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Text
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<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s13346-020-00829-x</a>
ISSN
2190-3948 2190-393X
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED Department
NEOMED Student Publications
Department of Pharmaceutical Sciences
Dublin Core
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Title
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Overcoming barriers confronting application of protein therapeutics in bone fracture healing.
Publisher
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Drug delivery and Translational Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-08-11
Subject
The topic of the resource
Osteoporosis; Drug delivery; Implants; Bone regeneration; Osteoinductive proteins; Osteopenia
Creator
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Czech T; Oyewumi MO
Description
An account of the resource
Bone fracture is a major contributor to debilitation and death among patients with bone diseases. Thus, osteogenic protein therapeutics and their delivery to bone have been extensively researched as strategies to accelerate fracture healing. To prevent morbidity and mortality of fractures, which occur frequently in the aging population, there is a critical need for development of first-line therapeutics. Bone morphogenic protein-2 (BMP-2) has been at the forefront of bone regeneration research for its potent osteoinduction, despite safety concerns and biophysiological obstacles of delivery to bone. However, continued pursuit of osteoinductive proteins as a therapeutic option is largely aided by drug delivery systems, playing an imperative role in enhancing safety and efficacy. In this work, we highlighted several types of drug delivery platforms and their biomaterials, to evaluate the suitability in overcoming challenges of therapeutic protein delivery for bone regeneration. To showcase the clinical considerations for each type of platform, we have assessed the most common route of administration strategies for bone regeneration, classifying the platforms as implantable or injectable. Additionally, we have analyzed the commonly utilized models and methodology for safety and efficacy evaluation of these osteogenic protein-loaded systems, to present clinical opinions for future directions of research in this field. It is hoped that this review will promote research and development of clinically translatable osteogenic protein therapeutics, while targeting first-line treatment status for achieving desired outcomes of fracture healing. Graphical abstract.
Identifier
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<a href="http://doi.org/10.1007/s13346-020-00829-x" target="_blank" rel="noreferrer noopener">10.1007/s13346-020-00829-x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
August 2020 List
Bone regeneration
Czech T
Department of Pharmaceutical Sciences
Drug delivery
Drug delivery and translational research
Implants
journalArticle
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
Osteoinductive proteins
osteopenia
Osteoporosis
Oyewumi MO
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s13346-013-0130-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s13346-013-0130-6</a>
Pages
318–329
Issue
4
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Contributory roles of innate properties of cetyl alcohol/gelucire nanoparticles to antioxidant and anti-inflammation activities of quercetin.
Publisher
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Drug delivery and translational research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-08
Creator
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Bi Lipeng; Wehrung Daniel; Oyewumi Moses O
Description
An account of the resource
The protective effects of synthetic lung surfactant Exosurf(R) (containing cetyl alcohol) against endotoxin-induced inflammation have been demonstrated in the literature. Thus, it is envisioned that nanoparticles loaded with quercetin (Q-NPs) prepared with binary mixtures of cetyl alcohol (CA) and Gelucire 44/14(R) (gelucire) as matrix materials will be capable of overcoming some of the protracted challenges confronting clinical application of quercetin and possess innate protective activity against inflammatory responses, which could be synergistic with quercetin. The NPs were stable in simulated biological media while retaining their particle size and spherical morphology. Further analysis by gel permeation chromatography, spectroscopic analysis (ultraviolet-visible, fluorescence, and Fourier transform infrared spectroscopy) indicated entrapment of quercetin in NPs. Q-NPs effectively enhanced xanthine oxidase inhibitory and free radical scavenging effect of quercetin. Furthermore, Q-NPs showed marked reduction (compared to quercetin alone) in production of nitric oxide and cytokine (interleukin-6 and tumor necrosis factor alpha) from lipopolysaccharide-activated macrophages. Superiority of Q-NPs over quercetin alone was confirmed from in vivo anti-inflammatory efficacy studies in BALB/c mice. Data from additional studies with blank NPs (without quercetin) showed that the NPs reported herein most likely possessed intrinsic protective properties against LPS-induced inflammation. Although further mechanistic studies are warranted, the overall work depicted a novel approach of possible exploiting innate protective properties of NPs in quercetin delivery for treating oxidative stress and inflammation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s13346-013-0130-6" target="_blank" rel="noreferrer noopener">10.1007/s13346-013-0130-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Bi Lipeng
Department of Pharmaceutical Sciences
Drug delivery and translational research
NEOMED College of Pharmacy
Oyewumi Moses O
Wehrung Daniel
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s13346-012-0117-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s13346-012-0117-8</a>
Pages
309–317
Issue
4
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Engineering triiodothyronine (T3) nanoparticle for use in ischemic brain stroke.
Publisher
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Drug delivery and translational research
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-08
Subject
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Blood-brain barrier; Brain stroke; Nanoparticles; Neuroprotection; Thyroid hormone
Creator
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Mdzinarishvili Alexander; Sutariya Vijaykumar; Talasila Phani K; Geldenhuys Werner J; Sadana Prabodh
Description
An account of the resource
A potential means of pharmacological management of ischemic stroke is rapid intervention using potent neuroprotective agents. Thyroid hormone (T3) has been shown to protect against ischemic damage in middle cerebral artery occlusion (MCAO) model of ischemic brain stroke. While thyroid hormone is permeable across the blood-brain barrier, we hypothesized that efficacy of thyroid hormone in ischemic brain stroke can be enhanced by encapsulation in nanoparticulate delivery vehicles. We tested our hypothesis by generating poly-(lactide-co-glycolide)-polyethyleneglycol (PLGA-b-PEG) nanoparticles that are either coated with glutathione or are not coated. We have previously reported that glutathione coating of PLGA-PEG nanoparticles is an efficient means of brain targeted drug delivery. Encapsulation of T3 in PLGA-PEG delivery vehicle resulted in particles that were in the nano range and exhibited a zeta potential of -6.51 mV (uncoated) or -1.70 mV (coated). We observed that both glutathione-coated and uncoated nanoparticles are taken up in cells wherein they stimulated the expression of thyroid hormone response element driven reporter robustly. In MCAO model of ischemic stroke, significant benefit of administering T3 in nanoparticulate form was observed over injection of a T3 solution. A 34 % decrease in tissue infarction and a 59 % decrease in brain edema were seen upon administration of T3 solution in MCAO stroke model. Corresponding measurements for uncoated T3 nanoparticles were 51 % and 68 %, whereas for the glutathione coated were 58 % and 75 %. Our study demonstrates that using nanoparticle formulations can significantly improve the efficacy of neuroprotective drugs in ischemic brain stroke.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s13346-012-0117-8" target="_blank" rel="noreferrer noopener">10.1007/s13346-012-0117-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Blood-brain barrier
Brain stroke
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drug delivery and translational research
Geldenhuys Werner J
Mdzinarishvili Alexander
Nanoparticles
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Neuroprotection
Sadana Prabodh
Sutariya Vijaykumar
Talasila Phani K
Thyroid hormone