1
40
132
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
76–77
Issue
7
Volume
32
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
High-Dose Flu Vaccine has Increased Immunogenicity in HIV Patients.
Publisher
An entity responsible for making the resource available
Infectious Disease Alert
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Ohio; Human; Dose-Response Relationship; Randomized Controlled Trials; Double-Blind Studies; Human Immunodeficiency Virus; Influenza Vaccine
Creator
An entity primarily responsible for making the resource
Watkins Richard R
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Department of Internal Medicine
Dose-Response Relationship
Double-Blind Studies
Human
Human Immunodeficiency Virus
Infectious Disease Alert
Influenza Vaccine
NEOMED College of Medicine
Ohio
RANDOMIZED controlled trials
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/MJT.0b013e31824ea644" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/MJT.0b013e31824ea644</a>
Pages
267–274
Issue
3
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Clinical impact of temporary therapy interruptions on anticoagulation control in patients treated with warfarin.
Publisher
An entity responsible for making the resource available
American Journal of Therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
Female; Male; Aged; Prospective Studies; International Normalized Ratio; Drug Administration Schedule; Preoperative Care; Postoperative Care; Human; Middle Age; Retrospective Design; Dose-Response Relationship; Drug; Treatment Outcomes; Drug Monitoring; Anticoagulants – Therapeutic Use; Anticoagulants – Administration and Dosage; Atrial Fibrillation – Drug Therapy; Blood Coagulation Disorders – Drug Therapy; Coronary Thrombosis – Drug Therapy; Euthanasia; Passive; Venous Thromboembolism – Drug Therapy; Warfarin – Administration and Dosage; Warfarin – Therapeutic Use
Creator
An entity primarily responsible for making the resource
Boros Melanie L; Rybarczyk Amy M; Gallegos Patrick J; Zimmerman Jacob P
Description
An account of the resource
This retrospective cohort study was completed to describe the impact of short-term therapy interruptions on anticoagulation control in patients receiving warfarin. Patients seen in a pharmacist-managed anticoagulation clinic were included if they were on a stable warfarin dose and then underwent a planned interruption in therapy. Patients were excluded if phytonadione was administered before the interruption or if medications known to interact with warfarin were altered during the interruption. Data were analyzed for 2 groups: (1) patients with a single interruption in therapy (group 1) and (2) patients with a single interruption in therapy plus patients with an extended interruption in therapy (group 2). The primary endpoint was the change in weekly maintenance warfarin dose from preinterruption to postinterruption. Evaluation of 199 patients resulted in 31 interruptions in group 1 and 34 interruptions in group 2. A change in dose was required in 58% of patients in group 1 and 56% of patients in group 2. The mean absolute change in dose was 2.03 ± 2.79 mg (P \textless 0.003) in group 1 and 1.96 ± 2.72 mg (P \textless 0.002) in group 2. For the majority of patients, the dose change represented \textless10% of their preinterruption weekly dose. Of patients requiring a dose change, 50% required an increase in dose. In conclusion, close follow-up is warranted after a warfarin therapy interruption as dose adjustments will likely be needed to regain anticoagulation control and the direction of this dose change cannot be predicted.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/MJT.0b013e31824ea644" target="_blank" rel="noreferrer noopener">10.1097/MJT.0b013e31824ea644</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Aged
American journal of therapeutics
Anticoagulants – Administration and Dosage
Anticoagulants – Therapeutic Use
Atrial Fibrillation – Drug Therapy
Blood Coagulation Disorders – Drug Therapy
Boros Melanie L
Coronary Thrombosis – Drug Therapy
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Dose-Response Relationship
Drug
Drug Administration Schedule
Drug Monitoring
Euthanasia
Female
Gallegos Patrick J
Human
International Normalized Ratio
Male
Middle Age
NEOMED College of Pharmacy
Passive
Postoperative Care
Preoperative Care
Prospective Studies
Retrospective Design
Rybarczyk Amy M
Treatment Outcomes
Venous Thromboembolism – Drug Therapy
Warfarin – Administration and Dosage
Warfarin – Therapeutic Use
Zimmerman Jacob P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
41–42
Issue
4
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Efficacy of Higher-dose Oseltamivir in Adults with Influenza A and B.
Publisher
An entity responsible for making the resource available
Infectious Disease Alert
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-01
Subject
The topic of the resource
Prospective Studies; Multicenter Studies; Dose-Response Relationship; Treatment Outcomes; Influenza A Virus; Influenza B Virus; Influenza – Drug Therapy; Oseltamivir – Adverse Effects; Oseltamivir – Therapeutic Use
Creator
An entity primarily responsible for making the resource
Watkins Richard R
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Department of Internal Medicine
Dose-Response Relationship
Infectious Disease Alert
Influenza – Drug Therapy
Influenza A Virus
Influenza B Virus
Multicenter Studies
NEOMED College of Medicine
Oseltamivir – Adverse Effects
Oseltamivir – Therapeutic Use
Prospective Studies
Treatment Outcomes
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
138–139
Issue
12
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Steroids Increase the Risk for Community-acquired Staphylococcus aureus Bacteremia...Smit J, Kaasch AJ, Sogaard M , t al. Use of glucocorticoids and risk of community-acquired Staphylococcus aureus bacteremia:A population-based case-control study. Mayo Clin Proc 2016 :91:873-880.
Publisher
An entity responsible for making the resource available
Infectious Disease Alert
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-09
Subject
The topic of the resource
Denmark; Dose-Response Relationship; Drug; Staphylococcus Aureus; Bacteremia – Risk Factors; Community-Acquired Infections – Risk Factors; Glucocorticoids – Adverse Effects; Staphylococcal Infections – Risk Factors
Creator
An entity primarily responsible for making the resource
Watkins Richard R
Description
An account of the resource
The article discusses case-control study revealing an increased risk for developing community-acquired Staphylococcus aureus bacteremia (SAB) with the use of systemic glucocorticoids. Topics discussed include data collected from a population-based registry from northern Denmark, use of conditional logistic regression to calculate crude and adjusted odds ratios (ORs) and pathophysiologic mechanisms by which steroid use might predispose to community-acquired (CA-SAB).
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Bacteremia – Risk Factors
Community-Acquired Infections – Risk Factors
Denmark
Department of Internal Medicine
Dose-Response Relationship
Drug
Glucocorticoids – Adverse Effects
Infectious Disease Alert
NEOMED College of Medicine
Staphylococcal Infections – Risk Factors
Staphylococcus aureus
Watkins Richard R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
17–24, 27
Issue
4
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Reexamining interstitial radiotherapy for PCa.
