1
40
37
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
267–273
Issue
2
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
Female; Male; Animals; Mice; Sex Factors; Body Weight/drug effects; Organ Size/drug effects; Dopamine/*metabolism; Body Temperature/drug effects; Methamphetamine/*toxicity; Corpus Striatum/*metabolism; Orchiectomy; Ovariectomy; Drug Interactions; Estrogens/pharmacology/*physiology; Heart Rate/drug effects; Heart Ventricles/metabolism; Norepinephrine/metabolism; Pituitary Gland/anatomy & histology; Testosterone/pharmacology/*physiology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Anderson Linda I; Pilati Charles F
Description
An account of the resource
Methamphetamine (MA)-related deaths and nigrostriatal dopaminergic (NSDA) neurotoxicity are greater in males. The exact basis for this gender difference is not known, but data, which show that estrogen (E) can function as a protectant of both the cardiovascular and NSDA systems, suggest an important role for gonadal steroids in modulating toxicity to this psychostimulant. In the present report, we examined the effects of treatment with the gonadal steroid hormones E and testosterone (T) upon MA-induced toxicity within intact and castrated female and male CD-1 mice. Treatment of intact males with E produced a severe acute toxicity to MA, with only 41% (7/17) males surviving at 24-h post-MA. This incidence of mortality was significantly different from that of nonhormonally treated mice receiving an identical regimen of MA [94% survival (16/17)]. None of the other treatment groups showed mortality rates, which differed significantly from the nonhormonally treated mice. Striatal dopamine (DA) concentrations of E-treated female mice (intact or castrated) were significantly greater than that of the nonhormonally treated mice, which failed to differ statistically among each other. In an attempt to understand some of the bases for the mortality rates in
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Anderson Linda I
Animals
Body Temperature/drug effects
Body Weight/drug effects
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Drug Interactions
Estrogens/pharmacology/*physiology
Female
Heart Rate/drug effects
Heart Ventricles/metabolism
Inbred Strains
Male
Methamphetamine/*toxicity
Mice
Neurotoxicology and teratology
Norepinephrine/metabolism
Orchiectomy
Organ Size/drug effects
Ovariectomy
Pilati Charles F
Pituitary Gland/anatomy & histology
Sex Factors
Testosterone/pharmacology/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.7717/peerj.1175" target="_blank" rel="noreferrer noopener">http://doi.org/10.7717/peerj.1175</a>
Pages
e1175–e1175
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson's disease.
Publisher
An entity responsible for making the resource available
PeerJ
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
1905-07
Subject
The topic of the resource
Locomotion; MPTP; Behavior; Gait; Gender-bias
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Guseman Tamara L; Pienaar Ilse S; Dluzen Dean E; Young Jesse W
Description
An account of the resource
Parkinson's disease (PD) is an age-associated neurodegenerative disorder hallmarked by a loss of mesencephalic dopaminergic neurons. Accurate recapitulation of the PD movement phenotype in animal models of the disease is critical for understanding disease etiology and developing novel therapeutic treatments. However, most existing behavioral assays currently applied to such animal models fail to adequately detect and subsequently quantify the subtle changes associated with the progressive stages of PD. In this study, we used a video-based analysis system to develop and validate a novel protocol for tracking locomotor performance in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. We anticipated that (1) treated mice should use slower, shorter, and less frequent strides and (2) that gait deficits should monotonically increase following MPTP administration, as the effects of neurodegeneration become manifest. Video-based biomechanical analyses, utilizing behavioral measures motivated by the comparative biomechanics literature, were used to quantify gait dynamics over a seven-day period following MPTP treatment. Analyses revealed shuffling behaviors consistent with the gait symptoms of advanced PD in humans. Here we also document dramatic gender-based differences in locomotor performance during the progression of the MPTP-induced lesion, despite male and female mice showing similar losses of striatal dopaminergic cells following MPTP administration. Whereas female mice appeared to be protected against gait deficits, males showed multiple changes in gait kinematics, consistent with the loss of locomotor agility and stability. Overall, these data show that the novel video analysis protocol presented here is a robust method capable of detecting subtle changes in gait biomechanics in a mouse model of PD. Our findings indicate that this method is a useful means by which to easily and economically screen preclinical therapeutic compounds for protecting against or reversing neuropathology associated with PD neurodegeneration.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.7717/peerj.1175" target="_blank" rel="noreferrer noopener">10.7717/peerj.1175</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Behavior
Department of Anatomy & Neurobiology
Dluzen Dean E
Gait
Geldenhuys Werner J
Gender-bias
Guseman Tamara L
Locomotion
MPTP
NEOMED College of Medicine
PeerJ
Pienaar Ilse S
Young Jesse W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1385/ENDO:27:3:259" target="_blank" rel="noreferrer noopener">http://doi.org/10.1385/ENDO:27:3:259</a>
Pages
259–267
Issue
3
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, testosterone, and gender differences.
Publisher
An entity responsible for making the resource available
Endocrine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-08
Subject
The topic of the resource
Female; Humans; Male; *Sex Characteristics; *Gender Identity; Estrogens/*physiology; Testosterone/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The purpose of this report is to gain some current perspective on the definition, bases, and trends for research associated with gender differences. To accomplish this goal an analysis on the number of citations from a 1994-2004 Medline search with the terms estrogen, testosterone, gender differences, sex differences as well as the combinations of these terms was performed. Other combinations of terms included separate searches of estrogen, testosterone, and their combination within males or females, and an analysis of gender and sex differences with the terms human and animal. The salient results from this survey include: (1) An overall greater ratio of estrogen:testosterone citations when these terms were searched alone or in combination with gender differences; (2) an overall greater ratio of testosterone:estrogen citations when these terms were combined with sex differences or conducted separately within males or females, although this trend was shifting toward decreased testosterone and increased estrogen citation numbers toward the latter years of the survey; (3) a trend for increasing numbers of estrogen and gender differences citations over the period of the survey; (4) a clear indication for the term gender differences to be associated with the search term human; and (5) a very small number of citations when the terms estrogen and testosterone were combined. Interpretations and implications of these results are discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1385/ENDO:27:3:259" target="_blank" rel="noreferrer noopener">10.1385/ENDO:27:3:259</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gender Identity
*Sex Characteristics
2005
Dluzen Dean E
Endocrine
Estrogens/*physiology
Female
Humans
Male
Testosterone/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1369.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1369.025</a>
Pages
282–294
Volume
1074
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, testosterone, and methamphetamine toxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-08
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/metabolism; Dopamine Agents/*administration & dosage/toxicity; Drug Interactions; Estrogens/*pharmacology; Female; Male; Methamphetamine/*administration & dosage/toxicity; Mice; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
The gonadal steroid hormone, estrogen, can diminish the degree of striatal dopamine depletion resulting from methamphetamine. In this article, we describe the conditions of this estrogen neuroprotection as well as the potential for estrogen and testosterone to enhance methamphetamine-induced neurodegeneration of the nigrostriatal dopaminergic system. When administered prior to a neurotoxic regimen of methamphetamine, estrogen significantly decreases the amount of striatal dopamine depletion in intact or gonadectomized female, but not male, mice. This capacity for estrogen to function as a neuroprotectant can occur quite rapidly, at 30 min prior to methamphetamine administration, and with relatively low doses of estrogen (1 microg estradiol benzoate). Estrogen remains an effective neuroprotectant in neonatally gonadectomized female mice treated with testosterone, but not in female mice that were gonadectomized prior to puberty. Nor does estrogen demonstrate any beneficial effects when administered after methamphetamine. Recent data have indicated some conditions where gonadal steroids can increase the extent of striatal neurodegeneration in response to methamphetamine. Specifically, when some existing perturbation is present in the nigrostriatal dopaminergic system, treatment with estrogen enhances the extent of striatal dopamine depletion to methamphetamine. Similarly, increased striatal dopamine depletion to methamphetamine is observed in gonadectomized male mice treated with testosterone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1369.025" target="_blank" rel="noreferrer noopener">10.1196/annals.1369.025</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Animals
Annals of the New York Academy of Sciences
Corpus Striatum/drug effects/metabolism
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Drug Interactions
Estrogens/*pharmacology
Female
Male
McDermott Janet L
Methamphetamine/*administration & dosage/toxicity
Mice
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1316.026" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1316.026</a>
Pages
205–220
Volume
1025
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Developmental and genetic influences upon gender differences in methamphetamine-induced nigrostriatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-10
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects/growth & development/metabolism; Dopamine/*metabolism; Female; Humans; Male; Methamphetamine/*toxicity; Substantia Nigra/*drug effects/growth & development/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
The gonadal steroid hormone estrogen (E) may play an important role in sex differences in methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system because E can serve as a neuroprotectant in female, but not male, mice. Gonadal steroid hormones also exert important organizational/developmental effects upon the brain at critical developmental periods. In Part 1 we assessed whether organizational (neonatal) or developmental (prepubertal) effects of gonadal steroids would alter gender/E-dependent neuroprotection of MA-induced NSDA neurotoxicity. Attempts to feminize male mice by gonadectomy at either the neonatal or prepubertal period failed to enable E to function as a neuroprotectant within the adult male mouse. Attempts to masculinize the female by testosterone administration at the neonatal period did not abolish the capacity for E to function as a neuroprotectant. However, prepubertal gonadectomy of female mice did disrupt E's capacity to serve as a neuroprotectant. These results suggest that genetic sex may prove the primary determinant for the sex differences observed in response to MA-induced NSDA neurotoxicity. In Part 2 we examined whether gender differences in response to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1316.026" target="_blank" rel="noreferrer noopener">10.1196/annals.1316.026</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2004
Animals
Annals of the New York Academy of Sciences
Corpus Striatum/*drug effects/growth & development/metabolism
Dluzen Dean E
Dopamine/*metabolism
Female
Humans
Male
McDermott Janet L
Methamphetamine/*toxicity
Substantia Nigra/*drug effects/growth & development/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000095338</a>
Pages
295–302
Issue
5
Volume
83
