1
40
55
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)91256-g</a>
Pages
236–242
Issue
2
Volume
506
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-01
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Corpus Striatum/*metabolism; Amphetamines/*pharmacology; Electrochemistry; Sulpiride/*pharmacology; Inbred Strains; Receptors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Dopamine/drug effects; Dopamine D2
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Pehek E A
Description
An account of the resource
The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicated a significant rostrocaudal gradient in dopamine release following amphetamine. The increase in dopamine release was highest in the rostral areas (over 800% of baseline values) and lowest in the most caudal subregion (425% of baseline). No lateromedial differences in dopamine release were observed. DOPAC levels decreased in dialysates but were similar for all 6 subregions examined. In contrast, D2 blockade with (-)-sulpiride revealed a lateromedial gradient in the increases seen for dopamine and DOPAC such that greater increases were observed in the lateral subregions. (-)-Sulpiride did not produce any differential effects along the rostrocaudal axis. The regional gradients detected in extracellular fluid changes of dopamine and DOPAC indicate that dopamine release is locally regulated by an interaction between the density of dopaminergic innervation to a particular subregion and the D2 receptor density.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)91256-g</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Amphetamines/*pharmacology
Animals
Brain research
Corpus Striatum/*metabolism
Dopamine D2
Dopamine/*metabolism
Dopamine/drug effects
Electrochemistry
Inbred Strains
Male
Pehek E A
Rats
Receptors
Sulpiride/*pharmacology
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(88)90564-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(88)90564-x</a>
Pages
195–203
Issue
2
Volume
148
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Consciousness; Amphetamines/*pharmacology; Brain/drug effects/metabolism; Caudate Nucleus/drug effects/metabolism; Nucleus Accumbens/drug effects/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Spanos L J
Description
An account of the resource
The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine [+/-)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical detection. Monitored over a 3 h period, the magnitude of increase in dopamine release and the onset of effect were dose-dependent and similar for both brain areas following the 2.5 and 5 mg/kg dose of the drug. However, responses were different for these brain regions using 10 mg/kg of MDMA; the magnitude of increase was greater and the onset of effect more immediate in caudate. Analysis of dopamine and DOPAC tissue content in both caudate and nucleus accumbens verified the voltammetry results. This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(88)90564-x" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(88)90564-x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
3
4-Dihydroxyphenylacetic Acid/metabolism
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Brain/drug effects/metabolism
Caudate Nucleus/drug effects/metabolism
Consciousness
Dopamine/*metabolism
European journal of pharmacology
Inbred Strains
Male
N-Methyl-3
Nucleus Accumbens/drug effects/metabolism
Rats
Spanos L J
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(90)90041-o</a>
Pages
1171–1176
Issue
12
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Male; Animals; Rats; Molecular Structure; Structure-Activity Relationship; Reference Values; Kinetics; Dopamine/*metabolism; Brain/drug effects/*metabolism; Psychotropic Drugs/*pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Caudate Nucleus/metabolism; Homovanillic Acid/metabolism; Nucleus Accumbens/metabolism; Putamen/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D; Yamamoto B K
Description
An account of the resource
The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of dopamine and metabolites in both regions of the brain simultaneously, after intraperitoneal administration of 0.8, 1.6 or 3.2 mg/kg of either drug (doses expressed as the salts). Both drugs increased levels of dopamine but decreased levels of metabolites in a dose-dependent manner. However, the relative magnitude of these effects depended upon the specific drug, the dose and area of the brain examined. At the largest dose used, amphetamine had a relatively greater effect than cathinone on dopamine in both caudate and accumbens. However, among smaller doses, this difference was only observed in the nucleus accumbens after administration of 1.6 mg/kg. The results also demonstrated a differential regional effect of both drugs at 3.2 mg/kg, in that both had a greater effect on dopamine in the caudate, as opposed to the accumbens. These findings demonstrate a functional heterogeneity of the striatum of the rat, that may be relevant to the understanding of both normal brain function and the neural responses to psychoactive drugs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(90)90041-o</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Brain/drug effects/*metabolism
Caudate Nucleus/metabolism
Dopamine/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Kinetics
Male
Molecular Structure
Neuropharmacology
Nucleus Accumbens/metabolism
Pehek E A
Psychotropic Drugs/*pharmacology
Putamen/metabolism
Rats
Reference Values
Schechter M D
Structure-Activity Relationship
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a>
Pages
235–241
Issue
2
Volume
481
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Indoles/*pharmacology; Nomifensine/*pharmacology; Homovanillic Acid/metabolism; Electrochemistry; Caudate Nucleus/drug effects/*metabolism; Mazindol/*pharmacology; Neurotransmitter Uptake Inhibitors/*pharmacology; Putamen/drug effects/*metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a lateral-to-medial and rostral-to-caudal gradient in the effect of uptake blockade. The percentage increase in dopamine was greatest in the rostrolateral area (300%) and least in the caudomedial area (10%). The existence of these lateromedial and rostrocaudal gradients was confirmed by tissue content measures of DOPAC and dopamine to DOPAC ratios in each area. The rostrocaudal gradient in the effect of uptake blockade was independent of the rostrocaudal gradient in dopamine tissue content. The regional gradients detected in dopamine uptake blockade may indicate a heterogeneous distribution in the number of uptake sites, a regional variation in the affinity of the uptake site for the blocker and/or altered neuronal activity mediated by an action of the blocker on dopaminergic cell bodies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Caudate Nucleus/drug effects/*metabolism
Dopamine/*metabolism
Electrochemistry
Glynn G E
Homovanillic Acid/metabolism
Inbred Strains
Indoles/*pharmacology
Male
Mazindol/*pharmacology
Neurotransmitter Uptake Inhibitors/*pharmacology
Nomifensine/*pharmacology
Putamen/drug effects/*metabolism
Rats
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
94–101
Issue
1
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulatory effects of testosterone on
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
Male; Animals; Mice; Species Specificity; Reference Values; Dopamine/*metabolism; Corpus Striatum/drug effects/*metabolism; Orchiectomy; Drug Implants; Testosterone/administration & dosage/*pharmacology; Neurotoxins/antagonists & inhibitors/*toxicity; *MPTP Poisoning; Levodopa/pharmacology; Inbred Strains; Inbred C57BL; 3; 1-Methyl-4-phenyl-1; 2; Parkinson Disease; 6-tetrahydropyridine/antagonists & inhibitors; Secondary/chemically induced/*physiopathology
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B
Description
An account of the resource
In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine/antagonists & inhibitors
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D
Dopamine/*metabolism
Drug Implants
Inbred C57BL
Inbred Strains
Jain R
Journal of neurochemistry
Levodopa/pharmacology
Liu B
Male
Mice
Neurotoxins/antagonists & inhibitors/*toxicity
Orchiectomy
Parkinson Disease
Reference Values
Secondary/chemically induced/*physiopathology
Species Specificity
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
267–273
Issue
2
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
Female; Male; Animals; Mice; Sex Factors; Body Weight/drug effects; Organ Size/drug effects; Dopamine/*metabolism; Body Temperature/drug effects; Methamphetamine/*toxicity; Corpus Striatum/*metabolism; Orchiectomy; Ovariectomy; Drug Interactions; Estrogens/pharmacology/*physiology; Heart Rate/drug effects; Heart Ventricles/metabolism; Norepinephrine/metabolism; Pituitary Gland/anatomy & histology; Testosterone/pharmacology/*physiology; Inbred Strains
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Anderson Linda I; Pilati Charles F
Description
An account of the resource
Methamphetamine (MA)-related deaths and nigrostriatal dopaminergic (NSDA) neurotoxicity are greater in males. The exact basis for this gender difference is not known, but data, which show that estrogen (E) can function as a protectant of both the cardiovascular and NSDA systems, suggest an important role for gonadal steroids in modulating toxicity to this psychostimulant. In the present report, we examined the effects of treatment with the gonadal steroid hormones E and testosterone (T) upon MA-induced toxicity within intact and castrated female and male CD-1 mice. Treatment of intact males with E produced a severe acute toxicity to MA, with only 41% (7/17) males surviving at 24-h post-MA. This incidence of mortality was significantly different from that of nonhormonally treated mice receiving an identical regimen of MA [94% survival (16/17)]. None of the other treatment groups showed mortality rates, which differed significantly from the nonhormonally treated mice. Striatal dopamine (DA) concentrations of E-treated female mice (intact or castrated) were significantly greater than that of the nonhormonally treated mice, which failed to differ statistically among each other. In an attempt to understand some of the bases for the mortality rates in
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Anderson Linda I
Animals
Body Temperature/drug effects
Body Weight/drug effects
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Drug Interactions
Estrogens/pharmacology/*physiology
Female
Heart Rate/drug effects
Heart Ventricles/metabolism
Inbred Strains
Male
Methamphetamine/*toxicity
Mice
Neurotoxicology and teratology
Norepinephrine/metabolism
Orchiectomy
Organ Size/drug effects
Ovariectomy
Pilati Charles F
Pituitary Gland/anatomy & histology
Sex Factors
Testosterone/pharmacology/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf01244706" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf01244706</a>
Pages
145–156
Issue
2
Volume
85
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.
