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Text
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<a href="http://doi.org/10.1016/0091-3057(88)90342-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90342-5</a>
Pages
249–254
Issue
2
Volume
31
Dublin Core
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Title
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Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.
Publisher
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Pharmacology, biochemistry, and behavior
Date
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1988
1988-10
Subject
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Male; Animals; Rats; Pentobarbital/pharmacology; Carbolines/pharmacology; Chlordiazepoxide/pharmacology; Discrimination (Psychology)/drug effects/*physiology; Flumazenil/pharmacology; gamma-Aminobutyric Acid/analogs & derivatives/pharmacology; Pentylenetetrazole/pharmacology; Pyrazoles/antagonists & inhibitors/*metabolism; Dose-Response Relationship; Drug; Inbred Strains; Receptors; GABA-A/*physiology
Creator
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Leidenheimer N J; Schechter M D
Description
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Male rats were trained to discriminate the stimulus effects of CGS 9896 (30.0 mg/kg) from its vehicle. Once trained, discriminative performance was observed to be dose-responsive in the 3.75-30.0 mg/kg range and analysis of the dose-response curve generated an ED50 of 6.44 mg/kg. Generalization testing with chlordiazepoxide and pentobarbital produced CGS 9896-appropriate responding, whereas administration of the GABA agonists SL 75 102 resulted in 75% (intermediate) generalization to the CGS 9896 discriminative stimulus. Although full antagonism of the CGS 9896 cue was obtained following administration of Ro15-1788 and pentylenetetrazole, the inverse agonist DMCM failed to provide complete antagonism. These results suggest that the discriminative properties of CGS 9896 are consistent with its activity as a benzodiazepine receptor agonist.
Identifier
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<a href="http://doi.org/10.1016/0091-3057(88)90342-5" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90342-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Carbolines/pharmacology
Chlordiazepoxide/pharmacology
Discrimination (Psychology)/drug effects/*physiology
Dose-Response Relationship
Drug
Flumazenil/pharmacology
GABA-A/*physiology
gamma-Aminobutyric Acid/analogs & derivatives/pharmacology
Inbred Strains
Leidenheimer N J
Male
Pentobarbital/pharmacology
Pentylenetetrazole/pharmacology
Pharmacology, biochemistry, and behavior
Pyrazoles/antagonists & inhibitors/*metabolism
Rats
Receptors
Schechter M D