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Androgens/administration & dosage; Animals; Dopamine Agents/*administration & dosage/toxicity; Dopamine/metabolism; Dose-Response Relationship; Drug; Drug Administration Schedule; Estradiol/administration & dosage/*analogs & derivatives/physiology; Estrogen Antagonists/administration & dosage; Female; Methamphetamine/*administration & dosage/toxicity; Mice; Neostriatum/*drug effects/metabolism; Nerve Degeneration/chemically induced/prevention & control; Neuroprotective Agents/administration & dosage; Neurotoxins/*administration & dosage; Ovariectomy; Parkinson Disease/physiopathology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/administration & dosage
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agents–tamoxifen (TMX, 12.5 microg), testosterone (5 microg) and dehydroepiandrosterone (DHEA, 3 mg) in this paradigm. In experiment 1, ovariectomized mice received an initial treatment with MA. At 1 week after MA, mice were treated with EB, TMX, testosterone, DHEA or oil vehicle and 24 h later a second MA treatment. Striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in the MA-treated groups were decreased compared to the non-MA-treated control. Neither EB nor any of the other agents tested showed enhanced neurodegenerative or neuroprotective effects against a second MA invasion. To verify that estrogen was capable of showing a neuroprotective effect under a condition of two administrations of MA, in experiment 2, EB was administered either once or twice prior to each of the two MA treatments. EB treatment prior to the first MA invasion or first and second MA protected the NSDA system against DA and DOPAC depletion. These results imply that a lower dose of EB, TMX, testosterone and DHEA cannot exert neurodegenerative or neuroprotective effects in the impaired NSDA model. However, EB administered prior to the introduction of neurotoxicity can protect the NSDA system. This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">10.1159/000095338</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Androgens/administration & dosage
Animals
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Dopamine/metabolism
Dose-Response Relationship
Drug
Drug Administration Schedule
Estradiol/administration & dosage/*analogs & derivatives/physiology
Estrogen Antagonists/administration & dosage
Female
Liu Bin
Methamphetamine/*administration & dosage/toxicity
Mice
Neostriatum/*drug effects/metabolism
Nerve Degeneration/chemically induced/prevention & control
Neuroendocrinology
Neuroprotective Agents/administration & dosage
Neurotoxins/*administration & dosage
Ovariectomy
Parkinson Disease/physiopathology
Substantia Nigra/*drug effects/metabolism
Tamoxifen/administration & dosage
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000090983" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000090983</a>
Pages
78–86
Issue
2
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in methamphetamine-evoked striatal dopamine output are abolished following gonadectomy: comparisons with potassium-evoked output and responses in prepubertal mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005
Subject
The topic of the resource
Animals; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*pharmacology; Mice; Neostriatum/drug effects/*metabolism; Orchiectomy; Ovariectomy; Potassium/*pharmacology; Sex Characteristics; Sexual Maturation
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Salvaterra Ty J
Description
An account of the resource
Sex differences are reported for methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system. In an attempt to understand some of the bases for these differences, we investigated MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of intact and male and female CD-1 mice. These responses were compared with that of gonadectomized mice, potassium-evoked DA responses in intact mice and responses in prepubertal mice. In experiment 1, DA responses were tested using infusion of MA at doses of 1, 10, 100 and 1,000 microM. In intact mice, mean peak MA-evoked DA responses were consistently increased and significantly greater in male vs. female mice at the 1,000 microM dose. No such significant differences were observed between gonadectomized male vs. female mice (experiment 2). In contrast to MA, potassium-stimulated DA responses were increased in intact female mice, with statistically significant differences at doses of 30 and 60 mM (experiment 3). No statistically significant differences between intact prepubertal male and female mice were obtained in response to a 1,000 microM dose of MA (experiment 4) or to a 60 mM dose of potassium (experiment 5). These results indicate that intact male mice show greater sensitivity to MA-evoked DA output. This sex difference is abolished following gonadectomy, is not observed with potassium, nor is it present in prepubertal mice. The increased sensitivity to MA shown by intact males may be related to the greater degree of striatal dopaminergic neurotoxicity observed in male mice in response to this psychostimulant and appears to be attributable to differences in gonadal steroid hormones between male and female mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000090983" target="_blank" rel="noreferrer noopener">10.1159/000090983</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Animals
Dluzen Dean E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Female
In Vitro Techniques
Male
Methamphetamine/*pharmacology
Mice
Neostriatum/drug effects/*metabolism
Neuroendocrinology
Orchiectomy
Ovariectomy
Potassium/*pharmacology
Salvaterra Ty J
Sex Characteristics
Sexual Maturation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079710</a>
Pages
305–316
Issue
6
Volume
79
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects; Animals; Behavior; Brain Chemistry/drug effects; Dopamine/*metabolism; Dose-Response Relationship; Drug; Drug Interactions; Estrogen Antagonists/pharmacology; Estrogens/*pharmacology; Female; Methamphetamine/*toxicity; Mice; Movement/drug effects; Neostriatum/*drug effects/physiology; Neurotoxins/*toxicity; Organ Size/drug effects; Ovariectomy/methods; Stereotyped Behavior/drug effects; Substantia Nigra/drug effects/physiology; Tamoxifen/*pharmacology; Uterus
Creator
An entity primarily responsible for making the resource
Mickley Katherine R; Dluzen Dean E
Description
An account of the resource
In the present experiment we evaluated the dose-response effects of estrogen (estradiol benzoate; EB) and tamoxifen (TMX) in modulating the acute behavioral and chronic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system in ovariectomized (OVX) mice. EB over a range of doses from 1-40 microg resulted in a neuroprotective effect upon the NSDA system as defined by both a preservation of striatal dopamine (DA) concentrations and a decrease in DOPAC/DA ratios. Interestingly, the neuroprotective effect of the 1-microg EB dose occurred in the absence of any statistically significant effect upon the bioassay parameter of uterine weight. With the exception of an increase in stereotypy time as a response to the 40-microg dose, EB at any of the doses tested failed to alter any acute behavioral responses evoked by MA. In response to TMX, a statistically significant NSDA neuroprotectant response was obtained for DOPAC/DA ratios, but not DA concentrations, to doses ranging from 12.5 to 500 microg. No statistically significant effects upon uterine weights were obtained for any of the doses of TMX tested. Behaviorally, TMX at 500 microg had the effect of increasing the amount of time spent in the center of the cage. Taken together these results demonstrate: (1) EB and TMX at relatively low doses can exert a neuroprotective effect against MA; (2) these neuroprotective effects of EB and TMX can occur in the absence of an effect upon the bioassay parameter–uterine weights; (3) the parameter of DOPAC/DA ratio may indicate a more sensitive index of NSDA neuroprotection, and (4) modulatory effects of EB and TMX upon acute behavioral responses of the NSDA system to MA can be distinguished from their neuroprotective actions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">10.1159/000079710</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects
Animals
Behavior
Brain Chemistry/drug effects
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Drug Interactions
Estrogen Antagonists/pharmacology
Estrogens/*pharmacology
Female
Methamphetamine/*toxicity
Mice
Mickley Katherine R
Movement/drug effects
Neostriatum/*drug effects/physiology
Neuroendocrinology
Neurotoxins/*toxicity
Organ Size/drug effects
Ovariectomy/methods
Stereotyped Behavior/drug effects
Substantia Nigra/drug effects/physiology
Tamoxifen/*pharmacology
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000070278" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000070278</a>
Pages
232–238
Issue
4
Volume
77
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Animals; Dopamine/metabolism; Female; Inbred Strains; Male; Messenger/drug effects; Methamphetamine/*toxicity; Mice; Neostriatum/*drug effects/metabolism; Neurodegenerative Diseases/*chemically induced/genetics; Neurotoxins/*toxicity; RNA; Sex Factors; Substantia Nigra/*drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Tweed Christopher; Anderson Linda I; Laping Nicholas J
Description
An account of the resource
In this report female and male CD-1 mice were treated with a neurotoxic regimen of methamphetamine (MA) to compare gender differences in striatal dopamine depletion and concordant changes in mRNA markers of the transforming growth factor-beta injury response associated with neurodegeneration. Striatal dopamine concentrations of MA-treated female mice were less depleted and significantly greater than that of identically treated males. Associated with this gender difference in striatal dopamine depletion were significantly decreased mRNA levels of plasminogen activator inhibitor-1 and a trend for increased (p = 0.06) mRNA levels of glial fibrillary acidic protein within females. No statistically significant differences between MA-treated female and male mice were obtained in mRNA levels for transforming growth factor-beta, transforming growth factor-beta type 2 receptor, activin-like kinase-5 or fibronectin. These data demonstrate the presence of changes in two specific molecular markers of the transforming growth factor-beta injury response which are in accordance with gender differences in
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000070278" target="_blank" rel="noreferrer noopener">10.1159/000070278</a>
Rights
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2003
Anderson Linda I
Animals
Dluzen Dean E
Dopamine/metabolism
Female
Inbred Strains
Laping Nicholas J
Male
Messenger/drug effects
Methamphetamine/*toxicity
Mice
Neostriatum/*drug effects/metabolism
Neurodegenerative Diseases/*chemically induced/genetics
Neuroendocrinology
Neurotoxins/*toxicity
RNA
Sex Factors
Substantia Nigra/*drug effects/metabolism
Tweed Christopher
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1749-6632.2002.tb04157.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1749-6632.2002.tb04157.x</a>
Pages
136–156
Volume
965
Dublin Core
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Title
A name given to the resource
Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-06
Subject
The topic of the resource
*Neurotoxins; *Sex Characteristics; Animals; Biological; Estrogen Antagonists/*pharmacology; Estrogens/*physiology; Female; Humans; Male; Methamphetamine/*toxicity; Mice; Models; Tamoxifen/pharmacology; Testosterone/pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
In Part 1 of this report, we review data on the effects of estrogen (E), the anti-E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)-induced neurotoxicity in female and male CD-1 mice. Treatment of gonadectomized females with a physiological regimen of E significantly diminished the amount of striatal dopamine (DA) depletion to METH compared with non-E-treated mice. If these
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1749-6632.2002.tb04157.x" target="_blank" rel="noreferrer noopener">10.1111/j.1749-6632.2002.tb04157.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Neurotoxins
*Sex Characteristics
2002
Animals
Annals of the New York Academy of Sciences
Biological
Dluzen Dean E
Estrogen Antagonists/*pharmacology
Estrogens/*physiology
Female
Humans
Male
McDermott Janet L
Methamphetamine/*toxicity
Mice
Models
Tamoxifen/pharmacology
Testosterone/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1440-1681.2007.04616.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1440-1681.2007.04616.x</a>
Pages
555–565
Issue
7
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease.
