Evidence Of Incomplete Behavioral Sexual-differentiation In Obese Male Zucker Rats
Behavioral Sciences; Psychology
Doherty P C; Baum M J; Finkelstein J A
Physiology & Behavior
1985
1985
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/0031-9384(85)90102-7" target="_blank" rel="noreferrer noopener">10.1016/0031-9384(85)90102-7</a>
Decreased Erectile Function And Fertility In Hyperprolactinemic Male-rats
Anatomy & Morphology
Doherty P C
Anatomical Record
1988
1988-04
Journal Article or Conference Abstract Publication
n/a
HYPERPROLACTINEMIA INHIBITS DEVELOPMENT OF LEYDIG-CELL TUMORS IN AGING FISCHER RATS
Psychology; Geriatrics & Gerontology
Bartke A; Sweeney C A; Johnson L; Castracane V D; Doherty P C
Experimental Aging Research
1985
1985
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1080/03610738508259291" target="_blank" rel="noreferrer noopener">10.1080/03610738508259291</a>
Hyperprolactinemia preferentially inhibits erectile function in adrenalectomized male rats.
Male; Animals; Chronic Disease; Body Weight; Rats; Testosterone/pharmacology; Adrenalectomy; Prolactin/blood/metabolism; *Penile Erection/drug effects; Hyperprolactinemia/*physiopathology; Luteinizing Hormone/blood/*metabolism; Pituitary Gland/transplantation; Inbred F344
To determine if the inhibitory effects of hyperprolactinemia on sexual arousal and serum LH levels could be dissociated from those on erectile function, copulatory behavior was examined in pituitary-grafted, adrenalectomized male rats that had been castrated and given 20mm subcutaneous testosterone implants. Whereas transplantation of three pituitaries under the kidney capsules inhibited mounting rates in intact animals, pituitary grafting did not significantly reduce mounting rates in the adrenalectomized group beyond the effect of adrenalectomy alone. In contrast, the effects of pituitary grafting on erectile function were enhanced in the adrenalectomized animals. Hyperprolactinemia also caused a significant reduction in serum LH, but only in the intact animals. These results suggest that: 1. the effects of hyperprolactinemia on erectile function occur independently from those on sexual arousal, and 2. the inhibitory effects of hyperprolactinemia on sexual arousal are linked to the effects of hyperprolactinemia on LH release.
Doherty P C; Wu D E; Matt K S
Life sciences
1990
1905-6
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0024-3205(90)90227-i" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(90)90227-i</a>
Preferential increase in pituitary prolactin versus vasoactive intestinal peptide as a function of estradiol benzoate dose in the ovariectomized rat.
Animals; Brain/drug effects/*metabolism; Dose-Response Relationship; Drug; Estradiol/*pharmacology; Female; Inbred Strains; Organ Specificity; Ovariectomy; Pituitary Gland/drug effects/*metabolism; Prolactin/blood/*metabolism; Rats; Thyrotropin/blood/metabolism; Vasoactive Intestinal Peptide/*metabolism
Vasoactive intestinal peptide (VIP) is synthesized in various tissues, including the anterior pituitary gland, where it may stimulate the release of PRL. Because estrogen plays a central role in the regulation of PRL, it becomes important to determine the effects of this steroid on both pituitary VIP and PRL. To study this, pituitary VIP and PRL and plasma PRL were assayed in ovariectomized rats after treatment with estradiol benzoate (EB; 0.007, 0.07, 0.7, 7 or 70 microgram/rat). Pituitary and plasma TSH were also determined as well as VIP content in the medial basal hypothalamus, suprachiasmatic region, cerebral cortex, and jejunum. Oil-treated rats served as controls. Injection of 0.7 or 7 microgram EB resulted in a significant increase in pituitary PRL without changing plasma PRL levels or pituitary VIP content compared to values in the control group. Only treatment with 70 microgram EB produced a significant increase in both pituitary VIP and PRL as well as in plasma PRL compared to control values. EB treatment at any of the doses used had no significant effect on pituitary and plasma TSH or VIP content in any of the other tissues examined. These data show that pituitary PRL and VIP are differentially regulated in response to estrogen. The increases in pituitary VIP and basal plasma PRL after treatment with the highest dose of EB suggest that pituitary VIP may be involved in the development of estrogen-induced hyperprolactinemia. These data also show that the regulations of pituitary VIP and TSH are independent of each other in the estrogen-treated rat.
Carrillo A J; Doherty P C; Guan X B; Sturtevant J R; Walro D G
Endocrinology
1991
1991-01
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1210/endo-128-1-131" target="_blank" rel="noreferrer noopener">10.1210/endo-128-1-131</a>
Lack of an inhibitory effect of hyperprolactinemia on androgen-dependent marking.
Animal/*physiology; Animals; Arousal/physiology; Brain/*physiology; Defecation/physiology; Inbred F344; Male; Mesencephalon/physiology; Neural Inhibition/*physiology; Neural Pathways/physiology; Preoptic Area/physiology; Prolactin/*physiology; Rats; Sex Attractants/*urine; Sexual Behavior; Testosterone/*physiology; Urination/*physiology
An experiment was performed to determine if hyperprolactinemia (chronically elevated serum prolactin levels), which inhibits testosterone-activated male sexual activity, also affects other androgen-dependent behaviors. Thus defecation and urine marking in response to a novel environment were examined in sham-operated and pituitary-grafted (hyperprolactinemic) male rats that had been castrated or castrated and given subcutaneous testosterone implants. Both castration and pituitary grafting significantly inhibited defecation, with the inhibitory effects of hyperprolactinemia being most pronounced in the castrated non-testosterone-treated animals. In contrast, castration significantly reduced the amount of urine marking observed, but pituitary grafting was without effect on this behavior. Thus, although hyperprolactinemia may inhibit sexual activity through an antagonism of the activational effects of testosterone, these results suggest that this effect is specific to sexual behavior and does not involve a more generalized inhibition of the effects of testosterone on androgen-dependent behaviors.
Doherty P C
Physiology & behavior
1991
1991-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/0031-9384(91)90435-q" target="_blank" rel="noreferrer noopener">10.1016/0031-9384(91)90435-q</a>