Publisher
An entity responsible for making the resource available
Journal of neural transmission. General section
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
Male; Animals; Rats; Corpus Striatum/*drug effects/metabolism; Aging/metabolism; In Vitro Techniques; Dopamine/*metabolism; Amphetamine/pharmacology; Levodopa/pharmacology; Selegiline/*pharmacology; 3; 4-Dihydroxyphenylacetic Acid/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
In the present experiment, male rats (15-17 months) were injected with deprenyl (0.25 mg/kg) three times per week for six months. At 21-23 months of age the male rats were sacrificed, the corpus striatum removed and superfused in vitro. Basal and evoked dopamine and DOPAC levels, as obtained with either two infusions of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf01244706" target="_blank" rel="noreferrer noopener">10.1007/bf01244706</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-Dihydroxyphenylacetic Acid/*metabolism
Aging/metabolism
Amphetamine/pharmacology
Animals
Corpus Striatum/*drug effects/metabolism
Dluzen D E
Dopamine/*metabolism
In Vitro Techniques
Journal of neural transmission. General section
Levodopa/pharmacology
Male
McDermott J L
Rats
Selegiline/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1316.026" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1316.026</a>
Pages
205–220
Volume
1025
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Developmental and genetic influences upon gender differences in methamphetamine-induced nigrostriatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-10
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects/growth & development/metabolism; Dopamine/*metabolism; Female; Humans; Male; Methamphetamine/*toxicity; Substantia Nigra/*drug effects/growth & development/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
The gonadal steroid hormone estrogen (E) may play an important role in sex differences in methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system because E can serve as a neuroprotectant in female, but not male, mice. Gonadal steroid hormones also exert important organizational/developmental effects upon the brain at critical developmental periods. In Part 1 we assessed whether organizational (neonatal) or developmental (prepubertal) effects of gonadal steroids would alter gender/E-dependent neuroprotection of MA-induced NSDA neurotoxicity. Attempts to feminize male mice by gonadectomy at either the neonatal or prepubertal period failed to enable E to function as a neuroprotectant within the adult male mouse. Attempts to masculinize the female by testosterone administration at the neonatal period did not abolish the capacity for E to function as a neuroprotectant. However, prepubertal gonadectomy of female mice did disrupt E's capacity to serve as a neuroprotectant. These results suggest that genetic sex may prove the primary determinant for the sex differences observed in response to MA-induced NSDA neurotoxicity. In Part 2 we examined whether gender differences in response to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1316.026" target="_blank" rel="noreferrer noopener">10.1196/annals.1316.026</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2004
Animals
Annals of the New York Academy of Sciences
Corpus Striatum/*drug effects/growth & development/metabolism
Dluzen Dean E
Dopamine/*metabolism
Female
Humans
Male
McDermott Janet L
Methamphetamine/*toxicity
Substantia Nigra/*drug effects/growth & development/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000090983" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000090983</a>
Pages
78–86
Issue
2
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in methamphetamine-evoked striatal dopamine output are abolished following gonadectomy: comparisons with potassium-evoked output and responses in prepubertal mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005
Subject
The topic of the resource
Animals; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*pharmacology; Mice; Neostriatum/drug effects/*metabolism; Orchiectomy; Ovariectomy; Potassium/*pharmacology; Sex Characteristics; Sexual Maturation
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Salvaterra Ty J
Description
An account of the resource
Sex differences are reported for methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system. In an attempt to understand some of the bases for these differences, we investigated MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of intact and male and female CD-1 mice. These responses were compared with that of gonadectomized mice, potassium-evoked DA responses in intact mice and responses in prepubertal mice. In experiment 1, DA responses were tested using infusion of MA at doses of 1, 10, 100 and 1,000 microM. In intact mice, mean peak MA-evoked DA responses were consistently increased and significantly greater in male vs. female mice at the 1,000 microM dose. No such significant differences were observed between gonadectomized male vs. female mice (experiment 2). In contrast to MA, potassium-stimulated DA responses were increased in intact female mice, with statistically significant differences at doses of 30 and 60 mM (experiment 3). No statistically significant differences between intact prepubertal male and female mice were obtained in response to a 1,000 microM dose of MA (experiment 4) or to a 60 mM dose of potassium (experiment 5). These results indicate that intact male mice show greater sensitivity to MA-evoked DA output. This sex difference is abolished following gonadectomy, is not observed with potassium, nor is it present in prepubertal mice. The increased sensitivity to MA shown by intact males may be related to the greater degree of striatal dopaminergic neurotoxicity observed in male mice in response to this psychostimulant and appears to be attributable to differences in gonadal steroid hormones between male and female mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000090983" target="_blank" rel="noreferrer noopener">10.1159/000090983</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Animals
Dluzen Dean E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Female
In Vitro Techniques
Male
Methamphetamine/*pharmacology
Mice
Neostriatum/drug effects/*metabolism
Neuroendocrinology
Orchiectomy
Ovariectomy
Potassium/*pharmacology
Salvaterra Ty J
Sex Characteristics
Sexual Maturation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079710</a>
Pages
305–316
Issue
6
Volume
79
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects; Animals; Behavior; Brain Chemistry/drug effects; Dopamine/*metabolism; Dose-Response Relationship; Drug; Drug Interactions; Estrogen Antagonists/pharmacology; Estrogens/*pharmacology; Female; Methamphetamine/*toxicity; Mice; Movement/drug effects; Neostriatum/*drug effects/physiology; Neurotoxins/*toxicity; Organ Size/drug effects; Ovariectomy/methods; Stereotyped Behavior/drug effects; Substantia Nigra/drug effects/physiology; Tamoxifen/*pharmacology; Uterus
Creator
An entity primarily responsible for making the resource
Mickley Katherine R; Dluzen Dean E
Description
An account of the resource
In the present experiment we evaluated the dose-response effects of estrogen (estradiol benzoate; EB) and tamoxifen (TMX) in modulating the acute behavioral and chronic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system in ovariectomized (OVX) mice. EB over a range of doses from 1-40 microg resulted in a neuroprotective effect upon the NSDA system as defined by both a preservation of striatal dopamine (DA) concentrations and a decrease in DOPAC/DA ratios. Interestingly, the neuroprotective effect of the 1-microg EB dose occurred in the absence of any statistically significant effect upon the bioassay parameter of uterine weight. With the exception of an increase in stereotypy time as a response to the 40-microg dose, EB at any of the doses tested failed to alter any acute behavioral responses evoked by MA. In response to TMX, a statistically significant NSDA neuroprotectant response was obtained for DOPAC/DA ratios, but not DA concentrations, to doses ranging from 12.5 to 500 microg. No statistically significant effects upon uterine weights were obtained for any of the doses of TMX tested. Behaviorally, TMX at 500 microg had the effect of increasing the amount of time spent in the center of the cage. Taken together these results demonstrate: (1) EB and TMX at relatively low doses can exert a neuroprotective effect against MA; (2) these neuroprotective effects of EB and TMX can occur in the absence of an effect upon the bioassay parameter–uterine weights; (3) the parameter of DOPAC/DA ratio may indicate a more sensitive index of NSDA neuroprotection, and (4) modulatory effects of EB and TMX upon acute behavioral responses of the NSDA system to MA can be distinguished from their neuroprotective actions.
Identifier
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<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">10.1159/000079710</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects
Animals
Behavior
Brain Chemistry/drug effects
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Drug Interactions
Estrogen Antagonists/pharmacology
Estrogens/*pharmacology
Female
Methamphetamine/*toxicity
Mice
Mickley Katherine R
Movement/drug effects
Neostriatum/*drug effects/physiology
Neuroendocrinology
Neurotoxins/*toxicity
Organ Size/drug effects
Ovariectomy/methods
Stereotyped Behavior/drug effects
Substantia Nigra/drug effects/physiology
Tamoxifen/*pharmacology
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1995.78.4.1219" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1995.78.4.1219</a>
Pages
1219–1224
Issue
4
Volume
78
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-04
Subject
The topic of the resource
Animal/*physiology; Animals; Behavior; Chromatography; Circadian Rhythm; Corpus Striatum/cytology/*physiology; Dopamine/*metabolism; High Pressure Liquid; In Vitro Techniques; Male; Neuropsychological Tests; Organ Size; Perfusion; Physical Conditioning; Potassium/*metabolism; Psychomotor Performance/*physiology; Random Allocation; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Dluzen D E; Liu B; Chen C Y; DiCarlo S E
Description
An account of the resource
Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart, pituitary, or testes weights. DSR and control animals did differ in performance on a sensorimotor beam walking task, with DSR rats showing significantly shorter times required to cross the beam (60 +/- 17 vs. 119 +/- 14s; P \textless 0.02) as well as fewer slips off the beam (3.0 +/- 0.8 vs 6.2 +/- 1.1; P \textless 0.05). DSR animals also engaged in significantly greater durations of social investigation than control rats (43 +/- 5 vs 25 +/- 3 s; P \textless 0.01) when tested in a social investigation memory-recognition test. Basal dopamine release rates from superfused corpus striatal tissue fragments of DSR rats were about one-half those obtained from control animals (18 +/- 5 vs. 34 +/- 6 pg.mg-1.min-1; P \textless 0.05), whereas responses of these striatal tissue fragments to a depolarizing concentration of potassium were virtually identical (45 +/- 10 vs. 47 +/- 8 pg.mg-1.min-1). These data indicate that a relatively limited intensity of DSR insufficient to alter cardiovascular function can exert substantial effects on behavioral and neurochemical indicators of nigrostriatal dopaminergic activity.
