Browse Items · NEOMED Bibliography Database

Hypertonic Saline In Stabilized Hyperdynamic Sepsis

Hypertonic saline with or without colloidal solution has been successfully used for treating hemorrhagic shock in animal experiments and clinical studies. Due to its various effects at systemic, organ, and microcirculatory levels, the substance…

Serum Folate: A Pharmacodynamic Biomarker of Intracellular Nitrosylcobalamin Activity Following Intravenous Administration in Dogs

Background/Aim: Cobalamin and folate are interdependent co-factors of the methionine synthase pathway. This study evaluated the effect of intravenously-administered nitrosylcobalamin (NO-Cbl), a vitamin B12 analog, on serum folate concentrations in…

Pharmacokinetics of Intravenous Nitrosylcobalamin, an Antitumor Agent, in Healthy Beagle Dogs: A Pilot Study

Background/Aim: Nitrosylcobalamin (NO-Cbl) is a cobalamin-based anti-tumor agent. This study evaluated the pharmacokinetic parameters of NO-Cbl following intravenous administration in dogs. Materials and Methods: Four dogs received 10 mg/kg, 20 mg/kg…

Quick take. Tips for diagnosing and treating infections transmitted by dogs and cats.

Tags: 1998, Cats, Consultant (00107069), Dogs, Symptoms, Tan J S, Zoonoses, Zoonoses – Diagnosis, Zoonoses – Drug Therapy, Zoonoses – Prevention and Control

Human zoonotic infections transmitted by dogs and cats.

Tags: 1997, Animals, Archives of internal medicine, Bacterial Infections, Bacterial Infections – Transmission, Cats, Disease Vectors, Dogs, Ectoparasitic Infestations, Ectoparasitic Infestations – Transmission, Helminthiasis – Transmission, Protozoan Infections – Transmission, Tan J S, Zoonoses – Transmission

The effect of renal range dopamine and norepinephrine infusions on the renal vasculature.

Renal range dopamine's value was assessed in 15 hypotensive canines using an endotoxin shock model and concurrent pharmacological pressor support. The dogs were prospectively randomized into three treatment groups (fluid resuscitation, fluid and…

Tags: 1990, Animals, Cardiac Output, Creatine/pharmacokinetics, Dogs, Dopamine/*pharmacology, Kidney/*drug effects/metabolism, Norepinephrine/*pharmacology, Petrinec D, Renal Circulation/*drug effects, Strigle T R, The American surgeon

Effect of intracoronary infusion of histamine or compound 48/80 on coronary vascular permeability and myocardial fluid balance.

This study was undertaken to determine if coronary vascular permeability (CVP) increases and if myocardial edema develops in the canine heart after local exposure to histamine. Histamine (50 or 15 micrograms/min) or compound 48/80 (0.1-0.2 mg/kg) was…

Tags: 1991, Animals, Blood Pressure/drug effects, Coronary Circulation/*drug effects, Dogs, Female, Histamine/*administration & dosage, Infusions, Intra-Arterial, Lymph/drug effects, Male, Microvascular research, Myocardium/*metabolism, p-Methoxy-N-methylphenethylamine/*administration & dosage, Pilati C F, Water-Electrolyte Balance/*drug effects

Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema.

Case reports of neurogenic pulmonary edema (NPE) often indicate that the edema resolves quickly. Because plasma epinephrine concentration may be elevated in NPE, and epinephrine has been shown to increase the rate of alveolar liquid clearance (ALC),…

Tags: 1998, Adrenal Glands/*metabolism, Adrenalectomy, Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use, Adrenergic beta-Antagonists/therapeutic use, American journal of respiratory and critical care medicine, Amiloride/therapeutic use, Animal, Animals, Awender N E, Blood, Blood Pressure, Brain Diseases/chemically induced/*complications, Central Nervous System Agents/adverse effects, Cisterna Magna, Disease Models, Diuretics/therapeutic use, Dogs, Epinephrine/blood/*physiology/therapeutic use, Extravascular Lung Water/chemistry/*metabolism, Female, Hypertension, Injections, Lane S M, Maender K C, Male, Maron M B, Propanolamines/therapeutic use, Proteins/analysis, Pulmonary Alveoli/*metabolism, Pulmonary Artery, Pulmonary Edema/etiology/*metabolism/prevention & control, Pulmonary/prevention & control, Sodium Channel Blockers, Veratrine/adverse effects

Isolation of canine coronary sinus musculature from the atria by radiofrequency catheter ablation prevents induction of atrial fibrillation.

