1
40
11
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
1–6
Issue
1
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tetrahydro-beta-carboline may produce its stimulus effects via 5HT1B receptors.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/*metabolism; Piperazines/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Carbolines/*pharmacology; Metergoline/pharmacology; Inbred Strains; Receptors
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
To further clarify the role of 5-hydroxytryptamine (5HT) in the behavioral effects of tetrahydro-beta-carboline, male rats were trained to discriminate either 20 mg/kg THBC from its vehicle (n = 10) or 2.0 mg/kg fenfluramine from saline (n = 5). THBC was observed to produce fenfluramine-like effects in the fenfluramine-trained rats while fenfluramine produced THBC-like effects in the
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
Animals
Carbolines/*pharmacology
Discrimination Learning/drug effects
Inbred Strains
Male
Metergoline/pharmacology
Pharmacology, biochemistry, and behavior
Piperazines/pharmacology
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90536-q" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90536-q</a>
Pages
623–626
Issue
4
Volume
37
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Functional consequences of fenfluramine neurotoxicity.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Male; Animals; Rats; Discrimination Learning/drug effects; Reinforcement Schedule; Fenfluramine/*toxicity; Nervous System Diseases/*chemically induced/psychology; Dose-Response Relationship; Drug; Inbred Strains; Conditioning; Operant/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Male Sprague-Dawley rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-motivated (fixed-ratio 10 schedule) two-lever operant task. Once trained, doses of 0.5, 1.0 and 1.5 mg/kg fenfluramine tested 20 min after IP administration produced dose-responsive discrimination performance. Subsequently, noncontingent twice-a-day administrations of 1 ml/kg saline were made for 4 days and the dose-effect relationship redetermined on the 13th to 15th day after initiation of the chronic saline regimen. Results of these dose-response experiments indicated that there was no significant effect upon fenfluramine discrimination after multiple saline injections or after 10 days without training. Following four days of retraining, 6.25 mg/kg fenfluramine twice-a-day for four days was followed 10 days later by another dose-response determination. This purportedly neurotoxic regimen of fenfluramine significantly increased the rats' ability to discriminate fenfluramine. These results suggest the possibility that chronic release of serotonin or selective damage to serotonin-containing neurons produced by fenfluramine may lead to postsynaptic supersensitivity as manifested by the functionally increased discriminative performance observed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90536-q" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90536-q</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Animals
Conditioning
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Fenfluramine/*toxicity
Inbred Strains
Male
Nervous System Diseases/*chemically induced/psychology
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Reinforcement Schedule
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90582-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90582-m</a>
Pages
7–11
Issue
1
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of learned behavior upon conditioned place preference to cathinone.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/physiology; Cues; Discrimination (Psychology)/drug effects; Discrimination Learning/drug effects; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Alkaloids/*pharmacology; Learning/*physiology; Inbred Strains; Receptors; Conditioning; Operant/*drug effects; Dopamine/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The purpose of this study was to examine whether first training rats to discriminate the stimulus cues produced by an indirect dopamine agonist, cathinone, would influence a subsequent test of preference. The conditioned place preference (CPP) paradigm was used to evaluate the reinforcing effects of l-cathinone in four differently treated groups of rats. Half of the animals were trained to discriminate the interoceptive cues produced by 0.8 mg/kg cathinone in a two-lever, food-motivated operant task. The other animals were equally divided between two groups, one receiving saline and noncontingent reinforcements on the same schedule as those trained to discriminate cathinone; the other group, the "yoked-control" rats, received the same cathinone and saline regimen of administration as the discrimination-trained animals. Results of CPP testing indicate that cathinone produced a statistically significant conditioned place preference only in the group trained to discriminate cathinone and not in the saline or yoked control groups. Furthermore, when half of the cathinone discrimination-trained rats were pretreated with the dopamine release inhibitor CGS 10746B, the conditioned place preference to cathinone was attenuated. The results would indicate that pairing cathinone with a nonpreferred environment tended to make the rat spend more time in that environment and the amount of time spent in the cathinone-associated environment can be increased by prior discrimination training and decreased by diminished dopamine function in the brain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90582-m" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90582-m</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Alkaloids/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Conditioning
Cues
