1
40
7
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
27
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Regulation Of Prostaglandin E2 Signaling By Cysteinyl Leukotrienes In Human Mast Cells
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Kondeti V; Duah E; Emory A; Thodeti C K; Paruchuri S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Biochemistry & Molecular Biology
Cell Biology
Duah E
Emory A
Faseb Journal
Journal Article or Conference Abstract Publication
Kondeti V
Life Sciences & Biomedicine - Other
Paruchuri S
Thodeti C K
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0071536" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0071536</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
8-8
Issue
8
Volume
8
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differential Regulation Of Cysteinyl Leukotriene Receptor Signaling By Protein Kinase C In Human Mast Cells
Publisher
An entity responsible for making the resource available
Plos One
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-08
Subject
The topic of the resource
activation; antagonist; asthmatic subjects; desensitization; expression; hyperresponsiveness; intestinal epithelial-cells; proliferation; pulmonary inflammation; responses; Science & Technology - Other Topics
Creator
An entity primarily responsible for making the resource
Kondeti V; Duah E; Al-Azzam N; Thodeti C K; Boyce J A; Paruchuri S
Description
An account of the resource
Cysteinyl leukotrienes (cys-LTs) are a group of lipid mediators that are potent bronchoconstrictors, powerful inducers of vascular leakage and potentiators of airway hyperresponsiveness. Cys-LTs play an essential role in asthma and are synthesized as well as activated in mast cells (MCs). Cys-LTs relay their effects mainly through two known GPCRs, CysLT(1)R and CysLT(2)R. Although protein kinase C (PKC) isoforms are implicated in the regulation of CysLT(1)R function, neither the role of PKCs in cys-LT-dependent MC inflammatory signaling nor the involvement of specific isoforms in MC function are known. Here, we show that PKC inhibition augmented LTD4 and LTE4-induced calcium influx through CysLT(1)R in MCs. In contrast, inhibition of PKCs suppressed c-fos expression as well MIP1 beta generation by cys-LTs. Interestingly, cys-LTs activated both PKC alpha and PKC epsilon isoforms in MC. However, knockdown of PKC alpha augmented cys-LT mediated calcium flux, while knockdown of PKC epsilon attenuated cys-LT induced c-fos expression and MIP1 beta generation. Taken together, these results demonstrate for the first time that cys-LT signaling downstream of CysLT(1)R in MCs is differentially regulated by two distinct PKCs which modulate inflammatory signals that have significant pathobiologic implications in allergic reactions and asthma pathology.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0071536" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0071536</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
activation
Al-Azzam N
Antagonist
asthmatic subjects
Boyce J A
Desensitization
Duah E
expression
hyperresponsiveness
intestinal epithelial-cells
Journal Article or Conference Abstract Publication
Kondeti V
Paruchuri S
PloS one
proliferation
pulmonary inflammation
responses
Science & Technology - Other Topics
Thodeti C K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Volume
30
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cysteinyl Leukotriene 2 Receptor Enhances Angiogenesis, Vascular Permeability And Tumor Metastasis
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Duah E; Kondeti V; Al-Azzam N; Adapala R; Patil P; Thodeti C; Paruchuri S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2016
Adapala R
Al-Azzam N
Biochemistry & Molecular Biology
Cell Biology
Duah E
Faseb Journal
Kondeti V
Life Sciences & Biomedicine - Other
Paruchuri S
Patil P
Thodeti C
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
27
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inflammatory Role Of Cysteinyl Leukotrienes In Human Vascular Endothelial Cells
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Duah E; Kondeti V; Adapala R K; Sanford J; Thodeti C K; Paruchuri S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Adapala R K
Biochemistry & Molecular Biology
Cell Biology
Duah E
Faseb Journal
Kondeti V
Life Sciences & Biomedicine - Other
Paruchuri S
Sanford J
Thodeti C K
