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/PEC.0000000000002046" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/PEC.0000000000002046</a>
Pages
e96-e98
Issue
2
Volume
36
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<a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1097/PEC.0000000000002046" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1097/PEC.0000000000002046</a>
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
What Is That? Innumerable Mysterious Densities Identified on Abdominal Imaging.
Publisher
An entity responsible for making the resource available
Pediatric emergency care
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-02
Creator
An entity primarily responsible for making the resource
Kaiser Nicole; Blackford Martha G
Description
An account of the resource
Radiopaque densities can be observed on imaging after the ingestion of either foreign bodies or some medications. Our case report discusses an 11-year-old boy with autism spectrum disorder and attention deficient disorder who presented to the emergency department because of concerns for constipation and dehydration. Incidentally, an abdominal x-ray showed numerous radiopaque densities throughout his intestines in addition to his constipation. He was admitted, and his home regimen was reviewed to attempt to identify a potential source for these radiopaque densities. This case presented an interesting teaching opportunity in the identification of the radiopaque densities and review of pharmacokinetics.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/PEC.0000000000002046" target="_blank" rel="noreferrer noopener">10.1097/PEC.0000000000002046</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2020
Akron Children's Hospital
Blackford Martha G
Department of Pediatrics
Kaiser Nicole
NEOMED College of Medicine
Pediatric emergency care
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00240-020-01183-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00240-020-01183-w</a>
ISSN
2194-7236 2194-7228
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics; Department of Anatomy & Neurobiology
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Bone mineral density in adolescent urinary stone formers: is sex important?
Publisher
An entity responsible for making the resource available
Urolithiasis
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03-31
Subject
The topic of the resource
Bone; children; disease; fracture; health; inflammation; kidney-stones; nephrolithiasis; osteoporosis; Pediatrics; risk; Sex; Urolithiasis; Urolithiasis
Creator
An entity primarily responsible for making the resource
Kusumi Kirsten; Schwaderer Andrew L; Clark Curtis; Budge Kevin; Hussein Nazar; Raina Rupesh; Denburg Michelle; Safadi Fayez F
Description
An account of the resource
Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This pilot study was undertaken to assess an adolescent kidney stone cohort's BMD and evaluate for an inverse correlation between BMD and urine concentration of lithogenic minerals and/or inflammatory levels. Prospective case-control study was carried out at a large pediatric center. 15 participants with USD (12-18 years of age, 8 female) were matched by age, sex, and body mass index to 15 controls. Lumbar and total body BMD z-score did not differ between groups. When stone formers were separated by sex, there was a significant difference between male stone formers vs. controls total body BMD z-score (Fig. 1). BMD z-score did not significantly correlate with urine calcium, oxalate, citrate or magnesium. Higher urine IL-13 did significantly correlate with higher total body BMD z-score (r = 0.677, p = 0.018). Total body BMD z-score did significantly correlate with body mass index (BMI) as expected for the control group (r = 0.6321, p = 0.0133). However, this relationship was not present in the USD group (r = - 0.1629, p = 0.5619). This is a small but hypothesis-generating study which demonstrates novel evidence of male-specific low BMD in adolescent stone formers. Furthermore, we demonstrated a positive association between urine
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00240-020-01183-w" target="_blank" rel="noreferrer noopener">10.1007/s00240-020-01183-w</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Akron Children's Hospital
Bone
Budge Kevin
Children
Clark Curtis
Denburg Michelle
Department of Anatomy & Neurobiology
Department of Pediatrics
Disease
Fracture
Health
Hussein Nazar
Inflammation
Journal Article
journalArticle
June 2020 Update I
kidney-stones
Kusumi Kirsten
NEOMED College of Medicine
nephrolithiasis
Osteoporosis
Pediatrics
Raina Rupesh
Risk
Safadi Fayez F
Schwaderer Andrew L
sex
urolithiasis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1212/NXG.0000000000000402" target="_blank" rel="noreferrer noopener">http://doi.org/10.1212/NXG.0000000000000402</a>
Pages
e402
Issue
2
Volume
6
ISSN
2376-7839 2376-7839
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics; Department of Integrative Medical Sciences
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mitochondrial diseases in North America: An analysis of the NAMDC Registry.