Discrimination (Psychology)/drug effects
Discrimination Learning/drug effects
Dopamine/drug effects
Dopamine/physiology
Inbred Strains
Learning/*physiology
Male
Operant/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90083-t</a>
Pages
817–820
Issue
4
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopaminergic nature of acute cathine tolerance.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Dopamine/*physiology; Discrimination (Psychology)/drug effects; Discrimination Learning/drug effects; Alkaloids/pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Appetite Depressants/*pharmacology; Phenylpropanolamine/*pharmacology; Generalization (Psychology)/drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8 mg/kg d-cathine and, once trained, administration of another Khat constituent, cathinone, was shown to produce cathine-like effects. This generalization to cathinone was dose-responsive when testing occurred 24 hr after vehicle administration, whereas prior administration of cathine resulted in a diminished discriminative response to subsequent cathinone administration possibly as a result of the development of acute tolerance. CGS 10746B, a compound that blocks presynaptic release of dopamine, significantly decreased rats' ability to discriminate cathine when it was administered 25 min prior to cathine testing and it reversed the acute tolerance observed when cathine was tested 24 hr after cathine administration. These results indicate that a previously reported acute tolerance effect to cathine after cathinone administration in cathinone-trained rats appears to be symmetrical in that there is acute tolerance to cathinone after cathine in these cathine-trained rats. The results with CGS 10746B would suggest that both the cathine-induced discriminative cue and cathine's ability to produce acute tolerance are mediated by presynaptic dopamine release.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90083-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/pharmacology
Animals
Antipsychotic Agents/pharmacology
Appetite Depressants/*pharmacology
Discrimination (Psychology)/drug effects
Discrimination Learning/drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Drug Tolerance
Generalization (Psychology)/drug effects
Inbred Strains
Male
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90595-s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90595-s</a>
Pages
99–104
Issue
1
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inverse agonist properties of the FG 7142 discriminative stimulus.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Male; Animals; Rats; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Reinforcement Schedule; Appetite Depressants/*pharmacology; Carbolines/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/drug effects; GABA-A/drug effects
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained rats with a variety of benzodiazepine receptor ligands. Administration of the inverse agonist DMCM (0.15-0.30 mg/kg) dose-dependently mimicked the FG 7142 stimulus. In contrast, the benzodiazepine receptor agonist chlordiazepoxide, partial agonist ZK 91 296, mixed agonist/antagonist CGS 9896 and antagonist RO 15-1788 blocked the FG 7142 cue. These results indicate that the FG 7142 discriminative stimulus is based on its inverse agonist activity. The generalization of FG 7142 to the anxiogenic/convulsant compound pentylenetetrazole (PTZ), but not to the anorectic agent norfenfluramine, indicates that the anxiogenic properties of FG 7142, rather than its anorectic actions, may underlie the FG 7142 discriminative stimulus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90595-s" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90595-s</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Appetite Depressants/*pharmacology
Carbolines/antagonists & inhibitors/*pharmacology
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
GABA-A/drug effects
Generalization
Inbred Strains
Leidenheimer N J
Male
Pharmacology, biochemistry, and behavior
Rats
Receptors
Reinforcement Schedule
Schechter M D
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
347–353
Issue
3
Volume
202
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Possible serotonergic and dopaminergic mediation of the
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Motor Activity/drug effects; Designer Drugs/pharmacology; Fenclonine/pharmacology; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology; Dopamine/*drug effects; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
Animals
Boja J W
Designer Drugs/pharmacology
Discrimination Learning/drug effects
Dopamine/*drug effects
European journal of pharmacology
Fenclonine/pharmacology
Inbred Strains
Male
Motor Activity/drug effects
N-Methyl-3
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*drug effects
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(95)02004-7</a>
Pages
569–572
Issue
6
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Alcohol Drinking/*genetics/psychology; Animals; Central Nervous System Depressants/*pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Generalization; Male; N-Methyl-3; Piperazines/pharmacology; Rats; Serotonin Agents/*pharmacology; Serotonin Receptor Agonists/pharmacology; Stimulus
Creator
An entity primarily responsible for making the resource
Meehan S M; Gordon T L; Schechter M D
Description
An account of the resource
Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects of MDMA. These results provide additional information to the growing body of evidence suggesting serotonergic mediation of some of the behavioral effects of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(95)02004-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
4-methylenedioxyamphetamine/*pharmacology
Alcohol (Fayetteville, N.Y.)
