Browse Items · NEOMED Bibliography Database

The Role of Kv1.2 Channels in Coronary Metabolic Dilation

Tags: 2019, Chilian William, Department of Integrative Medical Sciences, Enrick Molly, Faseb Journal, Hakobyan Tatevik, Kolz Christopher L, NEOMED College of Medicine, Ohanyan Vahagn, Shockling Lindsay, Yin Liya

A Novel Murine Model to Study Postnatal Coronary Collateral Growth by Lineage Tracing

Tags: 2019, Chilian William M, Circulation research, Department of Anatomy & Neurobiology, Department of Integrative Medical Sciences, Enrick Molly, Gadd James, Jamaiyar Anurag, Juguilon Cody, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, NEOMED Student Publications, Richardson Devan, Wang Tao, Yin Liya

Cardioprotection During Ischemia by Induced Coronary Collateral Growth

Doxorubicin-induced cardiomyopathy: Prevention and treatment by a coronary specific vasodilator

Tags: 2019, Chilian William, Department of Integrative Medical Sciences, Enrick Molly, Faseb Journal, Gyulkhasyan Tigran, Hakobyan Tatevik, Kolz Christopher L, NEOMED College of Medicine, NEOMED College of Medicine Student, NEOMED Student Publications, Ohanyan Vahagn, Parikh Ankur, Peketi Punita, Shockling Lindsay

Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation.

RATIONALE: In the working heart, coronary blood flow is linked to the production of metabolites, which modulate tone of smooth muscle in a redox-dependent manner. Voltage-gated potassium channels (Kv), which play a role in controlling membrane…

Tags: 129 Strain, 2015, Animals, Bardakjian Raffi, Bratz Ian, Cardiac function, Chilian William M, Circulation research, contrast echocardiography, Coronary Circulation/*physiology, Coronary Vessels/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Enrick Molly, Fu Frances Kwan, Graham Jacqueline, Hakobyan Tatevik, Hou Huagang, Hydrogen peroxide, Inbred C57BL, ion channel, Janota Danielle, Khan Nadeem, Kmetz John, Knockout, Kolz Christopher, Kuppusamy Periannan, Kv1.5 Potassium Channel/*physiology, Lindner Jonathan R, Logan Suzanna, Luli Jordan, Mice, Muscle, Nagane Masaki, NEOMED College of Medicine, NEOMED College of Pharmacy, Ohanyan Vahagn, Oyewumi Moses O, Smooth, Transgenic, Transgenic mice, Vascular/*metabolism, vasodilation, Vasodilation/*physiology, voltage-gated potassium channels, Yin Liya

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling.

OBJECTIVE: Our goal was to determine the mechanism by which mitochondrial oxidative stress impairs collateral growth in the heart. APPROACH AND RESULTS: Rats were treated with rotenone (mitochondrial complex I inhibitor that increases reactive oxygen…

Tags: 2013, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Arteriosclerosis, thrombosis, and vascular biology, Body Weight/physiology, Cells, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Collateral Circulation, Coronary Circulation, Coronary Vessels/cytology/*enzymology, Cultured, Department of Integrative Medical Sciences, Disease Models, Dyck Jason R B, Endothelial Cells/cytology/*enzymology, Enrick Molly, Hardwick James P, Humans, Inbred WKY, Ischemia/metabolism/pathology, Kolz Christopher, Mitochondria, Mitochondria/drug effects/*metabolism, Myocardium/enzymology/pathology, NEOMED College of Medicine, Oxidative Stress/*physiology, Pung Yuh Fen, Rats, reactive oxygen species, Rotenone/pharmacology, Sam Wai Johnn, Signal Transduction/*physiology, Stevanov Kelly, Thakker Prashanth, TOR Serine-Threonine Kinases/metabolism, Uncoupling Agents/pharmacology, Yin Liya

Cardioprotection during ischemia by coronary collateral growth.

Ischemic heart diseases (IHD) cause millions of deaths around the world annually. While surgical and pharmacological interventions are commonly used to treat patients with IHD, their efficacy varies from patient to patient and is limited by the…

Tags: 2019, American journal of physiology. Heart and circulatory physiology, cardioprotection, Chilian William M, Coronary Circulation, coronary collateral growth, Cumpston Devan, Department of Integrative Medical Sciences, Dong Feng, Enrick Molly, ischemia, Jamaiyar Anurag, Juguilon Cody, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, Yin Liya

Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart.

The connection between metabolism and flow in the heart, metabolic dilation, is essential for cardiac function. We recently found redox-sensitive Kv1.5 channels play a role in coronary metabolic dilation; however, more than one ion channel likely…

Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.

Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has…

Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya

Browse Items (10 total)