1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jcp.22077" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.22077</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
519-529
Issue
2
Volume
223
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Differential Expression and Cellular Distribution of gamma-Tubulin and beta III-Tubulin in Medulloblastomas and Human Medulloblastoma Cell Lines
Publisher
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Journal of Cellular Physiology
Date
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2010
2010-05
Subject
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ring; Physiology; Cell Biology; complex; mammalian-cells; monoclonal-antibodies; candidate genes; cerebellar medulloblastomas; kinesin-like protein; microtubule nucleation; mitotic spindle; pale islands; posttranslational modification
Creator
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Caracciolo V; D'Agostino L; Draberova E; Sladkova V; Crozier-Fitzgerald C; Agamanolis D P; De Chadarevian J P; Legido A; Giordano A; Draber P; Katsetos C D
Description
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In previous studies, we have shown overexpression and ectopic subcellular distribution of gamma-tubulin and beta III-tubulin in human glioblastomas and glioblastoma cell lines (Katsetos et al., 2006,] Neuropathol Exp Neurol 65:455-467; Katsetos et al., 2007, Neurochem Res 32:1387-1398). Here we determined the expression of gamma-tubulin in surgically excised medulloblastomas (n = 20) and in the human medulloblastoma cell lines D283 Med and DAOY. In clinical tissue samples, the immunohistochemical distribution of gamma-tubulin labeling was pervasive and inversely related to neuritogenesis. Overexpression of gamma-tubulin was widespread in poorly differentiated, proliferating tumor cells but was significantly diminished in quiescent differentiating tumor cells undergoing neuritogenesis, highlighted by beta III-tubulin immunolabeling. By quantitative real-time PCR, gamma-tubulin transcripts for TUBG1, TUBG2, and TUBB3 genes were detected in both cell lines but expression was less prominent when compared with the human glioblastoma cell lines. Immunoblotting revealed comparable amounts of gamma-tubulin and beta III-tubulin in different phases of cell cycle; however, a larger amount of gamma-tubulin was detected in D283 Med when compared with DAOY cells. Interphase D283 Med cells exhibited predominantly diffuse cytoplasmic gamma-tubulin localization, in addition to the expected centrosome-associated distribution. Robust beta III-tubulin immunoreactivity was detected in mitotic spindles of DAOY cells. Our data indicate that overexpression of gamma-tubulin may be linked to phenotypic dedifferentiation (anaplasia) and tumor progression in medulloblastomas and may potentially serve as a promising tumor marker. J. Cell. Physiol. 223: 519-529,2010. (C) 2010 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/jcp.22077" target="_blank" rel="noreferrer noopener">10.1002/jcp.22077</a>
Format
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Journal Article or Conference Abstract Publication
2010
Agamanolis D P
candidate genes
Caracciolo V
Cell Biology
cerebellar medulloblastomas
complex
Crozier-Fitzgerald C
D'Agostino L
De Chadarevian J P
Draber P
Draberova E
Giordano A
Journal Article or Conference Abstract Publication
Journal of cellular physiology
Katsetos C D
kinesin-like protein
Legido A
mammalian-cells
microtubule nucleation
mitotic spindle
monoclonal-antibodies
pale islands
Physiology
posttranslational modification
ring
Sladkova V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/NEN.0b013e31816a686d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/NEN.0b013e31816a686d</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
341-354
Issue
4
Volume
67
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Class Iii Beta-tubulin Is Constitutively Coexpressed With Glial Fibrillary Acidic Protein And Nestin In Midgestational Human Fetal Astrocytes: Implications For Phenotypic Identity
Publisher
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Journal of Neuropathology and Experimental Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-04
Subject
The topic of the resource
adult mammalian; astrocytes; brain; class III beta-tubulin; fetal glia; gamma-tubulin; glial fibrillary acidic; microtubule associated protein 2; microtubule associated protein 2; monoclonal-antibody; nestin; neural stem cells; neural stem cells; neuronal differentiation; Neurosciences & Neurology; Pathology; posttranslational modification; protein; radial glia; spinal cord; subventricular zone; ventricular/subventricular zone
Creator
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Draberova E; Del Valle L; Gordon J; Markova V; Smejkalova B; Bertrand L; de Chadarevian J P; Agamanolis D P; Legido A; Khalili K; Draber P; Katsetos C D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/NEN.0b013e31816a686d" target="_blank" rel="noreferrer noopener">10.1097/NEN.0b013e31816a686d</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
adult mammalian
Agamanolis D P
Astrocytes
Bertrand L
Brain
class III beta-tubulin
De Chadarevian J P
Del Valle L
Draber P
Draberova E
fetal glia
gamma-tubulin
glial fibrillary acidic
Gordon J
Journal of Neuropathology and Experimental Neurology
Katsetos C D
Khalili K
Legido A
Markova V
microtubule associated protein 2
monoclonal-antibody
nestin
Neural stem cells
neuronal differentiation
Neurosciences & Neurology
Pathology
posttranslational modification
Protein
radial glia
Smejkalova B
Spinal Cord
subventricular zone
ventricular/subventricular zone