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Text
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URL Address
<a href="http://doi.org/10.1093/toxsci/11.1.221" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/toxsci/11.1.221</a>
Pages
221–228
Issue
2
Volume
11
Dublin Core
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Title
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Aspartame exposure and in vitro hippocampal slice excitability and plasticity.
Publisher
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Fundamental and applied toxicology : official journal of the Society of Toxicology
Date
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1988
1988-08
Subject
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Female; Time Factors; Animals; Rats; Electric Stimulation; Electrophysiology; Neurons/drug effects; Aspartame/*toxicity; Dipeptides/*toxicity; Hippocampus/*drug effects/physiopathology; Neuronal Plasticity/*drug effects
Creator
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Fountain S B; Hennes S K; Teyler T J
Description
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Aspartame (APM) is a low-calorie sweetener recently approved and released for widespread use in the United States. However, concerns still exist that APM consumption may be responsible for adverse neurological and psychological effects in some people. In addition, recent reports indicate that APM exposure may alter regional brain neurotransmitter levels. The present study assessed the effects of APM and its amino acid moieties on rat hippocampal slice excitability and plasticity. Specifically, tests of excitatory systems, inhibitory systems, and synaptic plasticity (induction of long-term potentiation–LTP) were administered postexposure. Exposures of 0.01, 0.1, 1, and 10 mM APM potentiated the response of hippocampal CA1 pyramidal cells, but had no apparent effect on local inhibitory systems. APM exposure did not block the establishment of LTP at any dose despite the potentiation of pyramidal cell response observed postexposure. In addition, 0.1 mM phenylalanine (PHE) produced a greater increase in excitability than that produced by an equivalent dose of APM, 0.1 mM aspartic acid (ASP) and 0.1 mM phenylalanine methyl ester (PM) produced effects comparable to those produced a smaller, but reliable, change in hippocampal CA1 excitability relative to baseline. Like APM, none of the amino acids produced detectable changes in inhibitory systems or neuronal plasticity.
Identifier
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<a href="http://doi.org/10.1093/toxsci/11.1.221" target="_blank" rel="noreferrer noopener">10.1093/toxsci/11.1.221</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Aspartame/*toxicity
Dipeptides/*toxicity
Electric Stimulation
Electrophysiology
Female
Fountain S B
Fundamental and applied toxicology : official journal of the Society of Toxicology
Hennes S K
Hippocampus/*drug effects/physiopathology
Neuronal Plasticity/*drug effects
Neurons/drug effects
Rats
Teyler T J
Time Factors