1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
94–101
Issue
1
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulatory effects of testosterone on
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
Male; Animals; Mice; Species Specificity; Reference Values; Dopamine/*metabolism; Corpus Striatum/drug effects/*metabolism; Orchiectomy; Drug Implants; Testosterone/administration & dosage/*pharmacology; Neurotoxins/antagonists & inhibitors/*toxicity; *MPTP Poisoning; Levodopa/pharmacology; Inbred Strains; Inbred C57BL; 3; 1-Methyl-4-phenyl-1; 2; Parkinson Disease; 6-tetrahydropyridine/antagonists & inhibitors; Secondary/chemically induced/*physiopathology
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B
Description
An account of the resource
In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine/antagonists & inhibitors
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D
Dopamine/*metabolism
Drug Implants
Inbred C57BL
Inbred Strains
Jain R
Journal of neurochemistry
Levodopa/pharmacology
Liu B
Male
Mice
Neurotoxins/antagonists & inhibitors/*toxicity
Orchiectomy
Parkinson Disease
Reference Values
Secondary/chemically induced/*physiopathology
Species Specificity
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)03221-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)03221-2</a>
Pages
63–69
Issue
1
Volume
892
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-02
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Drug Implants; Female; Male; Methamphetamine/*toxicity; Mice; Neuroprotective Agents/pharmacology; Neurotoxins/*toxicity; Orchiectomy; Ovariectomy; Potassium/pharmacology; Substantia Nigra/drug effects/*metabolism; Testosterone/administration & dosage/*pharmacology
Creator
An entity primarily responsible for making the resource
Gao X; Dluzen D E
Description
An account of the resource
The gonadal steroid hormone estrogen (E) can function as a neuroprotectant of nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the effects of T on methamphetamine (MA) induced neurotoxicity of the NSDA system were examined in gonadectomized female and male CD-1 mice. In Experiment 1, striatal dopamine (DA) concentrations and output from T-treated ovariectomized mice were not significantly different from that of non-T-treated mice following MA. These results suggest that T is not functioning as a modulator of MA-induced NSDA neurotoxicity in ovariectomized CD-1 mice. In Experiment 2, there were no significant differences in DA concentrations or output among
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)03221-2" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)03221-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Animals
Brain research
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Drug Implants
Female
Gao X
Male
Methamphetamine/*toxicity
Mice
Neuroprotective Agents/pharmacology
Neurotoxins/*toxicity
Orchiectomy
Ovariectomy
Potassium/pharmacology
Substantia Nigra/drug effects/*metabolism
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0892-0362(96)00086-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0892-0362(96)00086-4</a>
Pages
603–606
Issue
5
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice.
Publisher
An entity responsible for making the resource available
Neurotoxicology and teratology
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-10
Subject
The topic of the resource
*MPTP Poisoning; Animals; Corpus Striatum/drug effects/*metabolism/pathology; Dopamine/*metabolism; Drug Implants; Estradiol/administration & dosage/*pharmacology; Female; Inbred C57BL; Male; Mice; Neuroprotective Agents/administration & dosage/*pharmacology; Neurotoxins; Olfactory Pathways/drug effects/*metabolism/pathology; Orchiectomy; Ovariectomy; Sex Characteristics
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
Castrated retired breeder male and female mice were treated or not with a 17 beta-estradiol pellet. At 10 days postcastration +/- estrogen treatment all animals were treated with MPTP. Five days later, concentrations of dopamine were determined from the corpus striatum and olfactory tubercle. Both castrated male and female mice treated with estrogen had significantly greater concentrations of dopamine within the corpus striatum compared with their respective gender controls, which did not receive estrogen. By contrast, no statistically significant differences in olfactory tubercle dopamine concentrations were obtained. Overall concentrations of dopamine within the corpus striatum, but not olfactory tubercle, were substantially greater in female vs. male mice. These data demonstrate that treatment with estrogen prevents reductions in corpus striatal dopamine concentrations in castrated mice treated with MPTP. Interestingly, this effect of estrogen was observed in both male and female mice. These results suggest that estrogen may serve as a neuroprotectant against an agent that is toxic to the nigrostriatal dopaminergic system in both male and female animal models of Parkinsonism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0892-0362(96)00086-4" target="_blank" rel="noreferrer noopener">10.1016/0892-0362(96)00086-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
Animals
Corpus Striatum/drug effects/*metabolism/pathology
Dluzen D E
Dopamine/*metabolism
Drug Implants
Estradiol/administration & dosage/*pharmacology
Female
Inbred C57BL
Liu B
Male
McDermott J L
Mice
Neuroprotective Agents/administration & dosage/*pharmacology
Neurotoxicology and teratology
Neurotoxins
Olfactory Pathways/drug effects/*metabolism/pathology
Orchiectomy
Ovariectomy
Sex Characteristics