Publisher
An entity responsible for making the resource available
Contemporary urology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
Humans; Male; Ultrasonography; Treatment Outcome; Forecasting; *Brachytherapy/adverse effects/instrumentation/methods/trends; *Radioisotopes/adverse effects; Prostatectomy; Prostatic Neoplasms/diagnostic imaging/*radiotherapy; Dose-Response Relationship; Radiation
Creator
An entity primarily responsible for making the resource
Summers J L
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brachytherapy/adverse effects/instrumentation/methods/trends
*Radioisotopes/adverse effects
1994
Contemporary urology
Dose-Response Relationship
Forecasting
Humans
Male
Prostatectomy
Prostatic Neoplasms/diagnostic imaging/*radiotherapy
Radiation
Summers J L
Treatment Outcome
Ultrasonography
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3959(89)90046-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3959(89)90046-8</a>
Pages
329–335
Issue
3
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-12
Subject
The topic of the resource
Male; Animals; Rats; Injections; Enkephalins/*pharmacology; Naloxone/pharmacology; Anesthetics/*pharmacology; Biogenic Monoamines/*physiology; Pain/*metabolism; Spinal Cord/drug effects/metabolism/*physiopathology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Enkephalin; Ala(2)-MePhe(4)-Gly(5)-; Spinal; 5)-; D-Penicillamine (2; Opioid/drug effects/*physiology; Enkephalins; Intraspinal; Amines – Physiology; Anesthetics – Pharmacodynamics; Cell Surface – Drug Effects; Cell Surface – Physiology; Enkephalins – Pharmacodynamics; Naloxone – Pharmacodynamics; Pain – Metabolism; Spinal Cord – Drug Effects; Spinal Cord – Metabolism; Spinal Cord – Physiopathology
Creator
An entity primarily responsible for making the resource
Spanos L J; Stafinsky J L; Crisp T
Description
An account of the resource
The antinociceptive properties of intrathecally (i.t.) administered [D-Ala2,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3959(89)90046-8" target="_blank" rel="noreferrer noopener">10.1016/0304-3959(89)90046-8</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
5)-
Ala(2)-MePhe(4)-Gly(5)-
Amines – Physiology
Anesthetics – Pharmacodynamics
Anesthetics/*pharmacology
Animals
Biogenic Monoamines/*physiology
Cell Surface – Drug Effects
Cell Surface – Physiology
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins
Enkephalins – Pharmacodynamics
Enkephalins/*pharmacology
Inbred Strains
Injections
Intraspinal
Male
Naloxone – Pharmacodynamics
Naloxone/pharmacology
Opioid/drug effects/*physiology
Pain
Pain – Metabolism
Pain/*metabolism
Rats
Receptors
Spanos L J
Spinal
Spinal Cord – Drug Effects
Spinal Cord – Metabolism
Spinal Cord – Physiopathology
Spinal Cord/drug effects/metabolism/*physiopathology
Stafinsky J L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90044-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90044-0</a>
Pages
835–840
Issue
4
Volume
32
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-04
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Behavior; Motor Activity/*drug effects; Amphetamines/*pharmacology; Designer Drugs/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; 3; Animal/*drug effects; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Spanos L J; Yamamoto B K
Description
An account of the resource
Specific behaviors comprising the serotonin syndrome (low body posture, forepaw treading, headweaving) and the autonomic signs of piloerection and salivation were determined and analyzed with locomotor activity in response to MDMA at three doses (2.5, 5.0, and 7.5 mg/kg). All behaviors were dose-responsive. Serotonin syndrome behaviors increased in both intensity and duration of response with increasing doses. In contrast, locomotion varied only in intensity. Subchronic injections, in the same group of animals, permitted an analysis of acute vs. subchronic effects on these same behaviors. Both the serotonin syndrome and locomotor behaviors were augmented on subsequent testing, indicating that, (+/-)MDMA, like amphetamine, is capable of producing behavioral sensitization.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90044-0" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90044-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animal/*drug effects
Animals
Behavior
Designer Drugs/*pharmacology
Dose-Response Relationship
Drug
Inbred Strains
Male
Motor Activity/*drug effects
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Receptors
Serotonin/*drug effects
Spanos L J
Time Factors
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90424-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90424-8</a>
Pages
55–64
Issue
1
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-05
Subject
The topic of the resource
Male; Animals; Rats; Ethanol/*pharmacology; Cues; Discrimination (Psychology)/*physiology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Conditioning; Serotonin/drug effects/*physiology; Dopamine/drug effects/*physiology; Operant/physiology
Creator
An entity primarily responsible for making the resource
Signs S A; Schechter M D
Description
An account of the resource
The drug discrimination paradigm was used to evaluate the contribution of dopamine or serotonin receptors in the mediation of the stimulus properties of ethanol. Briefly, rats were trained to discriminate between ethanol (600 mg/kg, IP) and water vehicle. Dose-response relationships were observed for ethanol and rats were tested with various dopamine and serotonin receptor agonists and antagonists. The specific dopamine receptor agonists SKF 38393 (DA1) and LY 171555 (DA2) failed to produce appreciable ethanol-like stimulus effects. Furthermore, the dopamine receptor antagonists SCH 23390 (DA1) and haloperidol (DA2) did not affect ethanol-appropriate responding when administered in combination with the training dose of ethanol. A number of specific serotonergic receptor ligands were also tested. Quipazine, 5-MeODMT, buspirone, 8-OH-DPAT elicited intermediate ethanol-like stimulus properties in rats. The serotonin receptor blockers pizotifen, pirenperone and (-)propranolol were ineffective in blocking the interoceptive cue produced by 600 mg/kg ethanol. However, TFMPP produced strong ethanol-like discriminative properties and completely substituted for the training dose of ethanol. These results indicate that the stimulus properties of TFMPP are similar to those of a low dose of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90424-8" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90424-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Conditioning
Cues
Discrimination (Psychology)/*physiology
Dopamine/drug effects/*physiology
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Inbred Strains
Male
Operant/physiology
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/drug effects/*physiology
Signs S A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90310-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90310-3</a>
Pages
53–57
Issue
1
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Use of TFMPP stimulus properties as a model of 5-HT1B receptor activation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Pharmaceutical Vehicles; Discrimination Learning/*drug effects; Norfenfluramine/pharmacology; Piperazines/*pharmacology; Dose-Response Relationship; Drug; Receptors; Biological; Models; Serotonin/*drug effects/physiology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Recent evidence indicates that when 1-(3-trifluoromethylphenyl)piperazine (TFMPP) is used as a training drug in the drug discrimination paradigm it produces a stimulus effect that is site-selective at the 5-HT1B receptor. The present study sought to employ this procedure in order to assess the similarity of novel agents to TFMPP. First, rats were trained to reliably discriminate between the stimulus properties of intraperitoneally administered 1.0 mg/kg TFMPP and its vehicle. Following the acquisition of this discrimination, administration of various doses of TFMPP produced a typical dose-response relationship with an ED50 of 0.27 mg/kg. Rats were subsequently tested with another 5-HT1B specific agonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90310-3" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90310-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Biological
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Male
Models
Norfenfluramine/pharmacology
Pharmaceutical Vehicles
Pharmacology, biochemistry, and behavior
Piperazines/*pharmacology
Rats
Receptors
Schechter M D
Serotonin/*drug effects/physiology
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(89)90049-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(89)90049-9</a>
Pages
445–449
Issue
6
Volume
6
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Time-dependent effect of ethanol upon discrimination behavior.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-12
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Ethanol/*pharmacology; Discrimination (Psychology)/*drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The discriminative stimulus properties produced by ethanol were employed to demonstrate differences in discriminative performance over time in rats trained at different postinjection times. Thus, one group of rats was trained to discriminate between intraperitoneally administered 600 mg/kg ethanol and its distilled water vehicle at 6-min postadministration, whereas a second group of rats was trained to make this discrimination when trained at 30-min postinjection. Subsequent to reaching criterion performance, dose-response relations to doses of ethanol from 150-900 mg/kg were determined to be similar in both groups. This indicated that the discriminative stimulus effects at the two postadministration times were equally effective for training of behavioral responding to ethanol. The rats trained at 30 min postadministration maintained criterion level discrimination performance when tested at 6-, 15- and 60-min postinjection. In contrast, the rats trained at 6-min postadministration discriminated ethanol at a reduced level (40%) when tested at 30-min postinjection. These results suggest that the nature of the discriminable stimuli produced by a low dose of ethanol are different at 6-min and at 30-min postadministration. Evidence is cited to further suggest that the earlier stimuli are excitatory whereas the later stimuli are sedative.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(89)90049-9" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(89)90049-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Alcohol (Fayetteville, N.Y.)