Publisher
An entity responsible for making the resource available
Clinical and experimental pharmacology & physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-07
Subject
The topic of the resource
Animal; Animals; Basal Ganglia/drug effects/*metabolism/pathology; Disease Models; Dopamine/*metabolism; Estrogens/*metabolism/pharmacology/therapeutic use; Humans; Nerve Degeneration/drug therapy/*metabolism/pathology; Neurons/metabolism/pathology; Neuroprotective Agents/*metabolism/pharmacology/therapeutic use; Parkinson Disease/drug therapy/*metabolism/pathology; Parkinsonian Disorders/drug therapy/*metabolism/pathology; Substantia Nigra/drug effects/*metabolism/pathology
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
1. The exact nature of oestrogen (positive, negative or no effect) in the dopaminergic neurodegenerative disorder Parkinson's disease is controversial. 2. In the present review, we summarize the data on oestrogen and nigrostriatal dopaminergic neurodegeneration in animal models and clinical reports of Parkinson's disease. 3. Most animal studies support the ability of oestrogen to function as a neuroprotectant against neurotoxins that target the nigrostriatal dopaminergic system. 4. Retrospective and prospective clinical studies generally support the findings from animal studies that oestrogen exerts a positive, or, at worst, no effect, in Parkinson's disease. 5. Oestrogen was chosen as one of the 12 neuroprotective compounds to be attractive candidates for further clinical trials (Phase II or III) in 2003.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1440-1681.2007.04616.x" target="_blank" rel="noreferrer noopener">10.1111/j.1440-1681.2007.04616.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Animal
Animals
Basal Ganglia/drug effects/*metabolism/pathology
Clinical and experimental pharmacology & physiology
Disease Models
Dluzen Dean E
Dopamine/*metabolism
Estrogens/*metabolism/pharmacology/therapeutic use
Humans
Liu Bin
Nerve Degeneration/drug therapy/*metabolism/pathology
Neurons/metabolism/pathology
Neuroprotective Agents/*metabolism/pharmacology/therapeutic use
Parkinson Disease/drug therapy/*metabolism/pathology
Parkinsonian Disorders/drug therapy/*metabolism/pathology
Substantia Nigra/drug effects/*metabolism/pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s1550-8579(08)80005-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s1550-8579(08)80005-8</a>
Pages
24–35
Issue
1
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in methamphetamine use and responses: a review.
Publisher
An entity responsible for making the resource available
Gender Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-03
Subject
The topic of the resource
*Amphetamine-Related Disorders; *Gender Identity; *Sex Characteristics; Animals; Central Nervous System Stimulants/pharmacokinetics/*pharmacology; Depressive Disorder/drug therapy; Female; Humans; Male; Methamphetamine/pharmacokinetics/*pharmacology; Sex Factors; Substance-Related Disorders
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Liu Bin
Description
An account of the resource
BACKGROUND: Men and women differ markedly with regard to their use of, and responses to, methamphetamine (MA) and related amphetamines. However, these gender differences oftentimes are given only a cursory consideration in the analyses of these MA effects. OBJECTIVE: In this brief review, we summarize the data on gender differences in various parameters of MA use and responses. Such information on the pattern of male versus female differences in the use and responses to this psychostimulant can aid in tailoring gender-dependent treatment strategies. METHODS: English-language articles were identified from MEDLINE as well as from reference lists of identified articles for the years 1966 to 2007. Search terms included various combinations of men/male, women/female, methamphetamine, and gender/sex differences. Only studies with human subjects were reviewed. RESULTS: Women tend to begin MA use at earlier ages, appear more dependent on MA, but also respond better to treatment than do men. MA use appears to be associated with depression in women, and women seem more committed to MA, whereas men are more likely to use other drugs in the absence of access to MA. Female MA abusers had both larger volumes within the corpus callosum and more hyperperfused regions in the parietal and occipital areas of the brain, along with more genetic alterations but less MA-induced toxicity. Amphetamine-stimulated dopamine release was greater in men. CONCLUSIONS: When considered in total, women seem more dependent on and committed to MA but show diminished (amphetamine-stimulated) dopamine responses and a decreased degree of toxicity, as indicated by a lower incidence of emergency department-related deaths involving MA. A pervasive comorbidity of depression or depression-related characteristics were present in women MA users, suggesting that MA may serve as a type of self-medication for their depression. These findings not only highlight the need for consideration of gender when assessing MA use, but also can serve to direct efforts at prevention and treatment programs that address the specific needs of men and women.
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<a href="http://doi.org/10.1016/s1550-8579(08)80005-8" target="_blank" rel="noreferrer noopener">10.1016/s1550-8579(08)80005-8</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Amphetamine-Related Disorders
*Gender Identity
*Sex Characteristics
2008
Animals
Central Nervous System Stimulants/pharmacokinetics/*pharmacology
Depressive Disorder/drug therapy
Dluzen Dean E
Female
Gender medicine
Humans
Liu Bin
Male
Methamphetamine/pharmacokinetics/*pharmacology
Sex Factors
Substance-Related Disorders
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0304-3940(02)00412-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0304-3940(02)00412-3</a>
Pages
81–84
Issue
2
Volume
328
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-08
Subject
The topic of the resource
Animal/drug effects/physiology; Animals; Atomoxetine Hydrochloride; Extracellular Space/metabolism; Fluoxetine/*analogs & derivatives/*pharmacology; Male; Microdialysis; Norepinephrine Plasma Membrane Transport Proteins; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*metabolism; Orchiectomy/*adverse effects; Presynaptic Terminals/drug effects/metabolism; Propylamines/pharmacology; Rats; Reproduction/*physiology; Sexual Behavior; Smell/drug effects/physiology; Sprague-Dawley; Symporters/antagonists & inhibitors/*metabolism; Testosterone/*deficiency/metabolism; Up-Regulation/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Shang Yili; Dluzen Dean E
Description
An account of the resource
In the present experiment we compared differences in extracellular norepinephrine levels in vivo within the olfactory bulb of intact and castrated male rats following infusion of the norepinephrine transport inhibitors, nisoxetine and tomoxetine. With this approach it was possible to assess whether dynamic changes in in vivo norepinephrine transporter function occur as a function of the gonadal state of the animal. Norepinephrine levels following infusion of nisoxetine were significantly increased in castrated compared with intact male rats. While a similar trend was present in response to tomoxetine infusion, these differences failed to achieve a statistically significant difference. These results demonstrate that castration of male rats alters norepinephrine transporter function within the olfactory bulbs. The increased extracellular levels of norepinephrine in response to agents which inhibit transporter function suggest that castration reduces transporter activity. Such effects have important implications not only with regard to processes involving the norepinephrine system in the olfactory bulb but also to the generalized sites and mechanisms by which gonadal steroid hormones modulate central nervous system functions.
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<a href="http://doi.org/10.1016/s0304-3940(02)00412-3" target="_blank" rel="noreferrer noopener">10.1016/s0304-3940(02)00412-3</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Animal/drug effects/physiology
Animals
Atomoxetine Hydrochloride
Dluzen Dean E
Extracellular Space/metabolism
Fluoxetine/*analogs & derivatives/*pharmacology
Male
Microdialysis
Neuroscience letters
Norepinephrine Plasma Membrane Transport Proteins
Norepinephrine/*metabolism
Olfactory Bulb/drug effects/*metabolism
Orchiectomy/*adverse effects
Presynaptic Terminals/drug effects/metabolism
Propylamines/pharmacology
Rats
Reproduction/*physiology
Sexual Behavior
Shang Yili
Smell/drug effects/physiology
Sprague-Dawley
Symporters/antagonists & inhibitors/*metabolism
Testosterone/*deficiency/metabolism
Up-Regulation/drug effects/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0169-328x(02)00520-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0169-328x(02)00520-x</a>
Pages
121–128
Issue
1
Volume
108
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen.
