Browse Items · NEOMED Bibliography Database

Stability of the stimulus properties of drugs over time.

Three separate groups of rats were trained to discriminate the stimulus effects of either 600 mg/kg ethanol (n = 5), 0.8 mg/kg d-amphetamine (n = 8) or 1.0 mg/kg

Tags: *Discrimination (Psychology), 1989, Animals, Boja J W, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Drug Tolerance, Ethanol/*pharmacology, Inbred Strains, Pharmacology, biochemistry, and behavior, Piperazines/*pharmacology, Rats, Schechter M D, Signs S A

Rats become acutely tolerant to cathine after amphetamine or cathinone administration.

The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine,…

Tags: 1990, Alkaloids/*pharmacology, Amphetamine/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Discrimination (Psychology)/drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Inbred Strains, Male, Phenylpropanolamine/*pharmacology, Psychopharmacology, Psychotropic Drugs/*pharmacology, Rats, Schechter M D, Thiazepines/pharmacology

Dopaminergic nature of acute cathine tolerance.

Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8…

Tags: 1990, Alkaloids/pharmacology, Animals, Antipsychotic Agents/pharmacology, Appetite Depressants/*pharmacology, Discrimination (Psychology)/drug effects, Discrimination Learning/drug effects, Dopamine/*physiology, Dose-Response Relationship, Drug, Drug Tolerance, Generalization (Psychology)/drug effects, Inbred Strains, Male, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/*pharmacology, Rats, Schechter M D, Thiazepines/pharmacology

Advantages and disadvantages of a rapid method to train drug discrimination.

In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training…

Tags: 1988, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Male, Methods, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.

The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior…

Tags: *Discrimination (Psychology)/drug effects, 1990, Alkaloids/*pharmacology, Animals, Catha, Domperidone/pharmacology, Drug Administration Schedule, Drug Tolerance, Haloperidol/pharmacology, Inbred Strains, Male, Pehek E A, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/antagonists & inhibitors/*pharmacology, Plant Extracts/analysis, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles.

The widespread clinical success with most gallium compounds in cancer therapy is markedly hampered by lack of tumor specific accumulation, poor tumor permeability and undesirable toxicity to healthy tissues. The aim of this work was to investigate…

Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.

Fourteenth generation high alcohol-sensitive (HAS) and low alcohol-sensitive (LAS) rats were trained to discriminate the effects of 600 mg/kg intraperitoneally administered ethanol from its vehicle at 6 and 30 min postadministration. Each of the…

Tags: *Discrimination Learning, 1992, Alcohol (Fayetteville, N.Y.), Animals, Dose-Response Relationship, Drug, Drug Tolerance, Ethanol/administration & dosage/*pharmacology, Male, Rats, Schechter M D, Time Factors

Opioids: a review.

Recent discoveries in opioid pharmacology help explain the enormous variability in clinical responses to these powerful analgesics. Although there is only one m opioid receptor gene, splice variants of that gene's expression result in a panoply of…

Tags: 2003, Analgesics, Animals, Chevlen Eric, Clinical Trials as Topic, Current pain and headache reports, Department of Internal Medicine, Drug Tolerance, Humans, mu/drug effects/genetics/physiology, NEOMED College of Medicine, Opioid, Opioid/*drug effects/genetics/physiology, Opioid/adverse effects/*therapeutic use, Pain/*drug therapy/physiopathology, Receptors, Trans-Activators/genetics

Browse Items (8 total)