BACKGROUND: The junction between the coronary sinus (CS) musculature and both atria contributes to initiation of atrial tachyarrhythmias. The current study investigated the effects of CS isolation from the atria by radiofrequency catheter ablation on…

Effect of high transcapillary pressures on capillary ultrastructure and permeability coefficients in dog lung.

To determine the correlation between ultrastructural and physiological changes in blood-gas barrier function in lungs transiently exposed to very high vascular pressures, we increased capillary transmural pressure (Ptm) of 6 canine isolated perfused…

Dose-response relationship between plasma epinephrine concentration and alveolar liquid clearance in dogs.

Previously, alveolar liquid clearance (ALC) was observed to increase in a canine model of neurogenic pulmonary edema (NPE) by adrenal epinephrine (S. M. Lane, K. C. Maender, N. E. Awender, and M. B. Maron. Am. J. Respir. Crit. Care Med. 158:

Tags: 1998, Algorithms, Animals, Blood Pressure/drug effects/physiology, Cardiac Output/drug effects/physiology, Catecholamines/blood, Dogs, Dose-Response Relationship, Drug, Epinephrine/*blood, Female, Hematocrit, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Pulmonary Alveoli/*physiopathology, Pulmonary Circulation/drug effects/physiology, Pulmonary Edema/*blood/*physiopathology, Pulmonary Wedge Pressure/drug effects/physiology

Alveolar liquid clearance in multiple nonperfused canine lung lobes.

We evaluated the ability of canine isolated nonperfused lung lobes to absorb fluid from their air spaces by simultaneously measuring alveolar liquid clearance (ALC) in three lobes removed from the same dog. Autologous plasma was instilled in the air…

Tags: 1997, Animals, Dogs, Female, Grimme J D, Journal of applied physiology (Bethesda, Md. : 1985), Lane S M, Lung/drug effects/*metabolism, Male, Maron M B, Pulmonary Alveoli/drug effects/*metabolism, Pulmonary Edema/metabolism, Terbutaline/pharmacology

Time course of blood volume changes in an isolated lung lobe after venous pressure elevation.

The elevation of venous pressure (Pv) in isolated perfused organs causes organ weight to increase in a biphasic manner. The initial rapid phase results primarily from an increase in blood volume (BV), whereas the second slower phase is generally…

Tags: *Blood Volume/drug effects, *Pulmonary Circulation, *Venous Pressure, 1994, Animals, Dogs, Extravascular Lung Water/metabolism, Female, In Vitro Techniques, Indicator Dilution Techniques, Indocyanine Green, Journal of applied physiology (Bethesda, Md. : 1985), Lane S M, Lung/*physiology, Male, Maron M B, Papaverine/pharmacology, Perfusion, Time Factors

Edema development and recovery in neurogenic pulmonary edema.

We determined the time course of changes in extravascular lung water (EVLW) that occur after massive sympathetic activation produced by intracisternal veratrine administration in chloralose-anesthetized dogs. Three groups of dogs were studied. In the…

Pulmonary vascular protein sieving capability after exposure to high vascular pressures.

We evaluated the ability of the canine in situ left lower lobe (LLL) vasculature to sieve endogenous plasma proteins of various molecular radii (34-124 A) after LLL arterial pressure had been transiently elevated to 23.8 +/- 0.9 (control group, n =…

Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.

We tested the possibility that neuropeptide Y (NPY) may contribute to the pulmonary hypertension that occurs after massive sympathetic activation produced by intracisternal veratrine administration in the chloralose-anesthetized dog. In six dogs,…

Tags: 1992, Adrenal Glands/drug effects/physiology, Adrenalectomy, Animals, Dogs, Hypertension, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Maender K C, Maron M B, Neuropeptide Y/*physiology, Norepinephrine/pharmacology, Pilati C F, Pulmonary Circulation/drug effects, Pulmonary/chemically induced/*physiopathology, Sympathetic Nervous System/*physiology, Veratrine/pharmacology

Hemodynamic basis for cocaine-induced pulmonary edema in dogs.

We tested the hypothesis that cocaine-induced impairment of left ventricular function results in cardiogenic pulmonary edema. Mongrel dogs, anesthetized with alpha-chloralose, were injected with two doses of cocaine (5 mg/kg iv) 27 min apart. Cocaine…

Tags: 1991, Animals, Blood Pressure/drug effects, Cardiac Output/drug effects, Cocaine/*toxicity, Coronary Circulation/drug effects, Dogs, Female, Heart Rate/drug effects, Hemodynamics/*drug effects, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Male, Maron M B, Pulmonary Circulation/drug effects, Pulmonary Edema/chemically induced/*physiopathology, Stroke Volume/drug effects, Vascular Resistance/drug effects

Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.