Publisher
An entity responsible for making the resource available
Neurology. Genetics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-04
Subject
The topic of the resource
criteria; dna; melas; merrf; natural-history; nuclear; prevalence
Creator
An entity primarily responsible for making the resource
Barca Emanuele; Long Yuelin; Cooley Victoria; Schoenaker Robert; Emmanuele Valentina; DiMauro Salvatore; Cohen Bruce H; Karaa Amel; Vladutiu Georgirene D; Haas Richard; Van Hove Johan L K; Scaglia Fernando; Parikh Sumit; Bedoyan Jirair K; DeBrosse Susanne D; Gavrilova Ralitza H; Saneto Russell P; Enns Gregory M; Stacpoole Peter W; Ganesh Jaya; Larson Austin; Zolkipli-Cunningham Zarazuela; Falk Marni J; Goldstein Amy C; Tarnopolsky Mark; Gropman Andrea; Camp Kathryn; Krotoski Danuta; Engelstad Kristin; Rosales Xiomara Q; Kriger Joshua; Grier Johnston; Buchsbaum Richard; Thompson John L P; Hirano Michio
Description
An account of the resource
Objective: To describe clinical, biochemical, and genetic features of participants with mitochondrial diseases (MtDs) enrolled in the North American Mitochondrial Disease Consortium (NAMDC) Registry. Methods: This cross-sectional, multicenter, retrospective database analysis evaluates the phenotypic and molecular characteristics of participants enrolled in the NAMDC Registry from September 2011 to December 2018. The NAMDC is a network of 17 centers with expertise in MtDs and includes both adult and pediatric specialists. Results: One thousand four hundred ten of 1,553 participants had sufficient clinical data for analysis. For this study, we included only participants with molecular genetic diagnoses (n = 666). Age at onset ranged from infancy to adulthood. The most common diagnosis was multisystemic disorder (113 participants), and only a minority of participants were diagnosed with a classical mitochondrial syndrome. The most frequent classical syndromes were Leigh syndrome (97 individuals) and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (71 individuals). Pathogenic variants in the mitochondrial DNA were more frequently observed (414 participants) than pathogenic nuclear gene variants (252 participants). Pathogenic variants in 65 nuclear genes were identified, with POLG1 and PDHA1 being the most commonly affected. Pathogenic variants in 38 genes were reported only in single participants. Conclusions: The NAMDC Registry data confirm the high variability of clinical, biochemical, and genetic features of participants with MtDs. This study serves as an important resource for future enhancement of MtD research and clinical care by providing the first comprehensive description of participant with MtD in North America.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1212/NXG.0000000000000402" target="_blank" rel="noreferrer noopener">10.1212/NXG.0000000000000402</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Akron Children's Hospital
Barca Emanuele
Bedoyan Jirair K
Buchsbaum Richard
Camp Kathryn
Cohen Bruce H
Cooley Victoria
criteria
DeBrosse Susanne D
Department of Integrative Medical Sciences
Department of Pediatrics
DiMauro Salvatore
DNA
Emmanuele Valentina
Engelstad Kristin
Enns Gregory M
Falk Marni J
Ganesh Jaya
Gavrilova Ralitza H
Goldstein Amy C
Grier Johnston
Gropman Andrea
Haas Richard
Hirano Michio
Journal Article
journalArticle
June 2020 Update I
Karaa Amel
Kriger Joshua
Krotoski Danuta
Larson Austin
Long Yuelin
melas
merrf
natural-history
NEOMED College of Medicine
Neurology. Genetics
nuclear
Parikh Sumit
Prevalence
Rosales Xiomara Q
Saneto Russell P
Scaglia Fernando
Schoenaker Robert
Stacpoole Peter W
Tarnopolsky Mark
Thompson John L P
Van Hove Johan L K
Vladutiu Georgirene D
Zolkipli-Cunningham Zarazuela
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1212/WNL.0000000000009525" target="_blank" rel="noreferrer noopener">http://doi.org/10.1212/WNL.0000000000009525</a>
ISSN
1526-632X 0028-3878
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update II
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Department of Integrative Medical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quality improvement in neurology: Neurology Outcomes Quality Measurement Set.
Publisher
An entity responsible for making the resource available
Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05-12
Creator
An entity primarily responsible for making the resource
Sico Jason J; Sarwal Aarti; Benish Sarah M; Busis Neil A; Cohen Bruce H; Das Rohit R; Finsilver Shari; Halperin John J; Kelly Adam G; Meunier Lisa; Phipps Michael S; Thirumala Parthasarathy D; Villanueva Raissa; von Gaudecker Jane; Bennett Amy; Shenoy Anant M
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1212/WNL.0000000000009525" target="_blank" rel="noreferrer noopener">10.1212/WNL.0000000000009525</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Benish Sarah M
Bennett Amy
Busis Neil A
Cohen Bruce H
Das Rohit R
Department of Integrative Medical Sciences
Department of Pediatrics
Finsilver Shari
Halperin John J
journalArticle
June 2020 Update II
Kelly Adam G
Meunier Lisa
NEOMED College of Medicine
Neurology
Phipps Michael S
Sarwal Aarti
Shenoy Anant M
Sico Jason J
Thirumala Parthasarathy D
Villanueva Raissa
von Gaudecker Jane
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/oncotarget.27583</a>
Pages
1876–1893
Issue
20
Volume
11
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma.
