1
40
8
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s11916-003-0005-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s11916-003-0005-5</a>
Pages
15–23
Issue
1
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Opioids: a review.
Publisher
An entity responsible for making the resource available
Current pain and headache reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-02
Subject
The topic of the resource
Analgesics; Animals; Clinical Trials as Topic; Drug Tolerance; Humans; mu/drug effects/genetics/physiology; Opioid; Opioid/*drug effects/genetics/physiology; Opioid/adverse effects/*therapeutic use; Pain/*drug therapy/physiopathology; Receptors; Trans-Activators/genetics
Creator
An entity primarily responsible for making the resource
Chevlen Eric
Description
An account of the resource
Recent discoveries in opioid pharmacology help explain the enormous variability in clinical responses to these powerful analgesics. Although there is only one m opioid receptor gene, splice variants of that gene's expression result in a panoply of different functioning receptors. Other sources of variable response include polymorphisms in the m opioid receptor regulatory region, and pharmacokinetic differences because of cytochrome P-450 mono-oxygenase heterogeneity. Analgesic tolerance is likely the key phenomenon limiting the benefit of opioids. A plethora of intracellular pathways affects this. Among them are the N-methyl-D-aspartate receptor, protein kinase C gamma activity, nitric oxide synthase, and GM1 ganglioside content of the neuronal membrane. Clinical studies undercut the routine use of meperidine in most settings. Other studies have shown better ways to diminish opioid side effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s11916-003-0005-5" target="_blank" rel="noreferrer noopener">10.1007/s11916-003-0005-5</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Analgesics
Animals
Chevlen Eric
Clinical Trials as Topic
Current pain and headache reports
Department of Internal Medicine
Drug Tolerance
Humans
mu/drug effects/genetics/physiology
NEOMED College of Medicine
Opioid
Opioid/*drug effects/genetics/physiology
Opioid/adverse effects/*therapeutic use
Pain/*drug therapy/physiopathology
Receptors
Trans-Activators/genetics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(92)90021-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(92)90021-2</a>
Pages
117–122
Issue
2
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ethanol-produced interoceptive stimuli are time dependent in selectively bred HAS and LAS rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-04
Subject
The topic of the resource
*Discrimination Learning; Animals; Dose-Response Relationship; Drug; Drug Tolerance; Ethanol/administration & dosage/*pharmacology; Male; Rats; Time Factors
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Fourteenth generation high alcohol-sensitive (HAS) and low alcohol-sensitive (LAS) rats were trained to discriminate the effects of 600 mg/kg intraperitoneally administered ethanol from its vehicle at 6 and 30 min postadministration. Each of the earlier- and later-trained animals were given lower doses of ethanol and ED50 values at their trained postadministration interval were found to be nonsignificantly different. Thus, there was no difference between HAS and LAS animals as to their sensitivity to the discriminative effects of ethanol. Phase-generalization studies, where rats trained at 6 min postadministration were tested with the drug at 30 min postadministration were shown not to generalize, whereas the animals trained at 30 min postadministration and tested at 6 min postinjection were shown to readily discriminate the discriminative stimuli. This asymmetrical generalization lends evidence to the biphasic action of ethanol, and suggests that the earlier phase is quantitatively different than the latter phase. The similarity in sensitivity of the LAS and HAS animals, furthermore, suggests that the discrimination of ethanol is not based on its hypnotic effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(92)90021-2" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(92)90021-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1992
Alcohol (Fayetteville, N.Y.)
Animals
Dose-Response Relationship
Drug
Drug Tolerance
Ethanol/administration & dosage/*pharmacology
Male
Rats
Schechter M D
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1166/jbn.2013.1598" target="_blank" rel="noreferrer noopener">http://doi.org/10.1166/jbn.2013.1598</a>
Pages
1029–1040
Issue
6
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles.
