1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0194091" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0194091</a>
Pages
e0194091–e0194091
Issue
3
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Communication calls produced by electrical stimulation of four structures in the guinea pig brain.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
1905-07
Subject
The topic of the resource
Female; Male; Animals; Acoustic Stimulation/methods; Auditory Perception/physiology; Brain/*physiology; Electric Stimulation/methods; Guinea Pigs; Neurons/physiology; Animal/physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Green David B; Shackleton Trevor M; Grimsley Jasmine M S; Zobay Oliver; Palmer Alan R; Wallace Mark N
Description
An account of the resource
One of the main central processes affecting the cortical representation of conspecific vocalizations is the collateral output from the extended motor system for call generation. Before starting to study this interaction we sought to compare the characteristics of calls produced by stimulating four different parts of the brain in guinea pigs (Cavia porcellus). By using anaesthetised animals we were able to reposition electrodes without distressing the animals. Trains of 100 electrical pulses were used to stimulate the midbrain periaqueductal grey (PAG), hypothalamus, amygdala, and anterior cingulate cortex (ACC). Each structure produced a similar range of calls, but in significantly different proportions. Two of the spontaneous calls (chirrup and purr) were never produced by electrical stimulation and although we identified versions of chutter, durr and tooth chatter, they differed significantly from our natural call templates. However, we were routinely able to elicit seven other identifiable calls. All seven calls were produced both during the 1.6 s period of stimulation and subsequently in a period which could last for more than a minute. A single stimulation site could produce four or five different calls, but the amygdala was much less likely to produce a scream, whistle or rising whistle than any of the other structures. These three high-frequency calls were more likely to be produced by females than males. There were also differences in the timing of the call production with the amygdala primarily producing calls during the electrical stimulation and the hypothalamus mainly producing calls after the electrical stimulation. For all four structures a significantly higher stimulation current was required in males than females. We conclude that all four structures can be stimulated to produce fictive vocalizations that should be useful in studying the relationship between the vocal motor system and cortical sensory representation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0194091" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0194091</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Acoustic Stimulation/methods
Animal/physiology
Animals
Auditory Perception/physiology
Brain/*physiology
Electric Stimulation/methods
Female
Green David B
Grimsley Jasmine M S
Guinea Pigs
Male
Neurons/physiology
Palmer Alan R
PloS one
Shackleton Trevor M
Vocalization
Wallace Mark N
Zobay Oliver
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00419.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00419.2009</a>
Pages
1672–1683
Issue
3
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
Animals; Auditory Pathways/physiology; Biophysics; Brain Mapping; Chick Embryo; Cochlear Nucleus/*cytology; Electric Stimulation/methods; Excitatory Amino Acid Agents/pharmacology; GABA Agents/pharmacology; gamma-Aminobutyric Acid/*metabolism/pharmacology; In Vitro Techniques; Inhibitory Postsynaptic Potentials/drug effects/physiology; Nerve Net/*physiology; Neural Inhibition/drug effects/*physiology; Neurons/*physiology; Patch-Clamp Techniques/methods; Synaptic Transmission/drug effects/*physiology; Time Factors
Creator
An entity primarily responsible for making the resource
Tang Zheng-Quan; Gao Hongxiang; Lu Yong
Description
An account of the resource
Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus magnocellularis (NM) and GABAergic inhibition from the ipsilateral superior olivary nucleus. Here, we study metabotropic glutamate receptor (mGluR)- and GABAB receptor (GABABR)-mediated modulation of synaptic transmission in NL neurons. Gramicidin-perforated recordings from acute brain stem slice preparations showed that the reversal potential of the GABAergic responses in NL neurons was more depolarized than the spike threshold. Activation of the GABAergic input produced a mix of inhibitory and excitatory actions in NL neurons. The inhibitory action is known to be critical in improving the acuity of temporal processing of sounds. The excitatory action, however, would reduce the phase locking fidelity of NL neurons in response to their excitatory inputs from the NM. We show that activation of presynaptic mGluRs or GABABRs by either exogenous agonists or synaptically released neurotransmitters reduced the GABAergic responses, preventing the excitatory action of GABA while leaving the inhibitory action intact. Unlike most CNS synapses, the glutamatergic transmission in the NL was not modulated by either mGluRs or GABABRs, indicating that fixed (nonmodulatory) excitatory inputs to the NL may be optimal for coincidence detection. This study contributes to our understanding of how selective neuromodulation is achieved to suit a particular function of neuronal circuits in the brain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00419.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00419.2009</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Auditory Pathways/physiology
Biophysics
Brain Mapping
Chick Embryo
Cochlear Nucleus/*cytology
Department of Anatomy & Neurobiology
Electric Stimulation/methods
Excitatory Amino Acid Agents/pharmacology
GABA Agents/pharmacology
gamma-Aminobutyric Acid/*metabolism/pharmacology
Gao Hongxiang
In Vitro Techniques
Inhibitory Postsynaptic Potentials/drug effects/physiology
Journal of neurophysiology
Lu Yong
NEOMED College of Medicine
Nerve Net/*physiology
Neural Inhibition/drug effects/*physiology
Neurons/*physiology
Patch-Clamp Techniques/methods
Synaptic Transmission/drug effects/*physiology
Tang Zheng-Quan
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1101/lm.3.2-3.106" target="_blank" rel="noreferrer noopener">http://doi.org/10.1101/lm.3.2-3.106</a>
Pages
106–114
Issue
2
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Long-term potentiation induces synaptic plasticity at nontetanized adjacent synapses.
Publisher
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Learning & memory (Cold Spring Harbor, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-10
Subject
The topic of the resource
Action Potentials/physiology; Animals; Electric Stimulation/methods; Excitatory Postsynaptic Potentials/physiology; In Vitro Techniques; Long-Evans; Long-Term Potentiation/*physiology; Neuronal Plasticity/*physiology; Rats; Synapses/*physiology
Creator
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Coussens C M; Teyler T J
Description
An account of the resource
The two forms of long-term potentiation (LTP) and one form of long-term depression (LTD) in hippocampal area CA1 are induced by different afferent tetani: LTD is induced by a 3- to 5-Hz tetanus, whereas higher frequencies are necessary for LTP mediated by NMDA receptors (25- to 50-Hz tetanus) and LTP mediated by voltage-dependent calcium channels (200-Hz tetanus). It has been suggested that the three forms are induced by graded increases in postsynaptic calcium, with LTD being induced at the lowest calcium concentration. We hypothesized that synapses near a site of LTP induction would elicit LTD owing to diffusion of calcium or its binding proteins. This was tested using a fixed multistimulating electrode array spanning stratum radiatum in area CA1 of rat hippocampal slices. The tetanized sites all displayed LTP. Nontetanized sites displayed LTD following a 50-Hz tetanus, whereas LTD was often seen following a
Identifier
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<a href="http://doi.org/10.1101/lm.3.2-3.106" target="_blank" rel="noreferrer noopener">10.1101/lm.3.2-3.106</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Action Potentials/physiology
Animals
Coussens C M
Electric Stimulation/methods
Excitatory Postsynaptic Potentials/physiology
In Vitro Techniques
Learning & memory (Cold Spring Harbor, N.Y.)
Long-Evans
Long-Term Potentiation/*physiology
Neuronal Plasticity/*physiology
Rats
Synapses/*physiology
Teyler T J