Publisher
An entity responsible for making the resource available
Brain research. Molecular brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-12
Subject
The topic of the resource
*Membrane Glycoproteins; *Nerve Tissue Proteins; Animals; Delayed-Action Preparations; Dopamine Plasma Membrane Transport Proteins; Drug Combinations; Estrogen Antagonists/administration & dosage; Estrogens/administration & dosage/*pharmacology; Female; Inbred Strains; Membrane Transport Proteins/*genetics/metabolism; Messenger/*metabolism; Mice; Molecular Sequence Data; Norepinephrine Plasma Membrane Transport Proteins; Olfactory Bulb/*drug effects/enzymology/*physiology; Ovariectomy; Rats; RNA; Symporters/*genetics/metabolism; Tyrosine 3-Monooxygenase/*genetics/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Park June-Hee; Kim Kyungjin
Description
An account of the resource
Since estrogen exerts wide ranging effects within the central nervous system, it is important to investigate the sites and actions of this gonadal steroid hormone at extra-hypothalamic locations. In the present report, the effects of estrogen upon catecholaminergic function within the olfactory bulb were examined. To assess the role of estrogen at this site, ovariectomized mice received either no further hormonal treatment or were treated with estrogen, the anti-estrogen, tamoxifen, or a combination of estrogen and tamoxifen as administered in a 21-day release pellet. At 14 days post-hormonal treatment, the olfactory bulbs were assayed for mRNA levels of tyrosine hydroxylase, dopamine transporter and norepinephrine transporter using competitive-PCR. Tyrosine hydroxylase mRNA levels in either estrogen or estrogen+tamoxifen treated females were significantly decreased compared with non-hormonally treated controls. In addition, tyrosine hydroxylase mRNA levels of tamoxifen-treated mice were significantly greater than that of estrogen-treated mice. Dopamine transporter mRNA levels of tamoxifen-treated females were significantly greater than that of non-hormonally treated controls and estrogen treated mice. The combination of estrogen+tamoxifen significantly increased dopamine transporter mRNA levels compared to that of estrogen treated mice. No overall statistically significant differences in norepinephrine transporter mRNA levels were obtained among the four treatment groups. The data demonstrate that estrogen can exert significant modulatory effects upon olfactory bulb catecholaminergic function. Therefore, events which alter estrogen levels (menstrual/estrogen cycle, pregnancy/lactation, menopause, tamoxifen treatment) can modulate olfactory bulb catecholaminergic functions which may be involved with the detection and processing of olfactory stimuli.
Identifier
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<a href="http://doi.org/10.1016/s0169-328x(02)00520-x" target="_blank" rel="noreferrer noopener">10.1016/s0169-328x(02)00520-x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Membrane Glycoproteins
*Nerve Tissue Proteins
2002
Animals
Brain research. Molecular brain research
Delayed-Action Preparations
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins
Drug Combinations
Estrogen Antagonists/administration & dosage
Estrogens/administration & dosage/*pharmacology
Female
Inbred Strains
Kim Kyungjin
Membrane Transport Proteins/*genetics/metabolism
Messenger/*metabolism
Mice
Molecular Sequence Data
Norepinephrine Plasma Membrane Transport Proteins
Olfactory Bulb/*drug effects/enzymology/*physiology
Ovariectomy
Park June-Hee
Rats
RNA
Symporters/*genetics/metabolism
Tyrosine 3-Monooxygenase/*genetics/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.tips.2005.08.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.tips.2005.08.001</a>
Pages
485–487
Issue
10
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Unconventional effects of estrogen uncovered.
Publisher
An entity responsible for making the resource available
Trends in pharmacological sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-10
Subject
The topic of the resource
Animals; Corpus Striatum/*metabolism/physiology; Dopamine D2/metabolism; Dopamine/*metabolism; Estrogens/*physiology; GTP-Binding Proteins/metabolism; Humans; Receptors; Signal Transduction/physiology; Substantia Nigra/*metabolism/physiology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The nigrostriatal dopamine system shows marked gender differences that, in many cases, can be attributable to estrogen. However, the virtual absence of conventional estrogen receptors within the nigrostriatal dopamine system has made it difficult to understand how estrogen can function within this system. Recent findings have helped to uncover how estrogen can affect a discrete function of striatal dopamine-containing neurons–transporter activity–in a manner similar to that achieved through alterations in dopamine D(2) receptors and their associated G protein. These findings suggest that the effects of estrogen on dopamine transporter function could result from a signal transduction interaction involving D(2) receptor-G protein coupling.
Identifier
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<a href="http://doi.org/10.1016/j.tips.2005.08.001" target="_blank" rel="noreferrer noopener">10.1016/j.tips.2005.08.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Animals
Corpus Striatum/*metabolism/physiology
Dluzen Dean E
Dopamine D2/metabolism
Dopamine/*metabolism
Estrogens/*physiology
GTP-Binding Proteins/metabolism
Humans
Receptors
Signal Transduction/physiology
Substantia Nigra/*metabolism/physiology
Trends in pharmacological sciences
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.pbb.2004.10.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pbb.2004.10.007</a>
Pages
27–33
Issue
1
Volume
80
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; Male; Mice; Motor Activity/drug effects/physiology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Mickley Katherine R
Description
An account of the resource
It has been demonstrated that the gonadal steroid hormone estrogen can exert neuroprotective effects upon the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA)-induced neurotoxicity in female, but not male, mice. In contrast, the anti-estrogen, tamoxifen (TMX) can function as a NSDA neuroprotectant within both female and male mice. In an attempt to understand these effects of TMX, the effects of this anti-estrogen upon both behavioral and neurochemical indices of NSDA function were examined within female and male mice following treatment with MA. In general, TMX exerted markedly different (bi-directional) effects upon NSDA function between female and male mice. Notably, treatment with TMX resulted in a relative decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations within male mice and a relative increase in female mice when treated with MA to produce a significant gender difference. Similar effects were obtained for locomotor behaviors related with NSDA function. That is, TMX produced increases in horizontal activity, number of movements and total distance traveled within
Identifier
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<a href="http://doi.org/10.1016/j.pbb.2004.10.007" target="_blank" rel="noreferrer noopener">10.1016/j.pbb.2004.10.007</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2005
Animals
Corpus Striatum/*drug effects/metabolism
Dluzen Dean E
Dopamine/*metabolism
Female
Male
Mice
Mickley Katherine R
Motor Activity/drug effects/physiology
Pharmacology, biochemistry, and behavior
Substantia Nigra/*drug effects/metabolism
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ntt.2012.03.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2012.03.003</a>
Pages
338–343
Issue
3
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
Animals; Biomarkers/metabolism; Blotting; Body Temperature/drug effects; Body Weight/drug effects; Corpus Striatum/*drug effects/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine/*metabolism; Drug Synergism; HSP70 Heat-Shock Proteins/metabolism; Inbred Strains; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/*etiology/metabolism; Oxidative Stress/drug effects; Testosterone Propionate/*pharmacology; Vesicular Monoamine Transport Proteins/metabolism; Western
Creator
An entity primarily responsible for making the resource
Buletko A Blake; Dluzen Dean E; McDermott Janet L; Darvesh Altaf S; Geldenhuys Werner J
Description
An account of the resource
Intact male CD-1 mice received an injection of testosterone propionate (TP–5 ug), progesterone (P–5 mg), the oil vehicle or remained untreated (control). At 24 hours after hormonal treatments the mice received an injection of methamphetamine (MA–40 mg/kg) and rectal temperatures were measured. At 5 days post-MA, assays were performed to assess effects of these treatments. Maximal increases in body temperatures, that were significantly greater than oil-treated controls, were obtained in TP-treated mice. At 5 days post-MA, maximal weight reductions were obtained with TP-treated mice, while P-treated mice showed no significant decrease between the pre- versus post-MA determinations. Striatal dopamine concentrations showed maximal reductions and heat-shock protein-70 maximal increases in the TP group, with both differing significantly as compared with all other groups. Protein levels of dopamine transporters were significantly decreased in P-treated mice, while vesicular monoamine transporter-2 was significantly decreased in TP-treated mice. Taken together, these results suggest that testosterone exacerbates the deleterious effects of MA within male mice as indicated by a number of markers related to neurotoxicity. The changes in markers as associated with this enhanced neurotoxicity suggest that TP may increase thermal/energy responses and/or oxidative stress to produce this effect.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ntt.2012.03.003" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2012.03.003</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Biomarkers/metabolism
Blotting
Body Temperature/drug effects
Body Weight/drug effects
Buletko A Blake
Corpus Striatum/*drug effects/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/metabolism
Dopamine/*metabolism
Drug Synergism
Geldenhuys Werner J
HSP70 Heat-Shock Proteins/metabolism
Inbred Strains
Male
McDermott Janet L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neurotoxicity Syndromes/*etiology/metabolism
Neurotoxicology and teratology
Oxidative Stress/drug effects
Testosterone Propionate/*pharmacology
Vesicular Monoamine Transport Proteins/metabolism
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ntt.2006.07.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2006.07.001</a>
Pages
557–562
Issue
5
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects; Dopamine Agents/pharmacology; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Drug Interactions; Female; Male; Methamphetamine/pharmacology; Mice; Nomifensine/*pharmacology; Potassium/pharmacology
Creator
An entity primarily responsible for making the resource
Kunnathur Vidhya; Shemisa Kamal; Liu Bin; Salvaterra Ty J; Dluzen Dean E
Description
An account of the resource
Male mice show more severe striatal dopamine depletions to the psychostimulant, methamphetamine (MA). To gain some understanding for this sex difference, we examined MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of male and female mice under conditions of a dopamine transporter which was either unaltered (Experiment 1) or inhibited, with use of the drug, nomifensine (Experiment 2). In Experiment 1, MA-evoked DA was significantly greater in male versus female mice. In Experiment 2, diminished, albeit statistically significant, DA responses to MA infusion in the presence of nomifensine were obtained from striatal tissue of female, but not male, mice. In Experiment 3, potassium-evoked DA responses and sex differences were abolished in the presence of nomifensine. These data demonstrate a clear sex difference in DA responses to MA. Interestingly, under conditions where dopamine transporter function is inhibited, MA retains its ability to evoke DA. However, this capacity was only observed within striatal tissue fragments of female mice and not under conditions of potassium-evoked DA. These results indicate an additional component for the bases of sex differences in nigrostriatal dopaminergic function in health and in disease. In particular, the present findings have important implications in suggesting an alternative, non-traditional, mechanism for MA effects and indicate that such a function is limited to females.
