Browse Items · NEOMED Bibliography Database

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

Antipsychotic effects of verapamil in schizophrenia.

The antipsychotic effects of verapamil were tested in a double-blind, placebo-controlled, randomized study in 18 patients who met Research Diagnostic Criteria for acute schizophrenia. The antipsychotic effect of verapamil as measured by the…

Tags: 1987, Adult, Clinical Trials as Topic, Double-Blind Method, Female, Haloperidol/therapeutic use, Humans, Male, Middle Aged, Price W A, Random Allocation, Schizophrenia/*drug therapy, The Hillside journal of clinical psychiatry, Verapamil/*therapeutic use

Randomized comparison of gastric pH control with intermittent and continuous intravenous infusion of famotidine in ICU patients.

OBJECTIVE: To compare gastric pH control using intravenous famotidine as a primed, continuous infusion versus intermittent infusion. METHODS: In a prospective, double-blind study, 40 ICU patients at risk for stress ulceration were randomly assigned…

Clonidine in the treatment of premenstrual syndrome: a subgroup study.

The authors studied the effects of clonidine on a subgroup of women who had symptoms associated with premenstrual syndrome; the subgroup comprised 24 women aged 19 to 41 years who had "moderate" to "severe" cyclic decreases in beta-endorphin levels.…

Tags: 1988, Adult, beta-Endorphin/blood, Clinical Trials as Topic, Clonidine/*therapeutic use, Double-Blind Method, Female, Giannini A J, Humans, Loiselle R H, Placebos, Premenstrual Syndrome/blood/*drug therapy/psychology, Psychiatric Status Rating Scales, Sarachene J, Sullivan B, The Journal of clinical psychiatry

Bromocriptine therapy in cocaine withdrawal.

Twenty-four cocaine addicts who experienced withdrawal symptoms were studied for six weeks in a double-blind design. Half of the group received daily treatment with bromocriptine and the other half with placebo. Significant relief with bromocriptine…

Tags: *Cocaine, 1987, Adult, Baumgartel P, Bromocriptine/*therapeutic use, Clinical Trials as Topic, DiMarzio L R, Double-Blind Method, Giannini A J, Humans, Journal of clinical pharmacology, Male, Psychiatric Status Rating Scales, Random Allocation, Substance Withdrawal Syndrome/*drug therapy/psychology

Mechanical Ventilation Antioxidant Trial.

BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy…

Tags: 2015, 80 and over, Acetylcysteine, Adult, Aged, American journal of critical care : an official publication, American Association of Critical-Care Nurses, Antioxidants, Antioxidants/*therapeutic use, Artificial, Artificial/*adverse effects, Ascorbic Acid – Administration and Dosage, Ascorbic Acid/therapeutic use, Chi Square Test, Clochesy John M, Critical Care/*methods, Critical Illness, Critically Ill Patients, Cystine/analogs & derivatives/therapeutic use, Data Analysis Software, Department of Internal Medicine, Dietary Supplementation, Double-Blind Method, Double-Blind Studies, Female, Funding Source, Goldstein Lawrence S, Howe Kimberly P, Human, Humans, Inflammation/*drug therapy/*etiology, Intensive Care Units, Length of Stay, Log-Rank Test, Male, Mantel-Haenszel Test, Middle Age, Middle Aged, NEOMED College of Medicine, Owen Hugh, Oxidative Stress, Oxidative Stress/*drug effects, Prospective Studies, RANDOMIZED controlled trials, Respiration, T-Tests, Time Factors, Treatment Outcome, Ventilator Weaning, Vitamin E, Vitamin E/therapeutic use, Vitamins/therapeutic use

The use of sensory electrical stimulation for pressure ulcer prevention.