Animals
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Inbred Strains
Male
Rats
Schechter M D
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90284-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90284-o</a>
Pages
527–531
Issue
3
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Temporal differences in behavioral effect of fenfluramine and norfenfluramine.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-03
Subject
The topic of the resource
Male; Animals; Rats; Behavior; Stereoisomerism; Injections; Discrimination Learning/*drug effects; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Intraperitoneal; Animal/*drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Ten male rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-reinforced (fixed-ratio 10 schedule) two-lever operant task. Once learned, the fenfluramine stimulus was dose-dependent (ED50 = 0.8 mg/kg) and stereoselective with the d-isomer (ED50 = 0.6 mg/kg) approximate twice as potent as the l-isomer (ED50 = 1.2 mg/kg). Time-course data indicate that the fenfluramine metabolite norfenfluramine produces a significantly faster onset and longer duration of action than does the parent compound. The results suggest that both stereoisomers of fenfluramine have discriminative stimulus properties and that the fenfluramine metabolite, norfenfluramine, contributes to the discriminative stimulus properties of the parent drug.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90284-o" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90284-o</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Animal/*drug effects
Animals
Behavior
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Fenfluramine/*analogs & derivatives/*pharmacology
Inbred Strains
Injections
Intraperitoneal
Male
Norfenfluramine/*pharmacology
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Stereoisomerism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90256-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90256-6</a>
Pages
361–364
Issue
1
Volume
32
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability of the stimulus properties of drugs over time.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Animals; Rats; Ethanol/*pharmacology; *Discrimination (Psychology); Drug Tolerance; Piperazines/*pharmacology; Dextroamphetamine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D; Signs S A; Boja J W
Description
An account of the resource
Three separate groups of rats were trained to discriminate the stimulus effects of either 600 mg/kg ethanol (n = 5), 0.8 mg/kg d-amphetamine (n = 8) or 1.0 mg/kg
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90256-6" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90256-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)
1989
Animals
Boja J W
Dextroamphetamine/*pharmacology
Dose-Response Relationship
Drug
Drug Tolerance
Ethanol/*pharmacology
Inbred Strains
Pharmacology, biochemistry, and behavior
Piperazines/*pharmacology
Rats
Schechter M D
Signs S A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90390-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90390-5</a>
Pages
817–824
Issue
4
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-12
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Dopamine Agents/*pharmacology; Discrimination (Psychology)/*drug effects; Serotonin/*physiology; *Dopamine Antagonists; Serotonin Antagonists/*pharmacology; Amphetamines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; N-Methyl-3; Stimulus; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; *Generalization
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
A series of three experiments were conducted to investigate the possible serotonergic and dopaminergic mediation of the discriminative stimulus properties of the "designer" drug MDMA. In Experiment 1, rats trained to discriminate 1.5 mg/kg (+/-)-MDMA from its vehicle at 20 min postadministration were shown to generalize to another drug of abuse, N-ethyl-3,4-methylenedioxyamphetamine (MDE) and to the serotonergically-active agents norfenfluramine and TFMPP. In contrast, testing of various dopaminergically-active agonists did not result in MDMA-like responding. In Experiment 2, dopaminergic and serotonergic antagonist were employed to observe their effect upon MDMA discrimination at 20 min postinjection. The serotonin antagonist pirenperone significantly decreased MDMA discrimination, whereas the dopamine decreasing drugs CGS 10746B and haloperidol had no effect. In Experiment 3, another group of rats were trained to discriminate MDMA at 105 min postadministration to investigate if, at this (later) time, the dopaminergic properties of MDMA may be more salient. Indeed, the dopaminergically-active drugs had a heightened effect upon MDMA at this later time, although the serotonergic component of the MDMA discriminative stimulus was predominant. The results suggest that the effects of MDMA at 20 min postadministration are solely serotonergic in nature. At 105 min postinjection there appears to be the presence of a weak dopaminergic component. This biphasic serotonergic-then-dopaminergic action of MDMA may explain the reported human experience with the drug, as well as the often controversial results in the literature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90390-5" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90390-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Dopamine Antagonists
*Generalization
1988
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Discrimination (Psychology)/*drug effects
Dopamine Agents/*pharmacology
Dose-Response Relationship
Drug
Inbred Strains
Male
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Antagonists/*pharmacology
Serotonin/*physiology
Stimulus
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02253729" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02253729</a>
Pages
126–131
Issue
1
Volume
101
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rats become acutely tolerant to cathine after amphetamine or cathinone administration.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Discrimination (Psychology)/drug effects; Psychotropic Drugs/*pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Phenylpropanolamine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n = 6) trained with cathinone (ED50 = 3.03 mg/kg) and in rats (n = 8) trained with amphetamine (ED50 = 2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02253729" target="_blank" rel="noreferrer noopener">10.1007/bf02253729</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Discrimination (Psychology)/drug effects
Dose-Response Relationship
Drug
Drug Tolerance
Inbred Strains
Male
Phenylpropanolamine/*pharmacology
Psychopharmacology
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90144-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90144-x</a>
Pages
1085–1088
Issue
4
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lack of generalization of nisoxetine with amphetamine in the rat.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Male; Animals; Rats; Reference Values; *Discrimination (Psychology); Dextroamphetamine/*pharmacology; Fluoxetine/*analogs & derivatives/pharmacology; Norepinephrine/antagonists & inhibitors; Dose-Response Relationship; Drug; Inbred Strains; Conditioning; Operant/*drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D; Boja J W
Description
An account of the resource
Rats were trained to discriminate between the stimulus properties of intraperitoneally administered d-amphetamine (0.8 mg/kg) and its vehicle in a two-lever, food-motivated operant task. Once trained, doses of the norepinephrine reuptake inhibiting agent nisoxetine, ranging from 10 to 20 mg/kg, were administered to investigate if the amphetamine-trained rats would generalize to this agent. This did not, however, occur. Thus, it would seem that noradrenergic mechanisms have a negligible role in the production of the amphetamine-induced discriminative stimulus cue in the rat. Previous evidence that indicated a noradrenergic mediation of amphetamine discrimination in the mouse contrasted with the present results in rats and this discrepancy should warrant caution in comparing results of discriminative studies in these two species.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90144-x" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90144-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)
1988
Animals
Boja J W
Conditioning
Dextroamphetamine/*pharmacology
Dose-Response Relationship
Drug
Fluoxetine/*analogs & derivatives/pharmacology
Inbred Strains
Male
Norepinephrine/antagonists & inhibitors
Operant/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Reference Values
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(88)90075-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(88)90075-4</a>
Pages
331–335
Issue
4
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interaction of ethanol and tetrahydro-beta-carboline (THBC) in a discriminative task.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Male; Animals; Rats; Ethanol/*pharmacology; Behavior; Drug Interactions; Discrimination Learning/*drug effects; Conditioning (Psychology)/drug effects; Carbolines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Animal/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D; Signs S A
Description
An account of the resource
Rats (n = 10) were trained to discriminate between ethanol (600 mg/kg, IP) and its vehicle, or between THBC (20 mg/kg) and its vehicle in a two-lever food-motivated operant task. Once the discriminative training criterion was attained, rats in each group were administered different doses of both ethanol and THBC. The ED50 of ethanol in the ethanol-trained rats was 298.0 mg/kg and 15 mg/kg THBC produced ethanol-like responding. The ED50 of THBC in the THBC-trained rats was 3.63 mg/kg and 1200 mg/kg ethanol produced THBC-like responding. The cross-generalization between ethanol and THBC is, thus, indicated and relates to previous evidence in which both ethanol- and THBC-trained rats generalize to a common agent, TFMPP, a putatively specific 5HT1B receptor agonist. Taken together, these observations suggest that beta-carbolines may play a role in the discriminative stimulus properties of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(88)90075-4" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(88)90075-4</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Alcohol (Fayetteville, N.Y.)
Animal/drug effects
Animals
Behavior
Carbolines/*pharmacology
Conditioning (Psychology)/drug effects
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Drug Interactions
Ethanol/*pharmacology
Inbred Strains
Male
Rats
Schechter M D
Signs S A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90536-q" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90536-q</a>
Pages
623–626
Issue
4
Volume
37
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Functional consequences of fenfluramine neurotoxicity.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Male; Animals; Rats; Discrimination Learning/drug effects; Reinforcement Schedule; Fenfluramine/*toxicity; Nervous System Diseases/*chemically induced/psychology; Dose-Response Relationship; Drug; Inbred Strains; Conditioning; Operant/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Male Sprague-Dawley rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-motivated (fixed-ratio 10 schedule) two-lever operant task. Once trained, doses of 0.5, 1.0 and 1.5 mg/kg fenfluramine tested 20 min after IP administration produced dose-responsive discrimination performance. Subsequently, noncontingent twice-a-day administrations of 1 ml/kg saline were made for 4 days and the dose-effect relationship redetermined on the 13th to 15th day after initiation of the chronic saline regimen. Results of these dose-response experiments indicated that there was no significant effect upon fenfluramine discrimination after multiple saline injections or after 10 days without training. Following four days of retraining, 6.25 mg/kg fenfluramine twice-a-day for four days was followed 10 days later by another dose-response determination. This purportedly neurotoxic regimen of fenfluramine significantly increased the rats' ability to discriminate fenfluramine. These results suggest the possibility that chronic release of serotonin or selective damage to serotonin-containing neurons produced by fenfluramine may lead to postsynaptic supersensitivity as manifested by the functionally increased discriminative performance observed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90536-q" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90536-q</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Animals
Conditioning
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Fenfluramine/*toxicity
Inbred Strains
Male
Nervous System Diseases/*chemically induced/psychology
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Reinforcement Schedule
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90010-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90010-y</a>
Pages
539–544
Issue
3
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of MDMA neurotoxicity upon its conditioned place preference and discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
Male; Animals; Rats; Discrimination Learning/*drug effects; Choice Behavior/*drug effects; Designer Drugs/*toxicity; Nervous System/*drug effects; Sodium Chloride/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; Conditioning; Classical/*drug effects; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/toxicity
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Experiments were conducted to investigate the functional consequences of a neurotoxic regimen of MDMA administration upon two behaviors, conditioned place preference and drug discrimination. Rats were trained to discriminate 1.5 mg/kg MDMA from its vehicle and their discriminative performance was shown to be dose-responsive. Subsequently, MDMA was observed to produce a conditioned place preference as three conditioning sessions with 1.5 mg/kg MDMA paired with the nonpreferred chamber increased the time the rats spent in the chamber paired with MDMA. Administration of a proportedly neurotoxic dose (20 mg/kg subcutaneous) of MDMA, twice-a-day for four days, did not affect this conditioned place preference when it was redetermined at a time of maximal neurochemical compromise. In contrast, sensitivity to 1.0 mg/kg MDMA in the drug discrimination task was shown to be significantly decreased after the neurotoxic regimen. Results are discussed in light of MDMA effects upon both central serotonergic and dopaminergic neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90010-y" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90010-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/toxicity
Animals
Choice Behavior/*drug effects
Classical/*drug effects
Conditioning
Designer Drugs/*toxicity
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Inbred Strains
Male
N-Methyl-3
Nervous System/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Sodium Chloride/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90083-t</a>
Pages
817–820
Issue
4
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopaminergic nature of acute cathine tolerance.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Dopamine/*physiology; Discrimination (Psychology)/drug effects; Discrimination Learning/drug effects; Alkaloids/pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Appetite Depressants/*pharmacology; Phenylpropanolamine/*pharmacology; Generalization (Psychology)/drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8 mg/kg d-cathine and, once trained, administration of another Khat constituent, cathinone, was shown to produce cathine-like effects. This generalization to cathinone was dose-responsive when testing occurred 24 hr after vehicle administration, whereas prior administration of cathine resulted in a diminished discriminative response to subsequent cathinone administration possibly as a result of the development of acute tolerance. CGS 10746B, a compound that blocks presynaptic release of dopamine, significantly decreased rats' ability to discriminate cathine when it was administered 25 min prior to cathine testing and it reversed the acute tolerance observed when cathine was tested 24 hr after cathine administration. These results indicate that a previously reported acute tolerance effect to cathine after cathinone administration in cathinone-trained rats appears to be symmetrical in that there is acute tolerance to cathinone after cathine in these cathine-trained rats. The results with CGS 10746B would suggest that both the cathine-induced discriminative cue and cathine's ability to produce acute tolerance are mediated by presynaptic dopamine release.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90083-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/pharmacology
Animals
Antipsychotic Agents/pharmacology
Appetite Depressants/*pharmacology
Discrimination (Psychology)/drug effects
Discrimination Learning/drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Drug Tolerance
Generalization (Psychology)/drug effects
Inbred Strains
Male
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
20–31
Volume
309
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus effect of phenylephrine.
