Browse Items · NEOMED Bibliography Database

Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.

Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and…

Tags: 1990, Amphetamine/pharmacology, Animals, Boja J W, Discrimination (Psychology)/*drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Inbred Strains, Male, Norfenfluramine/pharmacology, Pentobarbital/pharmacology, Psychopharmacology, Rats, Reinforcement Schedule, Schechter M D

The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.

In the present report, the peptides arginine vasopressin (AVP), oxytocin (OXT) or their respective antagonists were infused bilaterally into the olfactory bulb to assess their effects upon recognition responses. Recognition responses were determined…

Tags: *Social Behavior, 1998, Aging, Animals, Arginine Vasopressin/*pharmacology, Discrimination Learning/*drug effects, Dluzen D E, Engelmann M, Landgraf R, Male, Memory/drug effects, Muraoka S, Olfactory Bulb/*drug effects, Oxytocin/*pharmacology, Peptides, Rats

Discriminative stimulus control by the anxiogenic beta-carboline FG 7142: generalization to a physiological stressor.

Drug discrimination was employed to investigate the similarities between FG

Tags: 1988, Animals, Appetite Depressants/*pharmacology, Avoidance Learning/drug effects, Carbolines/*pharmacology, Discrimination Learning/*drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Physiological/*psychology, Rats, Schechter M D, Stimulus/*drug effects, Stress

Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.

Male rats were trained to discriminate the stimulus properties of the beta-carbolines 1,2,3,4-tetrahydro-beta-carboline (THBC) (15.0 mg/kg) or FG 7142 (5.0 mg/kg) from vehicle in a two-lever, food-motivated operant task. Consistent with the…

Tags: 1991, Animals, Avoidance Learning/drug effects, Carbolines/antagonists & inhibitors/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, GABA-A/*drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Stimulus/*drug effects

Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.

Two groups of rats were trained to discriminate between the stimulus properties of either intraperitoneally administered 10.0 mg/kg cocaine or 60 mg/kg ethanol and its vehicle in a two-lever operant chamber. Once trained, both groups exhibited a…

Tags: 1994, Animals, Cocaine/*analogs & derivatives/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Life sciences, Male, Rats, Schechter M D

Discriminative stimulus properties of isradipine: effect of other calcium channel blockers.

This study constitutes the first report of a calcium channel blocker used as a drug capable of controlling differential responding in a drug-discrimination paradigm. Male Sprague-Dawley rats were trained to discriminate between intraperitoneally…

Tags: 1995, Animals, Calcium Channel Blockers/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Generalization, Isradipine/*pharmacology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley, Stimulus/*drug effects

Differential training sequence effect upon psychostimulant discrimination.

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle…

Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Scopolamine-physostigmine combination does not substitute for nicotine.

1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be…

Discrimination of cocaethylene in rats trained to discriminate between its components.

Two groups of eight male Normalized/National Institutes of Health (N/Nih) rats were used in a food-motivated, 2-lever drug discrimination task with one group being trained to discriminate between 10 mg/kg cocaine vs. 1 g/kg ethanol, whereas the…

Tags: 1997, Animals, Cocaine/*analogs & derivatives/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, European journal of pharmacology, Male, Rats, Schechter M D

Candyflipping': synergistic discriminative effect of LSD and MDMA.

The co-administration of D-lysergic acid diethylamide (LSD; 'Acid') and 3,4-methylenedioxymethamphetamine (MDMA; 'Ecstasy'; 'XTC'), has reached a prevalence that has allowed for the street terminology 'candyflipping' to describe the combination.…

Tags: 1998, 4-methylenedioxyamphetamine/administration & dosage/*pharmacology, Animal/*drug effects, Animals, Behavior, Discrimination Learning/*drug effects, Drug Synergism, European journal of pharmacology, Hallucinogens/administration & dosage/*pharmacology, Lysergic Acid Diethylamide/administration & dosage/*pharmacology, Male, N-Methyl-3, Rats, Schechter M D, Serotonin Agents/administration & dosage/*pharmacology

Discrete versus cumulative dosing in dose-response discrimination studies.