Identifier
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<a href="http://doi.org/10.1016/j.ntt.2006.07.001" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2006.07.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2006
Animals
Corpus Striatum/*drug effects
Dluzen Dean E
Dopamine Agents/pharmacology
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Drug Interactions
Female
Kunnathur Vidhya
Liu Bin
Male
Methamphetamine/pharmacology
Mice
Neurotoxicology and teratology
Nomifensine/*pharmacology
Potassium/pharmacology
Salvaterra Ty J
Shemisa Kamal
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2010.04.004</a>
Pages
66–69
Issue
2
Volume
476
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Aging/*physiology; Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine/*metabolism; Heterozygote; Inbred C57BL; Knockout; Male; Mice; Motor Activity; Mutation; Substantia Nigra/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Ji Jing; McDermott Janet L
Description
An account of the resource
In this report we compared three different parameters of nigrostriatal dopaminergic (NSDA) function - locomotor activity, striatal dopamine (DA) levels and 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratios between heterozygous mutant dopamine transporter mice (+/- DAT) and their wild type controls (+/+ DAT) at three different age range periods: 4-10, 11-17 and 18-24 months of age. Locomotor activity of the +/- DAT mice failed to differ over the three age periods sampled. In +/+ DAT mice a significant decrease in locomotor activity was obtained at the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2010.04.004</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/*metabolism
Aging/*physiology
Animals
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine/*metabolism
Heterozygote
Inbred C57BL
Ji Jing
Knockout
Male
McDermott Janet L
Mice
Motor Activity
Mutation
Neuroscience letters
Substantia Nigra/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2008.10.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2008.10.011</a>
Pages
130–133
Issue
1
Volume
448
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-12
Subject
The topic of the resource
*Sex Characteristics; Animals; Castration/methods; Corpus Striatum/drug effects/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Dose-Response Relationship; Drug; Female; Male; Methamphetamine/*pharmacology; Mice; Testosterone Propionate/*pharmacology
Creator
An entity primarily responsible for making the resource
Lewis Chandani; Dluzen Dean E
Description
An account of the resource
We examined the effects of varying concentrations of testosterone propionate (T) treatment within intact and gonadectomized male and female mice with regard to its capacity to alter striatal dopamine (DA) depletion in response to a neurotoxic regimen of methamphetamine (MA). Administration of T at 24h prior to MA significantly increased striatal DA depletion in intact and gonadectomized male mice. Similar treatments administered to intact and gonadectomized female mice failed to alter striatal DA concentrations in response to MA. These results demonstrate that T can enhance MA-induced neurotoxicity in male, but not in female, mice. Such findings have important implications with regard to sex differences in nigrostriatal dopaminergic function, in general, and, in specific, to sex differences related to nigrostriatal dopaminergic neurotoxicity and neurodegeneration like that in response to MA and in Parkinson's disease, where a greater incidence is typically reported for males.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2008.10.011" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2008.10.011</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
Animals
Castration/methods
Corpus Striatum/drug effects/metabolism
Dluzen Dean E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Dose-Response Relationship
Drug
Female
Lewis Chandani
Male
Methamphetamine/*pharmacology
Mice
Neuroscience letters
Testosterone Propionate/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2004.01.061" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2004.01.061</a>
Pages
135–138
Issue
3
Volume
359
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
Animals; Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism; Central Nervous System Stimulants/poisoning; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Female; Humans; Male; Methamphetamine/*poisoning; Mice; Mutation; Neurotoxicity Syndromes/*etiology/*metabolism; Sex Factors; Structure-Activity Relationship; Substantia Nigra/drug effects/metabolism; Transgenic
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The interactive effects between gender and a selective alteration in the neurotrophin, brain-derived neurotrophic factor (BDNF) upon methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system were assessed. MA treatment produced a greater degree of NSDA neurotoxicity (indicated by greater reductions in corpus striatal dopamine levels) in wild type control BDNF male versus female mice. This sex difference was unaltered in heterozygous mutant BDNF (BDNF +/-) mice and in mice which overexpress BDNF (DBH:BDNF +). Both BDNF mutant conditions resulted in preservation of corpus striatal dopamine levels following MA treatment as compared with their respective MA-treated wild type controls. The relative amount of this preservation was greater in male BDNF mutants, with values being significantly greater than females in the BDNF +/- condition. These results suggest that alterations in BDNF do not alter basic gender differences in MA-induced NSDA neurotoxicity, but may produce a neuroprotection against MA which is relatively greater in males.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2004.01.061" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2004.01.061</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animals
Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism
Central Nervous System Stimulants/poisoning
Corpus Striatum/*drug effects/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Female
Humans
Male
Methamphetamine/*poisoning
Mice
Mutation
Neuroscience letters
Neurotoxicity Syndromes/*etiology/*metabolism
Sex Factors
Structure-Activity Relationship
Substantia Nigra/drug effects/metabolism
Transgenic
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2012.03.013</a>
Pages
806–808
Issue
8
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Drug Synergism; Inbred C57BL; Indoles/*pharmacology; Methamphetamine/*pharmacology; Mice
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Darvesh Altaf S; Dluzen Dean E
Description
An account of the resource
Dimebon is an anti-histamine with central nervous system activity. In this report the effects of dimebon as a neuroprotectant in animal models of Parkinson's disease were tested as assessed in methamphetamine- and MPTP-induced striatal dopaminergic toxicity. Dimebon (1mg/kg) administered at 30 min prior to methamphetamine (40mg/kg) significantly reduced the amount of striatal dopamine depletion in mice, without altering the initial methamphetamine-induced increase in body temperature. In contrast, dimebon at either 1 or 25mg/kg administered at 30 min prior to MPTP (35 mg/kg) was unable to prevent MPTP-induced striatal dopamine loss as determined at 7 days post-methamphetamine/MPTP. These data suggest that dimebon may be exerting a neurotoxin specific neuroprotective effect upon the striatal dopaminergic system and may serve as an important tool for discriminating the mechanistic basis of these two dopaminergic neurotoxins.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2012.03.013</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Corpus Striatum/*drug effects/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Dluzen Dean E
Dopamine/*metabolism
Drug Synergism
Geldenhuys Werner J
Inbred C57BL
Indoles/*pharmacology
Methamphetamine/*pharmacology
Mice
NEOMED College of Pharmacy
Neurochemistry international
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuint.2011.04.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2011.04.005</a>
Pages
101–103
Issue
2
Volume
59
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Parity decreases methamphetamine-induced striatal dopaminergic perturbation.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
*Parity; Animals; Corpus Striatum/*drug effects/metabolism/physiology; Dopamine/*metabolism; Female; Methamphetamine/*pharmacology; Mice; Pregnancy
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The role of parity upon methamphetamine-induced neurotoxicity of the striatal dopaminergic system was assessed. Female CD-1 mice either remained nulliparous or underwent one or three complete pregnancies and were designated as the 0, 1 or 3 pregnancy groups. The mice were then treated with a neurotoxic regimen of methamphetamine (MA–40 mg/kg) or its saline vehicle (control) and striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were measured at
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuint.2011.04.005" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2011.04.005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Parity
2011
Animals
Corpus Striatum/*drug effects/metabolism/physiology
Dluzen Dean E
Dopamine/*metabolism
Female
Methamphetamine/*pharmacology
Mice
Neurochemistry international
Pregnancy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2011.02.031</a>
Pages
23–28
Issue
1
Volume
198
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of freezing and extraction upon striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-05
Subject
The topic of the resource
*Freezing; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Analysis of Variance; Animals; Chemical Fractionation/methods; Corpus Striatum/*metabolism; Cryopreservation/methods; Dopamine/*metabolism; Male; Mice; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1, these determinations were performed at 0 (control), 0.5, 1 or 2h postmortem. In Experiment 2, these two protocols were compared at 0 (control), 0.5 or 72 h after a neurotoxic regimen of methamphetamine. In Experiment 3, potassium-stimulated DA release from superfused striatal tissue was compared between frozen and fresh tissue. The results from the 0 h (control) groups of Experiments 1 and 2 revealed that FE results in significant reductions in DA concentrations as compared with the EF procedure. However, FE diminishes the time-dependent reductions in striatal DA and increases in DOPAC present in the EF group, as obtained under conditions of natural (Experiment 1) or neurotoxin-induced (Experiment 2) degradation. Potassium-stimulated DA release from superfused striatal tissue is significantly decreased when measured from frozen versus fresh tissue. While freezing seems to produce an initial detrimental effect upon measuring striatal DA concentrations and potassium-stimulated release, there appears to be a capacity for preservation of striatal DA and diminution in DOPAC production by freezing when tissue is undergoing degradation. Such results demonstrate the significance of the protocol used for determination of neurotransmitters in postmortem tissue and suggest a potential means for diminishing the adverse effects of insult to striatal tissue that may result from conditions like stroke and exposure to neurotoxins.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2011.02.031</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Freezing
2011
3
4-Dihydroxyphenylacetic Acid/metabolism
Analysis of Variance
Animals
Chemical Fractionation/methods
Corpus Striatum/*metabolism
Cryopreservation/methods
Dluzen Dean E
Dopamine/*metabolism
Journal of neuroscience methods
Male
Mice
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejphar.2009.08.012" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejphar.2009.08.012</a>
Pages
38–43
Issue
1
Volume
619
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-10
Subject
The topic of the resource
Animals; Biological Transport/drug effects; Buffers; Calcium Channels/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Extracellular Space/*drug effects/*metabolism; In Vitro Techniques; Male; Methamphetamine/pharmacology; Mice; Neostriatum/*cytology/drug effects; PC12 Cells; Perfusion; Potassium Channel Blockers/pharmacology; Potassium Channels; Potassium Chloride/pharmacology; Rats; Voltage-Gated/antagonists & inhibitors
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Bezuidenhout Lois-May; Dluzen Dean E
Description
An account of the resource
The dopamine transporter (DAT) plays an important role in substance abuse, schizophrenia, and dopaminergic toxicity associated with the Parkinsonian animal model toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Accordingly, the DAT serves as a critical component in regulating dopaminergic function in health and disease states. We have been working with a novel cage compound,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejphar.2009.08.012" target="_blank" rel="noreferrer noopener">10.1016/j.ejphar.2009.08.012</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Bezuidenhout Lois-May
Biological Transport/drug effects
Buffers
Calcium Channels/metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/metabolism
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
European journal of pharmacology
Extracellular Space/*drug effects/*metabolism
Geldenhuys Werner J
In Vitro Techniques
Male
Methamphetamine/pharmacology
Mice
Neostriatum/*cytology/drug effects
PC12 Cells
Perfusion
Potassium Channel Blockers/pharmacology
Potassium Channels
Potassium Chloride/pharmacology
Rats
Voltage-Gated/antagonists & inhibitors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cell.2014.03.039" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cell.2014.03.039</a>
Pages
858–868
Issue
4
Volume
157
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.
