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Text
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<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajog.2003.09.074</a>
Pages
340–345
Issue
1
Volume
191
Dublin Core
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Title
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Stimulation of distal airspace fluid clearance in guinea pigs involves bumetanide-sensitive ion transport.
Publisher
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American journal of obstetrics and gynecology
Date
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2004
2004-07
Subject
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*Ion Transport; Absorption; Adrenergic; Adrenergic beta-Antagonists/pharmacology; Animals; beta/physiology; Body Fluids/*metabolism; Bumetanide/*pharmacology; Diuretics/*pharmacology; Epinephrine/blood; Epithelium; Fetus/metabolism; Gestational Age; Guinea Pigs; Lung/*embryology/metabolism; Newborn; Propranolol/pharmacology; Receptors
Creator
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Ye Xin; Norlin Andreas; Folkesson Hans G
Description
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OBJECTIVE: This study was undertaken to test the hypothesis that beta-adrenoceptor stimulation of fetal lung fluid absorption in near-term guinea pig fetuses involves bumetanide-sensitive ion transport. STUDY DESIGN: Fetuses were obtained from timed-pregnant guinea pigs at 61 to 69 days' gestation with and without oxytocin-induced preterm labor. The fetuses were placed on continuous positive airway pressure oxygenation, and an isosmolar 5% albumin solution was instilled into the lungs. Distal airspace fluid clearance was measured over 1 hour from the increase in distal airspace protein concentration as fluid was reabsorbed with and without the Cl(-) transport inhibitor bumetanide. RESULTS: Fetal lungs began to absorb distal airspace fluid at 64 to 66 days' gestation, and at birth, distal airspace fluid clearance rapidly quadrupled. Labor induction by oxytocin stimulated distal airspace fluid clearance. Distal airspace fluid clearance, when present, was sensitive to propranolol-inhibition and depended on beta-adrenoceptor stimulation. Fluid secretion at 61 days' gestation was reduced by bumetanide instillation. Bumetanide addition was only inhibitory when distal airspace fluid clearance was propranolol-sensitive. CONCLUSION: Beta-adrenoceptor stimulation from endogenous fetal epinephrine increased fetal distal airspace fluid clearance and involved bumetanide-sensitive ion transport.
Identifier
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<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">10.1016/j.ajog.2003.09.074</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ion Transport
2004
Absorption
Adrenergic
Adrenergic beta-Antagonists/pharmacology
American journal of obstetrics and gynecology
Animals
beta/physiology
Body Fluids/*metabolism
Bumetanide/*pharmacology
Diuretics/*pharmacology
Epinephrine/blood
Epithelium
Fetus/metabolism
Folkesson Hans G
Gestational Age
Guinea Pigs
Lung/*embryology/metabolism
Newborn
Norlin Andreas
Propranolol/pharmacology
Receptors
Ye Xin