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Text
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URL Address
<a href="http://doi.org/10.1080/03639045.2018.1483381" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/03639045.2018.1483381</a>
Pages
1583–1590
Issue
10
Volume
44
Dublin Core
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Title
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Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration.
Publisher
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Drug development and industrial pharmacy
Date
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2018
2018-10
Subject
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Animals; bone; Bone Regeneration/*drug effects/physiology; drug delivery; Drug Delivery Systems/*methods; Drug Evaluation; Drug Repositioning/methods; Emulsifying Agents/administration & dosage/*chemical synthesis; Glycerides/administration & dosage/*chemical synthesis; Mice; nanoemulsions; nanoparticles; Nanoparticles/administration & dosage/*chemistry; osteoblasts; Osteoblasts/drug effects/physiology; Osteoclasts; Preclinical/methods; RAW 264.7 Cells; Simvastatin/administration & dosage/*chemical synthesis; Waxes/chemical synthesis/pharmacology
Creator
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Eskinazi-Budge Aaron; Manickavasagam Dharani; Czech Tori; Novak Kimberly; Kunzler James; Oyewumi Moses O
Description
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Simvastatin (Sim) is a widely known drug in the treatment of hyperlipidemia, which has attracted so much attention in bone regeneration due to its potential osteoanabolic effect. However, repurposing of Sim in bone regeneration will require suitable delivery systems that can negate undesirable off-target/side effects. In this study, we have investigated a new lipid nanoparticle (NP) platform that was fabricated using a binary blend of emulsifying wax (Ewax) and glyceryl monooleate (GMO). Using the binary matrix materials, NPs loaded with Sim (0-500 microg/mL) were prepared and showed an average particle size of about 150 nm. NP size stability was dependent on Sim concentration loaded in NPs. The suitability of NPs prepared with the binary matrix materials in Sim delivery for potential application in bone regeneration was supported by biocompatibility in pre-osteoclastic and pre-osteoblastic cells. Additional data demonstrated that biofunctional Sim was released from NPs that facilitated differentiation of osteoblasts (cells that form bones) while inhibiting differentiation of osteoclasts (cells that resorb bones). The overall work demonstrated the preparation of NPs from Ewax/GMO blends and characterization to ascertain potential suitability in Sim delivery for bone regeneration. Additional studies on osteoblast and osteoclast functions are warranted to fully evaluate the efficacy of Sim-loaded Ewax/GMO NPs using in-vitro and in-vivo approaches.
Identifier
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<a href="http://doi.org/10.1080/03639045.2018.1483381" target="_blank" rel="noreferrer noopener">10.1080/03639045.2018.1483381</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animals
Bone
Bone Regeneration/*drug effects/physiology
Czech Tori
Department of Pharmaceutical Sciences
Drug delivery
Drug Delivery Systems/*methods
Drug development and industrial pharmacy
Drug Evaluation
Drug Repositioning/methods
Emulsifying Agents/administration & dosage/*chemical synthesis
Eskinazi-Budge Aaron
Glycerides/administration & dosage/*chemical synthesis
Kunzler James
Manickavasagam Dharani
Mice
nanoemulsions
Nanoparticles
Nanoparticles/administration & dosage/*chemistry
NEOMED College of Pharmacy
Novak Kimberly
Osteoblasts
Osteoblasts/drug effects/physiology
Osteoclasts
Oyewumi Moses O
Preclinical/methods
RAW 264.7 Cells
Simvastatin/administration & dosage/*chemical synthesis
Waxes/chemical synthesis/pharmacology