Publisher
An entity responsible for making the resource available
Oncotarget
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05
Subject
The topic of the resource
DNA methylation; neuronatin; osteosarcoma; tumor suppressor genes
Creator
An entity primarily responsible for making the resource
Saeed H; Sinha S; Mella C; Kuerbitz JS; Cales ML; Steele MA; Stanke J; Damron D; Safadi F; Kuerbitz SJ
Description
An account of the resource
The paternally imprinted neuronatin (NNAT) gene has been identified as a target of aberrant epigenetic silencing in diverse cancers, but no association with pediatric bone cancers has been reported to date. In screening childhood cancers, we identified aberrant CpG island hypermethylation in a majority of osteosarcoma (OS) samples and in 5 of 6 human OS cell lines studied but not in normal bone-derived tissue samples. CpG island hypermethylation was associated with transcriptional silencing in human OS cells, and silencing was reversible upon treatment with
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">10.18632/oncotarget.27583</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Cales ML
Damron D
Department of Anatomy & Neurobiology
Department of Pediatrics
Department of Pharmaceutical Sciences
DNA Methylation
journalArticle
July 2020 List
Kuerbitz JS
Kuerbitz SJ
Mella C
NEOMED College of Medicine
NEOMED College of Pharmacy
neuronatin
Oncotarget
osteosarcoma
Saeed H
Safadi F
Sinha S
Stanke J
Steele MA
tumor suppressor genes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/pbc.28599" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/pbc.28599</a>
Pages
e28599
ISSN
1545-5009
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Family & Community Medicine
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
"Living life as if i never had cancer": A study of the meaning of living well in adolescents and young adults who have experienced cancer
Publisher
An entity responsible for making the resource available
Pediatric Blood & Cancer
Subject
The topic of the resource
childhood; definition; quality of life; advance care planning; cancer; adolescent; advance care
Creator
An entity primarily responsible for making the resource
Schreiner K; Grossoehme DH; Friebert S; Baker JN; Needle J; Lyon ME
Description
An account of the resource
Background Cancer diagnoses pose challenges to adolescents' and young adults' (AYA) physical, mental, and emotional health, and developmental tasks. In order for AYAs, caregivers, clinicians, and other collaborators to optimize health outcomes (coproduction of health), understanding what living well means for AYAs who have experienced cancer is necessary. The objective was to develop an empirical definition of "living well" for AYAs who have experienced cancer to broadly understand AYA values and priorities. This definition may ultimately guide future conversations between caregivers and AYAs, eliciting thorough, personal definitions of living well from individual AYAs. Such conversations may enhance AYA participation in coproducing their health. Procedure Qualitative analysis using a phenomenological approach of N = 30 structuredRespecting Choicesinterviews conducted with AYAs (14-21 years; mean 84.2 [SD 69] months postcancer diagnosis with 21% on active treatment) from four tertiary pediatric hospitals in the context of a primary study of a pediatric advance care planning intervention trial. Results AYAs who have experienced cancer conceptualized "living well" as maintaining physical, mental, and emotional health, as well as engaging in purposeful, age-appropriate activities with people important to them. Living well had three components: living mindfully, living an identity as a healthy AYA, and spending time with friends and family. Conclusions Conversations with AYAs who have experienced cancer elicited rich, complex concepts of "living well." Provider initiation of discussions about living well may facilitate personalized goals of care conversations. This study may serve as the basis to design and prototype future clinical interventions to enhance AYA engagement.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/pbc.28599" target="_blank" rel="noreferrer noopener">10.1002/pbc.28599</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
Adolescent
advance care
advance care planning
Akron Children's Hospital
August 2020 List
Baker JN
Cancer
childhood
definition
Department of Family & Community Medicine
Department of Pediatrics
Friebert S
Grossoehme DH
journalArticle
Lyon ME
Needle J
NEOMED College of Medicine
Pediatric blood & cancer
Quality of Life
Schreiner K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1212/wnl.0000000000009525" target="_blank" rel="noreferrer noopener">http://doi.org/10.1212/wnl.0000000000009525</a>
Pages
982-990
Issue
22
Volume
94
ISSN
1526-632X 0028-3878
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Update Year & Number
September 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Quality improvement in neurology: neurology outcomes quality measurement set.
Publisher
An entity responsible for making the resource available
Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-06-02
Subject
The topic of the resource
Humans; Physician-Patient Relations; Quality of Life/psychology; Quality Improvement/standards; Nervous System Diseases/diagnosis/psychology/therapy; Neurology/methods/standards; Outcome Assessment Health Care/methods/standards; Quality Indicators Health Care/standards
Creator
An entity primarily responsible for making the resource
Sico JJ;Sarwal A;Benish SM;Busis NA;Cohen BH;Das RR;Finsilver S;Halperin JJ;Kelly AG;Meunier L;Phipps MS;Thirumala PD;Villanueva R;von Gaudecker J;Bennett A;Shenoy AM
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1212/wnl.0000000000009525" target="_blank" rel="noreferrer noopener">10.1212/wnl.0000000000009525</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Benish SM
Bennett A
Busis NA
Cohen BH
Das RR
Department of Pediatrics
Finsilver S
Halperin JJ
Humans
journalArticle
Kelly AG
Meunier L
NEOMED College of Medicine
Nervous System Diseases/diagnosis/psychology/therapy
Neurology
Neurology/methods/standards
Outcome Assessment Health Care/methods/standards
Phipps MS
Physician-Patient Relations
Quality Improvement/standards
Quality Indicators Health Care/standards
Quality of Life/psychology
Sarwal A
September 2020 List
Shenoy AM
Sico JJ
Thirumala PD
Villanueva R
von Gaudecker J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3949/ccjm.87a.19154" target="_blank" rel="noreferrer noopener">http://doi.org/10.3949/ccjm.87a.19154</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
671-682
Issue
11
Volume
87
ISSN
1939-2869 0891-1150
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3949/ccjm.87a.19154" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3949/ccjm.87a.19154</a>
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Using and interpreting electrodiagnostic tests.