Publisher
An entity responsible for making the resource available
Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-05
Subject
The topic of the resource
*Affect; *Circadian Rhythm; Animals; Bipolar Disorder/genetics; CLOCK Proteins/genetics/metabolism; Cytoplasmic and Nuclear/genetics/*metabolism; Dopamine/*metabolism; Genetic; Group A; Histones/metabolism; Humans; Inbred C57BL; Knockout; Male; Member 2/metabolism; Mesencephalon/*metabolism; Mice; Mood Disorders/genetics/metabolism; Nuclear Receptor Subfamily 4; Rats; Receptors; Repressor Proteins/genetics/*metabolism; Transcription; Tyrosine 3-Monooxygenase/genetics
Creator
An entity primarily responsible for making the resource
Chung Sooyoung; Lee Eun Jeong; Yun Seongsik; Choe Han Kyoung; Park Seong-Beom; Son Hyo Jin; Kim Kwang-Soo; Dluzen Dean E; Lee Inah; Hwang Onyou; Son Gi Hoon; Kim Kyungjin
Description
An account of the resource
The circadian nature of mood and its dysfunction in affective disorders is well recognized, but the underlying molecular mechanisms are still unclear. Here, we show that the circadian nuclear receptor REV-ERBalpha, which is associated with bipolar disorder, impacts midbrain dopamine production and mood-related behavior in mice. Genetic deletion of the Rev-erbalpha gene or pharmacological inhibition of REV-ERBalpha activity in the ventral midbrain induced mania-like behavior in association with a central hyperdopaminergic state. Also, REV-ERBalpha repressed tyrosine hydroxylase (TH) gene transcription via competition with nuclear receptor-related 1 protein (NURR1), another nuclear receptor crucial for dopaminergic neuronal function, thereby driving circadian TH expression through a target-dependent antagonistic mechanism. In conclusion, we identified a molecular connection between the circadian timing system and mood regulation, suggesting that REV-ERBalpha could be targeting in the treatment of circadian rhythm-related affective disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cell.2014.03.039" target="_blank" rel="noreferrer noopener">10.1016/j.cell.2014.03.039</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Affect
*Circadian Rhythm
2014
Animals
Bipolar Disorder/genetics
Cell
Choe Han Kyoung
Chung Sooyoung
CLOCK Proteins/genetics/metabolism
Cytoplasmic and Nuclear/genetics/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Genetic
Group A
Histones/metabolism
Humans
Hwang Onyou
Inbred C57BL
Kim Kwang-Soo
Kim Kyungjin
Knockout
Lee Eun Jeong
Lee Inah
Male
Member 2/metabolism
Mesencephalon/*metabolism
Mice
Mood Disorders/genetics/metabolism
Nuclear Receptor Subfamily 4
Park Seong-Beom
Rats
Receptors
Repressor Proteins/genetics/*metabolism
Son Gi Hoon
Son Hyo Jin
Transcription
Tyrosine 3-Monooxygenase/genetics
Yun Seongsik
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.12.013</a>
Pages
188–195
Issue
2
Volume
1035
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopamine transporter function differences between male and female CD-1 mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-02
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/physiology; Dopamine Plasma Membrane Transport Proteins; Dopamine/physiology; Female; Male; Membrane Glycoproteins/*physiology; Membrane Transport Proteins/*physiology; Mice; Nerve Tissue Proteins/*physiology
Creator
An entity primarily responsible for making the resource
Bhatt Sandeep D; Dluzen Dean E
Description
An account of the resource
It has been reported that male mice are more susceptible to the neurotoxic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system. Since MA utilizes the dopamine transporter (DAT) to exert its effects, in the present study, we tested for differences in the dynamics of DAT function between male and female mice as an approach to understand some of the bases for this sex difference in MA-induced NSDA neurotoxicity. To accomplish this goal, in Experiment 1, the amount of dopamine (DA) obtained following DA infusion into the superfused striatal tissue fragments of male and female mice was measured while in Experiment 2 responses to the DA uptake blocker, nomifensine (NMF), were assessed in these preparations. The differences obtained to these treatments demonstrate that marked differences in DA transporter activity exist between male and female mice. When combining the DA and DOPAC measures from these two experiments, the data suggest that the female mice show a more active and efficient recovery and vesicular packaging of extracellular DA. These findings have important implications for sex differences in NSDA functions and responses to neurotoxins which enter the neurons via the DAT.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.12.013</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2005
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Bhatt Sandeep D
Brain research
Corpus Striatum/physiology
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins
Dopamine/physiology
Female
Male
Membrane Glycoproteins/*physiology
Membrane Transport Proteins/*physiology
Mice
Nerve Tissue Proteins/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainres.2004.09.043" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.09.043</a>
Pages
186–194
Issue
2
Volume
1029
Dublin Core
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Title
A name given to the resource
Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-12
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine Agents/*pharmacology; Dopamine Plasma Membrane Transport Proteins; Dopamine/*metabolism; Drug Synergism; Estrogen Antagonists/*pharmacology; Inbred Strains; Male; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/metabolism; Methamphetamine/*pharmacology; Mice; Nerve Tissue Proteins/metabolism; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Willett Matthew C; Dluzen Dean E
Description
An account of the resource
The antiestrogen, tamoxifen (TMX), has been shown to function as a neuroprotectant against the nigrostriatal dopaminergic (NSDA) neurotoxin, methamphetamine (MA), within male mice. In the present report, we examined the effects of a combined infusion of TMX and MA within superfused striatal tissue fragments of male mice as an approach to understand some of the bases for TMX to function as a NSDA neuroprotectant within male mice. In Experiment 1, a coinfusion of TMX at 1, 10, or 100 pg/ml were all equally effective in increasing
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainres.2004.09.043" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.09.043</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animals
Brain research
Corpus Striatum/*drug effects/*metabolism
Dluzen Dean E
Dopamine Agents/*pharmacology
Dopamine Plasma Membrane Transport Proteins
Dopamine/*metabolism
Drug Synergism
Estrogen Antagonists/*pharmacology
Inbred Strains
Male
Membrane Glycoproteins/metabolism
Membrane Transport Proteins/metabolism
Methamphetamine/*pharmacology
Mice
Nerve Tissue Proteins/metabolism
Tamoxifen/*pharmacology
Willett Matthew C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bmcl.2011.06.060" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2011.06.060</a>
Pages
4798–4803
Issue
16
Volume
21
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Publisher
An entity responsible for making the resource available
Bioorganic & medicinal chemistry letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
Animals; Humans; Inbred C57BL; Male; Mice; Models; Molecular; Molecular Structure; Monoamine Oxidase Inhibitors/chemical synthesis/chemistry/*pharmacology; Monoamine Oxidase/*metabolism; Stereoisomerism; Structure-Activity Relationship; Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Creator
An entity primarily responsible for making the resource
Carroll Richard T; Dluzen Dean E; Stinnett Hilary; Awale Prabha S; Funk Max O; Geldenhuys Werner J
Description
An account of the resource
The neuroprotective activity of pioglitazone and rosiglitazone in the MPTP parkinsonian mouse prompted us to evaluate a set of thiazolidinedione (TZD) type compounds for monoamine oxidase A and B inhibition activity. These compounds were able to inhibit MAO-B over several log units of magnitude (82 nM to 600 muM). Initial structure-activity relationship studies identified key areas to modify the aromatic substituted TZD compounds. Primarily, substitutions on the aromatic group and the TZD nitrogen were key areas where activity was enhanced within this group of compounds.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bmcl.2011.06.060" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2011.06.060</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Awale Prabha S
Bioorganic & medicinal chemistry letters
Carroll Richard T
Dluzen Dean E
Funk Max O
Geldenhuys Werner J
Humans
Inbred C57BL
Male
Mice
Models
Molecular
Molecular Structure
Monoamine Oxidase Inhibitors/chemical synthesis/chemistry/*pharmacology
Monoamine Oxidase/*metabolism
Stereoisomerism
Stinnett Hilary
Structure-Activity Relationship
Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2009.07.004</a>
Pages
1401–1411
Issue
11
Volume
78
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.
