1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0306-4522(01)00014-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0306-4522(01)00014-8</a>
Pages
385–394
Issue
2
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
1905-6
Subject
The topic of the resource
Animals; Corpus Striatum/chemistry/*drug effects/metabolism; Dopamine/analysis/*metabolism; Estrogen Antagonists/*pharmacology; Estrogens/blood/*pharmacology; Female; Inbred Strains; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Ovariectomy; Substantia Nigra/chemistry/*drug effects/metabolism; Sympathomimetics/*toxicity; Tamoxifen/*pharmacology
Creator
An entity primarily responsible for making the resource
Gao X; Dluzen D E
Description
An account of the resource
The effects of 17beta-estradiol and the anti-estrogen, tamoxifen, on methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in ovariectomized CD-1 mice. In Experiment 1, striatal dopamine concentrations from estrogen treated mice were significantly greater than that from non-estrogen treated mice following methamphetamine. Dopamine concentrations from estrogen+tamoxifen+methamphetamine treated mice were decreased compared to estrogen+methamphetamine treated mice and not significantly different from those of tamoxifen+methamphetamine treated mice or mice receiving methamphetamine alone. These results suggest that estrogen is functioning as a neuroprotectant of methamphetamine-induced nigrostriatal dopaminergic neurotoxicity and that this neuroprotective effect of estrogen is abolished in the presence of tamoxifen. In Experiment 2, estrogen administration after methamphetamine treatment did not produce any significant changes in dopamine concentrations compared with methamphetamine treatment alone. The data from Experiment 2 show that estrogen cannot reverse the methamphetamine-induced neurotoxicity upon the nigrostriatal dopaminergic system. Similar results were observed for the potassium-stimulated dopamine outputs from these treatment conditions as evaluated with in vitro superfusion, although a difference between the two measures for the estrogen+methamphetamine treated group was obtained in Experiment 1. These results have important implications for estrogen-tamoxifen interactions upon the nigrostriatal dopaminergic system and the gender differences which are observed in Parkinson's disease and animal models of nigrostriatal dopaminergic neurotoxicity as well as for the proposed use of tamoxifen in pre-menopausal women at risk for breast cancer.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0306-4522(01)00014-8" target="_blank" rel="noreferrer noopener">10.1016/s0306-4522(01)00014-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Animals
Corpus Striatum/chemistry/*drug effects/metabolism
Dluzen D E
Dopamine/analysis/*metabolism
Estrogen Antagonists/*pharmacology
Estrogens/blood/*pharmacology
Female
Gao X
Inbred Strains
Methamphetamine/*toxicity
Mice
Neuroprotective Agents/pharmacology
Neuroscience
Ovariectomy
Substantia Nigra/chemistry/*drug effects/metabolism
Sympathomimetics/*toxicity
Tamoxifen/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6</a>
Pages
541–550
Issue
4
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-02
Subject
The topic of the resource
alpha-Macroglobulins/administration & dosage/*pharmacology; Animals; Cells; Choline O-Acetyltransferase/*antagonists & inhibitors; Corpus Striatum/drug effects/*enzymology/metabolism; Cultured; Dopamine Antagonists/*pharmacology; Dopamine/analysis/*metabolism; Enzyme Activation/drug effects; Injections; Intraventricular; Male; Neurons/drug effects/*enzymology/metabolism; Rats; Serotonin/pharmacology; Sprague-Dawley; Stereotaxic Techniques
Creator
An entity primarily responsible for making the resource
Hu Y Q; Liebl D J; Dluzen D E; Koo P H
Description
An account of the resource
Previous studies have implicated human alpha-2-macroglobulin (alpha2M) as a potential regulator of neuronal development and function. Rat alpha-1-macroglobulin (alpha1M) and acute-phase alpha-2-macroglobulin (alpha2M) are murine homologues of human alpha2M. In this report, we tested the effect of intracranially infused serotonin-activated rat alpha1M (5HT-alpha1M) on the concentration of dopamine (DA) in the corpus striatum in vivo and the effect of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1097-4547(19980215)51:4%3C541::AID-JNR14%3E3.0.CO;2-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
alpha-Macroglobulins/administration & dosage/*pharmacology
Animals
Cells
Choline O-Acetyltransferase/*antagonists & inhibitors
Corpus Striatum/drug effects/*enzymology/metabolism
Cultured
Dluzen D E
Dopamine Antagonists/*pharmacology
Dopamine/analysis/*metabolism
Enzyme Activation/drug effects
Hu Y Q
Injections
Intraventricular
Journal of neuroscience research
Koo P H
Liebl D J
Male
Neurons/drug effects/*enzymology/metabolism
Rats
Serotonin/pharmacology
Sprague-Dawley
Stereotaxic Techniques