Copper Deposition In A Variant Of Multiple Myeloma: Pathologic Changes In The Cornea And The Lens Capsule
central defect; copper deposition; deposition; Descemet membrane; descemets membrane; hypercupremia; immunoglobulin; leukomas; monoclonal gammopathy; multiple myeloma; ocular; Ophthalmology; true exfoliation; wilsons-disease
Edward D P; Patil A J; Sugar J; Parikh M
Cornea
2011
2011-03
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/ICO.0b013e3181ee67fd" target="_blank" rel="noreferrer noopener">10.1097/ICO.0b013e3181ee67fd</a>
Human anterior chamber angle development without cell death or macrophage involvement
Ophthalmology; Biochemistry & Molecular Biology; light; aqueous outflow system; human eye; human trabecular meshwork; iridocorneal angle
Purpose: The iridocorneal angle in the mammalian eye including the trabecular meshwork (TM) develops from undifferentiated mesenchyme/neural crest between the iris root and cornea. The precise mechanisms underlying anterior angle development are unclear, and the contribution of cell death and phagocytic resorption by macrophages in angle development is controversial. In this study, we examined the human anterior chamber angle during various stages of development for evidence of cell death and phagocytic resorption. Methods: Eyes from the human fetus (F) of 7, 8, 9, 10, 11, 13, 15, 18, 19, 21, 22, 23, and 27 weeks as well as eyes from 5-and 11-month-old children and donors 24, 48, and 67 years of age were obtained. Formalin-fixed and paraffin-embedded sections were examined by hematoxylin and eosin (H&E) staining. Immunohistochemistry was performed using polyclonal antibodies against CD68. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) labeling was also performed to evaluate cell death. Results: By light microscopy, the development of human angle structures appeared to progress as previously described. Histological evidence of cellular death or resorption by macrophages was not observed. Furthermore, the chamber angle tissues did not stain with CD68 at any stage of development. Few CD68 positive cells were observed in the iris stroma and the anterior ciliary body between fetal weeks 10 and 18 (F10w and F18w). TUNEL labeled nuclei were not detected in the anterior chamber angle in any fetal or infant eyes. By contrast, TUNEL positive nuclei in TM cells were observed in the examined adult donor specimens. Conclusions: The results suggest that at the time points examined, neither cell death nor phagocytic resorption with macrophages appear to play a role in the development of the human anterior chamber angle.
Meghpara B; Li X; Nakamura H; Khan A; Bejjani B A; Lin S; Edward D P
Molecular Vision
2008
2008-12
Journal Article or Conference Abstract Publication
n/a
Iris Neovascularization and Neovascular Glaucoma in Neurofibromatosis Type 1: Report of 3 Cases in Children
anti-VEGF treatment; disease; ectropion uvea; expression; hamartoma; iris neovascularization; ischemia; neurofibromatosis type 1; Ophthalmology; peripheral retinal; retina; vasoproliferative tumors
Purpose: To report the clinical findings and outcomes in 3 patients with neurofibromatosis 1 (NF1) and retinal vascular abnormalities that resulted in angle closure secondary to iris neovascularization and describe the histopathologic abnormalities in 1 case. Patients and Methods: Retrospective case series of patients with NF1 and angle closure due to iris neovascularization secondary to retinal vascular abnormalities. Histopathologic analysis of an enucleated eye in 1 case. Results: Three children whose age ranged from 5 to 10 years at presentation, developed unilateral retinal vascular abnormalities that resulted in iris neovascularization and angle closure with a wide range of intraocular pressures. Two patients had retinal vasoproliferative lesions of which the affected eye became blind in 1 patient and the other retained useful vision after treatment with intracameral Bevacizumab, ablation of the retinal lesions, and surgical treatment of the neovascular glaucoma. The third patient underwent enucleation and had pathologic evidence of retinal ischemia. Conclusions: A variety of retinal vascular lesions occurring in NF1 are capable of producing iris neovascularization, ectropion uvea, and neovascular glaucoma. Although a spectrum of serious complications resulting in total vision loss can occur, retention of useful vision is possible, in some cases, with aggressive treatment of the retinal lesions and associated neovascular glaucoma. This report highlights the need for careful examination of the posterior segment with special attention to peripheral retinal vascular abnormalities or tumors in young patients with NF1.
Al Freihi S H; Edward D P; Nowilaty S R; Abouammoh M A; Morales J
Journal of Glaucoma
2013
2013-04
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1097/IJG.0b013e318239c35d" target="_blank" rel="noreferrer noopener">10.1097/IJG.0b013e318239c35d</a>
Bimatoprost - a review
acid; aqueous-humor; bimatoprost; clinical-trial; cost-effectiveness; elevated intraocular-pressure; fixed combination; free; glaucoma; human eyes; Intraocular pressure; ocular hypertension; open-angle glaucoma; Pharmacology & Pharmacy; prostaglandin; prostaglandin-ethanolamides; prostamide; prostamides
Bimatoprost is a synthetic prostamide analog that is efficacious in the treatment of open-angle glaucoma, ocular hypertension and other forms of glaucoma. it reduces intraocular pressure (IOP) by increasing uveoscleral and trabecular outflow. When used as a 0.03% topical preparation once daily, it demonstrates sustained lowering of IOP of 7 - 8 mmHg over a 24-h period. The drug has been found to be more effective than timolol. In some studies it has shown greater ability to lower IOP when compared with other prostaglandin analogs; whereas in others all three clinically used prostaglandin analogs were found to be equally effective. it shows good IOP reduction when used in combination with other glaucoma medications. A common side effect includes mild conjunctival hyperemia, which is generally reversible. Other side effects include periorbital pigmentation, discomfort, ocular surface hyperemia and skin changes. Pharmacoeconomic data indicate that bimatoprost is cost effective in the treatment of open-angle glaucoma.
Patil A J; Vajaranant T S; Edward D P
Expert Opinion on Pharmacotherapy
2009
2009-11
Journal Article
<a href="http://doi.org/10.1517/14656560903292649" target="_blank" rel="noreferrer noopener">10.1517/14656560903292649</a>