Identifier
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<a href="http://doi.org/10.1152/jappl.1995.78.4.1219" target="_blank" rel="noreferrer noopener">10.1152/jappl.1995.78.4.1219</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animal/*physiology
Animals
Behavior
Chen C Y
Chromatography
Circadian Rhythm
Corpus Striatum/cytology/*physiology
DiCarlo S E
Dluzen D E
Dopamine/*metabolism
High Pressure Liquid
In Vitro Techniques
Journal of applied physiology (Bethesda, Md. : 1985)
Liu B
Male
Neuropsychological Tests
Organ Size
Perfusion
Physical Conditioning
Potassium/*metabolism
Psychomotor Performance/*physiology
Random Allocation
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1749-6632.2000.tb05189.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1749-6632.2000.tb05189.x</a>
Pages
112–126
Volume
914
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-09
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Drug Interactions; Estrogens/*administration & dosage; Methamphetamine/antagonists & inhibitors/*toxicity; Neurotoxins/antagonists & inhibitors/*toxicity; Substantia Nigra/*drug effects/metabolism; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
In this report we describe some of the data on the capacity for estrogen to function as a neuroprotectant of the nigrostriatal dopaminergic (NSDA) system. The data show that estrogen (E) can alter two different response characteristics to NSDA neurotoxins. The first being that striatal DA concentrations of ovariectomized rodents treated with E are consistently greater than non-E-treated animals in response to neurotoxins which produce degeneration of the NSDA system. The second being that E significantly reduces the amount of DA output upon initial exposure to the NSDA neurotoxin, 1-methyl-4-phenylpyridium ion (MPP+). At present, it is not known whether these two response characteristics are related. An intriguing possibility is that the E-dependent changes in initial DA output are related to the resultant neurotoxicity (attenuations in DA concentration reductions). So far our incipient findings do not seem to support this eventuality. However, additional testing on this topic is required. The present data suggest that one of the mechanisms by which E can exert these effects is through inhibition of DAT activity. This conclusion results from data which show that E produces: 1) an inhibition of [3H]DA uptake, 2) a reduction in DA clearance rates, and 3) an effect upon DA recovery that is similar to that observed to the putative DA uptake blocker, nomifensine. The capacity and significance for steroid hormones to modulate neurotransmitter transporters has been recently reviewed.
Identifier
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<a href="http://doi.org/10.1111/j.1749-6632.2000.tb05189.x" target="_blank" rel="noreferrer noopener">10.1111/j.1749-6632.2000.tb05189.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Animals
Annals of the New York Academy of Sciences
Corpus Striatum/*drug effects/metabolism
Dluzen D E
Dopamine/*metabolism
Drug Interactions
Estrogens/*administration & dosage
McDermott J L
Methamphetamine/antagonists & inhibitors/*toxicity
Neurotoxins/antagonists & inhibitors/*toxicity
Substantia Nigra/*drug effects/metabolism
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1440-1681.2007.04616.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1440-1681.2007.04616.x</a>
Pages
555–565
Issue
7
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease.
Publisher
An entity responsible for making the resource available
Clinical and experimental pharmacology & physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-07
Subject
The topic of the resource
Animal; Animals; Basal Ganglia/drug effects/*metabolism/pathology; Disease Models; Dopamine/*metabolism; Estrogens/*metabolism/pharmacology/therapeutic use; Humans; Nerve Degeneration/drug therapy/*metabolism/pathology; Neurons/metabolism/pathology; Neuroprotective Agents/*metabolism/pharmacology/therapeutic use; Parkinson Disease/drug therapy/*metabolism/pathology; Parkinsonian Disorders/drug therapy/*metabolism/pathology; Substantia Nigra/drug effects/*metabolism/pathology
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
1. The exact nature of oestrogen (positive, negative or no effect) in the dopaminergic neurodegenerative disorder Parkinson's disease is controversial. 2. In the present review, we summarize the data on oestrogen and nigrostriatal dopaminergic neurodegeneration in animal models and clinical reports of Parkinson's disease. 3. Most animal studies support the ability of oestrogen to function as a neuroprotectant against neurotoxins that target the nigrostriatal dopaminergic system. 4. Retrospective and prospective clinical studies generally support the findings from animal studies that oestrogen exerts a positive, or, at worst, no effect, in Parkinson's disease. 5. Oestrogen was chosen as one of the 12 neuroprotective compounds to be attractive candidates for further clinical trials (Phase II or III) in 2003.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1440-1681.2007.04616.x" target="_blank" rel="noreferrer noopener">10.1111/j.1440-1681.2007.04616.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Animal
Animals
Basal Ganglia/drug effects/*metabolism/pathology
Clinical and experimental pharmacology & physiology
Disease Models
Dluzen Dean E
Dopamine/*metabolism
Estrogens/*metabolism/pharmacology/therapeutic use
Humans
Liu Bin
Nerve Degeneration/drug therapy/*metabolism/pathology
Neurons/metabolism/pathology
Neuroprotective Agents/*metabolism/pharmacology/therapeutic use
Parkinson Disease/drug therapy/*metabolism/pathology
Parkinsonian Disorders/drug therapy/*metabolism/pathology
Substantia Nigra/drug effects/*metabolism/pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1365-2826.2007.01581.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1365-2826.2007.01581.x</a>
Pages
725–731
Issue
9
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice.
Publisher
An entity responsible for making the resource available
Journal of neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-09
Subject
The topic of the resource
Adrenergic Uptake Inhibitors/*metabolism; Animals; Corpus Striatum/anatomy & histology/*metabolism; Dopamine Agents/metabolism; Dopamine/*metabolism; Female; Male; Methamphetamine/metabolism; Mice; Potassium/*metabolism; Reserpine/*metabolism; Sex Factors; Tissue Culture Techniques; Vesicular Monoamine Transport Proteins/metabolism
Creator
An entity primarily responsible for making the resource
Ji J; McDermott J L; Dluzen D E
Description
An account of the resource
Reserpine inhibits vesicular monoamine transporter-2 (VMAT-2) function and thereby impairs vesicular dopamine (DA) storage within nerve terminals. The present report compared the effects of reserpine treatment upon the striatal dopaminergic system in male and female mice as a means to assess potential sex differences in VMAT-2/DA storage function. After treatment with reserpine, male mice showed significantly greater striatal DA concentrations and K+ -evoked DA output from the striatum compared to females. By contrast, no statistically significant sex differences were observed in methamphetamine-evoked DA output in reserpine-treated mice. These results demonstrate a clear sex difference in the striatal dopaminergic responses to reserpine and suggest that females possess a more active VMAT-2/DA storage capacity, as indicated by the greater degree of deficits observed when VMAT-2/DA storage function is inhibited by reserpine. Such findings have important implications for understanding some of the bases for sex differences in neurotoxicity and neurodegeneration of the nigrostriatal dopaminergic system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1111/j.1365-2826.2007.01581.x" target="_blank" rel="noreferrer noopener">10.1111/j.1365-2826.2007.01581.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Adrenergic Uptake Inhibitors/*metabolism
Animals
Corpus Striatum/anatomy & histology/*metabolism
Dluzen D E
Dopamine Agents/metabolism
Dopamine/*metabolism
Female
Ji J
Journal of neuroendocrinology
Male
McDermott J L
Methamphetamine/metabolism
Mice
Potassium/*metabolism
Reserpine/*metabolism
Sex Factors
Tissue Culture Techniques
Vesicular Monoamine Transport Proteins/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1996.66020658.x</a>
Pages
658–666
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
*MPTP Poisoning; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; Inbred C57BL; Inbred Strains; Levodopa/pharmacology; Mice; Osmolar Concentration; Ovariectomy
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrations of C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopamine release values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1996.66020658.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
Inbred C57BL
Inbred Strains
Journal of neurochemistry
Levodopa/pharmacology
Liu B
McDermott J L
Mice
Osmolar Concentration
Ovariectomy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1365-2826.2001.00675.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1365-2826.2001.00675.x</a>
Pages
618–624
Issue
7
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice.
