1
40
2
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Text
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<a href="http://doi.org/10.1002/acm2.12592" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/acm2.12592</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
31-38
Issue
6
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Comparison of multiparametric MRI-based and transrectal ultrasound-based preplans with intraoperative ultrasound-based planning for low dose rate interstitial prostate seed implantation
Publisher
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Journal of Applied Clinical Medical Physics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-06
Subject
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brachytherapy; LDR; MRI; multiparametric; prostate; TRUS
Creator
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Fredman Elisha T; Traughber Bryan J; Gross Andrew; Podder Tarun; Colussi Valdir; Vinkler Robert; Machtay Mitchell; Ellis Rodney J
Description
An account of the resource
PURPOSE: Transrectal ultrasound images are routinely acquired for low dose rate (LDR) prostate brachytherapy dosimetric preplanning (pTRUS), although diagnostic multiparametric magnetic resonance imaging (mpMRI) may serve this purpose as well. We compared the predictive abilities of TRUS vs MRI relative to intraoperative TRUS (iTRUS) to assess the role of mpMRI in brachytherapy preplanning. MATERIALS AND METHODS: Retrospective analysis was performed on 32 patients who underwent iTRUS-guided prostate LDR brachytherapy as either mono- or combination therapy. 56.3% had pTRUS-only volume studies and 43.7% had both 3T-mpMRI and pTRUS preplanning. MRI was used for preplanning and its image fusion with iTRUS was also used for intraoperative guidance of seed placement. Differences in gland volume, seed number, and activity and procedure time were examined, as well as the identification of lesions suspicious for tumor foci. Pearson correlation coefficient and Fisher's Z test were used to estimate associations between continuous measures. RESULTS: There was good correlation of planning volumes between iTRUS and either pTRUS or MRI (r = 0.89, r = 0.77), not impacted by the addition of hormonal therapy (P = 0.65, P = 0.33). Both consistently predicted intraoperative seed number (r = 0.87, r = 0.86). MRI/TRUS fusion did not significantly increase surgical or anesthesia time (P = 0.10, P = 0.46). mpMRI revealed suspicious focal lesions in 11 of 14 cases not visible on pTRUS, that when correlated with histopathology, were incorporated into the plan. CONCLUSIONS: Relative to pTRUS, MRI yielded reliable preplanning measures, supporting the role of MRI-only LDR treatment planning. mpMRI carries numerous diagnostic, staging and preplanning advantages that facilitate better patient selection and delivery of novel dose escalation and targeted therapy, with no additional surgical or anesthesia time. Prospective studies assessing its impact on treatment planning and delivery can serve to establish mpMRI as the standard of care in LDR prostate brachytherapy planning.
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<a href="http://doi.org/10.1002/acm2.12592" target="_blank" rel="noreferrer noopener">10.1002/acm2.12592</a>
2019
brachytherapy
Colussi Valdir
Ellis Rodney J
Fredman Elisha T
Gross Andrew
Journal of Applied Clinical Medical Physics
June 2019 Update
LDR
Machtay Mitchell
MRI
multiparametric
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
Podder Tarun
Prostate
Traughber Bryan J
TRUS
Vinkler Robert
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ijrobp.2010.05.053" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ijrobp.2010.05.053</a>
Pages
29–34
Issue
1
Volume
81
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Ten-year outcomes: the clinical utility of single photon emission computed tomography/computed tomography capromab pendetide (Prostascint) in a cohort diagnosed with localized prostate cancer.