Publisher
An entity responsible for making the resource available
Cleveland Clinic Journal of Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11-02
Creator
An entity primarily responsible for making the resource
Ginsberg MR;Morren JA;Levin K
Description
An account of the resource
Electrodiagnostic testing, consisting of nerve conduction studies and needle electrode examination, serves as an extension of a neurologic examination for evaluating a variety of focal and generalized neuromuscular conditions. By providing important clues on location, chronicity, severity, and pathophysiology, it can help to establish a diagnosis, evaluate the need for surgery, and assess patients who do not improve as expected after surgery.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3949/ccjm.87a.19154" target="_blank" rel="noreferrer noopener">10.3949/ccjm.87a.19154</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Akron Children's Hospital
Cleveland Clinic journal of medicine
Department of Pediatrics
Ginsberg MR
journalArticle
Levin K
Morren JA
NEOMED College of Medicine
October 2020 List
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jpeds.2020.10.040" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jpeds.2020.10.040</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1097-6833 0022-3476
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.jpeds.2020.10.040" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.jpeds.2020.10.040</a>
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Improving pediatric readiness in general emergency departments: A prospective interventional study.
Publisher
An entity responsible for making the resource available
The Journal of Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-30
Subject
The topic of the resource
emergency medicine; EMSC; facility recognition; Pediatric readiness
Creator
An entity primarily responsible for making the resource
Abulebda K;Whitfill T;Montgomery EE;Thomas A;Dudas RA;Leung JS;Scherzer DJ;Aberesold M;Van IWL;Kant S;Walls TA;Sessa AK;Janofsky S;Fenster DB;Kessler DO;Chatfield J;Okada P;Arteaga G M;Berg MD;Knight LJ;Keilman A;Makharashvili A;Good G;Bingham L;Mathias EJ;Nagy K;Hamilton MF;Vora S;Mathias K;Auerbach M A
Description
An account of the resource
OBJECTIVE: To describe the impact of a national interventional collaborative on pediatric readiness within General Emergency Departments. STUDY DESIGN: A prospective, multicenter, interventional study measured pediatric readiness in general emergency departments before and after participation in a pediatric readiness improvement intervention. Pediatric readiness was assessed using the weighted pediatric readiness score (WPRS) on a 100-point scale. The study protocol extended over six months and involved three phases: 1) a baseline on-site assessment of pediatric readiness and simulated quality of care, 2) pediatric readiness interventions, and 3) a follow-up on-site assessment of WPRS. The intervention phase included a benchmarking performance report, resources toolkits, and ongoing interactions between general emergency departments and academic medical centers. RESULTS: Thirty-six general emergency departments were enrolled, and 34 (94%) completed the study. Four EDs (11%) were located in Canada, and the rest were in the U.S. The mean improvement in WPRS was 16.3 (p<0.001) from a baseline of 62.4 (SEM=2.2) to 78.7 (SEM=2.1), with significant improvement in the domains of administration/coordination of care; policies, protocol and procedures; and quality improvement. Six EDs (17%) were fully adherent to the protocol timeline. CONCLUSION: Implementing a collaborative intervention model including simulation and quality improvement initiatives is associated with improvement in weighted pediatric readiness scores (WPRS) when disseminated to a diverse group of general emergency departments partnering with their regional pediatric academic medical centers. This work provides evidence that innovative collaboration facilitated by academic medical centers can serve as an effective strategy to improve pediatric readiness and processes of care.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jpeds.2020.10.040" target="_blank" rel="noreferrer noopener">10.1016/j.jpeds.2020.10.040</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Aberesold M
Abulebda K
Akron Children's Hospital
Arteaga G M
Auerbach M A
Berg MD
Bingham L
Chatfield J
Department of Pediatrics
Dudas RA
Emergency Medicine
EMSC
facility recognition
Fenster DB
Good G
Hamilton MF
Janofsky S
journalArticle
Kant S
Keilman A
Kessler DO
Knight LJ
Leung JS
Makharashvili A
Mathias EJ
Mathias K
Montgomery EE
Nagy K
NEOMED College of Medicine
October 2020 List
Okada P
Pediatric readiness
Scherzer DJ
Sessa AK
The Journal of pediatrics
Thomas A
Van IWL
Vora S
Walls TA
Whitfill T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ymgme.2020.09.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ymgme.2020.09.006</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1096-7206 1096-7192
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Department of General Surgery
NEOMED Student Publications
Affiliated Hospital
Akron Children's Hospital
Summa Health System Akron City Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Biochemical phenotype and its relationship to treatment in 16 individuals with PCCB c.1606A > G (p.Asn536Asp) variant propionic acidemia.