Publisher
An entity responsible for making the resource available
Journal of neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-07
Subject
The topic of the resource
Animals; Catecholamines/metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Estrogen Antagonists/*pharmacology; Female; Humans; Hypothalamus/metabolism; Inbred Strains; Male; Methamphetamine/*pharmacology; Mice; Neurotoxins/*pharmacology; Olfactory Bulb/metabolism; Organ Size/drug effects; Pituitary Gland/anatomy & histology; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Anderson L I
Description
An account of the resource
It has been demonstrated that the nigrostriatal dopaminergic system of male mice is more sensitive to the neurotoxic effects of methamphetamine (MA). The basis for this difference can be related to oestrogen, which has the capacity to function as a neuroprotectant against neurotoxins that target the nigrostriatal dopaminergic system. We examined the effects of the anti-oestrogen, tamoxifen (TMX), upon MA-induced neurotoxicity of the nigrostriatal dopaminergic system in intact female and male CD-1 mice. Striatal dopamine concentrations of TMX-treated female and male mice receiving MA were significantly greater than mice receiving MA alone. In female, but not male, mice, oestrogen treatment also resulted in greater striatal dopamine concentrations compared to mice receiving MA alone. Interestingly, male mice treated with oestrogen were particularly sensitive to the acute toxic effects of MA and displayed no evidence of nigrostriatal neuroprotection. The dihydroxyphenylacetic acid/dopamine ratios following MA for female and male mice treated with TMX or females treated with oestrogen were significantly reduced compared to MA-treated mice and oestrogen + MA-treated male mice. No differences among the treatment groups were obtained for dopamine in the hypothalamus or olfactory bulb. These data demonstrate that TMX treatment of intact female and male mice diminishes striatal dopamine depletions to the nigrostriatal dopaminergic neurotoxin, MA. Oestrogen also displayed this capacity when administered to female, but accentuated acute toxicity in male mice. These effects are relatively specific for the nigrostriatal dopaminergic system. Such data suggest that TMX can function as a nigrostriatal dopaminergic neuroprotectant against MA-induced neurotoxicity in intact female and male mice.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1365-2826.2001.00675.x" target="_blank" rel="noreferrer noopener">10.1046/j.1365-2826.2001.00675.x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Anderson L I
Animals
Catecholamines/metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Estrogen Antagonists/*pharmacology
Female
Humans
Hypothalamus/metabolism
Inbred Strains
Journal of neuroendocrinology
Male
McDermott J L
Methamphetamine/*pharmacology
Mice
Neurotoxins/*pharmacology
Olfactory Bulb/metabolism
Organ Size/drug effects
Pituitary Gland/anatomy & histology
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0304-3940(97)00487-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0304-3940(97)00487-4</a>
Pages
140–142
Issue
2
Volume
230
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-07
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; In Vitro Techniques; Kinetics; Male; Nicotine/*pharmacology; Orchiectomy; Ovariectomy; Rats; Sex Characteristics; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Dluzen D E; Anderson L I
Description
An account of the resource
In the present experiment we examined the effects of an in vitro infusion of nicotine (10 microM) upon dopamine release from superfused striatum of castrated male and female rats treated or not treated with estrogen. Estrogen exerted bidirectional effects on nicotine-evoked dopamine release as a function of the sex of the animal. Nicotine-evoked dopamine release was increased in estrogen treated females and decreased in estrogen treated males. Peak nicotine-evoked dopamine output from estrogen treated females was significantly greater than that of estrogen treated males. These results may be related to the gender differences in response to nicotine and smoking behavior.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0304-3940(97)00487-4" target="_blank" rel="noreferrer noopener">10.1016/s0304-3940(97)00487-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
Anderson L I
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
In Vitro Techniques
Kinetics
Male
Neuroscience letters
Nicotine/*pharmacology
Orchiectomy
Ovariectomy
Rats
Sex Characteristics
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0028-3908(03)00043-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0028-3908(03)00043-1</a>
Pages
624–632
Issue
5
Volume
44
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, but not testosterone, attenuates methamphetamine-evoked dopamine output from superfused striatal tissue of female and male mice.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Estrogens/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*pharmacology; Mice; Orchiectomy; Ovariectomy; Perfusion; Testosterone/*metabolism
Creator
An entity primarily responsible for making the resource
Myers R E; Anderson L I; Dluzen D E
Description
An account of the resource
The gonadal steroid hormone, estrogen, has the capacity to function as a neuroprotectant against methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system within female, but not male, mice. In an attempt to understand some of the bases for this effect of estrogen, the incipient effects of MA upon evoked dopamine output from superfused striatal tissue fragments of gonadectomized female and gonadectomized as well as intact male mice were evaluated under conditions where estrogen (or testosterone) was present in the medium. The amount of dopamine evoked by MA was significantly reduced when estrogen was co-infused with MA. This attenuation was obtained with striatal tissue fragments of gonadectomized female and gonadectomized and intact male mice. In contrast to estrogen, co-infusion of testosterone failed to produce an overall statistically significant change in MA-evoked dopamine output within superfused striatal tissue fragments of gonadectomized female and male mice. In this way, the gonadal steroid hormones, estrogen and testosterone, exert differential modulatory effects upon MA-evoked dopamine output from superfused striatal tissue fragments. However, similar effects to these gonadal steroid hormones were observed between gonadectomized female and gonadectomized or intact male mice. These data reveal an absence of a sexual dimorphism in striatal responsiveness with regard to estrogen's ability to alter MA-evoked DA output. Accordingly, the sexually dimorphic capacity for estrogen to function as a neuroprotectant may involve a composite of actions upon the nigrostriatal dopaminergic system involving events/sites other than the initial stimulation of dopamine output.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0028-3908(03)00043-1" target="_blank" rel="noreferrer noopener">10.1016/s0028-3908(03)00043-1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Anderson L I
Animals
Corpus Striatum/*drug effects/metabolism
Dluzen D E
Dopamine/*metabolism
Estrogens/*metabolism
Female
In Vitro Techniques
Male
Methamphetamine/*pharmacology
Mice
Myers R E
Neuropharmacology
Orchiectomy
Ovariectomy
Perfusion
Testosterone/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0014-2999(97)01438-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(97)01438-6</a>
Pages
23–32
Issue
1
Volume
341
Dublin Core
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Title
A name given to the resource
The effects of nicotine on dopamine and DOPAC output from rat striatal tissue.
Publisher
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European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Amphetamine/pharmacology; Animals; Central Nervous System Stimulants/pharmacology; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Ganglionic Stimulants/administration & dosage/*pharmacology; Male; Nicotine/administration & dosage/*pharmacology; Potassium Chloride/pharmacology; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Dluzen D E; Anderson L I
Description
An account of the resource
The effects of varying doses of nicotine infusion upon spontaneous (basal) and subsequent potassium chloride-stimulated dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatal tissue fragments of male rats were tested. Spontaneous dopamine and DOPAC outputs were increased in response to 1, 5 and 10, but not to 0.1 and 0 (control) microM concentrations of nicotine. Interestingly, the subsequent K+-stimulated (30 mM) dopamine output was completely abolished in preparations infused with the 5 and 10 microM nicotine, but not with the 1 or 0.1 microM nicotine. No overall significant differences in K+-stimulated DOPAC were obtained among the five doses. In experiment 2, the effects of an initial infusion of amphetamine (10 microM), potassium chloride (30 mM), nicotine (10 microM) or normal superfusion medium (control) were compared upon subsequent K+-evoked dopamine release. The amount of dopamine released in response to the second (subsequent) infusion of K+ was significantly greater in the potassium chloride and control conditions versus the nicotine and amphetamine stimulated groups. No overall differences in DOPAC output were observed among the four conditions of experiment 2. These results demonstrate that nicotine can exert differential modulatory effects upon striatal dopaminergic activity as a function of the dose. The augmented levels of DOPAC output along with the abolition of the K+-stimulated dopamine release in response to the 5 and 10 microM nicotine doses suggest that these doses may simultaneously produce an activation of intraneuronal metabolism of dopamine to DOPAC along with an activation of release and inhibition of uptake to diminish stores available for subsequent responses to K+ stimulation.