Publisher
An entity responsible for making the resource available
Archives internationales de pharmacodynamie et de therapie
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-02
Subject
The topic of the resource
Male; Animals; Rats; Cues; Adrenergic alpha-Antagonists/pharmacology; Discrimination (Psychology)/*drug effects; Reinforcement Schedule; Phenylephrine/*pharmacology; Adrenergic alpha-Agonists/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/drug effects; Adrenergic; alpha/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Rats were trained to discriminate phenylephrine in a two-lever, food-motivated operant task by increasing the i.p. administered training dose from 0.8 to 2 mg/kg. Stable discrimination to 2 mg/kg phenylephrine was established and testing of 0.5-2.5 mg/kg was shown to be dose-responsive and allowed for a calculated ED50 value of 0.87 mg/kg. Administration of methoxamine (0.5-6 mg/kg), another alpha 1-adrenoceptor agonist, produced a dose-responsive generalization, whereas only the lowest (0.04 mg/kg) and highest (0.12 mg/kg) doses of the alpha
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Adrenergic
Adrenergic alpha-Agonists/pharmacology
Adrenergic alpha-Antagonists/pharmacology
alpha/drug effects
Animals
Archives internationales de pharmacodynamie et de therapie
Cues
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Generalization
Inbred Strains
Male
Phenylephrine/*pharmacology
Rats
Receptors
Reinforcement Schedule
Schechter M D
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0024-3205(90)90561-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0024-3205(90)90561-5</a>
Pages
17–24
Issue
1
Volume
47
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Analysis of Variance; Discrimination Learning/*drug effects; Amphetamine/*pharmacology; *Food Deprivation; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Satiation/*drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Eight male rats were trained to discriminate between the internal states produced by food deprivation of 3 hours (satiation) and that produced by food deprivation of 27 hours duration (deprivation). One lever, in a two-lever operant chamber, had to be pressed to receive reinforcement in the satiation state, whereas pressing the other lever was required when the rat was in the deprivation state. Once the rats were trained, increasing the number of hours of food deprivation, from 1 to 48 hours, resulted in more deprivation-appropriate lever responses in the two-lever operant task. Administration of doses of fenfluramine (0.5-1.5 mg.kg), its active metabolite norfenfluramine (0.25-1.0 mg/kg) or d-amphetamine (0.5-1.5 mg/kg) produced a dose-responsive decrease in deprivation-appropriate responses when each drug/dose was injected (i.p.) 15 min prior to deprivation (27 hours) testing. Norfenfluramine was 1.5 times more potent than fenfluramine which was 1.5 times more potent than amphetamine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0024-3205(90)90561-5" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(90)90561-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Food Deprivation
1990
Amphetamine/*pharmacology
Analysis of Variance
Animals
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Fenfluramine/*analogs & derivatives/*pharmacology
Inbred Strains
Life sciences
Male
Norfenfluramine/*pharmacology
Rats
Satiation/*drug effects
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90145-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90145-1</a>
Pages
1089–1092
Issue
4
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CGS 10746B is able to attenuate the effects of amphetamine: further evidence for dopaminergic mediation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*physiology; Discrimination (Psychology)/*drug effects; Antipsychotic Agents/*pharmacology; Thiazepines/*pharmacology; Apomorphine/pharmacology; Cocaine/pharmacology; Alkaloids/pharmacology; Dextroamphetamine/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Conditioning; Operant/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D; Boja J W
Description
An account of the resource
Previous results indicate that agents which either decreases synthesis or block postsynaptic dopamine receptors will attenuate the discriminative stimulus produced by d-amphetamine. CGS 10746B has been reported to decrease dopamine release without changing its metabolism or occupying its receptors. In the present study, rats successfully trained to discriminate intraperitoneally administered (0.8 mg/kg) d-amphetamine in a two-lever, food-motivated operant task were observed to be unable to discriminate amphetamine when pretreated with 30 mg/kg CGS 10746B. This antagonism was shown to be dose-responsive and constitutes a third mechanism, i.e., dopamine release inhibition, that evidences the dopaminergic mediation of amphetamine in the discriminative paradigm. When both cathinone (0.8 mg/kg) and cocaine (10.0 mg/kg) were administered to the amphetamine-trained rats they each were recognized as amphetamine and are, thus, considered to generalize to the amphetamine discriminative stimulus. Coadministration of CGS 10746B and cathinone totally antagonized this generalization, whereas pretreatment with CGS 10746B prior to cocaine significantly reduced cocaine's effects. These results implicate dopamine mechanisms in the discriminative stimulus properties of the psychostimulants amphetamine, cathinone and cocaine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90145-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90145-1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Alkaloids/pharmacology
Animals
Antipsychotic Agents/*pharmacology
Apomorphine/pharmacology
Boja J W
Cocaine/pharmacology
Conditioning
Dextroamphetamine/antagonists & inhibitors/*pharmacology
Discrimination (Psychology)/*drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Male
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Thiazepines/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90340-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90340-1</a>
Pages
239–242
Issue
1
Volume
31
Dublin Core
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Title
A name given to the resource
Advantages and disadvantages of a rapid method to train drug discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-09
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Methods; Discrimination Learning/*drug effects; Amphetamines/*pharmacology; Dose-Response Relationship; Drug; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training drug in ten rats. This protocol consisted of one to three training sessions per day and it was compared to the more conventional method of once-per-day training in an equal number of rats. Results indicate that the fast-trained rats learned the discrimination in significantly fewer sessions than the slowly-trained rats. However, the subsequent dose-response experiments indicate that when the fast-trained rats are tested with various doses of MDMA, without prior vehicle treatment, their sensitivity to the drug is less than that of the slowly-trained rats. When a vehicle session is presented prior to drug dose-response testing, both groups perform similarly. It appears that the preceding vehicle sessions function as a reference point for the fast-trained rats and, although the more rapid training regimen allows for faster learning, these treatment regimens should be employed with caution when subsequent dose-response tests and generalization tests with other drugs are conducted.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90340-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90340-1</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Drug Tolerance
Male
Methods
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
191–195
Issue
1
Volume
304
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.