Publisher
An entity responsible for making the resource available
Molecular Genetics and Metabolism
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-03
Subject
The topic of the resource
Treatment; Phenotype; Biomarker; Propionic acidemia
Creator
An entity primarily responsible for making the resource
Wenger O;Brown M;Smith B;Chowdhury D;Crosby AH;Baple EL;Yoder M;Laxen W;Tortorelli S;Strauss KA
Description
An account of the resource
Propionic acidemia (PA) is caused by inherited deficiency of mitochondrial propionyl-CoA carboxylase (PCC) and results in significant neurodevelopmental and cardiac morbidity. However, relationships among therapeutic intervention, biochemical markers, and disease progression are poorly understood. Sixteen individuals homozygous for PCCB c.1606A > G (p.Asn536Asp) variant PA participated in a two-week suspension of therapy. Standard metabolic markers (plasma amino acids, blood spot methylcitrate, plasma/urine acylcarnitines, urine organic acids) were obtained before and after stopping treatment. These same markers were obtained in sixteen unaffected siblings. Echocardiography and electrocardiography were obtained from all subjects. We characterized the baseline biochemical phenotype of untreated PCCB c.1606A > G homozygotes and impact of treatment on PCC deficiency biomarkers. Therapeutic regimens varied widely. Suspension of therapy did not significantly alter branched chain amino acid levels, their alpha-ketoacid derivatives, or urine ketones. Carnitine supplementation significantly increased urine propionylcarnitine and its ratio to total carnitine. Methylcitrate blood spot and urine levels did not correlate with other biochemical measures or cardiac outcomes. Treatment of PCCB c.1606A > G homozygotes with protein restriction, prescription formula, and/or various dietary supplements has a limited effect on core biomarkers of PCC deficiency. These patients require further longitudinal study with standardized approaches to better understand the relationship between biomarkers and disease burden.
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<a href="http://doi.org/10.1016/j.ymgme.2020.09.006" target="_blank" rel="noreferrer noopener">10.1016/j.ymgme.2020.09.006</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Baple EL
Biomarker
Brown M
Chowdhury D
Crosby AH
Department of General Surgery
Department of Pediatrics
journalArticle
Laxen W
Molecular Genetics and Metabolism
NEOMED College of Medicine
NEOMED Student Publications
October 2020 List
Phenotype
Propionic acidemia
Smith B
Strauss KA
Tortorelli S
Treatment
Wenger O
Yoder M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S89
Issue
2
Volume
55
ISSN
8755-6863
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Dublin Core
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Title
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Predictors of technology success in patients with cystic fibrosis-related diabetes
Publisher
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Pediatric Pulmonology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10
Creator
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Jain A;Kaminski B;Kutney KA
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Department of Pediatrics
Jain A
journalArticle
Kaminski B
Kutney KA
October 2020 List
Pediatric Pulmonology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/noajnl/vdaa135" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/noajnl/vdaa135</a>
Pages
vdaa135
Issue
1
Volume
2
ISSN
2632-2498 2632-2498
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Update Year & Number
December 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Epidemiology of vestibular schwannoma in the United States, 2004-2016.