Identifier
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<a href="http://doi.org/10.1016/s0014-2999(97)01438-6" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(97)01438-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
3
4-Dihydroxyphenylacetic Acid/*metabolism
Amphetamine/pharmacology
Anderson L I
Animals
Central Nervous System Stimulants/pharmacology
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Dose-Response Relationship
Drug
European journal of pharmacology
Ganglionic Stimulants/administration & dosage/*pharmacology
Male
Nicotine/administration & dosage/*pharmacology
Potassium Chloride/pharmacology
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(97)00418-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(97)00418-6</a>
Pages
9–16
Issue
1
Volume
764
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen as a neuromodulator of MPTP-induced neurotoxicity: effects upon striatal dopamine release.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-08
Subject
The topic of the resource
*MPTP Poisoning; 1-Methyl-4-phenylpyridinium/toxicity; Animals; Dopamine Agents/*toxicity; Dopamine/*metabolism; Estradiol/pharmacology; Estrogens/*physiology; Female; Neostriatum/drug effects/*metabolism; Neurotransmitter Agents/*physiology; Ovariectomy; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Dluzen D E
Description
An account of the resource
The effects of estrogen upon MPTP-induced neurotoxicity were examined using in vitro superfusion. In Experiment 1, striatal tissue from ovariectomized rats was infused with MPP+ (10 microM), a combination of MPP+ and 17beta-estradiol (300 nM), the same dose of estradiol preceding MPP+, or no treatment infusion. The effects of these treatments on dopamine release rates during the infusion periods were determined. Infusion of MPP+ resulted in a significant increase in dopamine release as compared to the control. Estradiol added to the MPP+ infusion significantly attenuated this dopamine (DA) release, while estradiol treatment preceding the MPP+ had no effect. In Experiment 2, three different doses of estradiol (0.3, 3, or 300 nM) were infused simultaneously with the MPP+. Doses of estradiol below 300 nM did not attenuate the DA release. In Experiment 3, estradiol alone (300 nM) was infused, to determine dopamine release rate effects of the hormone itself. There was no difference between estradiol treated and non-infused control groups. These results demonstrate that the gonadal steroid hormone estradiol can modulate responses of striatal dopamine neurons to MPP+ by altering the immediate increase in dopamine release which occurs in response to this neurotoxin. These modulating effects of estradiol are dose-dependent, and represent a direct effect upon striatal neurons, most likely involving a non-genomic mechanism of action. These results implicate that hormonal modulation of nigrostriatal dopaminergic neurotoxicity may represent an important variable responsible for the sex differences which are reported in Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(97)00418-6" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(97)00418-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenylpyridinium/toxicity
1997
Animals
Brain research
Disshon K A
Dluzen D E
Dopamine Agents/*toxicity
Dopamine/*metabolism
Estradiol/pharmacology
Estrogens/*physiology
Female
Neostriatum/drug effects/*metabolism
Neurotransmitter Agents/*physiology
Ovariectomy
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)03221-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)03221-2</a>
Pages
63–69
Issue
1
Volume
892
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-02
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Drug Implants; Female; Male; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Neurotoxins/*toxicity; Orchiectomy; Ovariectomy; Potassium/pharmacology; Substantia Nigra/drug effects/*metabolism; Testosterone/administration & dosage/*pharmacology
Creator
An entity primarily responsible for making the resource
Gao X; Dluzen D E
Description
An account of the resource
The gonadal steroid hormone estrogen (E) can function as a neuroprotectant of nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the effects of T on methamphetamine (MA) induced neurotoxicity of the NSDA system were examined in gonadectomized female and male CD-1 mice. In Experiment 1, striatal dopamine (DA) concentrations and output from T-treated ovariectomized mice were not significantly different from that of non-T-treated mice following MA. These results suggest that T is not functioning as a modulator of MA-induced NSDA neurotoxicity in ovariectomized CD-1 mice. In Experiment 2, there were no significant differences in DA concentrations or output among
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)03221-2" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)03221-2</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Animals
Brain research
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Drug Implants
Female
Gao X
Male
Methamphetamine/*toxicity
Mice
Neuroprotective Agents/pharmacology
Neurotoxins/*toxicity
Orchiectomy
Ovariectomy
Potassium/pharmacology
Substantia Nigra/drug effects/*metabolism
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02329-5</a>
Pages
95–104
Issue
1
Volume
868
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-06
Subject
The topic of the resource
*Sex Characteristics; 1-Methyl-4-phenylpyridinium/*toxicity; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Estrogens/*pharmacology; Extracellular Space/metabolism; Female; Herbicides/*toxicity; Male; Microdialysis; Nerve Degeneration/chemically induced/metabolism; Parkinson Disease; Rats; Secondary/chemically induced/metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Dluzen D E
Description
An account of the resource
The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta estradiol) and subjected to microdialysis 6 days later. After baseline DA release was determined, 5 mM MPP(+) was infused through the microdialysis probe for one 20-min interval. Perfusion resumed with normal medium for the duration of the experiment. A significant attenuation of MPP(+)-induced DA release was obtained in estrogen-treated females. One week later, striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned and non-lesioned striata of each animal. MPP(+) infusion significantly decreased striatal DA concentrations, however, there was no effect of estrogen treatment on striatal DA depletion. This experiment was repeated using orchidectomized male rats treated with 0, 0.1, or 5 mg estradiol. In contrast to the females, no differences in MPP(+)-induced DA release were seen among these males, and there was no significant effect of the varying estrogen treatments on striatal DA or DOPAC concentrations. These results demonstrate that in vivo estrogen treatment attenuates MPP(+)-induced striatal DA release in gonadectomized female, but not male, rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02329-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1-Methyl-4-phenylpyridinium/*toxicity
2000
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Corpus Striatum/*metabolism
Disshon K A
Dluzen D E
Dopamine/*metabolism
Estrogens/*pharmacology
Extracellular Space/metabolism
Female
Herbicides/*toxicity
Male
Microdialysis
Nerve Degeneration/chemically induced/metabolism
Parkinson Disease
Rats
Secondary/chemically induced/metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.tips.2005.08.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.tips.2005.08.001</a>
Pages
485–487
Issue
10
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Unconventional effects of estrogen uncovered.
Publisher
An entity responsible for making the resource available
Trends in pharmacological sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-10
Subject
The topic of the resource
Animals; Corpus Striatum/*metabolism/physiology; Dopamine D2/metabolism; Dopamine/*metabolism; Estrogens/*physiology; GTP-Binding Proteins/metabolism; Humans; Receptors; Signal Transduction/physiology; Substantia Nigra/*metabolism/physiology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The nigrostriatal dopamine system shows marked gender differences that, in many cases, can be attributable to estrogen. However, the virtual absence of conventional estrogen receptors within the nigrostriatal dopamine system has made it difficult to understand how estrogen can function within this system. Recent findings have helped to uncover how estrogen can affect a discrete function of striatal dopamine-containing neurons–transporter activity–in a manner similar to that achieved through alterations in dopamine D(2) receptors and their associated G protein. These findings suggest that the effects of estrogen on dopamine transporter function could result from a signal transduction interaction involving D(2) receptor-G protein coupling.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.tips.2005.08.001" target="_blank" rel="noreferrer noopener">10.1016/j.tips.2005.08.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Animals
Corpus Striatum/*metabolism/physiology
Dluzen Dean E
Dopamine D2/metabolism
Dopamine/*metabolism
Estrogens/*physiology
GTP-Binding Proteins/metabolism
Humans
Receptors
Signal Transduction/physiology
Substantia Nigra/*metabolism/physiology
Trends in pharmacological sciences
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.pbb.2004.10.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pbb.2004.10.007</a>
Pages
27–33
Issue
1
Volume
80
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-01
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; Male; Mice; Motor Activity/drug effects/physiology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Mickley Katherine R
Description
An account of the resource
It has been demonstrated that the gonadal steroid hormone estrogen can exert neuroprotective effects upon the nigrostriatal dopaminergic (NSDA) system against methamphetamine (MA)-induced neurotoxicity in female, but not male, mice. In contrast, the anti-estrogen, tamoxifen (TMX) can function as a NSDA neuroprotectant within both female and male mice. In an attempt to understand these effects of TMX, the effects of this anti-estrogen upon both behavioral and neurochemical indices of NSDA function were examined within female and male mice following treatment with MA. In general, TMX exerted markedly different (bi-directional) effects upon NSDA function between female and male mice. Notably, treatment with TMX resulted in a relative decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations within male mice and a relative increase in female mice when treated with MA to produce a significant gender difference. Similar effects were obtained for locomotor behaviors related with NSDA function. That is, TMX produced increases in horizontal activity, number of movements and total distance traveled within
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pbb.2004.10.007" target="_blank" rel="noreferrer noopener">10.1016/j.pbb.2004.10.007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2005
Animals
Corpus Striatum/*drug effects/metabolism
Dluzen Dean E
Dopamine/*metabolism
Female
Male
Mice
Mickley Katherine R
Motor Activity/drug effects/physiology
Pharmacology, biochemistry, and behavior
Substantia Nigra/*drug effects/metabolism
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ntt.2012.03.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2012.03.003</a>
Pages
338–343
Issue
3
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
Animals; Biomarkers/metabolism; Blotting; Body Temperature/drug effects; Body Weight/drug effects; Corpus Striatum/*drug effects/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine/*metabolism; Drug Synergism; HSP70 Heat-Shock Proteins/metabolism; Inbred Strains; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/*etiology/metabolism; Oxidative Stress/drug effects; Testosterone Propionate/*pharmacology; Vesicular Monoamine Transport Proteins/metabolism; Western
Creator
An entity primarily responsible for making the resource
