1 40 5 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.2174/187152412800792670" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/187152412800792670</a> Pages 95–99 Issue 2 Volume 12 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The blood-brain barrier choline transporter. Publisher An entity responsible for making the resource available Central nervous system agents in medicinal chemistry Date A point or period of time associated with an event in the lifecycle of the resource 2012 2012-06 Subject The topic of the resource Humans; Animals; Drug Delivery Systems/*methods; Blood-Brain Barrier/drug effects/*metabolism; Membrane Transport Proteins/*metabolism; Organic Cation Transport Proteins/metabolism; Organic Cation Transporter 1/metabolism; Organic Cation Transporter 2 Creator An entity primarily responsible for making the resource Geldenhuys Werner J; Allen David D Description An account of the resource Drug delivery to the brain is made difficult by the blood-brain barrier (BBB) which is selectively permeable to organic drug compounds. Several membrane solute and nutrient transporters are expressed in the BBB vasculature, which may be utilized as mechanism of delivery of drugs to the brain. Of interest to us, are the organic cation transporters which could be used to transport cationic compounds into the CNS. In this mini-review, we will review the current understanding of the structural requirements for designing compounds which could effectively use organic cation transporters (OCT). For the first time, structural requirements for both OCT1 and OCT2 versus the BBB choline transporter (BBBCHT) are discussed and compared. The information gained here could increase the success rate in successful CNS drug delivery and therapeutics. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.2174/187152412800792670" target="_blank" rel="noreferrer noopener">10.2174/187152412800792670</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2012 Allen David D Animals Blood-Brain Barrier/drug effects/*metabolism Central nervous system agents in medicinal chemistry Drug Delivery Systems/*methods Geldenhuys Werner J Humans Membrane Transport Proteins/*metabolism Organic Cation Transport Proteins/metabolism Organic Cation Transporter 1/metabolism Organic Cation Transporter 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1111/nyas.13156" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/nyas.13156</a> Pages 80–86 Issue 1 Volume 1378 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Novel approaches to mitigating parathion toxicity: targeting cytochrome Publisher An entity responsible for making the resource available Annals of the New York Academy of Sciences Date A point or period of time associated with an event in the lifecycle of the resource 2016 2016-08 Subject The topic of the resource *menadione; *organophosphorus pesticides; *paraoxon; *parathion; *redox cycling; Animals; Cholinesterase Inhibitors/metabolism/*toxicity; Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism; Cytochrome P-450 Enzyme System/metabolism; Drug Delivery Systems/*methods; Humans; Insecticides/metabolism/toxicity; Organophosphate Poisoning/drug therapy/enzymology; Parathion/metabolism/*toxicity; Vitamin K 3/*administration & dosage/metabolism Creator An entity primarily responsible for making the resource Jan Yi-Hua; Richardson Jason R; Baker Angela A; Mishin Vladimir; Heck Diane E; Laskin Debra L; Laskin Jeffrey D Description An account of the resource Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1111/nyas.13156" target="_blank" rel="noreferrer noopener">10.1111/nyas.13156</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *menadione *organophosphorus pesticides *paraoxon *parathion *redox cycling 2016 Animals Annals of the New York Academy of Sciences Baker Angela A Cholinesterase Inhibitors/metabolism/*toxicity Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism Cytochrome P-450 Enzyme System/metabolism Department of Pharmaceutical Sciences Drug Delivery Systems/*methods Heck Diane E Humans Insecticides/metabolism/toxicity Jan Yi-Hua Laskin Debra L Laskin Jeffrey D Mishin Vladimir NEOMED College of Pharmacy Organophosphate Poisoning/drug therapy/enzymology Parathion/metabolism/*toxicity Richardson Jason R Vitamin K 3/*administration & dosage/metabolism Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1080/03639045.2018.1483381" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/03639045.2018.1483381</a> Pages 1583–1590 Issue 10 Volume 44 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration. Publisher An entity responsible for making the resource available Drug development and industrial pharmacy Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-10 Subject The topic of the resource Animals; bone; Bone