Pressure ulcer prevention is critically important for many people with reduced mobility. The authors investigated whether sensory (sub-motor-threshold) electrical stimulation (ES) may provide a convenient preventive intervention. A double-blinded,…

Tags: *Electric Stimulation Therapy, 2010, Adult, Aged, Blood Gas Monitoring, Bogie Kath, Buttocks, Clinical Trials, Double-Blind Method, Double-Blind Studies, Electric Stimulation – Methods, Electric Stimulation – Utilization, Funding Source, Ho Chester H, Human, Humans, Interface Pressure, Kim Jennifer, Male, Middle Age, Middle Aged, Muscle, Muscle Contraction, Ohio, Outcome Assessment, Paralysis/etiology/physiopathology/*therapy, Physiotherapy theory and practice, Pressure Ulcer – Prevention and Control, Pressure Ulcer/etiology/physiopathology/*prevention & control, Regional Blood Flow, Repeated Measures, Sensory Thresholds, Skeletal – Radiography, Skeletal/blood supply/diagnostic imaging/*innervation, Spinal Cord Injuries, Spinal Cord Injuries/complications/physiopathology/*therapy, Time Series, Tomography, Transcutaneous, Treatment Failure, Wang Xiaofeng, X-Ray Computed

A fixed-dose combination of adapalene 0.1%-BPO 2.5% allows an early and sustained improvement in quality of life and patient treatment satisfaction in severe acne.

INTRODUCTION: Acne has a significant negative impact on quality of life (QoL): lack of self-confidence, depressive symptoms and suicidal thoughts. The objective was to assess the impact of an initial and continued therapy in severe acne patients…

Gemifloxacin versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis. The 070 Clinical Study group.

Six hundred patients were evaluated in this randomized, double-blind, double-dummy, multicenter, parallel-group study comparing the efficacy and safety of gemifloxacin (320 mg once-daily for 5 days) and amoxicillin/clavulanate (500/125 mg three-times…

Tags: *Fluoroquinolones, 2000, 80 and over, Acute-Phase Reaction, Adult, Aged, Amoxicillin/pharmacology/therapeutic use, Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use, Bronchitis/*drug therapy, Chronic Disease, Clavulanic Acid/pharmacology/therapeutic use, Combination/pharmacology/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Female, File T, Garau J, Gemifloxacin, Haemophilus influenzae/drug effects, Humans, Journal of chemotherapy (Florence, Italy), Lode H, Lynch S, Male, Microbial Sensitivity Tests, Middle Aged, Moraxella (Branhamella) catarrhalis/drug effects, Multicenter Studies as Topic, Naphthyridines/adverse effects/pharmacology/*therapeutic use, NEOMED College of Medicine, Schlemmer B, Streptococcus pneumoniae/drug effects, Treatment Outcome, Young C

Topical brinzolamide (Azopt) versus placebo in the treatment of infantile nystagmus syndrome (INS).

PURPOSE: To test the hypothesis that the topical carbonic anhydrase inhibitor brinzolamide (Azopt) has beneficial effects versus placebo on measures of nystagmus and visual acuity in adult subjects with infantile nystagmus syndrome (INS). DESIGN:…

Intranasal lidocaine for the treatment of migraine headache: a randomized, controlled trial.

OBJECTIVE: To evaluate the effect of intranasal lidocaine for immediate relief (5 minutes) of migraine headache pain. METHODS: A randomized, double-blind, placebo-controlled clinical trial at two university-affiliated community teaching hospitals…

Dialysis leg cramps. Efficacy of quinine versus vitamin E.

A controlled randomized double-blind study was done to determine the frequency and severity of leg cramps in 40 patients on dialysis with a history of leg cramps. All patients entered a 2 month placebo washout and were randomized into a 2 month…

FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.

OBJECTIVES: Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and…

Tags: 2011, 80 and over, Aged, Bacteria, Bacteria/isolation & purification, Bacterial – Drug Therapy, Bacterial/*drug therapy, Ceftriaxone – Administration and Dosage, Ceftriaxone – Adverse Effects, Ceftriaxone/administration & dosage/adverse effects, Cephalosporins – Administration and Dosage, Cephalosporins – Adverse Effects, Cephalosporins/*administration & dosage/*adverse effects, Community-Acquired Infections – Drug Therapy, Community-Acquired Infections/*drug therapy, Critchley Ian A, Department of Internal Medicine, Double-Blind Method, Double-Blind Studies, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Human, Humans, Infusions, Intravenous, Lee Jon, Llorens Lily, Low Donald E, Male, Middle Age, Middle Aged, NEOMED College of Medicine, Pneumonia, RANDOMIZED controlled trials, Talbot George H, The Journal of antimicrobial chemotherapy, Thye Dirk A, Treatment Outcome, Treatment Outcomes

Gemifloxacin once daily for 5 days versus 7 days for the treatment of community-acquired pneumonia: a randomized, multicentre, double-blind study.

