1
40
16
-
Text
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n/a
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Pages
A946-A946
Issue
5
Volume
18
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Title
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Testosterone But Not Estrogen Increases Collagen Type I Synthesis In Rat Coronary Artery Adventitial Fibroblasts
Publisher
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Jenkins C; Milsted A; Doane K J; Meszaros J G; Ely D L
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n/a
Format
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Journal Article or Conference Abstract Publication
2004
Biochemistry & Molecular Biology
Cell Biology
Doane K J
Ely D L
Faseb Journal
Jenkins C
Journal Article or Conference Abstract Publication
Life Sciences & Biomedicine - Other
Meszaros J G
Milsted A
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
389-389
Volume
8
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Type Vi Collagen Promotes Cellular Adhesion And Survival
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Molecular Biology of the Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-11
Subject
The topic of the resource
Cell Biology
Creator
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Howell S J; Doane K J
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1997
Cell Biology
Doane K J
Howell S J
Journal Article or Conference Abstract Publication
Molecular Biology of the Cell
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Pages
2475-2475
Volume
7
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Title
A name given to the resource
Functional Interaction Between Beta(1) Integrins And Collagens May Prevent Apoptosis During Avian Corneal Stromal Development
Publisher
An entity responsible for making the resource available
Molecular Biology of the Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Howell S J; Doane K J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Cell Biology
Doane K J
Howell S J
Journal Article or Conference Abstract Publication
Molecular Biology of the Cell
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2476-2476
Volume
7
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Title
A name given to the resource
Anti-sense Beta 1 Integrin Perturbs Interactions Of Corneal Fibroblasts And Periocular Mesenchyme Cells With Fibronectin And Tenascin
Publisher
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Molecular Biology of the Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
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Cell Biology
Creator
An entity primarily responsible for making the resource
Bhattacharya R; Marchant J; Young B; Birk D E; Doane K J
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bhattacharya R
Birk D E
Cell Biology
Doane K J
Journal Article or Conference Abstract Publication
Marchant J
Molecular Biology of the Cell
Young B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2476-2476
Volume
7
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Title
A name given to the resource
Anti-sense Beta 1 Integrin Perturbs Interactions Of Corneal Fibroblasts And Periocular Mesenchyme Cells With Fibronectin And Tenascin
Publisher
An entity responsible for making the resource available
Molecular Biology of the Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Bhattacharya R; Marchant J; Young B; Birk D E; Doane K J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1996
Bhattacharya R
Birk D E
Cell Biology
Doane K J
Marchant J
Molecular Biology of the Cell
Young B
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1468-A1468
Issue
7
Volume
13
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Title
A name given to the resource
Isolation of a putative chicken homolog of the fibroblast growth factor binding protein (FGF-BP) that is expressed in the cornea
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Vernell R J; Doane K J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1999
Biochemistry & Molecular Biology
Cell Biology
Doane K J
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Topics
Vernell R J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A1428-A1429
Issue
6
Volume
21
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Title
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Cardiac fibroblast migration during in vitro wound healing: The role of specific collagen substrates
Publisher
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Shamhart P E; Naugle J E; Olson E R; Liruska M A; Doane K J; Meszaros J G
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2007
Biochemistry & Molecular Biology
Cell Biology
Doane K J
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Liruska M A
Meszaros J G
Naugle J E
Olson E R
Shamhart P E
