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Tags: Drug Carriers/administration & dosage/chemistry

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Antitumor effect of novel gallium compounds and efficacy of nanoparticle-mediated gallium delivery in lung cancer.

The widespread application of gallium (Ga) in cancer therapy has been greatly hampered by lack of specificity resulting in poor tumor accumulation and retention. To address the challenge, two lipophilic gallium (III) compounds (gallium hexanedione;…

Tags: 2012, Antineoplastic Agents/*administration & dosage/chemistry/pharmacokinetics, Biocompatible Materials/administration & dosage/chemistry/pharmacokinetics, Cell Line, Cell Survival/drug effects, Coordination Complexes/*administration & dosage/chemistry/pharmacokinetics, Department of Pharmaceutical Sciences, Drug Carriers/administration & dosage/chemistry, Drug Stability, Endocytosis/drug effects, Gallium/*administration & dosage/chemistry/pharmacokinetics, Hemolysis/drug effects, Humans, Journal of biomedical nanotechnology, Lung Neoplasms/*drug therapy/metabolism, Materials Testing, Membrane Potential, Mitochondrial/drug effects, Nanoparticles/*administration & dosage/chemistry, NEOMED College of Pharmacy, Oyewumi Moses O, Particle Size, Platelet Aggregation/drug effects, Reactive Oxygen Species/metabolism, Transferrin/chemistry/pharmacology, Tumor, Wehrung Daniel

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