Publisher
An entity responsible for making the resource available
Neuro-oncology Advances
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12
Subject
The topic of the resource
epidemiology; brain tumors; CBTRUS; vestibular schwannoma
Creator
An entity primarily responsible for making the resource
Cioffi G; Yeboa DN; Kelly M; Patil N; Manzoor N; Greppin K; Takaoka K; Waite K; Kruchko C; Barnholtz-Sloan JS
Description
An account of the resource
BACKGROUND: Vestibular schwannomas (VS) are nonmalignant tumors of the eighth cranial nerve and are the most common nonmalignant nerve sheath tumor. This study provides the most comprehensive and current analysis of VS epidemiology in the United States. METHODS: Incidence data were obtained from the Central Brain Tumor Registry of the United States, from 2004 to 2016 for VS. Age-adjusted incidence rates (AAIRs), rate ratios (AAIRRs), and prevalence ratios (AAPRs) per 100 000 were analyzed by age, sex, race and ethnicity, and laterality. Additional analyses were performed to assess differences in treatment, laterality, and diagnostic confirmation. RESULTS: Incidence of VS was highest among adults (aged 65-74 years, AAIR: 3.18, 95% confidence interval [CI]: 3.15-3.25). However, there was a much higher distribution of bilateral tumors compared to unilateral in children aged 0-19 years (28.5% vs 1.0%, P < .001). VS incidence was highest among white non-Hispanics (AAIR:1.30, 95% CI: 1.29-1. 31) and lowest among black non-Hispanics. Incidence of radiographically confirmed VS increased from 2004 to 2016 (annual percent change: 1.64, 95% CI: 0.15-3.16, P = .03). For treatment, 40.1% received surgery, while only 23.7% received radiation. There were an estimated 44 762 prevalent cases of VS in 2016 (AAPR: 12.17, 95% CI: 12.06-12.29). CONCLUSIONS: VS incidence and prevalence are highest among adults and white non-Hispanics. Bilateral VS was more common among children. There was an increase of radiographically confirmed VS over time. A higher proportion of patients received surgical treatment than radiotherapy. Population-based statistics provide healthcare professionals with vital information regarding disease burden and help improve patient care.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/noajnl/vdaa135" target="_blank" rel="noreferrer noopener">10.1093/noajnl/vdaa135</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Akron Children's Hospital
Barnholtz-Sloan JS
Brain tumors
CBTRUS
Cioffi G
December 2020 List
Department of Pediatrics
Epidemiology
Greppin K
journalArticle
Kelly M
Kruchko C
Manzoor N
NEOMED College of Medicine
Neuro-oncology Advances
Patil N
Takaoka K
vestibular schwannoma
Waite K
Yeboa DN
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jmd2.12153" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jmd2.12153</a>
Pages
70-81
Issue
1
Volume
56
ISSN
2192-8304 2192-8312 2192-8304
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Update Year & Number
December 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Department of Integrative Medical Sciences
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Title
A name given to the resource
Utility of specific amino acid ratios in screening for pyruvate dehydrogenase complex deficiencies and other mitochondrial disorders associated with congenital lactic acidosis and newborn screening prospects.
Publisher
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Jimd Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-11
Subject
The topic of the resource
ketogenic diet; alanine; ketogenic amino acids; lactic acidosis; mitochondrial disorder; newborn screening; proline; pyruvate dehydrogenase complex deficiency
Creator
An entity primarily responsible for making the resource
Bedoyan JK; Hage R; Shin HK; Linard S; Ferren E; Ducich N; Wilson K; Lehman A; Schillaci L; Manickam K; Mori Mari; Bartholomew D; DeBrosse S; Cohen B; Parikh S; Kerr D
Description
An account of the resource
Pyruvate dehydrogenase complex deficiencies (PDCDs) and other mitochondrial disorders (MtDs) can (a) result in congenital lactic acidosis with elevations of blood alanine (Ala) and proline (Pro), (b) lead to decreased ATP production, and (c) result in high morbidity and mortality. With ~140,000 live births annually in Ohio and ~1 in 9,000 overall prevalence of MtDs, we estimate 2 to 3 newborns will have PDCD and 13 to 14 others likely will have another MtD annually. We compared the sensitivities of plasma amino acids (AA) Alanine (Ala), Alanine:Leucine (Ala:Leu), Alanine:Lysine and the combination of Ala:Leu and Proline:Leucine (Pro:Leu), in subjects with known primary-specific PDCD due to PDHA1 and PDHB mutations vs controls. Furthermore, in collaboration with the Ohio newborn screening (NBS) laboratory, we determined Ala and Pro concentrations in dried blood spot (DBS) specimens using existing NBS analytic approaches and evaluated Ala:Leu and Pro:Leu ratios from DBS specimens of 123,414 Ohio newborns in a 12-month period. We used the combined Ala:Leu ≥4.0 and Pro:Leu ≥3.0 ratio criterion from both DBS and plasma specimens as a screening tool in our retrospective review of newborn data. The screening tool applied on DBS and/or plasma (or serum) AA specimens successfully identified three unrelated females with novel de novo PDHA1 mutations, one male with a novel de novo X-linked HSD17B10 mutation, and a female with VARS2 mutations. This work lays the first step for piloting an NBS protocol in Ohio for identifying newborns at high risk for primary-specific PDCD and other MtDs who might benefit from neonatal diagnosis and early institution of known therapy and/or potential novel therapies for such disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jmd2.12153" target="_blank" rel="noreferrer noopener">10.1002/jmd2.12153</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
alanine
Bartholomew D
Bedoyan JK
Cohen B
DeBrosse S
December 2020 List
Department of Integrative Medical Sciences
Department of Pediatrics
Ducich N
Ferren E
Hage R
Jimd Reports
journalArticle
Kerr D
ketogenic amino acids
Ketogenic diet
lactic acidosis
Lehman A
Linard S
Manickam K
mitochondrial disorder
Mori Mari
NEOMED College of Medicine
newborn screening
Parikh S
proline
pyruvate dehydrogenase complex deficiency
Schillaci L
Shin HK
Wilson K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jaip.2020.10.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jaip.2020.10.031</a>
ISSN
2213-2201
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Update Year & Number
December 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Practical Challenges and Considerations for Early Introduction of Potential Food Allergens for Prevention of Food Allergy.
