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Text
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URL Address
<a href="http://doi.org/10.1007/s00068-018-1043-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00068-018-1043-3</a>
Pages
843–850
Issue
6
Volume
44
Dublin Core
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Title
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No correlation between lower extremity deep vein thrombosis and pulmonary embolism proportions in trauma: a systematic literature review.
Publisher
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European journal of trauma and emergency surgery : official publication of the European Trauma Society
Date
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2018
2018-12
Subject
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Chemoprophylaxis; Chi Square Test; Deep vein thrombosis; Disease Surveillance – Evaluation; Emergency Patients; Fisher's Exact Test; Human; Lower Extremity – Pathology; Mechanical prophylaxis; PubMed; Pulmonary embolism; Pulmonary Embolism – Drug Therapy; Systematic Review; Ultrasound surveillance; Venous thromboembolism; Venous Thrombosis – Drug Therapy
Creator
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Aziz Hiba Abdel; Hileman Barbara M; Chance Elisha A
Description
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PURPOSE: To assess the effect of surveillance on deep vein thrombosis (DVT) and pulmonary embolism (PE) rates, the efficacy of chemoprophylaxis and mechanical prophylaxis, and the relationship between DVT and PE. METHODS: A 23 year, systematic literature review was performed in PubMed. Twenty publications with \textgreater 13,000 patients were reviewed. Analyzed traits included: DVT surveillance utilization, the total number of patients included in each study, the number of patients developing DVT and/or PE, chemoprophylaxis and mechanical prophylaxis utilization. When event proportions from individual studies were combined, a weighted mean proportion was computed based on the size of each individual cohort. Combined event proportions were compared with other combined event proportions, according to differences in intervention. Inter-group event proportions were compared using Chi-Square or Fisher's exact test, as appropriate. RESULTS: DVT rates increase with surveillance (10.7% vs. 2.5%, p \textless 0.001). PE rates were similar regardless of surveillance (p = 1.0). Chemoprophylaxis lowered both DVT rates (8.2% vs. 10.7%; p \textless 0.0001) and PE rates (1.2% vs. 1.9%; p = 0.0050). Mechanical prophylaxis did not decrease DVT rates (10.2% vs. 11.5%; p = 0.2980) or PE rates (1.7% vs. 1.6%; p = 1.0). In patients with neither chemoprophylaxis nor mechanical prophylaxis, DVT rate was 11.5%, PE was 1.6%. When chemoprophylaxis and/or mechanical prophylaxis were given, DVT rate was 8.6% (p \textless 0.0189) and PE was 1.3% (p = 0.4462). PE proportions were not decreased with mechanical prophylaxis or surveillance. DVT and PE rates were not associated (p = 0.7574). CONCLUSIONS: The results suggest that PE is not associated with lower extremity DVT in adult trauma patients.
Identifier
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<a href="http://doi.org/10.1007/s00068-018-1043-3" target="_blank" rel="noreferrer noopener">10.1007/s00068-018-1043-3</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Aziz Hiba Abdel
Chance Elisha A
Chemoprophylaxis
Chi Square Test
Deep vein thrombosis
Disease Surveillance – Evaluation
Emergency Patients
European journal of trauma and emergency surgery : official publication of the European Trauma Society
Fisher's Exact Test
Hileman Barbara M
Human
Lower Extremity – Pathology
Mechanical prophylaxis
PubMed
Pulmonary embolism
Pulmonary Embolism – Drug Therapy
systematic review
Ultrasound surveillance
Venous thromboembolism
Venous Thrombosis – Drug Therapy