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
16-16
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Title
A name given to the resource
Differential expression of leukocyte enzymes in the peripheral blood of maturing chick embryos
Publisher
An entity responsible for making the resource available
Journal of Leukocyte Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998
Subject
The topic of the resource
Cell Biology; Hematology; Immunology
Creator
An entity primarily responsible for making the resource
Niehaus G D; Bulgren J; Chung D; Doane K J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1998
Bulgren J
Cell Biology
Chung D
Doane K J
Hematology
Immunology
Journal Article
Journal of Leukocyte Biology
Niehaus G D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A311-A311
Issue
4
Volume
18
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Title
A name given to the resource
Growth and differentiation of cardiac fibroblasts and myoribroblasts: regulation by collagen types I, III and cyclic AMP
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Naugle J E; Olson E R; Zhang X J; Mase S; Doane K J; Meszaros J G
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2004
Biochemistry & Molecular Biology
Cell Biology
Doane K J
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Mase S
Meszaros J G
Naugle J E
Olson E R
Topics
Zhang X J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1469-7580.1998.19210013.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1469-7580.1998.19210013.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-23
Volume
192
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Title
A name given to the resource
Ultrastructural and cytochemical evaluation of sepsis-induced changes in the rat pulmonary intravascular mononuclear phagocytes
Publisher
An entity responsible for making the resource available
Journal of Anatomy
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
acid-phosphatase; Anatomy & Morphology; Blood; cells; coagulation; differentiation; endotoxin; expression; host defence; human macrophage; lung uptake; monocytes; mononuclear phagocyte system; surface-coat
Creator
An entity primarily responsible for making the resource
Singh B; Doane K J; Niehaus G D
Description
An account of the resource
Sepsis stimulates an increase in the number and activity of mononuclear phagocytes in systemic host-defence organs. The present study was conducted to define the ultrastructural and cytochemical characteristics of the mononuclear phagocytes that sequester in the lung microvasculature of septic rats, Fourteen rats were challenged with a single intraperitoneal injection of saline (0.5 ml/100 g), E. coli (2 x 10(7)/100 g) or glucan (4 mg/100 g), and euthanased 2, 4, or 7 d later. The lungs were inflation fixed and processed for transmission electron microscopy. Cellular morphology was used to identify the intravascular mononuclear phagocytes and acid phosphatase (AcPase) expression was monitored as an index of cellular differentiation and activation. Control rats contained a limited number of monocytes in the pulmonary vasculature. In contrast, large numbers of activated mononuclear phagocytes were seen in the microvasculature within 48 h of treatment with either microbial product. The recruited pulmonary intravascular mononuclear phagocytes (PIMP) exhibited AcPase-reactive Golgi complexes, accumulation of secretory vesicles and other features of cell activation consistent with enhanced biosynthetic activity. Subsequent electron microscopy, conducted 4 and 7 d posttreatment, suggested that a progressive decline in the number and activity of PIMPs then occurred. In order to quantify the sepsis-induced accumulation of AcPase-positive PIMP, the experimental challenges were repeated in 11 rats and, 48 h later, tissue samples were evaluated by light microscopy for tartrate-insensitive acid phosphatase. Control rats exhibited 0.148 +/- 0.107 AcPase-positive PIMP/alveoli. E. coli and glucan challenged animals exhibited significant (P < 0.01) increases in AcPase-positive mononuclear phagocytes, with 0.782+/-0.073 and 0.636+/-0.170 PIMP/alveoli respectively, The results demonstrate that focal sepsis stimulates a significant, but transient, recruitment of activated mononuclear phagocytes into the rat pulmonary microvasculature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1469-7580.1998.19210013.x" target="_blank" rel="noreferrer noopener">10.1046/j.1469-7580.1998.19210013.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1998
acid-phosphatase
Anatomy & Morphology
Blood
Cells
coagulation
differentiation
Doane K J
endotoxin
expression
host defence
human macrophage
Journal Article
Journal of anatomy
lung uptake
monocytes
mononuclear phagocyte system
Niehaus G D
Singh B
surface-coat
