1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1163/156855500750198762" target="_blank" rel="noreferrer noopener">http://doi.org/10.1163/156855500750198762</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
113-122
Issue
1
Volume
3
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Synthesis And Characterization Of Tubular Amphiphilic Networks With Controlled Pore Dimensions For Insulin Delivery
Publisher
An entity responsible for making the resource available
Designed Monomers and Polymers
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000
Subject
The topic of the resource
drug release; Polymer Science
Creator
An entity primarily responsible for making the resource
Kennedy J P; Fenyvesi G; Na S; Keszler B; Rosenthal K S
Description
An account of the resource
A convenient laboratory process for the preparation of thin-walled (similar to 0.02 cm) tubular amphiphilic membranes has been developed. The membranes are suitable for implantation and isolation of pancreatic islets from immune responses. The process involves the simultaneous free radical copolymerization/crosslinking of dimethyl acrylamide (DMAAm) and methacrylate ditelechelic polyisobutylene (MA-PIB-MA) in narrow-bore (similar to 4 mm inner diameter) glass tubes horizontally rotating in a thermostated oven. The pore sizes of the membranes can be controlled by the length, i.e. molecular weight, of the hydrophilic poly(dimethyl acrylamide) (PDMAAm) segment (M-c,M-hydrophilic). Pore sizes, M-c,M-hydrophilic's, and molecular weight cut-off (MWCO) ranges of designed amphiphilic membranes were characterized in terms of Stokes (or viscosity) radii (Rs) and the relationships between these parameters were evaluated. Membranes were designed to allow the rapid diffusion of molecules such as insulin (M-n = 5733 g/mol, R-s = 1.34 nm) but to be opaque to serum albumin (M-n > 66 000 g/mol, R-s > 3.62 nm) and larger proteins such as immunoglobulins. The diffusion coefficients (D) and permeabilities (P) of tubular and flat-sheet amphiphilic membranes have been compared and were found to be similar. Membrane pore size dimensions of the tubular devices were determined by the out-diffusion of commercially available protein markers of known molecular weights (M-n = 6500-66 000 g/mol) and dimensions (R-s = 1.50-3.62 nm). It was found that the minimum M-c,M-hydrophilic or R-s that still allows the diffusion of insulin is similar to 800 g/mol or similar to 1.34 nm, respectively, and that the maximum M-c,M-hydrophilic or R-s that prevents the ingress of antibodies is similar to 5000 g/mol or similar to 3.62 nm, respectively. According to diffusion experiments, the presence or absence of lightly crosslinked 1% calcium alginate does not affect the rate of diffusion of glucose and insulin through our tubules. These membranes are being used in vivo for encapsulating islet cells for implantation to correct type 1 diabetes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1163/156855500750198762" target="_blank" rel="noreferrer noopener">10.1163/156855500750198762</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2000
Designed Monomers and Polymers
Drug Release
Fenyvesi G
Journal Article or Conference Abstract Publication
Kennedy J P
Keszler B
Na S
Polymer Science
Rosenthal K S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
290-299
Volume
833
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Amphiphilic Gels With Controlled Mesh Dimensions For Insulin Delivery
Publisher
An entity responsible for making the resource available
Polymer Gels: Fundamentals and Applications
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003
Subject
The topic of the resource
drug release; islets; methacrylate)-1-polyisobutylene; networks; xenotransplantation
Creator
An entity primarily responsible for making the resource
Kennedy J P; Fenyvesi G; Na S; Keszler B; Rosenthal K S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
2003
Book Chapter
Drug Release
Fenyvesi G
islets
Kennedy J P
Keszler B
methacrylate)-1-polyisobutylene
Na S
networks
Polymer Gels: Fundamentals and Applications
Rosenthal K S
xenotransplantation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jnn.2017.13449</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
4867-4881
Issue
7
Volume
17
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Engineering Alkoxyphenacyl-Polycarbonate Nanoparticles for Potential Application in Near-Infrared Light-Modulated Drug Delivery via Photon Up-Conversion Process
Publisher
An entity responsible for making the resource available
Journal of Nanoscience and Nanotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-07
Subject
The topic of the resource