Publisher
An entity responsible for making the resource available
Biochemical pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Female; Male; Messenger/biosynthesis; Mice; Mutant Strains; Protein Binding; Reserpine/pharmacology; RNA; Sex Characteristics; Substantia Nigra/*metabolism; Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
Creator
An entity primarily responsible for making the resource
Ji Jing; Bourque Melanie; Di Paolo Therese; Dluzen Dean E
Description
An account of the resource
Female mice with a heterozygous mutation of their dopamine transporter (+/- DAT) showed relatively robust reductions in striatal DAT specific binding (38-50%), while +/- DAT males showed modest reductions (24-32%). Significant decreases in substantia nigra DAT specific binding (42%) and mRNA (24%) were obtained in +/- DAT females, but not +/- DAT males (19% and 5%, respectively). The effects of this DAT perturbation upon vesicular monoamine transporter-2 (VMAT-2) function revealed significantly greater reserpine-evoked DA output from +/+ and +/- DAT female as compared to male mice and the DA output profile differed markedly between +/+ and +/- DAT females, but not males. No changes in VMAT-2 protein or mRNA levels were present among these conditions. On the basis of these data, we propose: (1) a genetic mutation of the DAT does not exert equivalent effects upon the DAT in female and male mice, with females being more affected; (2) an alteration in the DAT may also affect VMAT-2 function; (3) this interaction between DAT and VMAT-2 function is more prevalent in female mice; and (4) the +/- DAT mutation affects VMAT-2 function through an indirect mechanism, that does not involve an alteration in VMAT-2 protein or mRNA. Such DAT/VMAT-2 interactions can be of significance to the gender differences observed in drug addiction and Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2009.07.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Biochemical pharmacology
Bourque Melanie
Corpus Striatum/*metabolism
Di Paolo Therese
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Female
Ji Jing
Male
Messenger/biosynthesis
Mice
Mutant Strains
Protein Binding
Reserpine/pharmacology
RNA
Sex Characteristics
Substantia Nigra/*metabolism
Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-007-0017-0</a>
Pages
809–817
Issue
6
Volume
115
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-06
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/drug effects/*metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine Uptake Inhibitors/pharmacology; Dopamine/*metabolism; Down-Regulation/drug effects/genetics; Female; Gene Expression Regulation/drug effects/genetics; Heterozygote; Knockout; Male; Methamphetamine/pharmacology; Mice; Mutation/*genetics; Neural Pathways/drug effects/metabolism; Potassium Chloride/metabolism/pharmacology; Substantia Nigra/drug effects/metabolism; Synaptic Transmission/drug effects/genetics; Up-Regulation/drug effects/genetics
Creator
An entity primarily responsible for making the resource
Ji Jing; Dluzen Dean E
Description
An account of the resource
The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA) stimulation between male and female mice was examined. Striatal DA and DOPAC concentrations of female +/- DAT mice were significantly decreased as compared with wild type (+/+) controls and male +/- DAT mice. No such changes were obtained from the olfactory tubercle suggesting that these effects might be specific for the striatum. Potassium-stimulated DA was increased in male and female +/- DAT mice and maximally stimulated DA was obtained from +/- DAT females, although these mice showed the lowest DA concentrations. MA-evoked DA was increased in male and female +/- mice. While MA-evoked DA was significantly increased in +/+ males versus +/+ females, the +/- females showed the highest DA responses, thereby showing a reversal in the results seen in wild-type conditions. These findings indicate: (1) that a deficiency in the DAT interacts with the sex of the subject, (2)+/- DAT females show more extreme changes in dopaminergic responses, and (3) the importance for considering such variables such as sex when examining differences among knock-out conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">10.1007/s00702-007-0017-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain/drug effects/*metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine Uptake Inhibitors/pharmacology
Dopamine/*metabolism
Down-Regulation/drug effects/genetics
Female
Gene Expression Regulation/drug effects/genetics
Heterozygote
Ji Jing
Journal of neural transmission (Vienna, Austria : 1996)
Knockout
Male
Methamphetamine/pharmacology
Mice
Mutation/*genetics
Neural Pathways/drug effects/metabolism
Potassium Chloride/metabolism/pharmacology
Substantia Nigra/drug effects/metabolism
Synaptic Transmission/drug effects/genetics
Up-Regulation/drug effects/genetics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf03033303" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf03033303</a>
Pages
15–21
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rotenone produces opposite effects upon mouse striatal dopamine function as a result of environmental temperature.
Publisher
An entity responsible for making the resource available
Neurotoxicity research
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-01
Subject
The topic of the resource
*Temperature; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Analysis of Variance; Animals; Brain Chemistry/drug effects/physiology/radiation effects; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Insecticides/*pharmacology; Methamphetamine/pharmacology; Mice; Rotenone/*pharmacology
Creator
An entity primarily responsible for making the resource
Crutchfield Karla C; Dluzen Dean E
Description
An account of the resource
Rotenone is a commonly used pesticide that can function as an environmental neurotoxin. Rotenone is a known mitochondrial complex I inhibitor which can lead to oxidative stress and results in dopaminergic cell death. Another environmental factor known to exacerbate oxidative stress and result in striatal dopaminergic cell death is elevated environmental temperature. In this study we evaluated the effects of a single injection of various doses of rotenone (0.65, 1.3 and 2.6 mg/kg) on striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in CD-1 mice and compared this with a single injection of two doses of methamphetamine (MA - 10 or 20 mg/kg), a known striatal DA depleting agent, as administered to mice maintained at 21 degrees C (Experiment 1). These results were then compared to striatal DA and DOPAC concentrations of mice treated with rotenone (1.3 or 2.6 mg/kg) or MA (10 or 20 mg/kg) administered to mice maintained at 28 degrees C (Experiment 2). A single injection of rotenone to mice maintained at 21 degrees C resulted in a significant increase in DA and decrease in DOPAC concentrations for all doses tested compared to controls, whereas a single injection of MA at the same temperature resulted in a significant decrease in DA and no change in DOPAC concentrations. At a temperature of 28 degrees C, a single injection of rotenone resulted in a significant decrease in both DA and DOPAC concentrations similar to that seen with the MA-treated mice. Collectively, these results indicate that rotenone interacts with environmental temperature to produce opposite effects upon striatal DA concentrations – significantly increasing striatal DA when administered at 21 degrees C and significantly decreasing striatal DA when administered at 28 degrees C, while producing similar decreases in striatal DOPAC under both temperatures.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf03033303" target="_blank" rel="noreferrer noopener">10.1007/bf03033303</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*temperature
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Analysis of Variance
Animals
Brain Chemistry/drug effects/physiology/radiation effects
Corpus Striatum/*drug effects/metabolism
Crutchfield Karla C
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Insecticides/*pharmacology
Methamphetamine/pharmacology
Mice
Neurotoxicity research
Rotenone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.21554" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.21554</a>
Pages
686–693
Issue
8
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nomifensine alters sex differences in striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Dopamine Plasma Membrane Transport Proteins/drug effects/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Female; Inbred Strains; Male; Methamphetamine/pharmacology; Mice; Neostriatum/drug effects/metabolism; Nomifensine/*pharmacology
Creator
An entity primarily responsible for making the resource
Poth Luke S; O'Connell Bryan P; McDermott Janet L; Dluzen Dean E
Description
An account of the resource
A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg kg(-)(1)), at 30 min prior to injection of methamphetamine (40 mg kg(-)(1)) significantly decreased the amount of striatal dopamine depletion in male, but not female, mice, thereby abolishing the sex difference in methamphetamine-induced neurotoxicity (males \textgreater females). In Experiment 2, the methamphetamine-evoked sex differences in dopamine and DOPAC output from superfused striatal tissue (males \textgreater females) were abolished in mice treated with nomifensine at 30 min prior to tissue removal. In Experiment 3, the potassium chloride-evoked sex differences in dopamine and DOPAC output from superfused striatal tissue (females \textgreater males) were reversed in mice treated with nomifensine at 30 min prior to tissue removal. Taken together these results demonstrate the critical role played by catecholamine transporters in sex differences of dopaminergic function and suggest that this may involve the dopamine transporter, due to its high concentrations within the striatum. Such findings highlight the need for gender-specific considerations in use of treatments that target reuptake transporters function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.21554" target="_blank" rel="noreferrer noopener">10.1002/syn.21554</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2012
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/drug effects/metabolism
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Female
Inbred Strains
Male
McDermott Janet L
Methamphetamine/pharmacology
Mice
Neostriatum/drug effects/metabolism
Nomifensine/*pharmacology
O'Connell Bryan P
Poth Luke S
Synapse (New York, N.Y.)
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20309</a>
Pages
347–353
Issue
5
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone modulation of striatal dopamine output in orchidectomized mice.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
Adrenergic Uptake Inhibitors/pharmacology; Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism/pharmacology; Male; Mice; Neural Pathways/drug effects/*metabolism; Orchiectomy; Potassium Chloride/pharmacology; Presynaptic Terminals/drug effects/metabolism; Reserpine/pharmacology; Sex Characteristics; Substantia Nigra/drug effects/*metabolism; Synaptic Transmission/drug effects/physiology; Synaptic Vesicles/drug effects/metabolism; Testosterone/*metabolism; Vesicular Monoamine Transport Proteins/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Shemisa Kamal; Kunnathur Vidhya; Liu Bin; Salvaterra Ty J; Dluzen Dean E
Description
An account of the resource
Three experiments are presented in which dopamine (DA) responses from superfused striatal tissue of orchidectomized (ORCH) mice treated or not with testosterone (T) are compared. In experiment 1, potassium-stimulated DA output was significantly greater in ORCH vs. ORCH+T mice. This profile was reversed when reserpine was infused in experiment 2, with DA output being significantly greater in ORCH+T vs. ORCH mice. In experiment 3, the amount of DA recovered following infusion of DA indicated no statistically significant differences in DA recoveries between ORCH and ORCH+T mice as tested in this paradigm. The findings that both potassium- and reserpine-induced DA responses are altered significantly by T suggests that one potential site of T action might involve the storage/uptake of DA within the vesicles of these neurons. Such results have important implications with regard to understanding the sex differences that are present in nigrostriatal dopaminergic function within health and diseased states.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">10.1002/syn.20309</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Adrenergic Uptake Inhibitors/pharmacology
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine/*metabolism/pharmacology
Kunnathur Vidhya
Liu Bin
Male
Mice
Neural Pathways/drug effects/*metabolism
Orchiectomy
Potassium Chloride/pharmacology
Presynaptic Terminals/drug effects/metabolism
Reserpine/pharmacology
Salvaterra Ty J
Sex Characteristics
Shemisa Kamal
Substantia Nigra/drug effects/*metabolism
Synapse (New York, N.Y.)