Alcohol Drinking/*genetics/psychology
Animals
Central Nervous System Depressants/*pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Generalization
Gordon T L
Male
Meehan S M
N-Methyl-3
Piperazines/pharmacology
Rats
Schechter M D
Serotonin Agents/*pharmacology
Serotonin Receptor Agonists/pharmacology
Stimulus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0166-4328(95)00167-0</a>
Pages
199–205
Issue
1
Volume
74
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.
Publisher
An entity responsible for making the resource available
Behavioural brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-01
Subject
The topic of the resource
Amphetamines/pharmacology; Animals; Antipsychotic Agents/*pharmacology; Cholinergic Agents/pharmacology; Clozapine/pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dopamine D1/*antagonists & inhibitors; Dose-Response Relationship; Drug; Generalization; Male; Rats; Receptors; Response/drug effects; Serotonin Agents/pharmacology; Serotonin Receptor Agonists/pharmacology; Sprague-Dawley; Thiazepines/*pharmacology
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated, two-choice, operant task to discriminate 20.0 mg/kg CGS 10746B from its vehicle. CGS 10746B was highly discriminable, producing rapid acquisition of the discrimination, and its effects were dose-responsive allowing generation of an ED50 value of 6.16 mg/kg. Substitution tests were conducted with other typical and atypical antipsychotic compounds: haloperidol, chlorpromazine, clozapine and SCH 23390. Additional tests examined generalization from the CGS 10746B stimulus properties to the calcium channel blocker isradipine, as well as to the anticholinergics atropine, scopolamine and methylscopolamine, as well as to the serotonergic agonist DOI. Clozapine and SCH 23390 were the only substances to substitute for the CGS 10746B stimulus cue. Results are discussed in terms of potential D1 receptor selectivity of CGS 10746B.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0166-4328(95)00167-0" target="_blank" rel="noreferrer noopener">10.1016/0166-4328(95)00167-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Amphetamines/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Behavioural brain research
Cholinergic Agents/pharmacology
Clozapine/pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dopamine D1/*antagonists & inhibitors
Dose-Response Relationship
Drug
Generalization
Male
Meehan S M
Rats
Receptors
Response/drug effects
Schechter M D
Serotonin Agents/pharmacology
Serotonin Receptor Agonists/pharmacology
Sprague-Dawley
Thiazepines/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90508-d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90508-d</a>
Pages
1233–1240
Issue
4
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
Alcohol Drinking/genetics/*psychology; Animals; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Inbred Strains; Male; Pentobarbital/pharmacology; Rats; Serotonin Antagonists/pharmacology; Sleep/drug effects; Time Factors; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Krimmer E C
Description
An account of the resource
Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min (HAD-2 and LAD-2 animals) and 30 min (HAD-30 and LAD-30 animals). ED50 values of 0.395 and 0.352 g/kg, respectively, for HAD-2 and LAD-2 animals and 0.269 and 0.314 g/kg, respectively, for HAD-30 and LAD-30 animals reflect the absence of any phenotypic difference for the discriminative stimulus effects of ethanol. HAD-2 animals were more responsive than LAD-2 animals to the stimulating effects of ethanol as measured by total response rates during training sessions. The differential ethanol response generalized to pentobarbital in all four groups but not to morphine, an alternative CNS depressant. The specific antagonist of 5-hydroxytryptamine3 receptors,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90508-d" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90508-d</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alcohol Drinking/genetics/*psychology
Animals
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Inbred Strains
Krimmer E C
Male
Pentobarbital/pharmacology
Pharmacology, biochemistry, and behavior
Rats
Serotonin Antagonists/pharmacology
Sleep/drug effects
Time Factors
Tropanes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90055-k" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90055-k</a>
Pages
37–41
Issue
1
Volume
41
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-01
Subject
The topic of the resource