Publisher
An entity responsible for making the resource available
Journal of biomedical nanotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-06
Subject
The topic of the resource
*Lethal Dose 50; Adenocarcinoma/*drug therapy/pathology; Animals; Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity; Cell Line; Dose-Response Relationship; Drug; Drug Stability; Drug Tolerance; Gallium/*administration & dosage/pharmacokinetics/*toxicity; Humans; Metabolic Clearance Rate; Mice; Nanocapsules/*administration & dosage/chemistry/*toxicity; Nude; Organ Specificity; Tissue Distribution; Treatment Outcome; Triglycerides/chemistry; Tumor
Creator
An entity primarily responsible for making the resource
Wehrung Daniel; Bi Lipeng; Geldenhuys Werner J; Oyewumi Moses O
Description
An account of the resource
The widespread clinical success with most gallium compounds in cancer therapy is markedly hampered by lack of tumor specific accumulation, poor tumor permeability and undesirable toxicity to healthy tissues. The aim of this work was to investigate for the first time antitumor mechanism of a new gallium compound (gallium acetylacetonate; GaAcAc) while assessing effectiveness of gelucire-stabilized nanoparticles (NPs) for potential application in gallium-based lung cancer therapy. NPs loaded with GaAcAc (Ga-NPs) were prepared using mixtures of cetyl alcohol with Gelucire 44/14 (Ga-NP-1) or Gelucire 53/13 (Ga-NP-2) as matrix materials. Of special note from this work is the direct evidence of involvement of microtubule disruption in antitumor effects of GaAcAc on human lung adenocarcinoma (A549). In-vivo tolerability studies were based on plasma ALT, creatinine levels and histopathological examination of tissues. The superior in-vivo antitumor efficacy of Ga-NPs over GaAcAc was depicted in marked reduction of tumor weight and tumor volume as well as histological assessment of excised tumors. Compared to free GaAcAc, Ga-NPs showed a 3-fold increase in tumor-to-blood gallium concentrations with minimized overall exposure to healthy tissues. Overall, enhancement of antitumor effects of GaAcAc by gelucire-stabilized NPs coupled with reduced exposure of healthy tissues to gallium would likely ensure desired therapeutic outcomes and safety of gallium-based cancer treatment.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1166/jbn.2013.1598" target="_blank" rel="noreferrer noopener">10.1166/jbn.2013.1598</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Lethal Dose 50
2013
Adenocarcinoma/*drug therapy/pathology
Animals
Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity
Bi Lipeng
Cell Line
Department of Pharmaceutical Sciences
Dose-Response Relationship
Drug
Drug Stability
Drug Tolerance
Gallium/*administration & dosage/pharmacokinetics/*toxicity
Geldenhuys Werner J
Humans
Journal of biomedical nanotechnology
Metabolic Clearance Rate
Mice
Nanocapsules/*administration & dosage/chemistry/*toxicity
NEOMED College of Pharmacy
Nude
Organ Specificity
Oyewumi Moses O
Tissue Distribution
Treatment Outcome
Triglycerides/chemistry
Tumor
Wehrung Daniel
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90402-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90402-4</a>
Pages
267–271
Issue
2
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus properties of (+)cathine, an alkaloid of the khat plant.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-06
Subject
The topic of the resource
Male; Animals; Rats; Drug Administration Schedule; Drug Tolerance; Psychotropic Drugs/*pharmacology; Haloperidol/pharmacology; Alkaloids/*pharmacology; *Discrimination (Psychology)/drug effects; Catha; Domperidone/pharmacology; Phenylpropanolamine/antagonists & inhibitors/*pharmacology; Plant Extracts/analysis; Inbred Strains
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D
Description
An account of the resource
The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this effect developed and dissipated rapidly. Thus, different dose-response curves were generated depending upon whether cathine or vehicle was administered the day before testing. The development of tolerance also shortened cathine's time course of action and enhanced the ability of haloperidol to antagonize the cathine cue. These results suggest caution in interpreting effects produced by intermittent drug injection schedules.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90402-4" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90402-4</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)/drug effects
1990
Alkaloids/*pharmacology
Animals
Catha
Domperidone/pharmacology
Drug Administration Schedule
Drug Tolerance
Haloperidol/pharmacology
Inbred Strains
Male
Pehek E A
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/antagonists & inhibitors/*pharmacology
Plant Extracts/analysis
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90340-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90340-1</a>
Pages
239–242
Issue
1
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Advantages and disadvantages of a rapid method to train drug discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-09
