1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2010.04.004</a>
Pages
66–69
Issue
2
Volume
476
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.
Publisher
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Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Aging/*physiology; Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine/*metabolism; Heterozygote; Inbred C57BL; Knockout; Male; Mice; Motor Activity; Mutation; Substantia Nigra/*metabolism
Creator
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Dluzen Dean E; Ji Jing; McDermott Janet L
Description
An account of the resource
In this report we compared three different parameters of nigrostriatal dopaminergic (NSDA) function - locomotor activity, striatal dopamine (DA) levels and 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratios between heterozygous mutant dopamine transporter mice (+/- DAT) and their wild type controls (+/+ DAT) at three different age range periods: 4-10, 11-17 and 18-24 months of age. Locomotor activity of the +/- DAT mice failed to differ over the three age periods sampled. In +/+ DAT mice a significant decrease in locomotor activity was obtained at the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2010.04.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/*metabolism
Aging/*physiology
Animals
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine/*metabolism
Heterozygote
Inbred C57BL
Ji Jing
Knockout
Male
McDermott Janet L
Mice
Motor Activity
Mutation
Neuroscience letters
Substantia Nigra/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2009.07.004</a>
Pages
1401–1411
Issue
11
Volume
78
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.
Publisher
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Biochemical pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Female; Male; Messenger/biosynthesis; Mice; Mutant Strains; Protein Binding; Reserpine/pharmacology; RNA; Sex Characteristics; Substantia Nigra/*metabolism; Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
Creator
An entity primarily responsible for making the resource
Ji Jing; Bourque Melanie; Di Paolo Therese; Dluzen Dean E
Description
An account of the resource
Female mice with a heterozygous mutation of their dopamine transporter (+/- DAT) showed relatively robust reductions in striatal DAT specific binding (38-50%), while +/- DAT males showed modest reductions (24-32%). Significant decreases in substantia nigra DAT specific binding (42%) and mRNA (24%) were obtained in +/- DAT females, but not +/- DAT males (19% and 5%, respectively). The effects of this DAT perturbation upon vesicular monoamine transporter-2 (VMAT-2) function revealed significantly greater reserpine-evoked DA output from +/+ and +/- DAT female as compared to male mice and the DA output profile differed markedly between +/+ and +/- DAT females, but not males. No changes in VMAT-2 protein or mRNA levels were present among these conditions. On the basis of these data, we propose: (1) a genetic mutation of the DAT does not exert equivalent effects upon the DAT in female and male mice, with females being more affected; (2) an alteration in the DAT may also affect VMAT-2 function; (3) this interaction between DAT and VMAT-2 function is more prevalent in female mice; and (4) the +/- DAT mutation affects VMAT-2 function through an indirect mechanism, that does not involve an alteration in VMAT-2 protein or mRNA. Such DAT/VMAT-2 interactions can be of significance to the gender differences observed in drug addiction and Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2009.07.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Biochemical pharmacology
Bourque Melanie
Corpus Striatum/*metabolism
Di Paolo Therese
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Female
Ji Jing
Male
Messenger/biosynthesis
Mice
Mutant Strains
Protein Binding
Reserpine/pharmacology
RNA
Sex Characteristics
Substantia Nigra/*metabolism
Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-007-0017-0</a>
Pages
809–817
Issue
6
Volume
115
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-06
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/drug effects/*metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine Uptake Inhibitors/pharmacology; Dopamine/*metabolism; Down-Regulation/drug effects/genetics; Female; Gene Expression Regulation/drug effects/genetics; Heterozygote; Knockout; Male; Methamphetamine/pharmacology; Mice; Mutation/*genetics; Neural Pathways/drug effects/metabolism; Potassium Chloride/metabolism/pharmacology; Substantia Nigra/drug effects/metabolism; Synaptic Transmission/drug effects/genetics; Up-Regulation/drug effects/genetics
Creator
An entity primarily responsible for making the resource
Ji Jing; Dluzen Dean E
Description
An account of the resource
The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA) stimulation between male and female mice was examined. Striatal DA and DOPAC concentrations of female +/- DAT mice were significantly decreased as compared with wild type (+/+) controls and male +/- DAT mice. No such changes were obtained from the olfactory tubercle suggesting that these effects might be specific for the striatum. Potassium-stimulated DA was increased in male and female +/- DAT mice and maximally stimulated DA was obtained from +/- DAT females, although these mice showed the lowest DA concentrations. MA-evoked DA was increased in male and female +/- mice. While MA-evoked DA was significantly increased in +/+ males versus +/+ females, the +/- females showed the highest DA responses, thereby showing a reversal in the results seen in wild-type conditions. These findings indicate: (1) that a deficiency in the DAT interacts with the sex of the subject, (2)+/- DAT females show more extreme changes in dopaminergic responses, and (3) the importance for considering such variables such as sex when examining differences among knock-out conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">10.1007/s00702-007-0017-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain/drug effects/*metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine Uptake Inhibitors/pharmacology
Dopamine/*metabolism
Down-Regulation/drug effects/genetics
Female
Gene Expression Regulation/drug effects/genetics
Heterozygote
Ji Jing
Journal of neural transmission (Vienna, Austria : 1996)
Knockout
Male
Methamphetamine/pharmacology
Mice
Mutation/*genetics
Neural Pathways/drug effects/metabolism
Potassium Chloride/metabolism/pharmacology
Substantia Nigra/drug effects/metabolism
Synaptic Transmission/drug effects/genetics
Up-Regulation/drug effects/genetics