Publisher
An entity responsible for making the resource available
The Journal Of Allergy And Clinical Immunology. In Practice
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-27
Subject
The topic of the resource
Guidelines; Prevention; Complementary feeding; Early introduction; Food allergy; Infant nutrition
Creator
An entity primarily responsible for making the resource
Schroer B; Groetch M; Mack DP; Venter C
Description
An account of the resource
Recent randomized controlled trials aimed at the prevention of food allergy have led to sweeping changes in food allergy prevention guidelines. Emphasis is now on the introduction of potential food allergens, particularly peanut and egg, rather than avoidance. Although guidelines recommend against delaying the introduction of other potential allergens, there remains little or no evidence of the benefit of their early introduction. Parents and physicians alike report a need for greater guidance and resources on early potential allergen introduction in the complementary feeding period. A thorough understanding of early introduction literature, current prevention guidelines, and infant nutrition will empower physicians to address patient needs and concerns both when advice is established as effective and where uncertainty remains. We discuss the state of the science, compare recommendations between guidelines, and provide practical options to introduce allergenic foods, alongside other complementary foods, within the first year of life. We include a review of the available literature, including review and suggestions of potential doses of food allergens, and the first published comparison of commercially available products and homemade early introduction foods to help clinicians support their patients. We address the nutritional, dietary, and practical considerations of introducing food allergens in the first year of life while adhering to infant feeding guidelines. Finally, given the limitations of existing guidelines, we review the need for shared decision-making between physicians and parents regarding early allergen introduction.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jaip.2020.10.031" target="_blank" rel="noreferrer noopener">10.1016/j.jaip.2020.10.031</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Complementary feeding
December 2020 List
Department of Pediatrics
Early introduction
Food allergy
Groetch M
guidelines
Infant nutrition
journalArticle
Mack DP
NEOMED College of Medicine
Prevention
Schroer B
The Journal Of Allergy And Clinical Immunology. In Practice
Venter C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/DBP.0000000000000897" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/DBP.0000000000000897</a>
Volume
Publish Ahead of Print
ISSN
1536-7312 0196-206X
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Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Dublin Core
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Title
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Use of telehealth in fellowship-affiliated developmental behavioral pediatric practices during the COVID-19 pandemic.
Publisher
An entity responsible for making the resource available
Journal of Developmental and Behavioral Pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-21
Creator
An entity primarily responsible for making the resource
Wallis KE; Mulé C; Mittal S; Cerda N; Shaffer R; Scott A; Langkamp D; Augustyn M; Perrin E; Soares N; Blum NJ
Description
An account of the resource
OBJECTIVE: This study aims to describe the use of telehealth in developmental behavioral pediatric (DBP) fellowship-affiliated practices during the coronavirus disease 2019 (COVID-19) global pandemic. METHODS: An electronic survey was disseminated to all DBP fellowship-associated practice locations to determine the use of telehealth in DBP care provision, before and since the beginning of the COVID-19 pandemic. We analyzed responses using descriptive statistics. RESULTS: A total of 35 of 42 eligible practice sites responded (83% response rate). Most sites (51.4%) reported using telehealth less than once per month before the COVID-19 pandemic. Since the onset of COVID-19, 100% of programs reported conducting video-based telehealth visits multiple days per week. Most sites reported conducting evaluations and follow-up visits for attention-deficit/hyperactivity disorder, autism spectrum disorder, behavioral concerns, developmental delay, genetic disorders, and learning disability. Most sites were able to continue medication management by telehealth (>88%), offer interpreter services for families with limited English proficiency participating in telehealth visits (>90%), and incorporate trainees and interdisciplinary team members in telehealth visits (>90%). Greater variability was observed in sites' ability to collect telehealth practice evaluation measures. CONCLUSION: Most sites are providing evaluations and ongoing care for DBP conditions through telehealth. The rapid adoption of telehealth can have ramifications for the way that DBP care is delivered in the future; therefore, it is imperative to understand current practice patterns and variations to determine the best use of telehealth.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/DBP.0000000000000897" target="_blank" rel="noreferrer noopener">10.1097/DBP.0000000000000897</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Augustyn M
Blum NJ
Cerda N
Department of Pediatrics
January 2021 List
Journal of Developmental and Behavioral Pediatrics
journalArticle
Langkamp D
Mittal S
Mulé C
NEOMED College of Medicine
Perrin E
Scott A
Shaffer R
Soares N
Wallis KE
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/neuonc/noaa295" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/neuonc/noaa295</a>
ISSN
1523-5866 1522-8517
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Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Epidemiology of brainstem high-grade gliomas in children and adolescents in the united states, 2000-2017.
