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Text
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URL Address
<a href="http://doi.org/10.1007/bf02246057" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02246057</a>
Pages
79–84
Issue
1
Volume
119
Dublin Core
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Title
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The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.
Publisher
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Psychopharmacology
Date
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1995
1995-05
Subject
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Amphetamine/pharmacology; Animals; Apomorphine/pharmacology; Benzazepines/pharmacology; Cocaine/pharmacology; Discrimination (Psychology); Dopamine Agonists/pharmacology; Dopamine D1/*agonists; Dose-Response Relationship; Drug; Male; Phenanthridines/*pharmacology; Rats; Receptors; Sprague-Dawley
Creator
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Schechter M D
Description
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The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist dihydrexidine (DHX) within 20 sessions using a training dose of 3.0 mg/kg. DHX (0.75-4.5 mg/kg) dose-dependently increased DHX-appropriate responding with an ED50 = 1.44 mg/kg. The selective D1 agonist SKF 38398 (2.0-8.0 mg/kg) dose-responsively generalized with an ED50 = 3.54 mg/kg; significantly less potent than DHX. The selective D1 antagonist SCH 23390 (0.06-0.12 mg/kg) dose-responsively decreased DHX-appropriate discriminative performance. These data would indicate that DHX is a selective D1 agonist that may allow for testing of the selectivity of other putative D1 agonists in this experimental procedure. Administration of non-selective dopaminergically active drugs, including apomorphine, amphetamine and cocaine, were each shown to produce intermediate
Identifier
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<a href="http://doi.org/10.1007/bf02246057" target="_blank" rel="noreferrer noopener">10.1007/bf02246057</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Amphetamine/pharmacology
Animals
Apomorphine/pharmacology
Benzazepines/pharmacology
Cocaine/pharmacology
Discrimination (Psychology)
Dopamine Agonists/pharmacology
Dopamine D1/*agonists
Dose-Response Relationship
Drug
Male
Phenanthridines/*pharmacology
Psychopharmacology
Rats
Receptors
Schechter M D
Sprague-Dawley