Buletko A Blake; Dluzen Dean E; McDermott Janet L; Darvesh Altaf S; Geldenhuys Werner J
Description
An account of the resource
Intact male CD-1 mice received an injection of testosterone propionate (TP–5 ug), progesterone (P–5 mg), the oil vehicle or remained untreated (control). At 24 hours after hormonal treatments the mice received an injection of methamphetamine (MA–40 mg/kg) and rectal temperatures were measured. At 5 days post-MA, assays were performed to assess effects of these treatments. Maximal increases in body temperatures, that were significantly greater than oil-treated controls, were obtained in TP-treated mice. At 5 days post-MA, maximal weight reductions were obtained with TP-treated mice, while P-treated mice showed no significant decrease between the pre- versus post-MA determinations. Striatal dopamine concentrations showed maximal reductions and heat-shock protein-70 maximal increases in the TP group, with both differing significantly as compared with all other groups. Protein levels of dopamine transporters were significantly decreased in P-treated mice, while vesicular monoamine transporter-2 was significantly decreased in TP-treated mice. Taken together, these results suggest that testosterone exacerbates the deleterious effects of MA within male mice as indicated by a number of markers related to neurotoxicity. The changes in markers as associated with this enhanced neurotoxicity suggest that TP may increase thermal/energy responses and/or oxidative stress to produce this effect.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ntt.2012.03.003" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2012.03.003</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Biomarkers/metabolism
Blotting
Body Temperature/drug effects
Body Weight/drug effects
Buletko A Blake
Corpus Striatum/*drug effects/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/metabolism
Dopamine/*metabolism
Drug Synergism
Geldenhuys Werner J
HSP70 Heat-Shock Proteins/metabolism
Inbred Strains
Male
McDermott Janet L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neurotoxicity Syndromes/*etiology/metabolism
Neurotoxicology and teratology
Oxidative Stress/drug effects
Testosterone Propionate/*pharmacology
Vesicular Monoamine Transport Proteins/metabolism
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ntt.2006.07.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2006.07.001</a>
Pages
557–562
Issue
5
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects; Dopamine Agents/pharmacology; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Drug Interactions; Female; Male; Methamphetamine/pharmacology; Mice; Nomifensine/*pharmacology; Potassium/pharmacology
Creator
An entity primarily responsible for making the resource
Kunnathur Vidhya; Shemisa Kamal; Liu Bin; Salvaterra Ty J; Dluzen Dean E
Description
An account of the resource
Male mice show more severe striatal dopamine depletions to the psychostimulant, methamphetamine (MA). To gain some understanding for this sex difference, we examined MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of male and female mice under conditions of a dopamine transporter which was either unaltered (Experiment 1) or inhibited, with use of the drug, nomifensine (Experiment 2). In Experiment 1, MA-evoked DA was significantly greater in male versus female mice. In Experiment 2, diminished, albeit statistically significant, DA responses to MA infusion in the presence of nomifensine were obtained from striatal tissue of female, but not male, mice. In Experiment 3, potassium-evoked DA responses and sex differences were abolished in the presence of nomifensine. These data demonstrate a clear sex difference in DA responses to MA. Interestingly, under conditions where dopamine transporter function is inhibited, MA retains its ability to evoke DA. However, this capacity was only observed within striatal tissue fragments of female mice and not under conditions of potassium-evoked DA. These results indicate an additional component for the bases of sex differences in nigrostriatal dopaminergic function in health and in disease. In particular, the present findings have important implications in suggesting an alternative, non-traditional, mechanism for MA effects and indicate that such a function is limited to females.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ntt.2006.07.001" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2006.07.001</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2006
Animals
Corpus Striatum/*drug effects
Dluzen Dean E
Dopamine Agents/pharmacology
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Drug Interactions
Female
Kunnathur Vidhya
Liu Bin
Male
Methamphetamine/pharmacology
Mice
Neurotoxicology and teratology
Nomifensine/*pharmacology
Potassium/pharmacology
Salvaterra Ty J
Shemisa Kamal
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2010.02.076</a>
Pages
985–993
Issue
4
Volume
167
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Age Factors; Animals; Body Temperature/drug effects; Central Nervous System Stimulants/*toxicity; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/etiology/*metabolism/physiopathology; Sex Factors; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Darvesh A S
Description
An account of the resource
A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and adult female and male mice. Adult females and males showed similar depletions in striatal DA at 0.5 h post-MA, but males showed greater DA depletions and DOPAC/DA ratios at 72 h post-MA. Juvenile mice showed neither sex differences, nor any MA neurotoxicity upon striatal DA or DOPAC/DA ratios. Following MA, body temperatures increased in all mice, but increases in adult males were greater than adult females; juveniles showed no sex differences and body temperature increases were similar to that of adult males. MA-evoked DA output was greater in adult compared to juvenile males and a biologically effective regimen of testosterone to juvenile males neither increased MA-evoked DA output nor decreased MA-induced striatal DA like that observed in adult males. These results demonstrate: (1) Unlike adults, juvenile mice show neither a sex difference for MA-induced neurotoxicity or body temperature increases, nor MA neurotoxicity, (2) Initial effects of MA (0.5 h) in adult females and males are similar, but at 72 h post-MA females show no further striatal DA depletion, (3) Increased striatal DA depletion within adult versus juvenile males may be related to initially higher MA-evoked DA responses, and (4) Testosterone fails to convert juvenile males into adults with regard to MA effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2010.02.076</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/metabolism
Age Factors
Animals
Body Temperature/drug effects
Central Nervous System Stimulants/*toxicity
Corpus Striatum/*drug effects/metabolism
Darvesh A S
Department of Pharmaceutical Sciences
Dluzen D E
Dopamine/*metabolism
Female
In Vitro Techniques
Male
McDermott J L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neuroscience
Neurotoxicity Syndromes/etiology/*metabolism/physiopathology
Sex Factors
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2008.04.051" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2008.04.051</a>
Pages
1488–1496
Issue
4
Volume
154
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differences in reserpine-induced striatal dopamine output and content between female and male mice: implications for sex differences in vesicular monoamine transporter 2 function.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-07
Subject
The topic of the resource
*Sex Characteristics; Adrenergic Uptake Inhibitors/*pharmacology; Animals; Chromatography; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Female; High Pressure Liquid; Male; Mice; Orchiectomy; Ovariectomy; Reserpine/*pharmacology; Vesicular Monoamine Transport Proteins/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; Bhatt S; McDermott J L
Description
An account of the resource
In this report a series of six in vitro experiments in which reserpine-evoked dopamine output and two in vivo experiments in which the effects of reserpine injections upon dopamine content from striatal tissue of female and male mice were performed as a means to assess possible sex differences in vesicular monoamine transporter 2 (VMAT2) function. Significantly greater amounts of dopamine were obtained from striatal tissue of female mice in response to either a brief (experiment 1) or continuous (experiment 2) infusion of reserpine. Similarly, reserpine-evoked dopamine output from striatal tissue of gonadectomized females was significantly greater that that of gonadectomized males (experiment 3). When reserpine-evoked dopamine responses were compared directly between intact versus gonadectomized females (experiment 4) or males (experiment 5) no statistically significant differences were obtained. Finally, comparisons of gonadectomized females treated or not with estrogen revealed no statistically significant differences in reserpine-evoked dopamine output (experiment 6). Injections of reserpine produced significantly greater depletions of striatal dopamine content within intact female versus male mice (experiment 7). Dopamine contents of gonadectomized females treated or not with estrogen did not differ following treatment with reserpine, but were significantly greater than that of gonadectomized males (experiment 8). Taken together, these results show that female striatal tissue is more responsive to reserpine-evoked dopamine output, and this sex difference appears to be estrogen independent. Similarly, the dopamine depleting effects of reserpine are greater in intact female mice, however, gonadectomy reverses this effect in an estrogen independent manner. The data suggest that female mice may have a greater amount/activity of VMAT2 function as revealed by the increased responsiveness to the VMAT2 blocking drug, reserpine. Such differences in VMAT2 function may be related to the gender differences observed in conditions like Parkinson's disease and drug addiction.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2008.04.051" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2008.04.051</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
Adrenergic Uptake Inhibitors/*pharmacology
Animals
Bhatt S
Chromatography
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Female
High Pressure Liquid
Male
McDermott J L
Mice
Neuroscience
Orchiectomy
Ovariectomy
Reserpine/*pharmacology
Vesicular Monoamine Transport Proteins/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2010.04.004</a>
Pages
66–69
Issue
2
Volume
476
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Aging/*physiology; Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine/*metabolism; Heterozygote; Inbred C57BL; Knockout; Male; Mice; Motor Activity; Mutation; Substantia Nigra/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; Ji Jing; McDermott Janet L
Description
An account of the resource
In this report we compared three different parameters of nigrostriatal dopaminergic (NSDA) function - locomotor activity, striatal dopamine (DA) levels and 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratios between heterozygous mutant dopamine transporter mice (+/- DAT) and their wild type controls (+/+ DAT) at three different age range periods: 4-10, 11-17 and 18-24 months of age. Locomotor activity of the +/- DAT mice failed to differ over the three age periods sampled. In +/+ DAT mice a significant decrease in locomotor activity was obtained at the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2010.04.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/*metabolism
Aging/*physiology
Animals
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine/*metabolism
Heterozygote
Inbred C57BL
Ji Jing
Knockout
Male
McDermott Janet L
Mice
Motor Activity
Mutation
Neuroscience letters
Substantia Nigra/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2008.10.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2008.10.011</a>
Pages
130–133
