A Rare Case of Occult Advanced Uterine Adenocarcinoma With a Neoplastic Enterouterine Fistula on Presentation
Creator
Rina Ghorpade
Vyshnavi Iswaravaka
Nitant Parekh
Fiona Tissavirasingham
Date
2022
Description
Enterouterine fistula is a rare complication of endometrial carcinoma, typically associated with a clinical presentation of malodorous vaginal discharge. We present a case of occult metastatic endometrial cancer with an initial presentation of embolic stroke, further complicated by an incidental finding of enterouterine fistula on imaging. This case uniquely describes a patient with no symptoms suggestive of uterine malignancy or enterouterine fistula, highlighting a rare presentation of this occult malignancy and further emphasizing the importance of preventative screening.
The impact of obesity and age on quality of life in gynecologic surgery
Creator
Von Gruenigen V E; Gil K M; Frasure H E; Jenison E L; Hopkins M P
Publisher
American Journal of Obstetrics and Gynecology
Date
2005
2005-10
Description
Objective: This study was undertaken to prospectively evaluate the effect of early stage endometrial cancer, age, and obesity on quality of life (QOL). Study design: Women undergoing surgery for endometrial cancer or an adnexal mass determined at surgery to be benign (controls) were enrolled preoperatively and followed for 6 months. Results: Seventy-nine women completed the study. Functional Assessment of Cancer Therapy (FACT-G) scores increased significantly in all women; however, significant differences by patient weight and age were obtained. Obesity was associated with decreased physical FACT-G and SF-36 scores. Older women had lower SF-36 physical scores, higher emotional scores, and less change over time. Conclusion: Women with early endometrial cancer had similar changes in QOL as those who received surgery for benign disease. Obese and elderly women had domain alterations. Given the aging population and rising incidence of obesity, these results emphasize the need for QOL interventions in postoperative gynecologic care of these patients. (C) 2005 Mosby, Inc. All rights reserved.
Obesity-related endometrial cancer: an update on survivorship approaches to reducing cardiovascular death.
Creator
Laskey R A; McCarroll M L; von Gruenigen V E
Publisher
BJOG : an international journal of obstetrics and gynaecology
Date
2016
2016-01
Description
As the rate of obesity increases worldwide, so will the number of women diagnosed with obesity-related malignancy. The strongest correlation between obesity and cancer is endometrial cancer (EC). Obesity is the most significant modifiable risk factor for development of EC and also contributes to the most common cause of death in EC survivors-cardiovascular disease (CVD). Most cancer survivors after diagnosis do not implement lifestyle changes aimed at weight-loss and CVD risk reduction. This selective review highlights recent novel and unique approaches for managing CVD co-morbidities in EC survivorship.
Feasibility of a lifestyle intervention for overweight/obese endometrial and breast cancer survivors using an interactive mobile application.
Creator
McCarroll Michele L; Armbruster Shannon; Pohle-Krauza Rachael J; Lyzen Amy M; Min Sarah; Nash David W; Roulette G Dante; Andrews Stephen J; von Gruenigen Vivian E
Publisher
Gynecologic oncology
Date
2015
2015-06
Description
OBJECTIVE: The study aimed to assess a one-month lifestyle intervention delivered via a web- and mobile-based weight-loss application (app) (LoseIt!) using a healthcare-provider interface. METHODS: Early-stage overweight/obese (body mass index [BMI]\textgreater/=25kg/m(2)) cancer survivors (CS) diagnosed in the past three years, and without recurrent disease were enrolled and received exercise and nutrition counseling using the LoseIt! app. Entry and exit quality of life (FACT-G) and Weight Efficacy Lifestyle Questionnaire (WEL) measuring self-efficacy were measured along with anthropometrics, daily food intake, and physical activity (PA) using the app. RESULTS: Mean participant age was 58.4+/-10.3years (n=50). Significant reductions (p\textless0.0006) in anthropometrics were noted between pre- and post-intervention weight (105.0+/-21.8kg versus 98.6+/-22.5kg); BMI (34.9+/-8.7kg/m(2) versus 33.9+/-8.4kg/m(2)); and waist circumference (108.1+/-14.9cm versus 103.7+/-15.1cm). A significant improvement in pre- and post-intervention total WEL score was noted (99.38+/-41.8 versus 120.19+/-47.1, p=0.043). No significant differences were noted in FACT-G, macronutrient consumption, and PA patterns. CONCLUSION: These results indicate that a lifestyle intervention delivered via a web- and mobile-based weight-loss app is a feasible option by which to elicit short-term reductions in weight. Though these results parallel the recent survivors of uterine cancer empowered by exercise and healthy diet (SUCCEED) trial, it is notable that they were achieved without encumbering significant cost and barrier-access issues (i.e. time, transportation, weather, parking, etc.).
Subject
*Mobile Applications; Adolescent; Adult; Aged; Breast Neoplasms/*therapy; Counseling/*methods; Diet; Endometrial cancer; Endometrial Neoplasms/*therapy; Exercise; Feasibility Studies; Female; Humans; Lifestyle; Middle Aged; Neoplasm Staging; Obesity/*therapy; Overweight/*therapy; Prospective Studies; Quality of Life; Surveys and Questionnaires; Survivors; Weight loss; Young Adult