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1103/PhysRevE.71.020702" target="_blank" rel="noreferrer noopener">http://doi.org/10.1103/PhysRevE.71.020702</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4-4
Issue
2
Volume
71
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Title
A name given to the resource
Real-time microbe detection based on director distortions around growing immune complexes in lyotropic chromonic liquid crystals
Publisher
An entity responsible for making the resource available
Physical Review E
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-02
Subject
The topic of the resource
cells; ligand-receptor binding; Physics
Creator
An entity primarily responsible for making the resource
Shiyanovskii S V; Schneider T; Smalyukh I I; Ishikawa T; Niehaus G D; Doane K J; Woolverton C J; Lavrentovich O D
Description
An account of the resource
We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a nontoxic lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the LCLC. Upon antibody-antigen binding, the growing immune complexes distort the director and cause detectable optical transmittance between crossed polarizers.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1103/PhysRevE.71.020702" target="_blank" rel="noreferrer noopener">10.1103/PhysRevE.71.020702</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
Cells
Doane K J
Ishikawa T
Journal Article
Lavrentovich O D
ligand-receptor binding
Niehaus G D
Physical Review E
Physics
Schneider T
Shiyanovskii S V
Smalyukh I I
Woolverton C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/15421400590957288" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/15421400590957288</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
587-598
Volume
434
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Title
A name given to the resource
Lyotropic chromonic liquid crystals for biological sensing applications
Publisher
An entity responsible for making the resource available
Molecular Crystals and Liquid Crystals
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005
Subject
The topic of the resource
biosensor; cells; Chemistry; chromonics; Crystallography; ligand-receptor binding; liquid crystal; Materials Science
Creator
An entity primarily responsible for making the resource
Shiyanovskii S V; Lavrentovich O D; Schneider T; Ishikawa T; Smalyukh I I; Woolverton C J; Niehaus G D; Doane K J
Description
An account of the resource
We describe director distortions in the nematic liquid crystal (LC) caused by a spherical particle with tangential surface orientation of the director and show that light transmittance through the distorted region is a steep function of the particle's size. The effect allows us to propose a real-time microbial sensor based on a lyotropic chromonic LC (LCLC) that detects and amplifies the presence of immune complexes. A cassette is filled with LCLC, antibody, and antigen-bearing particles. Small and isolated particles cause no macroscopic distortions of the uniformly aligned LCLC. Upon antibody-antigen binding, the growing immune complexes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/15421400590957288" target="_blank" rel="noreferrer noopener">10.1080/15421400590957288</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
biosensor
Cells
Chemistry
chromonics
Crystallography
Doane K J
Ishikawa T
Journal Article
Lavrentovich O D
ligand-receptor binding
liquid crystal
Materials Science
Molecular Crystals and Liquid Crystals
Niehaus G D
Schneider T
Shiyanovskii S V
Smalyukh I I
Woolverton C J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00321.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00321.2005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
A682-A682
Issue
4
Volume
19
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Title
A name given to the resource
Type VI collagen induces cardiac myofibroblast differentiation: implications for post-infarction remodeling
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-03
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Naugle J E; Olson E R; Zhang X J; Mase S E; Pilati C F; Doane K J; Meszaros J G
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00321.2005" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00321.2005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2005
Biochemistry & Molecular Biology
Cell Biology
Doane K J
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
Mase S E
Meszaros J G
Naugle J E
Olson E R
Pilati C F
Topics
Zhang X J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
263–275
Issue
2
Volume
39
Dublin Core
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Title
A name given to the resource
Identification and functional characterization of two type VI collagen receptors, alpha 3 beta 1 integrin and NG2, during avian corneal stromal development.
