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40
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Text
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Pages
994–1001
Issue
10
Volume
6
Dublin Core
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Title
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Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.
Publisher
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Current opinion in investigational drugs (London, England : 2000)
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-10
Subject
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Humans; Animals; Chronic Disease; *Lipid Metabolism; Hypoglycemic Agents/therapeutic use; Diabetes Mellitus/drug therapy/metabolism; Dyslipidemias/drug therapy/metabolism; Heart Diseases/*drug therapy/metabolism; Hypolipidemic Agents/therapeutic use; Liver Diseases/*drug therapy/metabolism; Metabolic Diseases/*drug therapy/metabolism; Receptors; Cytoplasmic and Nuclear/*metabolism
Creator
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Chiang John Y L
Description
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Lipids are essential components of biological membranes, fuel molecules and metabolic regulators that control cellular functions, metabolism and homeostasis. The liver plays a central role in regulating lipid metabolism and whole body lipid homeostasis. Sterols, bile acids and fatty acids are the endogenous ligands of the liver orphan receptor, farnesoid X receptor, peroxisome proliferator-activated receptor, vitamin D receptor, constitutive androstane receptor and pregnane X receptor. These metabolic receptors coordinately regulate lipid, glucose, energy and drug metabolism. Alteration of lipid homeostasis causes dyslipidemia, which is a major risk factor contributing to atherosclerotic cardiovascular diseases, diabetes, obesity and liver diseases. Advances in the understanding of the mechanisms of nuclear receptor regulation of lipid homeostasis have provided an opportunity to investigate potential therapeutic drugs targeted to nuclear receptors. This could be useful for the treatment of diabetes, and cardiovascular and chronic liver diseases.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Lipid Metabolism
2005
Animals
Chiang John Y L
Chronic Disease
Current opinion in investigational drugs (London, England : 2000)
Cytoplasmic and Nuclear/*metabolism
Department of Integrative Medical Sciences
Diabetes Mellitus/drug therapy/metabolism
Dyslipidemias/drug therapy/metabolism
Heart Diseases/*drug therapy/metabolism
Humans
Hypoglycemic Agents/therapeutic use
Hypolipidemic Agents/therapeutic use
Liver Diseases/*drug therapy/metabolism
Metabolic Diseases/*drug therapy/metabolism
NEOMED College of Medicine
Receptors