Issue
1
Volume
448
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-12
Subject
The topic of the resource
*Sex Characteristics; Animals; Castration/methods; Corpus Striatum/drug effects/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Dose-Response Relationship; Drug; Female; Male; Methamphetamine/*pharmacology; Mice; Testosterone Propionate/*pharmacology
Creator
An entity primarily responsible for making the resource
Lewis Chandani; Dluzen Dean E
Description
An account of the resource
We examined the effects of varying concentrations of testosterone propionate (T) treatment within intact and gonadectomized male and female mice with regard to its capacity to alter striatal dopamine (DA) depletion in response to a neurotoxic regimen of methamphetamine (MA). Administration of T at 24h prior to MA significantly increased striatal DA depletion in intact and gonadectomized male mice. Similar treatments administered to intact and gonadectomized female mice failed to alter striatal DA concentrations in response to MA. These results demonstrate that T can enhance MA-induced neurotoxicity in male, but not in female, mice. Such findings have important implications with regard to sex differences in nigrostriatal dopaminergic function, in general, and, in specific, to sex differences related to nigrostriatal dopaminergic neurotoxicity and neurodegeneration like that in response to MA and in Parkinson's disease, where a greater incidence is typically reported for males.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2008.10.011" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2008.10.011</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
Animals
Castration/methods
Corpus Striatum/drug effects/metabolism
Dluzen Dean E
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Dose-Response Relationship
Drug
Female
Lewis Chandani
Male
Methamphetamine/*pharmacology
Mice
Neuroscience letters
Testosterone Propionate/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2004.01.061" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2004.01.061</a>
Pages
135–138
Issue
3
Volume
359
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
Animals; Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism; Central Nervous System Stimulants/poisoning; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Female; Humans; Male; Methamphetamine/*poisoning; Mice; Mutation; Neurotoxicity Syndromes/*etiology/*metabolism; Sex Factors; Structure-Activity Relationship; Substantia Nigra/drug effects/metabolism; Transgenic
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The interactive effects between gender and a selective alteration in the neurotrophin, brain-derived neurotrophic factor (BDNF) upon methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic (NSDA) system were assessed. MA treatment produced a greater degree of NSDA neurotoxicity (indicated by greater reductions in corpus striatal dopamine levels) in wild type control BDNF male versus female mice. This sex difference was unaltered in heterozygous mutant BDNF (BDNF +/-) mice and in mice which overexpress BDNF (DBH:BDNF +). Both BDNF mutant conditions resulted in preservation of corpus striatal dopamine levels following MA treatment as compared with their respective MA-treated wild type controls. The relative amount of this preservation was greater in male BDNF mutants, with values being significantly greater than females in the BDNF +/- condition. These results suggest that alterations in BDNF do not alter basic gender differences in MA-induced NSDA neurotoxicity, but may produce a neuroprotection against MA which is relatively greater in males.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2004.01.061" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2004.01.061</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animals
Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism
Central Nervous System Stimulants/poisoning
Corpus Striatum/*drug effects/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Female
Humans
Male
Methamphetamine/*poisoning
Mice
Mutation
Neuroscience letters
Neurotoxicity Syndromes/*etiology/*metabolism
Sex Factors
Structure-Activity Relationship
Substantia Nigra/drug effects/metabolism
Transgenic
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2012.03.013</a>
Pages
806–808
Issue
8
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-06
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Drug Synergism; Inbred C57BL; Indoles/*pharmacology; Methamphetamine/*pharmacology; Mice
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Darvesh Altaf S; Dluzen Dean E
Description
An account of the resource
Dimebon is an anti-histamine with central nervous system activity. In this report the effects of dimebon as a neuroprotectant in animal models of Parkinson's disease were tested as assessed in methamphetamine- and MPTP-induced striatal dopaminergic toxicity. Dimebon (1mg/kg) administered at 30 min prior to methamphetamine (40mg/kg) significantly reduced the amount of striatal dopamine depletion in mice, without altering the initial methamphetamine-induced increase in body temperature. In contrast, dimebon at either 1 or 25mg/kg administered at 30 min prior to MPTP (35 mg/kg) was unable to prevent MPTP-induced striatal dopamine loss as determined at 7 days post-methamphetamine/MPTP. These data suggest that dimebon may be exerting a neurotoxin specific neuroprotective effect upon the striatal dopaminergic system and may serve as an important tool for discriminating the mechanistic basis of these two dopaminergic neurotoxins.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuint.2012.03.013" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2012.03.013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Animals
Corpus Striatum/*drug effects/metabolism
Darvesh Altaf S
Department of Pharmaceutical Sciences
Dluzen Dean E
Dopamine/*metabolism
Drug Synergism
Geldenhuys Werner J
Inbred C57BL
Indoles/*pharmacology
Methamphetamine/*pharmacology
Mice
NEOMED College of Pharmacy
Neurochemistry international
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuint.2011.04.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuint.2011.04.005</a>
Pages
101–103
Issue
2
Volume
59
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Parity decreases methamphetamine-induced striatal dopaminergic perturbation.
Publisher
An entity responsible for making the resource available
Neurochemistry international
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
*Parity; Animals; Corpus Striatum/*drug effects/metabolism/physiology; Dopamine/*metabolism; Female; Methamphetamine/*pharmacology; Mice; Pregnancy
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
The role of parity upon methamphetamine-induced neurotoxicity of the striatal dopaminergic system was assessed. Female CD-1 mice either remained nulliparous or underwent one or three complete pregnancies and were designated as the 0, 1 or 3 pregnancy groups. The mice were then treated with a neurotoxic regimen of methamphetamine (MA–40 mg/kg) or its saline vehicle (control) and striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) levels were measured at
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuint.2011.04.005" target="_blank" rel="noreferrer noopener">10.1016/j.neuint.2011.04.005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Parity
2011
Animals
Corpus Striatum/*drug effects/metabolism/physiology
Dluzen Dean E
Dopamine/*metabolism
Female
Methamphetamine/*pharmacology
Mice
Neurochemistry international
Pregnancy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2011.02.031</a>
Pages
23–28
Issue
1
Volume
198
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of freezing and extraction upon striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-05
Subject
The topic of the resource
*Freezing; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Analysis of Variance; Animals; Chemical Fractionation/methods; Corpus Striatum/*metabolism; Cryopreservation/methods; Dopamine/*metabolism; Male; Mice; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1, these determinations were performed at 0 (control), 0.5, 1 or 2h postmortem. In Experiment 2, these two protocols were compared at 0 (control), 0.5 or 72 h after a neurotoxic regimen of methamphetamine. In Experiment 3, potassium-stimulated DA release from superfused striatal tissue was compared between frozen and fresh tissue. The results from the 0 h (control) groups of Experiments 1 and 2 revealed that FE results in significant reductions in DA concentrations as compared with the EF procedure. However, FE diminishes the time-dependent reductions in striatal DA and increases in DOPAC present in the EF group, as obtained under conditions of natural (Experiment 1) or neurotoxin-induced (Experiment 2) degradation. Potassium-stimulated DA release from superfused striatal tissue is significantly decreased when measured from frozen versus fresh tissue. While freezing seems to produce an initial detrimental effect upon measuring striatal DA concentrations and potassium-stimulated release, there appears to be a capacity for preservation of striatal DA and diminution in DOPAC production by freezing when tissue is undergoing degradation. Such results demonstrate the significance of the protocol used for determination of neurotransmitters in postmortem tissue and suggest a potential means for diminishing the adverse effects of insult to striatal tissue that may result from conditions like stroke and exposure to neurotoxins.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2011.02.031</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Freezing
2011
3
4-Dihydroxyphenylacetic Acid/metabolism
Analysis of Variance
Animals
Chemical Fractionation/methods
Corpus Striatum/*metabolism
Cryopreservation/methods
Dluzen Dean E
Dopamine/*metabolism
Journal of neuroscience methods
Male
Mice
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ejphar.2009.08.012" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejphar.2009.08.012</a>
Pages
38–43
Issue
1
Volume
619
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-10
Subject
The topic of the resource
Animals; Biological Transport/drug effects; Buffers; Calcium Channels/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Extracellular Space/*drug effects/*metabolism; In Vitro Techniques; Male; Methamphetamine/pharmacology; Mice; Neostriatum/*cytology/drug effects; PC12 Cells; Perfusion; Potassium Channel Blockers/pharmacology; Potassium Channels; Potassium Chloride/pharmacology; Rats; Voltage-Gated/antagonists & inhibitors
Creator
An entity primarily responsible for making the resource
Geldenhuys Werner J; Bezuidenhout Lois-May; Dluzen Dean E
Description
An account of the resource
The dopamine transporter (DAT) plays an important role in substance abuse, schizophrenia, and dopaminergic toxicity associated with the Parkinsonian animal model toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Accordingly, the DAT serves as a critical component in regulating dopaminergic function in health and disease states. We have been working with a novel cage compound,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ejphar.2009.08.012" target="_blank" rel="noreferrer noopener">10.1016/j.ejphar.2009.08.012</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Bezuidenhout Lois-May
Biological Transport/drug effects
Buffers
Calcium Channels/metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/metabolism
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
European journal of pharmacology
Extracellular Space/*drug effects/*metabolism
Geldenhuys Werner J
In Vitro Techniques
Male
Methamphetamine/pharmacology
Mice
Neostriatum/*cytology/drug effects
PC12 Cells
Perfusion
Potassium Channel Blockers/pharmacology
Potassium Channels
Potassium Chloride/pharmacology
Rats
Voltage-Gated/antagonists & inhibitors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.cell.2014.03.039" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cell.2014.03.039</a>
Pages
858–868
Issue
4
Volume
157
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.