OBJECTIVES: Short-course therapy has been advocated for the treatment of community-acquired pneumonia (CAP). We compared the efficacy and safety of 5 and 7 day courses of gemifloxacin for outpatient treatment of mild-moderate CAP. PATIENTS AND…

Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.

BACKGROUND: Ceftaroline, the active form of ceftaroline fosamil, is a broad-spectrum cephalosporin with bactericidal activity against pathogens causing community-acquired pneumonia (CAP), including Streptococcus pneumoniae. Ceftaroline was evaluated…

The bronchodilator effect of intravenous glucagon in asthma exacerbation: a randomized, controlled trial.

STUDY OBJECTIVE: Glucagon is a rapid-acting smooth muscle relaxant with a short half-life. Previous studies suggested glucagon may have bronchodilator effects. We sought to determine whether intravenous glucagon produces clinically important…

Outcome of treatment of respiratory tract infections due to Streptococcus pneumoniae, including drug-resistant strains, with pharmacokinetically enhanced amoxycillin/clavulanate.

The efficacy of a new pharmacokinetically enhanced formulation of amoxycillin/clavulanate (AMX/CA) 2000/125 mg, twice daily, designed to provide adequate levels of amoxycillin over the 12-h dosing interval to eradicate penicillin-resistant…

Tags: *Treatment Outcome, 2002, 80 and over, Adolescent, Adult, Aged, Amoxicillin-Potassium Clavulanate Combination/administration & dosage/*pharmacokinetics/pharmacology/*therapeutic use, Amoxicillin/adverse effects/therapeutic use, Bacterial, Bacterial/drug therapy/immunology, Bronchitis/drug therapy/microbiology, Combination/adverse effects/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Administration Schedule, Drug Resistance, Drug Therapy, Female, File Thomas M Jr, Follow-Up Studies, Humans, International journal of antimicrobial agents, Jacobs Michael R, Male, Microbial Sensitivity Tests, Middle Aged, Multicenter Studies as Topic, NEOMED College of Medicine, Pneumonia, Poole Michael D, Respiratory Tract Infections/*drug therapy/metabolism/microbiology, Streptococcal Infections/*drug therapy/metabolism/microbiology, Streptococcus pneumoniae/*drug effects, Wynne Brian

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

BACKGROUND: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment…

Tags: 2017, 80 and over, Adult, Aged, Anti-Bacterial Agents/adverse effects/*therapeutic use, Atypical pathogen, Bacterial/*drug therapy, Ceftaroline fosamil, Ceftriaxone/adverse effects/*therapeutic use, Cephalosporins/adverse effects/*therapeutic use, Chlamydial Pneumonia, Chlamydophila pneumoniae, Clinical Trials, Combination/adverse effects/methods, Community-Acquired Infections/*drug therapy, Community-acquired pneumonia, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Humans, International journal of antimicrobial agents, Legionella pneumophila, Llorens Lily, Macrolide, Macrolides/adverse effects/*therapeutic use, Male, Middle Aged, Mycoplasma, Mycoplasma pneumoniae, NEOMED College of Medicine, Phase III as Topic, Pneumonia, Randomized Controlled Trials as Topic, Talbot George H, Time Factors, Treatment Outcome

Does preoperative rofecoxib (Vioxx) decrease postoperative pain with laparoscopic cholecystectomy?

BACKGROUND: A prospective, randomized, double-blinded clinical trial was designed to study the effects of preemptive rofecoxib (Vioxx) analgesia in patients undergoing elective laparoscopic cholecystectomy. METHODS: One hundred-twenty patients were…

Adverse reactions to aspartame: double-blind challenge in patients from a vulnerable population.

This study was designed to ascertain whether individuals with mood disorders are particularly vulnerable to adverse effects of aspartame. Although the protocol required the recruitment of 40 patients with unipolar depression and a similar number of…

Tags: 1993, Adult, Aspartame/*adverse effects/*therapeutic use, Biological psychiatry, Cross-Sectional Studies, Depressive Disorder/diagnosis/*drug therapy/psychology, Double-Blind Method, Eye Diseases/etiology/physiopathology, Female, Green-Waite R J, Headache/etiology, Hudak R, Humans, Male, Middle Aged, Placebos, Psychiatric Status Rating Scales, Vision Disorders/etiology/physiopathology, Walton R G

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