1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1432.010</a>
Pages
140–150
Volume
1139
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in dopamine- and vesicular monoamine-transporter functions.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/metabolism; Animal/drug effects; Animals; Behavior; Behavior/drug effects; Corpus Striatum/metabolism; Dopamine Agents/pharmacology; Dopamine Plasma Membrane Transport Proteins/*metabolism; Dopamine Uptake Inhibitors/metabolism; Female; Humans; Male; Methamphetamine/pharmacology; Mice; Nomifensine/metabolism; Reserpine/metabolism; Sex Factors; Vesicular Monoamine Transport Proteins/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
Men and women differ with regard to their use of, and responses to, methamphetamine (MA). Analogous sex differences with regard to MA are observed in animal models. In this report, data from a series of experiments that focus upon dopamine transporter (DAT) and vesicular monoamine transporter2 (VMAT2) function are reviewed by way of providing some understanding for these sex differences to MA. The amount of dopamine (DA) recovered after infusion of DA into superfused striatal tissue was greater in females and an accentuated amount of extracellular DA was obtained from females after infusion of the DAT-blocking drug, nomifensine. These data suggest a higher level of DAT activity in females. To evaluate the implications of this sex difference in DAT function as related to MA, the amount of DA evoked by an infusion of MA into superfused striatal tissue was tested and found to be significantly greater in males. In contrast, potassium chloride-stimulated DA release was greater in females. The results of these
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">10.1196/annals.1432.010</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/metabolism
Animal/drug effects
Animals
Annals of the New York Academy of Sciences
Behavior
Behavior/drug effects
Corpus Striatum/metabolism
Dluzen D E
Dopamine Agents/pharmacology
Dopamine Plasma Membrane Transport Proteins/*metabolism
Dopamine Uptake Inhibitors/metabolism
Female
Humans
Male
McDermott J L
Methamphetamine/pharmacology
Mice
Nomifensine/metabolism
Reserpine/metabolism
Sex Factors
Vesicular Monoamine Transport Proteins/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0091-3057(97)00415-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0091-3057(97)00415-2</a>
Pages
265–270
Issue
2
Volume
59
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-02
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Animals; Central Nervous System Stimulants/*pharmacology; Conditioning; Cues; Discrimination (Psychology)/drug effects; Dopamine Agents/pharmacology; Dose-Response Relationship; Drug; Generalization; Hallucinogens/*pharmacology; Inbred Strains; Male; N-Methyl-3; Operant/drug effects; Rats; Serotonin Agents/pharmacology; Serotonin/genetics/physiology; Sprague-Dawley; Stimulus/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion performance level, doses different than the training dose were used to generate a dose-response discrimination gradient. The ED50 value of MDMA was shown to be 0.136 mg/kg, not significantly different from that of previously trained Sprague-Dawley male rats. Thus, the Fawn-Hooded rat appears to not differ in its sensitivity to lower doses of MDMA. Testing for MDMA-like stimulus generalizations with other drugs indicated that the MDMA derivative MDE produced generalization at a dose of 2.25 mg/kg and allowed for an ED50 value of 0.496 mg/kg. Like MDE, the testing of alpha-ethyltryptamine was shown to produce
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0091-3057(97)00415-2" target="_blank" rel="noreferrer noopener">10.1016/s0091-3057(97)00415-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
4-methylenedioxyamphetamine/*pharmacology
Animals
Central Nervous System Stimulants/*pharmacology
Conditioning
Cues
Discrimination (Psychology)/drug effects
Dopamine Agents/pharmacology
Dose-Response Relationship
Drug
Generalization
Hallucinogens/*pharmacology
Inbred Strains
Male
N-Methyl-3
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Agents/pharmacology
Serotonin/genetics/physiology
Sprague-Dawley
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ntt.2006.07.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ntt.2006.07.001</a>
Pages
557–562
Issue
5
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
*Sex Characteristics; Animals; Corpus Striatum/*drug effects; Dopamine Agents/pharmacology; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Drug Interactions; Female; Male; Methamphetamine/pharmacology; Mice; Nomifensine/*pharmacology; Potassium/pharmacology
Creator
An entity primarily responsible for making the resource
Kunnathur Vidhya; Shemisa Kamal; Liu Bin; Salvaterra Ty J; Dluzen Dean E
Description
An account of the resource
Male mice show more severe striatal dopamine depletions to the psychostimulant, methamphetamine (MA). To gain some understanding for this sex difference, we examined MA-evoked dopamine (DA) responses from superfused striatal tissue fragments of male and female mice under conditions of a dopamine transporter which was either unaltered (Experiment 1) or inhibited, with use of the drug, nomifensine (Experiment 2). In Experiment 1, MA-evoked DA was significantly greater in male versus female mice. In Experiment 2, diminished, albeit statistically significant, DA responses to MA infusion in the presence of nomifensine were obtained from striatal tissue of female, but not male, mice. In Experiment 3, potassium-evoked DA responses and sex differences were abolished in the presence of nomifensine. These data demonstrate a clear sex difference in DA responses to MA. Interestingly, under conditions where dopamine transporter function is inhibited, MA retains its ability to evoke DA. However, this capacity was only observed within striatal tissue fragments of female mice and not under conditions of potassium-evoked DA. These results indicate an additional component for the bases of sex differences in nigrostriatal dopaminergic function in health and in disease. In particular, the present findings have important implications in suggesting an alternative, non-traditional, mechanism for MA effects and indicate that such a function is limited to females.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ntt.2006.07.001" target="_blank" rel="noreferrer noopener">10.1016/j.ntt.2006.07.001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2006
Animals
Corpus Striatum/*drug effects
Dluzen Dean E
Dopamine Agents/pharmacology
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Drug Interactions
Female
Kunnathur Vidhya
Liu Bin
Male
Methamphetamine/pharmacology
Mice
Neurotoxicology and teratology
Nomifensine/*pharmacology
Potassium/pharmacology
Salvaterra Ty J
Shemisa Kamal
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90226-r" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90226-r</a>
Pages
549–551
Issue
2
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lack of neuroleptic-like activity of l-fenfluramine.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-06
Subject
The topic of the resource
Animals; Antipsychotic Agents/*pharmacology; Cues; Discrimination (Psychology)/drug effects; Dopamine Agents/pharmacology; Dopamine Antagonists; Fenfluramine/*pharmacology; Inbred Strains; Male; Phenylpropanolamine/pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Rats were trained to differentiate between the dopaminergically mediated discriminative stimuli produced by intraperitoneal administration of 4.8 mg/kg cathine and its vehicle. Once trained, three doses of l-fenfluramine (1.0, 2.0 and 2.5 mg/kg) were administered to determine if this agent would produce cathine-appropriate discriminative performance. All doses of l-fenfluramine were observed to produce vehicle-like responding. The 2.0 mg/kg dose of l-fenfluramine as well as 3.0 mg/kg chlorpromazine were administered in separate experiments prior to either cathine or vehicle. Chlorpromazine attenuated cathine-lever responding after cathine administration but did not affect vehicle responding. In contrast, l-fenfluramine had no effect upon cathine discrimination. The results indicate that l-fenfluramine shares neither agonist nor antagonist activity in the dopamine-mediated discriminative performance produced by cathine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90226-r" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90226-r</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Antipsychotic Agents/*pharmacology
Cues
Discrimination (Psychology)/drug effects
Dopamine Agents/pharmacology
Dopamine Antagonists
Fenfluramine/*pharmacology
Inbred Strains
Male
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/pharmacology
Rats
Schechter M D