Publisher
An entity responsible for making the resource available
Neuro-oncology
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-21
Subject
The topic of the resource
Brainstem; CBTRUS; DIPG; Glioma; High-Grade Glioma
Creator
An entity primarily responsible for making the resource
Patil N; Kelly ME; Yeboa DN; Buerki RA; Cioffi G; Balaji S; Ostrom QT; Kruchko C; Barnholtz-Sloan J
Description
An account of the resource
BACKGROUND: Limited population-based data exists for the brainstem gliomas for children ages ≤19 years, which includes high-grade aggressively-growing tumors such as diffuse intrinsic pontine glioma (DIPG). We examined the overall incidence and survival patterns in children with brainstem High-Grade glioma (HGG) by age, sex, and race and ethnicity. METHODS: We used data from Central Brain Tumor Registry of the United States (CBTRUS), obtained through data use agreements with the Centers for Disease Control (CDC) and the National Cancer Institute (NCI) from 2000 - 2017, and survival data from the CDC's National Program of Cancer Registries (NPCR), from 2001 - 2016 for malignant brainstem HGG for ages ≤19 years (per WHO ICD-O-3 codes). HGG was determined by established histologic and/or imaging criteria. Age-adjusted incidence rates and survival data were used to assess differences overall and by age, sex race, and ethnicity. RESULTS: The incidence of brainstem HGG was higher among the female and Non-Hispanic population. Majority (69.8%) of these tumors were diagnosed radiographically. Incidence was higher in children aged 01-09 years compared to older children. Whites had a higher incidence compared to Blacks. However, the risk of death was higher among Blacks and Other race compared to Whites. There was no difference in survival by sex. CONCLUSIONS: We report the most comprehensive incidence and survival data on these lethal brainstem HGGs. Incidence and survival among patients with brainstem HGGs differed significantly by race, ethnicity, age-groups and grade.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/neuonc/noaa295" target="_blank" rel="noreferrer noopener">10.1093/neuonc/noaa295</a>
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Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
Balaji S
Barnholtz-Sloan J
Brainstem
Buerki RA
CBTRUS
Cioffi G
Department of Pediatrics
DIPG
Glioma
High-Grade Glioma
January 2021 List
journalArticle
Kelly ME
Kruchko C
NEOMED College of Medicine
Neuro-oncology
Ostrom QT
Patil N
Yeboa DN
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/petr.13940" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/petr.13940</a>
Pages
e13940
ISSN
1399-3046 1397-3142
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Update Year & Number
January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics
Affiliated Hospital
Akron Children's Hopsital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Promoting bone health in children and adolescents following solid organ transplantation.
Publisher
An entity responsible for making the resource available
Pediatric Transplantation
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-12-19
Subject
The topic of the resource
bisphosphonates; bone; calcium; magnesium; metabolic bone disease; phosphorous; physical activity; solid organ transplant; vitamin D
Creator
An entity primarily responsible for making the resource
Kusumi K; Shaikhkhalil A; Patel HP; Mahan John D
Description
An account of the resource
Solid organ transplantation in children and adolescents provides many benefits through improving critical organ function, including better growth, development, cardiovascular status, and quality of life. Unfortunately, bone status may be adversely affected even when overall status is improving, due to issues with pre-existing bone disease as well as medications and nutritional challenges inherent post-transplantation. For all children and adolescents, bone status entering adulthood is a critical determinant of bone health through adulthood. The overall health and bone status of transplant recipients benefits from attention to regular physical activity, good nutrition, adequate calcium, phosphorous, magnesium and vitamin D intake and avoidance/minimization of soda, extra sodium, and obesity. Many immunosuppressive agents, especially glucocorticoids, can adversely affect bone function and development. Minimizing exposure to "bone-toxic" medications is an important part of promoting bone health in children post-transplantation. Existing guidelines detail how regular monitoring of bone status and biochemical markers can help detect bone abnormalities early and facilitate valuable bone-directed interventions. Attention to calcium and vitamin D supplementation, as well as tapering and withdrawing glucocorticoids as early as possible after transplant, can provide best bone outcomes for these children. Dual-energy X-ray absorptiometry can be useful to detect abnormal bone mass and fracture risk in this population and newer bone assessment methods are being evaluated in children at risk for poor bone outcomes. Newer bone therapies being explored in adults with transplants, particularly bisphosphonates and the RANKL inhibitor denosumab, may offer promise for children with low bone mass post-transplantation.
Identifier
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<a href="http://doi.org/10.1111/petr.13940" target="_blank" rel="noreferrer noopener">10.1111/petr.13940</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Akron Children's Hospital
bisphosphonates
Bone
calcium
Department of Pediatrics
January 2021 List
journalArticle
Kusumi K
Magnesium
Mahan John D
METABOLIC BONE DISEASE
NEOMED College of Medicine
Patel HP
Pediatric Transplantation
phosphorous
Physical Activity
Shaikhkhalil A
Solid organ transplant
Vitamin D