1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
760–766
Issue
2
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb.
Publisher
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The European journal of neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-02
Subject
The topic of the resource
Male; Animals; *Social Behavior; Rats; Adrenergic beta-Antagonists/pharmacology; Adrenergic beta-Agonists/pharmacology; Microdialysis; Adrenergic alpha-Antagonists/pharmacology; Phentolamine/pharmacology; Isoproterenol/pharmacology; Clonidine/pharmacology; Norepinephrine/pharmacology; Social Dominance; Adrenergic alpha-Agonists/pharmacology; Memory/*drug effects/physiology; Olfactory Bulb/*drug effects/physiology; Oxytocin/*pharmacology; Timolol/pharmacology; Receptors; Adrenergic; Wistar; alpha/*drug effects/physiology; Oxytocin/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen D E; Muraoka S; Engelmann M; Ebner K; Landgraf R
Description
An account of the resource
In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses. The present data indicate that oxytocin exerts this preservation of social recognition through a specific, receptor-mediated mechanism within the olfactory bulb (experiment 1). The involvement of the olfactory bulb norepinephrine system is revealed by the demonstration that retrodialysis of oxytocin into the olfactory bulb increases norepinephrine release (experiment 4). Our data suggest that the increased output of olfactory bulb norepinephrine resulting from oxytocin appears to activate alpha-adrenoceptors to produce this preservation in recognition because infusions of clonidine into the olfactory bulb preserve recognition responses in a manner similar to that observed with oxytocin (experiment 2). In addition, a co-infusion of oxytocin with phentolamine abolishes recognition responses (experiment 3). Accordingly, this model affords the opportunity to study neuropeptide-catecholamine interactions, link these interactions with a specific behavioural outcome and identify a novel function/site of action for oxytocin in the male.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2000
Adrenergic
Adrenergic alpha-Agonists/pharmacology
Adrenergic alpha-Antagonists/pharmacology
Adrenergic beta-Agonists/pharmacology
Adrenergic beta-Antagonists/pharmacology
alpha/*drug effects/physiology
Animals
Clonidine/pharmacology
Dluzen D E
Ebner K
Engelmann M
Isoproterenol/pharmacology
Landgraf R
Male
Memory/*drug effects/physiology
Microdialysis
Muraoka S
Norepinephrine/pharmacology
Olfactory Bulb/*drug effects/physiology
Oxytocin/*pharmacology
Oxytocin/drug effects/*physiology
Phentolamine/pharmacology
Rats
Receptors
Social Dominance
The European journal of neuroscience
Timolol/pharmacology
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0196-9781(98)00047-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(98)00047-3</a>
Pages
999–1005
Issue
6
Volume
19
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1905-06
Subject
The topic of the resource
*Social Behavior; Aging; Animals; Arginine Vasopressin/*pharmacology; Discrimination Learning/*drug effects; Male; Memory/drug effects; Olfactory Bulb/*drug effects; Oxytocin/*pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Dluzen D E; Muraoka S; Engelmann M; Landgraf R
Description
An account of the resource
In the present report, the peptides arginine vasopressin (AVP), oxytocin (OXT) or their respective antagonists were infused bilaterally into the olfactory bulb to assess their effects upon recognition responses. Recognition responses were determined in a social discrimination paradigm and consisted of measuring the amount of investigation directed to either the same (previously exposed) or novel juvenile rats under conditions in which clear recognition responses are either present as tested with a 30 min inter-exposure interval or absent as tested with a 120 min inter-exposure interval. Infusion of AVP or OXT resulted in preserved recognition responses, as tested with a 120 min inter-exposure interval, compared with that observed in vehicle-infused controls. When animals were infused with the AVP or OXT antagonists using two different doses and tested for the display of recognition as tested with the 30 min inter-exposure interval, no effects of these antagonists were obtained with either dose. These results demonstrate that the olfactory bulb represents an additional important central nervous system target site where these peptides can act to preserve social recognition responses. Moreover, our results suggest that the underlying mechanisms by which peptides function within the olfactory bulb differ as a function of whether they are involved with the display versus preservation of recognition responses.
Identifier
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<a href="http://doi.org/10.1016/s0196-9781(98)00047-3" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(98)00047-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
1998
Aging
Animals
Arginine Vasopressin/*pharmacology
Discrimination Learning/*drug effects
Dluzen D E
Engelmann M
Landgraf R
Male
Memory/drug effects
Muraoka S
Olfactory Bulb/*drug effects
Oxytocin/*pharmacology
Peptides
Rats