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/srep03274" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/srep03274</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
6-6
Volume
3
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cysteinyl Leukotrienes Regulate Endothelial Cell Inflammatory And Proliferative Signals Through Cyslt(2) And Cyslt(1) Receptors
Publisher
An entity responsible for making the resource available
Scientific Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-11
Subject
The topic of the resource
atherosclerosis; barrier; dysfunction; expression; gamma; intestinal epithelial-cells; ischemia-reperfusion injury; migration; pathway; Science & Technology - Other Topics; thrombin
Creator
An entity primarily responsible for making the resource
Duah E; Adapala R K; Al-Azzam N; Kondeti V; Gombedza F; Thodeti C K; Paruchuri S
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/srep03274" target="_blank" rel="noreferrer noopener">10.1038/srep03274</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Adapala R K
Al-Azzam N
Atherosclerosis
barrier
Duah E
dysfunction
expression
gamma
Gombedza F
intestinal epithelial-cells
ischemia-reperfusion injury
Kondeti V
migration
Paruchuri S
pathway
Science & Technology - Other Topics
Scientific reports
Thodeti C K
Thrombin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jcp.24777" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.24777</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
595-602
Issue
3
Volume
230
Search for Full-text
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulation of Mast Cell Proliferative and Inflammatory Responses by Leukotriene D-4 and Stem Cell Factor Signaling Interactions
Publisher
An entity responsible for making the resource available
Journal of Cellular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-03
Subject
The topic of the resource
activation; Cell Biology; cysteinyl leukotrienes; fc-epsilon-ri; immune; induced airway hyperreactivity; innate; kit ligand; Physiology; protein-kinase-c; receptor; survival
Creator
An entity primarily responsible for making the resource
Al-Azzam N; Kondeti V; Duah E; Gombedza F; Thodeti C K; Paruchuri S
Description
An account of the resource
Mast cells (MCs) are important effector cells in asthma and pulmonary inflammation, and their proliferation and maturation is maintained by stem cell factor (SCF) via its receptor, c-Kit. Cysteinyl leukotrienes (cys-LTs) are potent inflammatory mediators that signal through CysLT(1)R and CysLT(2)R located on the MC surface, and they enhance MC inflammatory responses. However, it is not known if SCF and cys-LTs cross-talk and influence MC hyperplasia and activation in inflammation. Here, we report the concerted effort of the growth factor SCF and the inflammatory mediator LTD4 in MC activation. Stimulation of MCs by LTD4 in the presence of SCF enhances c-Kit-mediated proliferative responses. Similarly, SCF synergistically enhances LTD4-induced calcium, c-fos expression and phosphorylation, as well as MIP1 generation in MCs. These findings suggest that integration of SCF and LTD4 signals may contribute to MC hyperplasia and hyper-reactivity during airway hyper-response and inflammation. J. Cell. Physiol. 230: 595-602, 2015. (c) 2014 Wiley Periodicals, Inc., A Wiley Company
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jcp.24777" target="_blank" rel="noreferrer noopener">10.1002/jcp.24777</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2015
activation
Al-Azzam N
Cell Biology
cysteinyl leukotrienes
Duah E
fc-epsilon-ri
Gombedza F
Immune
induced airway hyperreactivity
Innate
Journal Article or Conference Abstract Publication
Journal of cellular physiology
kit ligand
Kondeti V
Paruchuri S
Physiology
protein-kinase-c
Receptor
Survival
Thodeti C K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
31
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Targetting Cysteinyl Leukotriene 2 Receptor as a Therapeutic Target for Tumor Growth and Metastasis: A New Function for an Old Receptor
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Teegala L R; Duah E; Kondeti V; Al-Azzam N Z; Adapala R; Ghebreigziabher S; Thodeti C; Paruchuri S
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2017
Adapala R
Al-Azzam N Z
Biochemistry & Molecular Biology
Cell Biology
Duah E
Faseb Journal
Ghebreigziabher S
Journal Article
Kondeti V
Life Sciences & Biomedicine - Other
Paruchuri S
Teegala L R
Thodeti C
Topics