This study describes the results of a 'side-by-side' comparison of two measurement techniques and two dosing regimens in a discrimination study using rats trained to either 10 mg/kg cocaine or 2 mg/kg 3,4-methylenedioxymethamphetamine (MDMA). The…

Tags: 1997, 4-methylenedioxyamphetamine/*pharmacology, Animals, Chemical, Cocaine/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Evaluation, European journal of pharmacology, Male, N-Methyl-3, Preclinical, Rats, Schechter M D, Sprague-Dawley, Stimulation

Discriminative characteristics of high and low cocaine administration: effect of other psychostimulants.

Two groups of N/Nih male rats were trained to discriminate saline vehicle from either 2.0 mg/kg (n = 10) or 10.0 mg/kg (n = 10) cocaine in a food-motivated, two-lever operant paradigm. The rats trained at the low-dose cocaine took a significantly…

Rohypnol ("roofies") control of drug discrimination: effect of coadministered ethanol or flumenazil.

The benzodiazepine flunitrazepam (Rohypnol) was employed to control differentially discriminative performance in 10 Sprague-Dawley rats on a food-motivated FR10 schedule. The training dose was 2.5 mg/kg, and 20 min was employed between…

Tags: 1998, Animals, Anti-Anxiety Agents/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Administration Schedule, Ethanol/*pharmacology, Flumazenil/*pharmacology, Flunitrazepam/*pharmacology, GABA Antagonists/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley

Advantages and disadvantages of a rapid method to train drug discrimination.

In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training…

Tags: 1988, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Male, Methods, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.

Eight male rats were trained to discriminate between the internal states produced by food deprivation of 3 hours (satiation) and that produced by food deprivation of 27 hours duration (deprivation). One lever, in a two-lever operant chamber, had to…

Tags: *Food Deprivation, 1990, Amphetamine/*pharmacology, Analysis of Variance, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Life sciences, Male, Norfenfluramine/*pharmacology, Rats, Satiation/*drug effects, Schechter M D

Effect of MDMA neurotoxicity upon its conditioned place preference and discrimination.

Experiments were conducted to investigate the functional consequences of a neurotoxic regimen of MDMA administration upon two behaviors, conditioned place preference and drug discrimination. Rats were trained to discriminate 1.5 mg/kg MDMA from its…

Temporal differences in behavioral effect of fenfluramine and norfenfluramine.

Ten male rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-reinforced (fixed-ratio 10 schedule) two-lever operant task. Once learned, the fenfluramine…

Tags: 1990, Animal/*drug effects, Animals, Behavior, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Injections, Intraperitoneal, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Stereoisomerism

Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.

Recent evidence indicates that when 1-(3-trifluoromethylphenyl)piperazine (TFMPP) is used as a training drug in the drug discrimination paradigm it produces a stimulus effect that is site-selective at the 5-HT1B receptor. The present study sought to…

Tags: 1988, Animals, Biological, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Male, Models, Norfenfluramine/pharmacology, Pharmaceutical Vehicles, Pharmacology, biochemistry, and behavior, Piperazines/*pharmacology, Rats, Receptors, Schechter M D, Serotonin/*drug effects/physiology, Serotonin/pharmacology

The NMDA receptor antagonist MK-801 produces ethanol-like discrimination in the rat.

Two groups of rats, one derived from N/Nih stock and the second from the (putatively) serotonin-compromised Fawn-Hooded line, were trained to discriminate ethanol from its vehicle in a drug discrimination paradigm. Once each of the two groups…

Tags: 1993, Alcohol (Fayetteville, N.Y.), Animals, Department of Anatomy & Neurobiology, Discrimination Learning/*drug effects, Dizocilpine Maleate/*pharmacology, Ethanol/*pharmacology, Gordon T L, McBurney D M, Meehan S M, N-Methyl-D-Aspartate/physiology, NEOMED College of Medicine, Rats, Receptors, Schechter M D

Interaction of ethanol and tetrahydro-beta-carboline (THBC) in a discriminative task.

Rats (n = 10) were trained to discriminate between ethanol (600 mg/kg, IP) and its vehicle, or between THBC (20 mg/kg) and its vehicle in a two-lever food-motivated operant task. Once the discriminative training criterion was attained, rats in each…

Tags: 1988, Alcohol (Fayetteville, N.Y.), Animal/drug effects, Animals, Behavior, Carbolines/*pharmacology, Conditioning (Psychology)/drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Male, Rats, Schechter M D, Signs S A

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