Regeneration/*drug effects/physiology; drug delivery; Drug Delivery Systems/*methods; Drug Evaluation; Drug Repositioning/methods; Emulsifying Agents/administration & dosage/*chemical synthesis; Glycerides/administration & dosage/*chemical synthesis; Mice; nanoemulsions; nanoparticles; Nanoparticles/administration & dosage/*chemistry; osteoblasts; Osteoblasts/drug effects/physiology; Osteoclasts; Preclinical/methods; RAW 264.7 Cells; Simvastatin/administration & dosage/*chemical synthesis; Waxes/chemical synthesis/pharmacology Creator An entity primarily responsible for making the resource Eskinazi-Budge Aaron; Manickavasagam Dharani; Czech Tori; Novak Kimberly; Kunzler James; Oyewumi Moses O Description An account of the resource Simvastatin (Sim) is a widely known drug in the treatment of hyperlipidemia, which has attracted so much attention in bone regeneration due to its potential osteoanabolic effect. However, repurposing of Sim in bone regeneration will require suitable delivery systems that can negate undesirable off-target/side effects. In this study, we have investigated a new lipid nanoparticle (NP) platform that was fabricated using a binary blend of emulsifying wax (Ewax) and glyceryl monooleate (GMO). Using the binary matrix materials, NPs loaded with Sim (0-500 microg/mL) were prepared and showed an average particle size of about 150 nm. NP size stability was dependent on Sim concentration loaded in NPs. The suitability of NPs prepared with the binary matrix materials in Sim delivery for potential application in bone regeneration was supported by biocompatibility in pre-osteoclastic and pre-osteoblastic cells. Additional data demonstrated that biofunctional Sim was released from NPs that facilitated differentiation of osteoblasts (cells that form bones) while inhibiting differentiation of osteoclasts (cells that resorb bones). The overall work demonstrated the preparation of NPs from Ewax/GMO blends and characterization to ascertain potential suitability in Sim delivery for bone regeneration. Additional studies on osteoblast and osteoclast functions are warranted to fully evaluate the efficacy of Sim-loaded Ewax/GMO NPs using in-vitro and in-vivo approaches. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1080/03639045.2018.1483381" target="_blank" rel="noreferrer noopener">10.1080/03639045.2018.1483381</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2018 Animals Bone Bone Regeneration/*drug effects/physiology Czech Tori Department of Pharmaceutical Sciences Drug delivery Drug Delivery Systems/*methods Drug development and industrial pharmacy Drug Evaluation Drug Repositioning/methods Emulsifying Agents/administration & dosage/*chemical synthesis Eskinazi-Budge Aaron Glycerides/administration & dosage/*chemical synthesis Kunzler James Manickavasagam Dharani Mice nanoemulsions Nanoparticles Nanoparticles/administration & dosage/*chemistry NEOMED College of Pharmacy Novak Kimberly Osteoblasts Osteoblasts/drug effects/physiology Osteoclasts Oyewumi Moses O Preclinical/methods RAW 264.7 Cells Simvastatin/administration & dosage/*chemical synthesis Waxes/chemical synthesis/pharmacology Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.ejpb.2014.07.011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ejpb.2014.07.011</a> Pages 962–972 Issue 3 Volume 88 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Formulation and photoirradiation parameters that influenced photoresponsive drug delivery using alkoxylphenacyl-based polycarbonates. Publisher An entity responsible for making the resource available European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Date A point or period of time associated with an event in the lifecycle of the resource 2014 2014-11 Subject The topic of the resource Animals; Biocompatibility; Cardiotoxicity; Cell Line; Chemistry; Dose-Response Relationship; Doxorubicin; Drug; Drug Delivery Systems/*methods; Heart/drug effects; Humans; Inbred BALB C; Mice; Nanotechnology; Pharmaceutical; Photic Stimulation/*methods; Photoresponsive; Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity; Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity; Polymer chain scission; Stimuli-responsive; Tumor Creator An entity primarily responsible for making the resource Wehrung Daniel; Chamsaz Elaheh A; Joy Abraham; Oyewumi Moses O Description An account of the resource Recently, we reported the synthesis and biocompatibility of alkoxylphenacyl-based polycarbonates (APP); a promising new class of polymers that undergo photo-induced chain scission. In the current study, nanoparticles (NPs) were prepared from the APP polymer (APP-NPs) and loaded with doxorubicin (DOX) (DOX-APP-NPs) in order to identify and evaluate formulation and photoirradiation parameters that influence photoresponsive