800 nm; alkoxylphenacyl-based polycarbonates; biocompatibility; Chemistry; Doxorubicin; Drug Release; luminescence; Materials Science; mesoporous-silica; nanocrystals; Nanotechnology; Near-Infrared Light; photodynamic therapy; Physics; release; Science & Technology - Other Topics; Stimuli-Responsive; upconverting nanoparticles; uv
Creator
An entity primarily responsible for making the resource
Wehrung D; Chamsaz E A; Andrews J H; Joy A; Oyewumi M O
Description
An account of the resource
Photoresponsive delivery systems that are activated by high energy photo-triggers have been accorded much attention because of the capability to achieve reliable photoreactions at short irradiation times. However, the application of a high energy photo-trigger (UV light) is not clinically viable. Meanwhile, the process of photon-upconversion is an effective strategy to generate a high energy photo-trigger (in-situ) through exposure to clinically relevant near-infrared (NIR) light. In this regard, we synthesized photon upconverting nanocrystals (UCNCs) that were subsequently loaded into photoresponsive nanoparticles (NPs) that were prepared using alkoxyphenacyl-based polycarbonate homopolymer (UCNC-APP-NPs). UCNC loading affected resultant NP size, size distribution, colloidal stability but not the zeta potential. The efficiency of NIR-modulated drug delivery was impacted by the heterogenetic nature of the resultant UCNC-APP-NPs which was plausibly formed through a combination of UCNC entrapment within the polymeric NP matrix and nucleation of polymer coating on the surface of the UCNCs. The biocompatibility of UCNC-APP-NPs was demonstrated through cytotoxicity, macrophage activation, and red blood cell lysis assays. Studies in tumor-bearing (nu/nu) athymic mice showed a negligible distribution of UCNC-APP-NPs to reticuloendothelial tissues. Further, distribution of UCNC-APP-NPs to various tissues was in the order (highest to lowest): Lungs> Tumor > Kidneys > Liver > Spleen> Brain > Blood > Heart. In all, the work highlighted some important factors that may influence the effectiveness, reproducibility and biocompatibility of drug delivery systems that operate on the process of photon-upconversion.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1166/jnn.2017.13449" target="_blank" rel="noreferrer noopener">10.1166/jnn.2017.13449</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
800 nm
alkoxylphenacyl-based polycarbonates
Andrews J H
Biocompatibility
Chamsaz E A
Chemistry
Department of Pharmaceutical Sciences
Doxorubicin
Drug Release
Journal Article
Journal of nanoscience and nanotechnology
Joy A
luminescence
Materials Science
mesoporous-silica
nanocrystals
Nanotechnology
Near-Infrared Light
NEOMED College of Pharmacy
Oyewumi M O
photodynamic therapy
Physics
release
Science & Technology - Other Topics
Stimuli-responsive
upconverting nanoparticles
uv
Wehrung D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
157-163
Issue
2
Volume
35
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Amphiphilic networks .10. Diffusion of glucose and insulin (and nondiffusion of albumin) through amphiphilic membranes
Publisher
An entity responsible for making the resource available
Journal of Biomedical Materials Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-05
Subject
The topic of the resource
cells; Drug Release; Engineering; Materials Science; pancreas; sequential co-polymers; telechelic polymers; transfer agents inifers
Creator
An entity primarily responsible for making the resource
Shamlou S; Kennedy J P; Levy R P
Description
An account of the resource
Select semipermeable amphiphilic membranes have been prepared and their diffusional characteristics for glucose, insulin, and albumin investigated. The membranes were prepared by cast copolymerization of a hydrophilic monomer (i.e., N,N-dimethyl acrylamide, or N,N-dimethylaminoethyl methacrylate) with the hydrophobic crosslinker methacrylate-ditelechelic polyisobutylene. The products have sufficient mechanical properties for the fabrication of swollen membranes, sheets, tubes, etc. Membranes have been identified which allowed the rapid simultaneous countercurrent diffusion of glucose (M-n = 180 Da) and insulin (M-n = 5733 Da) but did not allow albumin (Mn similar to 60,000 Da) to pass. Evidently, the effective molecular weight cutoff point of these membranes is in the 6-60-KDa range. (C) 1997 John Wiley & Sons, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m" target="_blank" rel="noreferrer noopener">10.1002/(sici)1097-4636(199705)35:2%3C157::aid-jbm3%3E3.0.co;2-m</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1997
Cells
Drug Release
Engineering
Journal Article
Journal of Biomedical Materials Research
Kennedy J P
Levy R P
Materials Science
Pancreas
sequential co-polymers
Shamlou S
telechelic polymers
transfer agents inifers