Synaptic Transmission/drug effects/physiology
Synaptic Vesicles/drug effects/metabolism
Testosterone/*metabolism
Vesicular Monoamine Transport Proteins/drug effects/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.20307" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20307</a>
Pages
354–361
Issue
5
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity; Animal; Animals; Corpus Striatum/*drug effects/metabolism/physiopathology; Disease Models; Dopamine/metabolism; Estrogens/metabolism/*pharmacology/therapeutic use; Female; Male; Methamphetamine/*antagonists & inhibitors/toxicity; Mice; Nerve Degeneration/chemically induced/*drug therapy/prevention & control; Neural Pathways/drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/*pharmacology/therapeutic use; Neurotoxins/antagonists & inhibitors/toxicity; Orchiectomy; Ovariectomy; Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control; Substantia Nigra/*drug effects/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
In the present study, we investigated whether estrogen remains effective as a neuroprotectant within an impaired nigrostriatal dopaminergic (NSDA) system of gonadectomized female and male mice. In Experiment 1, mice were treated with four different regimens of methamphetamine (MA) to establish a protocol for an impaired NSDA system to be used in subsequent experiments. Based upon the results of Experiment 1, in Experiment 2 gonadectomized female mice received a treatment with either control (saline), low- or high-dose of MA to produce an initial NSDA impairment. At one week post-MA, mice received either estradiol benzoate (10 microg) or vehicle followed 24 h later with low-MA or saline. Estrogen altered the toxic effects of the second invasion of MA as indicated by a significant decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations. In addition, DA and DOPAC depletion was greater in high- vs. low-dose MA. In gonadectomized male mice (Experiment 3), striatal DA and DOPAC concentrations showed greater decreases following high-, vs. low-doses of MA; however, estrogen did not alter these responses. These results demonstrate that the capacity for estrogen to protect or worsen MA-induced neurotoxicity of dopaminergic neurons is limited to female mice and depends on the condition of the NSDA system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.20307" target="_blank" rel="noreferrer noopener">10.1002/syn.20307</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity
Animal
Animals
Corpus Striatum/*drug effects/metabolism/physiopathology
Disease Models
Dluzen Dean E
Dopamine/metabolism
Estrogens/metabolism/*pharmacology/therapeutic use
Female
Liu Bin
Male
Methamphetamine/*antagonists & inhibitors/toxicity
Mice
Nerve Degeneration/chemically induced/*drug therapy/prevention & control
Neural Pathways/drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/*pharmacology/therapeutic use
Neurotoxins/antagonists & inhibitors/toxicity
Orchiectomy
Ovariectomy
Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control
Substantia Nigra/*drug effects/metabolism/physiopathology
Synapse (New York, N.Y.)
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.10027" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.10027</a>
Pages
112–117
Issue
2
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Striatal dopamine output is compromised within +/- BDNF mice.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-02
Subject
The topic of the resource
Animals; Brain-Derived Neurotrophic Factor/*deficiency/genetics; Dopamine/*metabolism; Drug Interactions/physiology; Extracellular Space/drug effects/metabolism; Female; Genotype; Inbred BALB C; Knockout; Male; Methamphetamine/pharmacology; Mice; Neostriatum/drug effects/*metabolism/physiopathology; Neural Pathways/drug effects/*metabolism/physiopathology; Neurons/drug effects/*metabolism; Parkinsonian Disorders/genetics/*metabolism/physiopathology; Perfusion/methods; Potassium/metabolism/pharmacology; Substantia Nigra/drug effects/*metabolism/physiopathology
Creator
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Dluzen Dean E; Anderson Linda I; McDermott Janet L; Kucera Jan; Walro Jon M
Description
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We reported previously that mice lacking one brain-derived neurotrophic factor (BDNF) allele demonstrate elevated striatal dopamine (DA) concentrations but impaired behavioral responses involving the nigrostriatal dopaminergic (NSDA) system. To test the hypothesis that these elevated striatal DA concentrations are associated with perturbed NSDA functioning, we compared striatal DA output between heterozygous mutant (+/-) and wild-type littermate control (+/+) BDNF mice under conditions of an intact NSDA system, as well as following methamphetamine (MA)-induced neurotoxicity. Basal DA output from superfused CS tissue fragments did not differ between +/+ and +/- BDNF mice. Potassium (K+) stimulated DA outputs from intact striatal fragments of +/+ mice were significantly greater than that of +/- BDNF mice. Following MA treatment, K+ stimulated DA output of +/+ mice was statistically equivalent to +/- BDNF mice. Striatal DA concentrations of +/- BDNF mice were elevated, albeit not significantly, in both intact and MA-treated mice relative to +/+ mice. Following MA treatment, striatal DA concentrations were significantly decreased for both genotypes; however, the degree of DA depletion was significantly greater in +/+ mice. Analyzed collectively, these data show the differential effects exerted by a BDNF mutation upon striatal DA concentrations and output. Notably, lower striatal DA concentrations of +/+ vs. +/- BDNF mice can be contrasted with the significantly greater K+ stimulated DA output from the former. This difference was abolished following MA treatment. These results suggest that processes involved with the dynamics of DA release within the NSDA system may be compromised in +/- BDNF mutant mice.
Identifier
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<a href="http://doi.org/10.1002/syn.10027" target="_blank" rel="noreferrer noopener">10.1002/syn.10027</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Anderson Linda I
Animals
Brain-Derived Neurotrophic Factor/*deficiency/genetics
Dluzen Dean E
Dopamine/*metabolism
Drug Interactions/physiology
Extracellular Space/drug effects/metabolism
Female
Genotype
Inbred BALB C
Knockout
Kucera Jan
Male
McDermott Janet L
Methamphetamine/pharmacology
Mice
Neostriatum/drug effects/*metabolism/physiopathology
Neural Pathways/drug effects/*metabolism/physiopathology
Neurons/drug effects/*metabolism
Parkinsonian Disorders/genetics/*metabolism/physiopathology
Perfusion/methods
Potassium/metabolism/pharmacology
Substantia Nigra/drug effects/*metabolism/physiopathology
Synapse (New York, N.Y.)
Walro Jon M
-
Text
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URL Address
<a href="http://doi.org/10.1002/cbic.201300770" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cbic.201300770</a>
Pages
1591–1598
Issue
11
Volume
15
Dublin Core
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Title
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Methyl Yellow: A Potential Drug Scaffold for Parkinson's Disease.
Publisher
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Chembiochem : a European journal of chemical biology
Date
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2014
2014-07
Subject
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*MAO-B inhibitor; *methyl yellow; *MPTP mouse model; *Parkinson's disease; *TMRM
Creator
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Geldenhuys Werner J; Kochi Akiko; Lin Li; Sutariya Vijaykumar; Dluzen Dean E; Van der Schyf Cornelis J; Lim Mi Hee
Description
An account of the resource
Parkinson's disease (PD) is an age-related neurodegenerative disease affecting movement. To date, there are no currently available therapeutic agents which can prevent or slow disease progression. Here, we evaluated an azobenzene derivative, methyl yellow (MY), as a potential drug scaffold for PD; its inhibitory activity toward monoamine oxidase B (MAO-B) as well as drug-like properties were investigated. The inhibitory effect of MY on MAO activity was determined by a MAO enzyme inhibition assay. In addition, the in vitro properties of MY as a drug candidate (e.g., blood-brain barrier (BBB) permeability, serum albumin binding, drug efflux through P-glycoprotein (P-gp), drug metabolism by P450, and mitochondrial toxicity) were examined. In vivo effectiveness of MY was also evaluated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonian mouse model. MY selectively inhibited MAO-B in a dose-dependent and reversible manner. MY was BBB-permeable, bound relatively weakly to serum albumin, was an unlikely substrate for both systems of P-gp and P450, and did not cause mitochondrial toxicity. Results from the MPTP Parkinsonian mouse model indicated that, upon treatment with MY, neurotoxicity induced by MPTP was mitigated. Investigations of MY demonstrate its inhibitory activity toward MAO-B, compliant properties for drug consideration, and its neuroprotective capability in the MPTP Parkinsonian mouse model. These data provide insights into potential use, optimization, and new design of azobenzene derivatives for PD treatment.
Identifier
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<a href="http://doi.org/10.1002/cbic.201300770" target="_blank" rel="noreferrer noopener">10.1002/cbic.201300770</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MAO-B inhibitor
*methyl yellow
*MPTP mouse model
*Parkinson's disease
*TMRM
2014
Chembiochem : a European journal of chemical biology
Dluzen Dean E
Geldenhuys Werner J
Kochi Akiko
Lim Mi Hee
Lin Li
Sutariya Vijaykumar
Van der Schyf Cornelis J