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Methods; Discrimination Learning/*drug effects; Amphetamines/*pharmacology; Dose-Response Relationship; Drug; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training drug in ten rats. This protocol consisted of one to three training sessions per day and it was compared to the more conventional method of once-per-day training in an equal number of rats. Results indicate that the fast-trained rats learned the discrimination in significantly fewer sessions than the slowly-trained rats. However, the subsequent dose-response experiments indicate that when the fast-trained rats are tested with various doses of MDMA, without prior vehicle treatment, their sensitivity to the drug is less than that of the slowly-trained rats. When a vehicle session is presented prior to drug dose-response testing, both groups perform similarly. It appears that the preceding vehicle sessions function as a reference point for the fast-trained rats and, although the more rapid training regimen allows for faster learning, these treatment regimens should be employed with caution when subsequent dose-response tests and generalization tests with other drugs are conducted.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90340-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90340-1</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Drug Tolerance
Male
Methods
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90083-t</a>
Pages
817–820
Issue
4
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopaminergic nature of acute cathine tolerance.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Dopamine/*physiology; Discrimination (Psychology)/drug effects; Discrimination Learning/drug effects; Alkaloids/pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Appetite Depressants/*pharmacology; Phenylpropanolamine/*pharmacology; Generalization (Psychology)/drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8 mg/kg d-cathine and, once trained, administration of another Khat constituent, cathinone, was shown to produce cathine-like effects. This generalization to cathinone was dose-responsive when testing occurred 24 hr after vehicle administration, whereas prior administration of cathine resulted in a diminished discriminative response to subsequent cathinone administration possibly as a result of the development of acute tolerance. CGS 10746B, a compound that blocks presynaptic release of dopamine, significantly decreased rats' ability to discriminate cathine when it was administered 25 min prior to cathine testing and it reversed the acute tolerance observed when cathine was tested 24 hr after cathine administration. These results indicate that a previously reported acute tolerance effect to cathine after cathinone administration in cathinone-trained rats appears to be symmetrical in that there is acute tolerance to cathinone after cathine in these cathine-trained rats. The results with CGS 10746B would suggest that both the cathine-induced discriminative cue and cathine's ability to produce acute tolerance are mediated by presynaptic dopamine release.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90083-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/pharmacology
Animals
Antipsychotic Agents/pharmacology
Appetite Depressants/*pharmacology
Discrimination (Psychology)/drug effects
Discrimination Learning/drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Drug Tolerance
Generalization (Psychology)/drug effects
Inbred Strains
Male
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02253729" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02253729</a>
Pages
126–131
Issue
1
Volume
101
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rats become acutely tolerant to cathine after amphetamine or cathinone administration.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Discrimination (Psychology)/drug effects; Psychotropic Drugs/*pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Phenylpropanolamine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n = 6) trained with cathinone (ED50 = 3.03 mg/kg) and in rats (n = 8) trained with amphetamine (ED50 = 2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02253729" target="_blank" rel="noreferrer noopener">10.1007/bf02253729</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Discrimination (Psychology)/drug effects
Dose-Response Relationship
Drug
Drug Tolerance
Inbred Strains
Male
Phenylpropanolamine/*pharmacology
Psychopharmacology
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90256-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90256-6</a>
Pages
361–364
Issue
1
Volume
32
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability of the stimulus properties of drugs over time.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Animals; Rats; Ethanol/*pharmacology; *Discrimination (Psychology); Drug Tolerance; Piperazines/*pharmacology; Dextroamphetamine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D; Signs S A; Boja J W
Description
An account of the resource
Three separate groups of rats were trained to discriminate the stimulus effects of either 600 mg/kg ethanol (n = 5), 0.8 mg/kg d-amphetamine (n = 8) or 1.0 mg/kg
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90256-6" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90256-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination (Psychology)
1989
Animals
Boja J W
Dextroamphetamine/*pharmacology
Dose-Response Relationship
Drug
Drug Tolerance
Ethanol/*pharmacology
Inbred Strains
Pharmacology, biochemistry, and behavior
Piperazines/*pharmacology
Rats
Schechter M D
Signs S A