Publisher
An entity responsible for making the resource available
Biochemical and biophysical research communications
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-04
Subject
The topic of the resource
Humans; Cell Line; Gene Expression Regulation/drug effects; Pregnane X Receptor; Cholesterol 7-alpha-Hydroxylase/*genetics; ATP-Binding Cassette Transporters/*genetics; Chenodeoxycholic Acid/antagonists & inhibitors; DNA-Binding Proteins/*antagonists & inhibitors/metabolism; Pregnenediones/*pharmacology; Transcription Factors/*antagonists & inhibitors/metabolism; Transcriptional Activation/drug effects; Dose-Response Relationship; Drug; Receptors; ATP Binding Cassette Transporter; Subfamily B; Cytoplasmic and Nuclear/*metabolism; Steroid/*metabolism; Member 11
Creator
An entity primarily responsible for making the resource
Owsley Erika; Chiang John Y L
Description
An account of the resource
Bile acids activate a nuclear receptor, farnesoid X receptor (FXR), that induces bile salt export pump (BSEP) but inhibits cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription in the liver. Guggulsterone, a plant sterol that lowers serum cholesterol, has been shown to antagonize FXR activated genes. Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene. On the other hand, guggulsterone has no effect on FXR inhibition of the CYP7A1 gene, but strongly inhibits the human CYP7A1 gene by activation of pregnane X receptor (PXR). These results suggest that guggulsterone inhibits bile acid secretion from hepatocytes into bile and activates PXR to inhibit bile acid synthesis in the liver. Reduced conversion of cholesterol and bile acid excretion may lead to an increase of hepatic cholesterol and decrease of intestinal cholesterol absorption, and results in lowering serum cholesterol.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
ATP Binding Cassette Transporter
ATP-Binding Cassette Transporters/*genetics
Biochemical and biophysical research communications
Cell Line
Chenodeoxycholic Acid/antagonists & inhibitors
Chiang John Y L
Cholesterol 7-alpha-Hydroxylase/*genetics
Cytoplasmic and Nuclear/*metabolism
Department of Integrative Medical Sciences
DNA-Binding Proteins/*antagonists & inhibitors/metabolism
Dose-Response Relationship
Drug
Gene Expression Regulation/drug effects
Humans
Member 11
NEOMED College of Medicine
Owsley Erika
Pregnane X Receptor
Pregnenediones/*pharmacology
Receptors
Steroid/*metabolism
Subfamily B
Transcription Factors/*antagonists & inhibitors/metabolism
Transcriptional Activation/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90595-s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90595-s</a>
Pages
99–104
Issue
1
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inverse agonist properties of the FG 7142 discriminative stimulus.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Male; Animals; Rats; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Reinforcement Schedule; Appetite Depressants/*pharmacology; Carbolines/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/drug effects; GABA-A/drug effects
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained rats with a variety of benzodiazepine receptor ligands. Administration of the inverse agonist DMCM (0.15-0.30 mg/kg) dose-dependently mimicked the FG 7142 stimulus. In contrast, the benzodiazepine receptor agonist chlordiazepoxide, partial agonist ZK 91 296, mixed agonist/antagonist CGS 9896 and antagonist RO 15-1788 blocked the FG 7142 cue. These results indicate that the FG 7142 discriminative stimulus is based on its inverse agonist activity. The generalization of FG 7142 to the anxiogenic/convulsant compound pentylenetetrazole (PTZ), but not to the anorectic agent norfenfluramine, indicates that the anxiogenic properties of FG 7142, rather than its anorectic actions, may underlie the FG 7142 discriminative stimulus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90595-s" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90595-s</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Appetite Depressants/*pharmacology
Carbolines/antagonists & inhibitors/*pharmacology
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
GABA-A/drug effects
Generalization
Inbred Strains
Leidenheimer N J
Male
Pharmacology, biochemistry, and behavior
Rats
Receptors
Reinforcement Schedule
Schechter M D
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90007-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90007-o</a>
Pages
519–525
Issue
3
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inverse agonist properties of the THBC discriminative stimulus: asymmetrical generalization with FG 7142.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
Male; Animals; Rats; Discrimination Learning/*drug effects; Avoidance Learning/drug effects; Carbolines/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/*drug effects; GABA-A/*drug effects
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
Male rats were trained to discriminate the stimulus properties of the beta-carbolines 1,2,3,4-tetrahydro-beta-carboline (THBC) (15.0 mg/kg) or FG 7142 (5.0 mg/kg) from vehicle in a two-lever, food-motivated operant task. Consistent with the serotonergic properties of THBC, administration of the 5HT1B agonists TFMPP and mCPP to THBC-trained rats resulted in THBC-appropriate responding. Norharmane, a beta-carboline metabolite of THBC, also mimicked the THBC discriminative stimulus. In contrast, the benzodiazepine receptor partial inverse agonist FG 7142, the anxiogenic/convulsant pentylenetetrazole (PTZ), two physiological stressors and the alpha 2 adrenergic antagonists yohimbine and idazoxan failed to produce THBC-appropriate responding. In the FG 7142-trained rats, THBC and norharmane dose-dependently mimicked the FG 7142 discriminative stimulus. This generalization was not based upon the serotonergic properties of THBC and norharmane since administration of the serotonin agonist mCPP to FG
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90007-o" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90007-o</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Avoidance Learning/drug effects
Carbolines/antagonists & inhibitors/*pharmacology
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
GABA-A/*drug effects
Generalization
Inbred Strains
Leidenheimer N J
Male
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Stimulus/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90342-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90342-5</a>
Pages
249–254
Issue
2
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-10
Subject
The topic of the resource
Male; Animals; Rats; Pentobarbital/pharmacology; Carbolines/pharmacology; Chlordiazepoxide/pharmacology; Discrimination (Psychology)/drug effects/*physiology; Flumazenil/pharmacology; gamma-Aminobutyric Acid/analogs & derivatives/pharmacology; Pentylenetetrazole/pharmacology; Pyrazoles/antagonists & inhibitors/*metabolism; Dose-Response Relationship; Drug; Inbred Strains; Receptors; GABA-A/*physiology
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
Male rats were trained to discriminate the stimulus effects of CGS 9896 (30.0 mg/kg) from its vehicle. Once trained, discriminative performance was observed to be dose-responsive in the 3.75-30.0 mg/kg range and analysis of the dose-response curve generated an ED50 of 6.44 mg/kg. Generalization testing with chlordiazepoxide and pentobarbital produced CGS 9896-appropriate responding, whereas administration of the GABA agonists SL 75 102 resulted in 75% (intermediate) generalization to the CGS 9896 discriminative stimulus. Although full antagonism of the CGS 9896 cue was obtained following administration of Ro15-1788 and pentylenetetrazole, the inverse agonist DMCM failed to provide complete antagonism. These results suggest that the discriminative properties of CGS 9896 are consistent with its activity as a benzodiazepine receptor agonist.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90342-5" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90342-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Carbolines/pharmacology
Chlordiazepoxide/pharmacology
Discrimination (Psychology)/drug effects/*physiology
Dose-Response Relationship
Drug
Flumazenil/pharmacology
GABA-A/*physiology
gamma-Aminobutyric Acid/analogs & derivatives/pharmacology
Inbred Strains
Leidenheimer N J
Male
Pentobarbital/pharmacology
Pentylenetetrazole/pharmacology
Pharmacology, biochemistry, and behavior
Pyrazoles/antagonists & inhibitors/*metabolism
Rats
Receptors
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
353–357
Issue
4
Volume
16
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride.