Publisher
An entity responsible for making the resource available
Investigative ophthalmology & visual science
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-02
Subject
The topic of the resource
Animals; Chick Embryo; Fibroblasts/metabolism; Cell Movement/physiology; Immunoblotting; Integrins/*metabolism; Fluorescent Antibody Technique; Cell Culture Techniques; Extracellular Matrix/metabolism; Antigens/*metabolism; Cell Polarity/physiology; Cell Size/physiology; Collagen/*metabolism; Corneal Stroma/*embryology/*metabolism; Integrin alpha3beta1; Proteoglycans/*metabolism; Receptors; Indirect; Laminin/*metabolism
Creator
An entity primarily responsible for making the resource
Doane K J; Howell S J; Birk D E
Description
An account of the resource
PURPOSE: The development and maintenance of extracellular matrix architecture in the corneal stroma is associated with abundant type VI collagen deposition. This collagen has been implicated in mediating both cell-matrix and matrix-matrix interactions. Although corneal fibroblasts spread extensively on this collagen, its role in corneal development has not been elucidated. METHODS: To clarify the role of this collagen, two type VI collagen receptors were studied during corneal development using immunochemical techniques: alpha 3 beta 1 integrin and an integral membrane proteoglycan, NG2. RESULTS: At embryonic day 6, these receptors were present in a diffuse pattern on cells within the cornea and juxtacorneal regions, indicating a migratory phenotype. At embryonic day 14, when the stroma is fully differentiated, alpha 3 and NG2 were localized in a punctate pattern on a subset of corneal fibroblasts, whereas beta 1 was more ubiquitously expressed. Colocalization of NG2 and type VI collagen indicated that this collagen was present and punctate in its organization was associated with NG2-positive cells. Immunochemical analyses at embryonic days 5 and 14 revealed alpha 3 and beta 1 at 155 kDa and 120 kDa, respectively, and demonstrated that these subunits were interacting to form a heterodimer. NG2 was present with a core protein of 330 kDa and an intact proteoglycan of approximately 600 kDa, and analysis of stromal lysates indicated a chondroitin sulfate-containing proteoglycan. Matrix-receptor cross-linking demonstrated the interaction of beta 1 and NG2 in periocular mesenchyme cells and corneal fibroblasts with type VI collagen, whereas only a subset of cells expressed alpha 3, indicating the presence of another beta 1 integrin. No variations between in vivo and in vitro expression of either alpha 3 beta 1 or NG2 were observed. CONCLUSIONS: These data indicate that two receptors for type VI collagen, alpha 3 beta 1 and NG2, are present during corneal stromal development, with a functional interaction of these receptors with type VI collagen. These interactions may play a role in corneal cell migration, development, and maintenance of corneal architecture.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Animals
Antigens/*metabolism
Birk D E
Cell Culture Techniques
Cell Movement/physiology
Cell Polarity/physiology
Cell Size/physiology
Chick Embryo
Collagen/*metabolism
Corneal Stroma/*embryology/*metabolism
Doane K J
Extracellular Matrix/metabolism
Fibroblasts/metabolism
Fluorescent Antibody Technique
Howell S J
Immunoblotting
Indirect
Integrin alpha3beta1
Integrins/*metabolism
Investigative ophthalmology & visual science
Laminin/*metabolism
Proteoglycans/*metabolism
Receptors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/exer.1996.0033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/exer.1996.0033</a>
Pages
271–283
Issue
3
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.
Publisher
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Experimental eye research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
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*Extracellular Matrix; Animals; Cell Differentiation; Chick Embryo; Collagen/biosynthesis; Cornea/chemistry/*embryology/metabolism; Eye Proteins/analysis; Fibroblasts/cytology; Glycoproteins/analysis; Neural Crest/cytology; Proteoglycans/biosynthesis; Time Factors
Creator
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Doane K J; Ting W H; McLaughlin J S; Birk D E
Description
An account of the resource
The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both spatially and temporally. To elucidate the role of these matrices, extracellular matrix components in the periocular mesenchyme and cornea were analysed prior to and during migration and differentiation of corneal fibroblasts using antibodies against collagens, proteoglycans and glycoproteins. Previous work has concentrated on the matrix of the corneal stroma rather than the matrix of the periocular mesenchyme. Since the precursors of the corneal fibroblasts are present within the must migrate through the periocular mesenchyme prior to entry into the cornea proper, this environment was fully evaluated. The present study documents the matrix composition of both the cornea and periocular mesenchyme at developmental stages that are prior to and after initiation of corneal invasion by the corneal fibroblast precursors. Variations in matrix molecules comprising both the periocular mesenchyme and cornea were demonstrated. These include changes in the distribution of collagen types I, II, III, IV and VI; the proteoglycans decorin and lumican; as well as the adhesive glycoproteins tenascin, fibronectin and laminin. It is hypothesized that the variations in matrix localization are important in the regulation of cell migration and differentiation during normal corneal development. Any regulation is likely to involve a combination of components found in the extracellular matrices and therefore, a consideration of the matrix rather than isolated components is required.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/exer.1996.0033" target="_blank" rel="noreferrer noopener">10.1006/exer.1996.0033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Extracellular Matrix
1996
Animals
Birk D E
Cell Differentiation
Chick Embryo
Collagen/biosynthesis
Cornea/chemistry/*embryology/metabolism
Doane K J
Experimental eye research
Eye Proteins/analysis
Fibroblasts/cytology
Glycoproteins/analysis
McLaughlin J S
Neural Crest/cytology
Proteoglycans/biosynthesis
Time Factors
Ting W H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/excr.1998.4051" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/excr.1998.4051</a>
Pages
230–241
Issue
1
Volume
241
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Type VI collagen increases cell survival and prevents anti-beta 1 integrin-mediated apoptosis.