Publisher
An entity responsible for making the resource available
Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-05
Subject
The topic of the resource
*Affect; *Circadian Rhythm; Animals; Bipolar Disorder/genetics; CLOCK Proteins/genetics/metabolism; Cytoplasmic and Nuclear/genetics/*metabolism; Dopamine/*metabolism; Genetic; Group A; Histones/metabolism; Humans; Inbred C57BL; Knockout; Male; Member 2/metabolism; Mesencephalon/*metabolism; Mice; Mood Disorders/genetics/metabolism; Nuclear Receptor Subfamily 4; Rats; Receptors; Repressor Proteins/genetics/*metabolism; Transcription; Tyrosine 3-Monooxygenase/genetics
Creator
An entity primarily responsible for making the resource
Chung Sooyoung; Lee Eun Jeong; Yun Seongsik; Choe Han Kyoung; Park Seong-Beom; Son Hyo Jin; Kim Kwang-Soo; Dluzen Dean E; Lee Inah; Hwang Onyou; Son Gi Hoon; Kim Kyungjin
Description
An account of the resource
The circadian nature of mood and its dysfunction in affective disorders is well recognized, but the underlying molecular mechanisms are still unclear. Here, we show that the circadian nuclear receptor REV-ERBalpha, which is associated with bipolar disorder, impacts midbrain dopamine production and mood-related behavior in mice. Genetic deletion of the Rev-erbalpha gene or pharmacological inhibition of REV-ERBalpha activity in the ventral midbrain induced mania-like behavior in association with a central hyperdopaminergic state. Also, REV-ERBalpha repressed tyrosine hydroxylase (TH) gene transcription via competition with nuclear receptor-related 1 protein (NURR1), another nuclear receptor crucial for dopaminergic neuronal function, thereby driving circadian TH expression through a target-dependent antagonistic mechanism. In conclusion, we identified a molecular connection between the circadian timing system and mood regulation, suggesting that REV-ERBalpha could be targeting in the treatment of circadian rhythm-related affective disorders.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.cell.2014.03.039" target="_blank" rel="noreferrer noopener">10.1016/j.cell.2014.03.039</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Affect
*Circadian Rhythm
2014
Animals
Bipolar Disorder/genetics
Cell
Choe Han Kyoung
Chung Sooyoung
CLOCK Proteins/genetics/metabolism
Cytoplasmic and Nuclear/genetics/*metabolism
Dluzen Dean E
Dopamine/*metabolism
Genetic
Group A
Histones/metabolism
Humans
Hwang Onyou
Inbred C57BL
Kim Kwang-Soo
Kim Kyungjin
Knockout
Lee Eun Jeong
Lee Inah
Male
Member 2/metabolism
Mesencephalon/*metabolism
Mice
Mood Disorders/genetics/metabolism
Nuclear Receptor Subfamily 4
Park Seong-Beom
Rats
Receptors
Repressor Proteins/genetics/*metabolism
Son Gi Hoon
Son Hyo Jin
Transcription
Tyrosine 3-Monooxygenase/genetics
Yun Seongsik
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainres.2004.09.043" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.09.043</a>
Pages
186–194
Issue
2
Volume
1029
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-12
Subject
The topic of the resource
Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine Agents/*pharmacology; Dopamine Plasma Membrane Transport Proteins; Dopamine/*metabolism; Drug Synergism; Estrogen Antagonists/*pharmacology; Inbred Strains; Male; Membrane Glycoproteins/metabolism; Membrane Transport Proteins/metabolism; Methamphetamine/*pharmacology; Mice; Nerve Tissue Proteins/metabolism; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Willett Matthew C; Dluzen Dean E
Description
An account of the resource
The antiestrogen, tamoxifen (TMX), has been shown to function as a neuroprotectant against the nigrostriatal dopaminergic (NSDA) neurotoxin, methamphetamine (MA), within male mice. In the present report, we examined the effects of a combined infusion of TMX and MA within superfused striatal tissue fragments of male mice as an approach to understand some of the bases for TMX to function as a NSDA neuroprotectant within male mice. In Experiment 1, a coinfusion of TMX at 1, 10, or 100 pg/ml were all equally effective in increasing
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainres.2004.09.043" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.09.043</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
Animals
Brain research
Corpus Striatum/*drug effects/*metabolism
Dluzen Dean E
Dopamine Agents/*pharmacology
Dopamine Plasma Membrane Transport Proteins
Dopamine/*metabolism
Drug Synergism
Estrogen Antagonists/*pharmacology
Inbred Strains
Male
Membrane Glycoproteins/metabolism
Membrane Transport Proteins/metabolism
Methamphetamine/*pharmacology
Mice
Nerve Tissue Proteins/metabolism
Tamoxifen/*pharmacology
Willett Matthew C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0892-0362(96)00086-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0892-0362(96)00086-4</a>
Pages
603–606
Issue
5
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice.
Publisher
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Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-10
Subject
The topic of the resource
*MPTP Poisoning; Animals; Corpus Striatum/drug effects/*metabolism/pathology; Dopamine/*metabolism; Drug Implants; Estradiol/administration & dosage/*pharmacology; Female; Inbred C57BL; Male; Mice; Neuroprotective Agents/administration & dosage/*pharmacology; Neurotoxins; Olfactory Pathways/drug effects/*metabolism/pathology; Orchiectomy; Ovariectomy; Sex Characteristics
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
Castrated retired breeder male and female mice were treated or not with a 17 beta-estradiol pellet. At 10 days postcastration +/- estrogen treatment all animals were treated with MPTP. Five days later, concentrations of dopamine were determined from the corpus striatum and olfactory tubercle. Both castrated male and female mice treated with estrogen had significantly greater concentrations of dopamine within the corpus striatum compared with their respective gender controls, which did not receive estrogen. By contrast, no statistically significant differences in olfactory tubercle dopamine concentrations were obtained. Overall concentrations of dopamine within the corpus striatum, but not olfactory tubercle, were substantially greater in female vs. male mice. These data demonstrate that treatment with estrogen prevents reductions in corpus striatal dopamine concentrations in castrated mice treated with MPTP. Interestingly, this effect of estrogen was observed in both male and female mice. These results suggest that estrogen may serve as a neuroprotectant against an agent that is toxic to the nigrostriatal dopaminergic system in both male and female animal models of Parkinsonism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0892-0362(96)00086-4" target="_blank" rel="noreferrer noopener">10.1016/0892-0362(96)00086-4</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
Animals
Corpus Striatum/drug effects/*metabolism/pathology
Dluzen D E
Dopamine/*metabolism
Drug Implants
Estradiol/administration & dosage/*pharmacology
Female
Inbred C57BL
Liu B
Male
McDermott J L
Mice
Neuroprotective Agents/administration & dosage/*pharmacology
Neurotoxicology and teratology
Neurotoxins
Olfactory Pathways/drug effects/*metabolism/pathology
Orchiectomy
Ovariectomy
Sex Characteristics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(91)90175-i</a>
Pages
273–276
Issue
2
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Inbred Strains; Levodopa/*administration & dosage/pharmacology; Male; Pulsatile Flow; Rats
Creator
An entity primarily responsible for making the resource
Dluzen D; McDermott J
Description
An account of the resource
In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue fragments of immature (25-32 day) and adult (90-120 day) male rats. In response to two pulse infusions of L-DOPA (5 microM) a significantly greater amount of dopamine and DOPAC was released from the striatal fragments of immature vs adult males. In contrast, when L-DOPA was infused continuously throughout the superfusion virtually identical amounts of dopamine and DOPAC were obtained for immature and adult male rats. No differences in postsuperfusion dopamine tissue content were obtained between adult and immature rats following the two pulses or continuous infusion of L-DOPA. These results suggest that the corpus striatum of the immature rat has an enhanced capacity to convert and release dopamine in response to a submaximal pulsatile infusion of L-DOPA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(91)90175-i</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*metabolism
Animals
Brain research. Developmental brain research
Corpus Striatum/*metabolism
Dluzen D
Dopamine/*metabolism
Inbred Strains
Levodopa/*administration & dosage/pharmacology
Male
McDermott J
Pulsatile Flow
Rats
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90231-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90231-4</a>
Pages
807–812
Issue
4
Volume
41
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Further evidence for the mechanisms that may mediate nicotine discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-04
Subject
The topic of the resource
Animals; Calcium Channel Blockers/pharmacology; Dihydropyridines/pharmacology; Discrimination Learning; Dopamine/*metabolism; Dose-Response Relationship; Drug; Inbred Strains; Indoles/pharmacology; Isradipine; Male; Nicotine/administration & dosage/*pharmacology; Rats; Thiazepines/pharmacology; Tropisetron
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M
Description
An account of the resource
Rats were trained to discriminate the interoceptive stimuli produced by subcutaneously administered 0.4 mg/kg nicotine in a two-lever, food-motivated, operant task. Once criterion performance was attained, dose-response experiments indicated an ED50 value of 0.1 mg/kg and subsequent time course experiments showed a maximal effect between 10 and 30 min postadministration with a return to saline-like responding at 2 h. Pretreatment with the presynaptic dopamine release inhibitors CGS 10746B (30 mg/kg), as well as with the dihydropyridine calcium blocker isradipine (15 mg/kg), each produced a significant blockade of nicotine discrimination. In contrast, the 5-hydroxytryptamine (5-HT) receptor 5-HT3 antagonist ICS-205930 did not produce any effect upon nicotine discrimination. Thus, drugs that interfere with calcium influx, viz., isradipine, or with dopamine release (CGS 10746B) also interfere with nicotine discrimination and these results suggest that calcium influx and dopamine release may be necessary conditions for nicotine discrimination.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90231-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90231-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Calcium Channel Blockers/pharmacology
Dihydropyridines/pharmacology
Discrimination Learning
Dopamine/*metabolism
Dose-Response Relationship
Drug
Inbred Strains
Indoles/pharmacology
Isradipine
Male
Meehan S M
Nicotine/administration & dosage/*pharmacology
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Thiazepines/pharmacology
Tropisetron