Publisher
An entity responsible for making the resource available
Clinical & experimental metastasis
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-05
Subject
The topic of the resource
Female; Animals; Rats; Drug Administration Schedule; Antineoplastic Agents/*administration & dosage; Neoplasm Transplantation; Amiloride/*administration & dosage; Lung Neoplasms/pathology/*prevention & control/*secondary; Plasminogen Activators/antagonists & inhibitors; Urokinase-Type Plasminogen Activator/antagonists & inhibitors; Dose-Response Relationship; Drug; Mammary Neoplasms; Experimental/*pathology; Inbred F344
Creator
An entity primarily responsible for making the resource
Evans D M; Sloan-Stakleff K; Arvan M; Guyton D P
Description
An account of the resource
Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system. Inhibition of uPA prevents the conversion of plasminogen to tumor cell surface bound plasmin which is required for initiation of the metastatic process. MATB rat mammary cancer cells were introduced into the jugular venous system of 80 Fisher 344 female rats. Amiloride at high and low dosages was administered in the drinking water at the time of, prior to or several days following the tumor cell inoculation and continued daily for 10 days post inoculation. Control rats were maintained on water alone. The middle lobe of the right lung was examined microscopically for numbers of metastases. Suppression of metastases was significant at high amiloride dosages in all groups, and at low dosage when administered prior to inoculation. We conclude that amiloride suppresses induced metastases of rat mammary cancer, the effect being dose- and time-dependent.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Amiloride/*administration & dosage
Animals
Antineoplastic Agents/*administration & dosage
Arvan M
Clinical & experimental metastasis
Dose-Response Relationship
Drug
Drug Administration Schedule
Evans D M
Experimental/*pathology
Female
Guyton D P
Inbred F344
Lung Neoplasms/pathology/*prevention & control/*secondary
Mammary Neoplasms
Neoplasm Transplantation
Plasminogen Activators/antagonists & inhibitors
Rats
Sloan-Stakleff K
Urokinase-Type Plasminogen Activator/antagonists & inhibitors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90547-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90547-9</a>
Pages
497–501
Issue
3
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-11
Subject
The topic of the resource
Male; Animals; Rats; Analgesics/*pharmacology; Methysergide/pharmacology; Naltrexone/pharmacology; Amphetamines/*pharmacology; Pain/*metabolism; Morphine/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Serotonin/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Boja J W; Schechter M D
Description
An account of the resource
The antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not elevate tail-flick latency. In contrast, morphine (2-8 mg/kg, IP) produced analgesia on both the tail-flick and hot-plate tests in a dose-dependent manner. Neither the opiate antagonist naltrexone nor the adrenoceptor antagonist phentolamine effectively attenuated MDMA-induced analgesia. Conversely, the serotonin antagonist methysergide significantly reversed the analgesic effects of MDMA on the hot-plate test. These findings suggest that the antinociceptive effects of MDMA are serotonergically mediated. Furthermore, the results verify earlier findings describing the test-specific effects of serotonin-induced pain modulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90547-9" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90547-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Analgesics/*pharmacology
Animals
Boja J W
Crisp T
Dose-Response Relationship
Drug
Inbred Strains
Male
Methysergide/pharmacology
Morphine/pharmacology
N-Methyl-3
Naltrexone/pharmacology
Pain/*metabolism
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/drug effects/*physiology
Stafinsky J L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
282–286
Issue
1
Volume
643
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
Male; Animals; Rats; Analysis of Variance; Aging/*physiology; Injections; Analgesics/*pharmacology; Pain/*physiopathology; beta-Endorphin/administration & dosage/*pharmacology; Enkephalins/administration & dosage/*pharmacology; Spine/drug effects/growth & development/*physiology; Dose-Response Relationship; Drug; Enkephalin; Inbred F344; Ala(2)-MePhe(4)-Gly(5)-; Spinal; 5)-; D-Penicillamine (2
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Hoskins D L; Perni V C; Uram M; Gordon T L
Description
An account of the resource
These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. Various doses of the mu agonist DAGO, the delta agonist DPDPE or the putative epsilon beta-endorphin were injected i.t. in young (5-6-month-old), mature (15-16-month-old) and aged (25-26-month-old) Fischer 344 rats. Antinociception was measured using the rat tail-flick analgesiometric assay. The data demonstrated a decline in spinal opioid-induced antinociception as a function of age. For instance, the i.t. dose of DPDPE or beta-endorphin needed to produce antinociception in the 25-26-month-old rats was higher than that needed to elevate tail-flick latency in the young and mature animals. We also noted that the i.t. doses of the opioid agonists needed to produce 'antinociception' in the aged cohort were within a range of spinal doses that produced motor impairment. Apparently, the aging process alters the ability of opioid receptors to mediate antinociception. Perhaps an age-related decrease in the number and/or affinity of opioid receptor sites in the rat spinal cord accounts for these observations.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
5)-
Aging/*physiology
Ala(2)-MePhe(4)-Gly(5)-
Analgesics/*pharmacology
Analysis of Variance
Animals
beta-Endorphin/administration & dosage/*pharmacology
Brain research
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins/administration & dosage/*pharmacology
Gordon T L
Hoskins D L
Inbred F344
Injections
Male
Pain/*physiopathology
Perni V C
Rats
Spinal
Spine/drug effects/growth & development/*physiology
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
34–39
Issue
1
Volume
277
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone causes direct relaxation of rat thoracic aorta.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-04
Subject
The topic of the resource
Female; Male; Animals; Rats; In Vitro Techniques; Vasodilation/*drug effects; Testosterone/*pharmacology; Phenylephrine/pharmacology; Calcium Channels/drug effects; Dose-Response Relationship; Drug; Sprague-Dawley; Aorta; Endothelium; Thoracic/*drug effects/physiology; Vascular/physiology
Creator
An entity primarily responsible for making the resource
Costarella C E; Stallone J N; Rutecki G W; Whittier F C
Description
An account of the resource
Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic aorta. Aortic rings from male Sprague-Dawley (SD) rats with (+ENDO) and without (-ENDO) endothelium were prepared for isometric tension recording. In (+ENDO) male aortae precontracted with phenylephrine (PE), T produced dose-dependent relaxation from 25 microM (30.3 +/- 7.1%) to 300 microM (99.4 +/- 0.4%), whereas T vehicle (\textless or = 0.5% ethanol) had no effect. Pretreatment of (+ENDO) aortae with T (50 microM; 10 min) attenuated subsequent contractile responses to PE. Both maximal contraction and sensitivity to PE were reduced by T. Pretreatment of (+ENDO) aortae with both T and N omega-nitro-L-arginine methyl ester (250 microM) reversed in part the attenuating effects of T alone; however, both maximal response and sensitivity to PE were still reduced compared to control rings (without T or N omega-nitro-L-arginine methyl ester). Pretreatment of (-ENDO) aortae with T reduced sensitivity to PE, but had no effect on maximal contraction. T pretreatment (50 microM; 10 min) of both (+ENDO) female SD aortae and (+ENDO) male testicular-feminized rat aortae reduced maximal contraction and sensitivity to PE in both groups to a similar extent as in (+ENDO) male SD aortae. These data suggest that T has a direct vasodilating effect on the rat aorta, which involves endothelium-dependent (enhanced NO release) and -independent mechanisms and is gender- and intracellular androgen receptor-independent.
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Animals
Aorta
Calcium Channels/drug effects
Costarella C E
Department of Internal Medicine
Dose-Response Relationship
Drug
Endothelium
Female
In Vitro Techniques
Male
NEOMED College of Medicine
Phenylephrine/pharmacology
Rats
Rutecki G W
Sprague-Dawley
Stallone J N
Testosterone/*pharmacology
The Journal of pharmacology and experimental therapeutics
Thoracic/*drug effects/physiology
Vascular/physiology
Vasodilation/*drug effects
Whittier F C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
71–82
Volume
313
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).
Publisher
An entity responsible for making the resource available
Gene
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-08
Subject
The topic of the resource
Humans; Cell Line; Transfection; Gene Expression Regulation/drug effects; Base Sequence; Binding Sites/genetics; Response Elements/genetics; Molecular Sequence Data; Mutation; Chenodeoxycholic Acid/pharmacology; Transcription Factors/genetics/*metabolism; Hepatocyte Nuclear Factor 4; Mutagenesis; *DNA-Binding Proteins; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Bile Acids and Salts/*pharmacology; Cholestanetriol 26-Monooxygenase; DNA/chemistry/genetics; Luciferases/genetics/metabolism; Phosphoproteins/genetics/*metabolism; Recombinant Fusion Proteins/genetics/metabolism; Steroid Hydroxylases/*genetics; DNA; Dose-Response Relationship; Drug; Cultured; Receptors; Tumor Cells; Cloning; Molecular; Sequence Analysis; Promoter Regions; Genetic/*genetics; Cytoplasmic and Nuclear/genetics/metabolism; Site-Directed
Creator
An entity primarily responsible for making the resource
Chen Wenling; Chiang John Y L
Description
An account of the resource
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyses sterol side-chain oxidation of bile acid synthesis from cholesterol, and the first reaction of the acidic bile acid biosynthetic pathway. Hydrophobic bile acids suppress human CYP27A1 gene reporter activity when assayed in human hepatocellular blastoma HepG2 cells. Bile acids also inhibit CYP27A1 reporter activity in human embryonic kidney 293 cells. A putative bile acid response element (BARE) was mapped to a region downstream of nt -147 of the human CYP27A1 gene, within which a binding site for a liver-specific nuclear receptor, HNF4alpha, is identified. HNF4alpha strongly stimulates CYP27A1 gene transcription and mutation of its binding site markedly reduced promoter activity. Results suggest that human CYP27A1 gene transcription is suppressed by bile acids and HNF4alpha plays a pivotal role in transcriptional regulation of this gene.