The intracisternal administration of veratrine to the chloralose-anesthetized dog produces pulmonary hypertension (PH) and neurogenic pulmonary edema (NPE). To determine whether pulmonary vasoconstriction, mediated by a circulating agent, contributes…

Effect of elevated vascular pressure transients on protein permeability in the lung.

Neurogenic pulmonary edema (NPE) may develop in individuals with head trauma or seizures and is generally thought to have a hydrostatic basis in the severe degree of pulmonary hypertension that occurs. Recently, it has been suggested that vascular…

Tags: *Blood Pressure, 1989, Animals, Blood Proteins/*metabolism, Dogs, Female, Hypertension/physiopathology, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lung/metabolism/*physiopathology, Male, Maron M B, Pulmonary Edema/*etiology/metabolism/physiopathology

Effect of papaverine on pulmonary vascular permeability to proteins.

Previous studies have suggested that papaverine, a drug commonly used in studies of transvascular fluid and solute exchange to eliminate confounding effects of changes in vascular tone, may itself increase vascular permeability. In this study, we…

Tags: 1988, Animals, Blood Proteins/*metabolism, Capillary Permeability/*drug effects, Dogs, Female, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Osmosis, Papaverine/blood/*pharmacology, Pilati C F, Pulmonary Circulation/*drug effects, Serotonin/pharmacology, Vasodilation/drug effects, Water-Electrolyte Balance/drug effects

Macromolecular transport in canine coronary microvasculature.

Coronary vascular osmotic reflection coefficients (sigma dS) for total protein, albumin (Alb), immunoglobulin (Ig)G, and IgM were determined in the anesthetized dog. Myocardial lymph was collected from the anterior interventricular lymphatic trunk,…

Effect of pathological blood histamine levels on canine coronary vascular permeability.

We evaluated the effect of systemically administered histamine on coronary vascular permeability (CVP) of pentobarbital-anesthetized, open-chest dogs with and without beta-receptor blockade. We determined changes in CVP by comparing prenodal cardiac…

Tags: *Capillary Permeability, *Coronary Circulation, 1988, Animals, Blood Proteins/analysis, Dogs, Female, Hemodynamics, Histamine/*blood, Lymph/analysis, Male, Maron M B, Microcirculation, Pilati C F, The American journal of physiology

Oxygen consumption after massive sympathetic nervous system discharge.

We evaluated the possibility that massive, sympathetic nervous system (SNS) activation [as may precede the development of neurogenic pulmonary edema (NPE)] increases O2 demand. O2 consumption (VO2) and plasma concentrations of the calorigenic agents,…

Temporal changes in left ventricular function after massive sympathetic nervous system activation.

Intense activation of the sympathetic nervous system (SNS) decreases the contractile state of the rabbit left ventricle (LV). In this study, we determined the time course of LV dysfunction after massive central activation of the SNS in dogs.…

Life-threatening respiratory pasteurellosis associated with palliative pet care.

Pasteurella multocida is a zoonotic Gram-negative cocco-bacillus often associated with soft tissue infections due to dog and cat bites. Here we report 3 patients who developed life-threatening P. multocida respiratory tract infections after providing…

A neurochemical hypothesis for the origin of hominids.

It has always been difficult to account for the evolution of certain human characters such as language, empathy, and altruism via individual reproductive success. However, the striatum, a subcortical region originally thought to be exclusively motor,…

Role of prostaglandins in blood-induced vasoconstriction of canine cerebral arteries.

We tested the hypothesis that the vasoconstriction produced by the application of blood to the adventitial surfaces of the vessels of an isolated perfused canine circle of Willis preparation was mediated by products of prostaglandin metabolism. In…

Mohs fixed-tissue excision of dentoalveolar bone in canines: a histologic evaluation.

Mohs surgery is a well-established surgical technique that involves conservative, microscopically guided excision of malignant lesions, thereby sparing the maximum amount of normal surrounding tissue. Current surgical therapy for oral cancer…

Tags: *Mohs Surgery, *Orthognathic Surgical Procedures, *Zinc Compounds, 1993, Alveolar Process/drug effects, Animals, Bailin P L, Chlorides/toxicity, Dental Pulp/drug effects, Dogs, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Periodontal Dressings, Pilot Projects, Rossi E P, Stultz T W, Surgical Flaps, Vidimos A T, Zinc/toxicity

Effect of extreme elevations in venous pressure on reflection coefficient in the lung.

We determined whether the solvent drag reflection coefficient (sigma f) for total proteins of a canine perfused left lower lung lobe (LLL) preparation decreases at elevated venous pressures (Pv). We found that sigma f (estimated using the…

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