efficacy. Stable and spherical APP-NPs were prepared with diameters between 70-80nm depending on APP concentration (10-40mg/mL). There was a direct relationship between APP concentration and resultant particle size. Drug release studies indicated that exposure to the photo-trigger was capable of altering the rate and extent of DOX released. Photoresponsive DOX release was markedly influenced by the frequency of photoirradiation while the effect of APP concentration was most likely propagated through NP size. DOX released by photoactivation retained its efficacy as assessed by cytotoxicity studies in human lung adenocarcinoma (A549) cells. Studies in BALB/c mice indicated that DOX-APP-NPs induce less cardiotoxicity than DOX alone and that DOX-APP-NPs are not susceptible to dose dumping after photoirradiation. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.ejpb.2014.07.011" target="_blank" rel="noreferrer noopener">10.1016/j.ejpb.2014.07.011</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2014 Animals Biocompatibility Cardiotoxicity Cell Line Chamsaz Elaheh A Chemistry Department of Pharmaceutical Sciences Dose-Response Relationship Doxorubicin Drug Drug Delivery Systems/*methods European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Heart/drug effects Humans Inbred BALB C Joy Abraham Mice Nanotechnology NEOMED College of Pharmacy Oyewumi Moses O Pharmaceutical Photic Stimulation/*methods Photoresponsive Photosensitizing Agents/*chemical synthesis/radiation effects/toxicity Polycarboxylate Cement/*chemical synthesis/radiation effects/toxicity Polymer chain scission Stimuli-responsive Tumor Wehrung Daniel Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.bmcl.2009.12.088" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2009.12.088</a> Pages 819–823 Issue 3 Volume 20 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET. Publisher An entity responsible for making the resource available Bioorganic & medicinal chemistry letters Date A point or period of time associated with an event in the lifecycle of the resource 2010 2010-02 Subject The topic of the resource *Drug Design; Animals; Binding Sites/drug effects/physiology; Dose-Response Relationship; Drug; Drug Delivery Systems/*methods; Liver/drug effects/metabolism; Mitochondria; Mitochondrial Proteins/*metabolism; Protein Structure; Rats; Secondary; Structure-Activity Relationship; Thiazolidinediones/administration & dosage/*chemical synthesis/*metabolism Creator An entity primarily responsible for making the resource Geldenhuys Werner J; Funk Max O; Barnes Kendra F; Carroll Richard T Description An account of the resource Several PPAR-gamma agonists containing a thiazolidinedione moiety (referred to as glitazones) have been proposed to be neuroprotective and appear to alter mitochondrial function. Recently, a search for mitochondrial proteins that bind pioglitazone identified a novel protein, mitoNEET, which was later shown to regulate the oxidative capacity of the mitochondria. This identified an alternative target for the glitazones suggesting a possible new drug target for the treatment of neurodegenerative diseases. Molecular docking studies employing the reported crystal structure revealed five possible binding pockets on mitoNEET. We focused on two sites based on their physical characteristics. Using binding information gained from the analysis of two glitazones docked in these pockets, we designed and synthesized a ligand (NL-1) that would preferentially bind to site 1. Based on [(3)H]-binding data of the glitazones and comparisons to computer generated K(i)s, we were able to predict that site 1 was likely the target of the glitazones. NL-1 uncoupled isolated mitochondrial complex I respiration with an IC(50) of 2.4 microM and inhibited state III respiration up to 45%. To investigate the ability of NL-1 to block rotenone initiated free radicals from complex I, we found it was able to protect the human neuronal cell line SH-SY5Y against rotenone induced cell death. These data demonstrate that mitoNEET is a viable target for the design and synthesis of novel therapeutic agents aimed at altering mitochondrial function. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.bmcl.2009.12.088" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2009.12.088</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Drug Design 2010 Animals Barnes Kendra F Binding Sites/drug effects/physiology Bioorganic & medicinal chemistry letters Carroll Richard T Dose-Response Relationship Drug Drug Delivery Systems/*methods Funk Max O Geldenhuys Werner J Liver/drug effects/metabolism Mitochondria Mitochondrial Proteins/*metabolism Protein Structure Rats Secondary Structure-Activity Relationship Thiazolidinediones/administration & dosage/*chemical synthesis/*metabolism