1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0005-2736(88)90272-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0005-2736(88)90272-6</a>
Pages
38–44
Issue
1
Volume
942
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Herpes simplex virus type 1 penetration initiates mobilization of cell surface proteins.
Publisher
An entity responsible for making the resource available
Biochimica et biophysica acta
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-07
Subject
The topic of the resource
Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Actin Cytoskeleton/physiology; Vero Cells; Microscopy; Endocytosis; Amantadine/analogs & derivatives/pharmacology; Colchicine/pharmacology; Cytochalasin B/pharmacology; Herpes Simplex/*physiopathology; Membrane Fluidity; Membrane Proteins/*physiology; Microtubules/physiology; Simplexvirus/*physiology; Fluorescence
Creator
An entity primarily responsible for making the resource
Rosenthal K S; Roess D; Barisas B G
Description
An account of the resource
Changes in membrane structure resulting from herpes simplex virus 1 (HSV-1) penetration were detected using fluorescence photobleaching recovery methods. The effect could be blocked by inhibitors of viral and cellular processes involved in virus penetration. A rapid mode of HSV-1 strain KOS penetration into VERO cells at 37 degrees C normally occurs after a 5 min lag period and is 90-95% complete within 20-30 min. Rates of cell surface protein diffusion increase 2-3-fold after 5 min and return to normal after 25-30 min, this return correlating temporally with the penetration of the virus. At pH 6.3 the lag period preceeding penetration of HSV is increased to 20 min and penetration proceeds much more slowly than at pH 7.4. Inhibition of virus penetration with cytochalasin B or with the antiherpes drug tromantadine also prevents the HSV-1-induced increase in cell surface protein mobility. Colchicine, which does not block HSV-1 penetration, prevents the recovery of the membrane following virus penetration. Therefore, the changes in membrane structure characterized by increased cell surface protein mobility seem to be caused by virus penetration. Cytoskeletal function and integrity are required for the initiation of, and cell recovery from, virus penetration. A pH-sensitive activity, likely to be a virion fusion glycoprotein, is also required.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0005-2736(88)90272-6" target="_blank" rel="noreferrer noopener">10.1016/0005-2736(88)90272-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Actin Cytoskeleton/physiology
Amantadine/analogs & derivatives/pharmacology
Animals
Barisas B G
Biochimica et biophysica acta
Colchicine/pharmacology
Cytochalasin B/pharmacology
Endocytosis
Fluorescence
Herpes Simplex/*physiopathology
Hydrogen-Ion Concentration
In Vitro Techniques
Membrane Fluidity
Membrane Proteins/*physiology
Microscopy
Microtubules/physiology
Roess D
Rosenthal K S
Simplexvirus/*physiology
Vero Cells
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00205.2003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00205.2003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
L679-L689
Issue
4
Volume
286
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanisms Of Alveolar Protein Clearance In The Intact Lung
Publisher
An entity responsible for making the resource available
American Journal of Physiology-Lung Cellular and Molecular Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
acute respiratory distress syndrome; air-blood barrier; apoprotein sp-a; bronchoalveolar lavage fluid; diffusion; endocytosis; epithelial-cell monolayers; ii cells; instillation; intratracheal; junctions; opens tight; perfused rabbit lungs; Physiology; protein; rat lung; Respiratory System; respiratory-distress syndrome; transport pulmonary edema
Creator
An entity primarily responsible for making the resource
Hastings R H; Folkesson H G; Matthay M A
Description
An account of the resource
Transport of protein across the alveolar epithelial barrier is a critical process in recovery from pulmonary edema and is also important in maintaining the alveolar milieu in the normal healthy lung. Various mechanisms have been proposed for clearing alveolar protein, including transport by the mucociliary escalator, intra-alveolar degradation, or phagocytosis by macrophages. However, the most likely processes are endocytosis across the alveolar epithelium, known as transcytosis, or paracellular diffusion through the epithelial barrier. This article focuses on protein transport studies that evaluate these two potential mechanisms in whole lung or animal preparations. When protein concentrations in the air spaces are low, e. g., albumin concentrations <0.5 g/100 ml, protein transport demonstrates saturation kinetics, temperature dependence indicating high energy requirements, and sensitivity to pharmacological agents that affect endocytosis. At higher concentrations, the protein clearance rate is proportional to protein concentration without signs of saturation, inversely related to protein size, and insensitive to endocytosis inhibition. Temperature dependence suggests a passive process. Based on these findings, alveolar albumin clearance occurs by receptor-mediated transcytosis at low protein concentrations but proceeds by passive paracellular mechanisms at higher concentrations. Because protein concentrations in pulmonary edema fluid are high, albumin concentrations of 5 g/100 ml or more, clearance of alveolar protein occurs by paracellular pathways in the setting of pulmonary edema. Transcytosis may be important in regulating the alveolar milieu under nonpathological circumstances. Alveolar degradation may become important in long-term protein clearance, clearance of insoluble proteins, or under pathological conditions such as immune reactions or acute lung injury.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00205.2003" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00205.2003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
acute respiratory distress syndrome
air-blood barrier
American Journal of Physiology-Lung Cellular and Molecular Physiology
apoprotein sp-a
bronchoalveolar lavage fluid
diffusion
Endocytosis
epithelial-cell monolayers
Folkesson H G
Hastings R H
ii cells
instillation
Intratracheal
Journal Article or Conference Abstract Publication
junctions
Matthay M A
opens tight
perfused rabbit lungs
Physiology
Protein
rat lung
Respiratory System
respiratory-distress syndrome
transport pulmonary edema
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1099/0022-1317-70-4-857" target="_blank" rel="noreferrer noopener">http://doi.org/10.1099/0022-1317-70-4-857</a>
Pages
857–867
Volume
70 ( Pt 4)
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mild acidic pH inhibition of the major pathway of herpes simplex virus entry into HEp-2 cells.
Publisher
An entity responsible for making the resource available
The Journal of general virology
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-04
Subject
The topic of the resource
Animals; Cell Line; Electron; Electrophoresis; Endocytosis; Glycoproteins/analysis; Glycosylation; Humans; Hydrogen-Ion Concentration; Microscopy; Polyacrylamide Gel; Simplexvirus/*physiology/ultrastructure; Temperature; Time Factors; Vero Cells; Viral Proteins/analysis/metabolism
Creator
An entity primarily responsible for making the resource
Rosenthal K S; Killius J; Hodnichak C M; Venetta T M; Gyurgyik L; Janiga K
Description
An account of the resource
Penetration of the KOS strain of herpes simplex virus type 1 (HSV-1) and the MS and 333 strains of herpes simplex virus type 2 (HSV-2) into HEp-2 cells at pH 6.3 was at least 100-fold less efficient than at pH 7.4. Penetration of two low passage clinical isolates was completely blocked at pH 6.3. The syncytium-forming
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1099/0022-1317-70-4-857" target="_blank" rel="noreferrer noopener">10.1099/0022-1317-70-4-857</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Animals
Cell Line
Electron
Electrophoresis
Endocytosis
Glycoproteins/analysis
Glycosylation
Gyurgyik L
Hodnichak C M
Humans
Hydrogen-Ion Concentration
Janiga K
Killius J
Microscopy
Polyacrylamide Gel
Rosenthal K S
Simplexvirus/*physiology/ultrastructure
Temperature
The Journal of general virology
Time Factors
Venetta T M
Vero Cells
Viral Proteins/analysis/metabolism