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International Journal of Radiation Oncology, Biology, Physics
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-09
Subject
The topic of the resource
Male; Aged; Multivariate Analysis; Prognosis; Tomography; Antibodies; Human; Regression; Emission-Computed; Kaplan-Meier Estimator; X-Ray Computed – Methods; Prostate-Specific Antigen – Blood; Prostatic Neoplasms – Pathology; Brachytherapy – Methods; Monoclonal – Diagnostic Use; Prostate – Radiography; Prostatic Neoplasms – Blood; Prostatic Neoplasms – Radiography; Radioisotopes – Diagnostic Use; Single-Photon – Methods
Creator
An entity primarily responsible for making the resource
Ellis RJ; Kaminsky DA; Zhou EH; Fu P; Chen WD; Brelin A; Faulhaber PF; Bodner D; Ellis Rodney J; Kaminsky Deborah A; Zhou Esther H; Fu Pingfu; Chen Wei-Dong; Brelin Alaina; Faulhaber Peter F; Bodner Donald
Description
An account of the resource
Purpose: To evaluate the clinical utility of capromab pendetide imaging with single photon emission computed tomography coregistration with computed tomography (SPECT/CT) in primary prostate cancer (CaP) for pretreatment prognostic staging and localization of biologic target volumes (BTV) for individualized image-guided radiotherapy dose escalation (IGRT-DE). Methods and Materials: Patients consecutively presenting for primary radiotherapy (February 1997 to December 2002), having a clinical diagnosis of localized CaP, were evaluated for tumor stage using conventional staging and SPECT/CT (N=239). Distant metastatic uptake (mets) were identified by SPECT/CT in 22 (9.2%). None of the suspected mets could be clinically confirmed. Thus, all subjects were followed without alteration in disease management. The SPECT/CT pelvic images defined BTV for IGRT-DE (+150% brachytherapy dose) without (n=150) or with (n=89) external radiation of 45 Gy. The National Comprehensive Cancer Network criteria defined risk groups (RG). The median survivor follow-up was 7 years. Biochemical disease-free survival (bDFS) was reported by clinical nadir +2 ng/mL (CN+2) criteria. Statistical analyses included Kaplan-Meier, multivariate analysis, and Concordance-index models. Results: At 10-year analyses, overall survival was 84.8% and bDFS was 84.6%. With stratification by RG, CN+2 bDFS was 93.5% for the low-RG (n=116), 78.7% for the intermediate-RG (n=94), and 68.8% for the high-RG (n=29), p=0.0002. With stratification by pretreatment SPECT/CT findings, bDFS was 65.5% in patients with suspected mets (n=22) vs. 86.6% in patients with only localized uptake (n=217), p=0.0014. CaP disease-specific survival (DSS) was 97.7% for the cohort. With stratification by SPECT/CT findings, DSS was 86.4% (with suspected mets) vs. 99.0% (localized only), p=0.0001. Using multivariate analysis, the DSS hazard ratio for SPECT/CT findings (mets vs. localized) was 3.58 (p=0.0026). Concordance-index tests, based on all data, by CN+2 bDFS criteria were 0.710 for RG alone and 0.773 for SPECT/CT + RG. Conclusions: Through long-term outcomes we demonstrate statistically significant bDFS and DSS predictive value for pretreatment capromab pendetide SPECT/CT imaging in primary CaP. Dual clinical utility is demonstrated, using SPECT/CT to define BTV for individualized IGRT-DE.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ijrobp.2010.05.053" target="_blank" rel="noreferrer noopener">10.1016/j.ijrobp.2010.05.053</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Aged
Antibodies
Bodner D
Bodner Donald
Brachytherapy – Methods
Brelin A
Brelin Alaina
Chen WD
Chen Wei-Dong
Ellis RJ
Ellis Rodney J
Emission-Computed
Faulhaber Peter F
Faulhaber PF
Fu P
Fu Pingfu
Human
International Journal of Radiation Oncology, Biology, Physics
Kaminsky DA
Kaminsky Deborah A
Kaplan-Meier Estimator
Male
Monoclonal – Diagnostic Use
Multivariate Analysis
Prognosis
Prostate – Radiography
Prostate-Specific Antigen – Blood
Prostatic Neoplasms – Blood
Prostatic Neoplasms – Pathology
Prostatic Neoplasms – Radiography
Radioisotopes – Diagnostic Use
Regression
Single-Photon – Methods
Tomography
X-Ray Computed – Methods
Zhou EH
Zhou Esther H