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*DNA-Binding Proteins
2003
Base Sequence
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Bile Acids and Salts/*pharmacology
Binding Sites/genetics
Cell Line
Chen Wenling
Chenodeoxycholic Acid/pharmacology
Chiang John Y L
Cholestanetriol 26-Monooxygenase
Cloning
Cultured
Cytoplasmic and Nuclear/genetics/metabolism
Department of Integrative Medical Sciences
DNA
DNA/chemistry/genetics
Dose-Response Relationship
Drug
gene
Gene Expression Regulation/drug effects
Genetic/*genetics
Hepatocyte Nuclear Factor 4
Humans
Luciferases/genetics/metabolism
Molecular
Molecular Sequence Data
Mutagenesis
Mutation
NEOMED College of Medicine
Phosphoproteins/genetics/*metabolism
Promoter Regions
Receptors
Recombinant Fusion Proteins/genetics/metabolism
Response Elements/genetics
Sequence Analysis
Site-Directed
Steroid Hydroxylases/*genetics
Transcription Factors/genetics/*metabolism
Transfection
Tumor Cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90350-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90350-4</a>
Pages
305–311
Issue
2
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-10
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Behavior; Serotonin/pharmacology; Discrimination (Psychology)/*drug effects; Fenfluramine/*analogs & derivatives/*pharmacology; Norfenfluramine/*pharmacology; Serotonin/physiology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Animal/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90350-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90350-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animal/*drug effects
Animals
Behavior
Boja J W
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Fenfluramine/*analogs & derivatives/*pharmacology
Inbred Strains
Male
Norfenfluramine/*pharmacology
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/pharmacology
Serotonin/physiology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02245925" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02245925</a>
Pages
221–226
Issue
2
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Amphetamine/pharmacology; Discrimination Learning/*drug effects; Discrimination (Psychology)/*drug effects; Norfenfluramine/pharmacology; Reinforcement Schedule; Pentobarbital/pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02245925" target="_blank" rel="noreferrer noopener">10.1007/bf02245925</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Amphetamine/pharmacology
Animals
Boja J W
Discrimination (Psychology)/*drug effects
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Inbred Strains
Male
Norfenfluramine/pharmacology
Pentobarbital/pharmacology
Psychopharmacology
Rats
Reinforcement Schedule
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(87)90206-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(87)90206-1</a>
Pages
153–156
Issue
2
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-10
Subject
The topic of the resource
Male; Time Factors; Animals; United States; Rats; Discrimination (Psychology); Amphetamines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Legislation
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats were trained to discriminate 2.0 mg/kg
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(87)90206-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(87)90206-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Boja J W
Discrimination (Psychology)
Dose-Response Relationship
Drug
Inbred Strains
Legislation
Male
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Time Factors
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
991–997
Issue
10
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Time-dependent changes in norepinephrine-induced left ventricular dysfunction and histopathologic condition.
Publisher
An entity responsible for making the resource available
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-10
Subject
The topic of the resource
Female; Male; Animals; Rabbits; Myocardial Contraction/drug effects; Myocardial Infarction/chemically induced/pathology; Myocardium/pathology; Norepinephrine/*toxicity; Systole/drug effects/physiology; Ventricular Function; Dose-Response Relationship; Drug; Ventricular Dysfunction; Left/*chemically induced/pathology; Left/drug effects
Creator
An entity primarily responsible for making the resource
Allman F D; Herold W; Bosso F J; Pilati C F
Description
An account of the resource
BACKGROUND: Intense activation of the sympathetic nervous system or administration of high concentrations of catecholamines diminishes myocardial contractility and produces infarct-like lesions throughout the heart. This study was conducted to determine whether norepinephrine-induced left ventricular (LV) dysfunction reverses with time and whether the histopathologic condition and the cardiac dysfunction produced by high doses of norepinephrine are causally related. METHODS: Norepinephrine, 10 microg bolus followed by 2.5 microg/kg/min for 90 minutes, was administered to conscious New Zealand white rabbits. Control rabbits (n=8) received saline solution. LV function was evaluated either immediately (n=7), on day 4 (n=8), or on day 10 (n=7) after norepinephrine treatment. Transverse sections from the left ventricle were then prepared for light microscopic study. RESULTS: Animals studied immediately after norepinephrine treatment demonstrated severe LV dysfunction and a decrease in global LV compliance. In contrast, LV function and compliance were normal in rabbits studied on day 4, but tissue sections from the left ventricle showed diffuse areas of inflammation. By day 10 the inflammatory process had progressed, and substantial collagen deposition had occurred. LV systolic function was normal, but a decrease in LV compliance was evident at this time. CONCLUSIONS: The normal LV systolic function on days 4 and 10 in spite of multiple foci of inflammation suggests (1) that norepinephrine-induced LV systolic dysfunction is reversible and (2) that the histologic derangements and the LV dysfunction are not causally related.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Allman F D
Animals
Bosso F J
Dose-Response Relationship
Drug
Female
Herold W
Left/*chemically induced/pathology
Left/drug effects
Male
Myocardial Contraction/drug effects
Myocardial Infarction/chemically induced/pathology
Myocardium/pathology
Norepinephrine/*toxicity
Pilati C F
Rabbits
Systole/drug effects/physiology
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Ventricular Dysfunction
Ventricular Function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/nu9050436</a>
Issue
5
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.
Publisher
An entity responsible for making the resource available
Nutrients
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Female; Animals; Anti-Inflammatory Agents/*pharmacology; Rats; Gene Expression Regulation; Signal Transduction; Apoptosis/drug effects; anti-inflammatory effects; Anticarcinogenic Agents/pharmacology; breast tumor; COX-2; Cyclooxygenase 2/genetics/metabolism; DMBA; HSP90; HSP90 Heat-Shock Proteins/genetics/metabolism; I-kappa B Kinase/genetics/metabolism; NF-E2-Related Factor 2/genetics/*metabolism; NF-kappa B/genetics/*metabolism; NF-kappaB; Nrf2; Plant Preparations/*pharmacology; Punica granatum; Punicaceae/*chemistry; Pomegranate; Chemoprevention; Dose-Response Relationship; Drug; Neoplastic; Mammary Neoplasms; 10-Dimethyl-1; 9; Neoplastic/drug effects; Cell Transformation; 2-benzanthracene/toxicity; Experimental/*prevention & control; Animal Studies; Breast Neoplasms; Inflammation Mediators; Physical Education and Training; Neoplasms – Prevention and Control
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bhatia Deepak; Bishayee Anupam
Description
An account of the resource
Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a striking inhibition of dimethylbenz(a)anthracene (DMBA)-initiated rat mammary tumorigenesis via antiproliferative and apoptosis-inducing mechanisms. The objective of the present work is to investigate the anti-inflammatory mechanism of action of PE during DMBA rat mammary carcinogenesis by evaluating the expression of cyclooxygenase-2 (COX-2), heat shock protein 90 (HSP90), nuclear factor-kappaB (NF-kappaB) and nuclear factor erythroid 2p45 (NF-E2)-related factor 2 (Nrf2). Mammary tumor samples were harvested from our previous chemopreventive study in which PE (0.2-5.0 g/kg) was found to reduce mammary tumorigenesis in a dose-dependent manner. The expressions of COX-2, HSP90, NF-kappaB, inhibitory kappaBalpha (IkappaBalpha) and Nrf2 were detected by immunohistochemical techniques. PE decreased the expression of COX-2 and HSP90, prevented the degradation of IkappaBalpha, hindered the translocation of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/nu9050436" target="_blank" rel="noreferrer noopener">10.3390/nu9050436</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/toxicity
2017
9
Animal Studies
Animals
Anti-Inflammatory Agents/*pharmacology
anti-inflammatory effects
Anticarcinogenic Agents/pharmacology
Apoptosis/drug effects
Bhatia Deepak
Bishayee Anupam
Breast Neoplasms
breast tumor
Cell Transformation
Chemoprevention
COX-2
Cyclooxygenase 2/genetics/metabolism
DMBA
Dose-Response Relationship
Drug
Experimental/*prevention & control
Female
Gene Expression Regulation
HSP90
HSP90 Heat-Shock Proteins/genetics/metabolism
I-kappa B Kinase/genetics/metabolism
Inflammation Mediators
Mammary Neoplasms
Mandal Animesh
Neoplasms – Prevention and Control
Neoplastic
Neoplastic/drug effects
NF-E2-Related Factor 2/genetics/*metabolism
NF-kappa B/genetics/*metabolism
NF-kappaB
Nrf2
Nutrients
Physical Education and Training
Plant Preparations/*pharmacology
Pomegranate
Punica granatum
Punicaceae/*chemistry
Rats
Signal Transduction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3181/00379727-203-43579" target="_blank" rel="noreferrer noopener">http://doi.org/10.3181/00379727-203-43579</a>
Pages
100–107
Issue
1
Volume
203
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Persistent left ventricular dysfunction after cocaine treatment in rabbits.