Alkaloids/*pharmacology; Animals; Antipsychotic Agents/pharmacology; Calcium Channel Blockers/pharmacology; Dihydropyridines/pharmacology; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dopamine/*physiology; Dose-Response Relationship; Drug; Inbred Strains; Isradipine; Male; Neurotransmitter Agents/*physiology; Psychotropic Drugs/*pharmacology; Rats; Serotonin Antagonists/pharmacology; Serotonin/*physiology; Thiazepines/pharmacology; Tropanes/pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Rats were trained to discriminate between the stimulus properties of 0.8 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with lower cathinone doses. An analysis of the dose-response curve indicated an ED50 value of 0.23 mg/kg. Pretreatment with CGS 10746B (5-20 mg/kg) resulted in a dose-related decrease in cathinone discrimination with the highest dose blocking cathinone discrimination. In contrast to the ability of this dopamine release inhibitor to decrease cathinone discrimination, pretreatment with three doses of the calcium channel blocker isradipine (2.5-10 mg/kg) or with the 5-HT3 antagonist MDL 72222 (0.1-0.4 mg/kg) had no effect upon cathinone discrimination. The results suggest that cathinone controls differential responding in a discriminative stimulus task by a mechanism involving presynaptic release of dopamine, which may not be regulated by either neuronal calcium influx through L-type calcium channels or by serotonergic neurons.
Identifier
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<a href="http://doi.org/10.1016/0091-3057(92)90055-k" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90055-k</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alkaloids/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Calcium Channel Blockers/pharmacology
Dihydropyridines/pharmacology
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Inbred Strains
Isradipine
Male
Neurotransmitter Agents/*physiology
Pharmacology, biochemistry, and behavior
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*physiology
Thiazepines/pharmacology
Tropanes/pharmacology
-
Text
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URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90007-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90007-3</a>
Pages
619–623
Issue
4
Volume
42
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Direct microinjection of cathinone into the rat brain produces discriminative stimuli.
Publisher
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Pharmacology, biochemistry, and behavior
Date
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1992
1992-08
Subject
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*Brain/anatomy & histology; Alkaloids/administration & dosage/*pharmacology; Animals; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Inbred Strains; Injections; Intraventricular; Male; Microinjections; Nucleus Accumbens/anatomy & histology; Psychotropic Drugs/*pharmacology; Rats
Creator
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Schechter M D; Schechter J B; Calcagnetti D J
Description
An account of the resource
Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower cathinone doses in a dose-responsive manner after IP administration; an ED50 value of 330 micrograms/kg was calculated. Subsequently, guide cannulae were implanted into the lateral ventricle and bilaterally into the nucleus accumbens. After recovery, injections were made via cannulae that extended 0.5 mm past the tip of the guide cannulae. ICV administration of 256 micrograms cathinone/rat produced discriminative responding on the cathinone-appropriate lever to the same degree as did the peripherally administered training dose of cathinone. Decreasing ICV doses produced decreased discriminative performance and allowed the calculation of an ED50 value of 90.5 micrograms. Likewise, administration of 64 micrograms cathinone/nucleus accumbens (for a total of 128 micrograms/rat) substituted for the IP training dose of cathinone. These results evidence the central mediation of the cathinone-induced discriminative stimulus cue and show that administration of cathinone into the nucleus accumbens is sufficient to produce these stimuli. Thus, these data suggest that receptors in the nucleus accumbens are important for the discrimination of this psychostimulant.
Identifier
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<a href="http://doi.org/10.1016/0091-3057(92)90007-3" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90007-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain/anatomy & histology
1992
Alkaloids/administration & dosage/*pharmacology
Animals
Calcagnetti D J
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Inbred Strains
Injections
Intraventricular
Male
Microinjections
Nucleus Accumbens/anatomy & histology
Pharmacology, biochemistry, and behavior
Psychotropic Drugs/*pharmacology
Rats
Schechter J B
Schechter M D