Publisher
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Experimental cell research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-05
Subject
The topic of the resource
Animals; Antibodies; Apoptosis/*drug effects/physiology; Cell Nucleus/drug effects/metabolism; Cell Survival/drug effects/physiology; Cells; Chick Embryo; Collagen/*pharmacology; Cornea/drug effects/embryology/ultrastructure; Culture Media/chemistry/pharmacology; Cultured; DNA Fragmentation/drug effects; Extracellular Matrix/physiology; Eye/drug effects/embryology/ultrastructure; Fibroblasts/drug effects/metabolism/ultrastructure; Genetic Techniques; Integrins/immunology; Monoclonal/*drug effects/pharmacology
Creator
An entity primarily responsible for making the resource
Howell S J; Doane K J
Description
An account of the resource
Cell-matrix interactions are important in the development of the avian cornea. Type VI collagen is present within the periocular mesenchyme prior to the migration of cells into the corneal stroma and is abundant in the mature stroma. Whether the interaction of cells with type VI collagen is essential for cellular survival in the cornea is not known. In the present study, we examined the interaction of corneal cells with type VI collagen in vitro to determine if it can increase cell proliferation and decrease apoptosis. In vivo analysis demonstrated that apoptosis occurs in the periocular region during early stages of avian corneal development, but in fully mature corneas apoptosis only occurs in the corneal epithelium and not in the stroma. In vitro analysis examined the importance of beta 1 integrin interactions with type VI collagen in mature corneal fibroblasts and the precursor cells. Using an anti-beta 1 integrin blocking antibody, CSAT, integrin/matrix interactions were disrupted. Results indicated that viability of both corneal fibroblasts and periocular mesenchyme cells was greater on type VI collagen than on type I collagen or BSA-blocked glass. In addition, less apoptosis was observed for both cell types on type VI collagen when beta 1 integrin–matrix interactions were disrupted. These data indicated that these cells require intact beta 1 interactions with type I collagen and with BSA-coated glass controls to remain viable. Thus, type VI collagen may play a role in the rescue of corneal cells from anti-beta 1 integrin-induced apoptosis by increasing cell survival, probably via a non-beta 1 integrin-dependent mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/excr.1998.4051" target="_blank" rel="noreferrer noopener">10.1006/excr.1998.4051</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Animals
Antibodies
Apoptosis/*drug effects/physiology
Cell Nucleus/drug effects/metabolism
Cell Survival/drug effects/physiology
Cells
Chick Embryo
Collagen/*pharmacology
Cornea/drug effects/embryology/ultrastructure
Culture Media/chemistry/pharmacology
Cultured
DNA Fragmentation/drug effects
Doane K J
Experimental cell research
Extracellular Matrix/physiology
Eye/drug effects/embryology/ultrastructure
Fibroblasts/drug effects/metabolism/ultrastructure
Genetic Techniques
Howell S J
Integrins/immunology
Monoclonal/*drug effects/pharmacology