Publisher
An entity responsible for making the resource available
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
Female; Male; Animals; Rabbits; Blood Pressure/drug effects; In Vitro Techniques; Stroke Volume/drug effects; Epinephrine/blood; Anesthesia; Norepinephrine/blood; Cocaine/*pharmacology; Consciousness; Heart/drug effects/physiology/*physiopathology; Ventricular Function; Dose-Response Relationship; Drug; General; Left/*drug effects
Creator
An entity primarily responsible for making the resource
Pilati C F; Espinal A R; Pukys T F
Description
An account of the resource
The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n = 7) or pentobarbital-anesthetized (n = 7) rabbits, respectively. Seven conscious and seven anesthetized control rabbits received the saline vehicle. Two and one-half hours later, the hearts were removed from the animals and perfused under cocaine-free conditions. Left ventricular (LV) contractility was evaluated by plotting steady-state LV systolic and diastolic pressures as a function of LV end-diastolic volume (preload). LV systolic performance was diminished in a dose-related manner in hearts isolated from cocaine-treated rabbits, but was statistically different from control only at the higher cocaine dose (P \textless 0.05). In a second set of experiments, hearts (n = 6) were isolated, and their LV function was evaluated before, during, and after cocaine exposure. In these experiments, cocaine was added to the perfusate in increments to produce concentrations of 5, 10, and 15 mg/liter. After LV function was evaluated at the highest cocaine dose, cocaine-free perfusion conditions were restored, and LV function was reevaluated. In these experiments, cocaine produced a dose-dependent decrease in LV function that readily reversed when cocaine-free perfusion was reinstated. We conclude that cocaine diminishes LV contractility, and that the diminished cardiac performance may not readily reverse after in vivo exposure. Moreover, the rapid restoration of cardiac performance after exposure to cocaine in vitro suggests that the mechanism operating in vivo involves more than a simple direct action on the myocyte. Catecholamine cardiotoxicity does not appear to be a primary factor.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3181/00379727-203-43579" target="_blank" rel="noreferrer noopener">10.3181/00379727-203-43579</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Anesthesia
Animals
Blood Pressure/drug effects
Cocaine/*pharmacology
Consciousness
Dose-Response Relationship
Drug
Epinephrine/blood
Espinal A R
Female
General
Heart/drug effects/physiology/*physiopathology
In Vitro Techniques
Left/*drug effects
Male
Norepinephrine/blood
Pilati C F
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Pukys T F
Rabbits
Stroke Volume/drug effects
Ventricular Function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3109/13880209.2012.749922" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/13880209.2012.749922</a>
Pages
668–674
Issue
5
Volume
51
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.
Publisher
An entity responsible for making the resource available
Pharmaceutical biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
Humans; Time Factors; Hep G2 Cells; Desert Climate; Inhibitory Concentration 50; Liver Neoplasms/*drug therapy/pathology; Plant Extracts/administration & dosage/*pharmacology; Tetrazolium Salts/chemistry; Thiazoles/chemistry; Carcinoma; Dose-Response Relationship; Drug; Plants; Antineoplastic Agents; Aerial; Hepatocellular/*drug therapy/pathology; Medicinal/chemistry; Phytogenic/administration & dosage/*pharmacology; Plant Components
Creator
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Thoppil Roslin J; Harlev Eli; Mandal Animesh; Nevo Eviatar; Bishayee Anupam
Description
An account of the resource
CONTEXT: Phytochemicals are produced by desert plants to protect themselves against stressful environments. They have been shown to be useful in preventing and fighting adverse pathophysiological conditions and complex diseases, including cancer. Although many desert plants have been investigated for their antitumor properties, a large number of them still remain to be explored for possible therapeutic applications in oncologic diseases. OBJECTIVE: To screen the antitumor effects of selected desert plants, namely Achillea fragrantissima (Forssk.) Sch. Bip. (Compositae), Ochradenus baccatus Delile (Resedaceae), Origanum dayi Post (Lamiaceae), Phlomis platystegia Post (Lamiaceae) and Varthemia iphionoides Boiss (Compositae), against an in vitro tumor model utilizing HepG2 human hepatocellular carcinoma cells. MATERIALS AND METHODS: The aqueous extracts of aerial parts of the aforementioned plants were prepared and used for the in vitro experiments. The HepG2 cells were exposed to varying concentrations (0-4 mg/mL) of each plant extract for 24 or 48 h and the cytotoxicity was measured by the MTT assay. RESULTS: Following 24 h exposure, O. dayi extract exhibited a substantial antiproliferative effect in HepG2 cells (IC50 = 1.0 mg/mL) followed by O. baccatus (IC50 = 1.5 mg/mL). All plant extracts displayed cytotoxicity following 48 h exposure. Nevertheless, a substantial effect was observed with O. dayi (IC50 = 0.35 mg/mL) or O. baccatus (IC50 = 0.83 mg/mL). CONCLUSION: The aqueous extracts from aerial parts of O. dayi and O. baccatus possess antitumor effects against human liver cancer cells. These desert plants represent valuable resources for the development of potential anticancer agents.
Identifier
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<a href="http://doi.org/10.3109/13880209.2012.749922" target="_blank" rel="noreferrer noopener">10.3109/13880209.2012.749922</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Aerial
Antineoplastic Agents
Bishayee Anupam
Carcinoma
Desert Climate
Dose-Response Relationship
Drug
Harlev Eli
Hep G2 Cells
Hepatocellular/*drug therapy/pathology
Humans
Inhibitory Concentration 50
Liver Neoplasms/*drug therapy/pathology
Mandal Animesh
Medicinal/chemistry
Nevo Eviatar
Pharmaceutical biology
Phytogenic/administration & dosage/*pharmacology
Plant Components
Plant Extracts/administration & dosage/*pharmacology
Plants
Tetrazolium Salts/chemistry
Thiazoles/chemistry
Thoppil Roslin J
Time Factors
-
Text
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URL Address
<a href="http://doi.org/10.2165/00151829-200504001-00007" target="_blank" rel="noreferrer noopener">http://doi.org/10.2165/00151829-200504001-00007</a>
Pages
25–30
Volume
4 Suppl 1
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Solutions to the problem of bacterial resistance.
Publisher
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Treatments in respiratory medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
1905-06
Subject
The topic of the resource
Humans; *Practice Guidelines as Topic; Anti-Bacterial Agents/*therapeutic use; Drug Administration Schedule; Drug Utilization; Drug Prescriptions/standards; Professional Practice/*standards; Unnecessary Procedures; *Drug Resistance; Dose-Response Relationship; Drug; Bacterial
Creator
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File Thomas M Jr
Description
An account of the resource
The recent increase in bacterial resistance has been, and continues to be, unmatched by drug discovery and development. The judicious use of antibacterials must be observed so as to contain bacterial resistance and maintain the utility of agents currently on the market. Appropriate antibacterial use involves antibacterial avoidance when not indicated. When indicated, appropriate antibacterial use dictates that the optimal drug, dose and duration be utilized. Professional society guidelines facilitate drug selection as well as outline diagnostic criteria and important considerations for patient stratification. Pharmacodynamics is also key for drug selection and often guides determination of not only the optimal drug but also the optimal dose and duration. Importantly, bacterial eradication is essential, as it will reduce clinical failure, recurrence, or relapse and prevent the selection of resistance. Additional strategies to influence antibacterial prescribing and use such as formal continuing medical education, printed educational materials, better diagnostic tests, and vaccination contribute to the efforts to minimize bacterial resistance and are also addressed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2165/00151829-200504001-00007" target="_blank" rel="noreferrer noopener">10.2165/00151829-200504001-00007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Drug Resistance
*Practice Guidelines as Topic
2005
Anti-Bacterial Agents/*therapeutic use
Bacterial
Department of Internal Medicine
Dose-Response Relationship
Drug
Drug Administration Schedule
Drug Prescriptions/standards
Drug Utilization
File Thomas M Jr
Humans
NEOMED College of Medicine
Professional Practice/*standards
Treatments in respiratory medicine
Unnecessary Procedures