Browse Items (6 total)
- Tags: Enzyme Activation/drug effects
A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Tags: 2010, Calcitriol/*metabolism, Calcitriol/pharmacology, Cell Membrane/drug effects/metabolism, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/antagonists & inhibitors/genetics, Department of Integrative Medical Sciences, Ellis Ewa, Enzyme Activation/drug effects, Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors, Genetic/genetics, Han Shuxin, Hep G2 Cells, Hepatocyte Nuclear Factor 4/metabolism, Hepatocytes/*drug effects/enzymology/*metabolism, Humans, Intracellular Space/drug effects/metabolism, Li Tiangang, Ligands, Lithocholic Acid/*pharmacology, Mitogen-Activated Protein Kinase Kinases/metabolism, Molecular endocrinology (Baltimore, Md.), NEOMED College of Medicine, Phosphorylation/drug effects, Phosphotyrosine/metabolism, Promoter Regions, Protein Kinase Inhibitors/pharmacology, Protein Transport/drug effects, Proto-Oncogene Proteins c-raf/metabolism, Receptors, Retinoid X Receptor alpha/metabolism, Signal Transduction/*drug effects, src-Family Kinases/metabolism, Steroid Hydroxylases/genetics/metabolism, Strom Stephen, Vitamin D3 24-Hydroxylase
Oxytocin-induced labor augments IL-1beta-stimulated lung fluid absorption in fetal guinea pig lungs.
Tags: *Labor, 2005, Absorption/drug effects, American journal of physiology. Lung cellular and molecular physiology, Amiloride/administration & dosage, Animals, Bhattacharjee Reshma, Enzyme Activation/drug effects, Enzyme Inhibitors/administration & dosage, Epinephrine/metabolism, Extravascular Lung Water/*metabolism, Female, Fetal Organ Maturity/drug effects, Fetus/metabolism, Folkesson Hans G, Guinea Pigs, Hydrocortisone/metabolism, Induced, Interleukin-1/*administration & dosage/metabolism, Ion Transport/drug effects, Li Tianbo, Lung/*embryology, Maternal-Fetal Exchange/drug effects, Metyrapone/administration & dosage, Nair Prem K, Oxytocics/*administration & dosage, Oxytocin/*administration & dosage, Pregnancy, Propranolol/administration & dosage, Sodium Channel Blockers/administration & dosage, Sodium-Potassium-Chloride Symporters/metabolism, Vasodilator Agents/administration & dosage, Ye Xin
High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor.
Tags: *Cancer, *Compound library, *Kinase, *Notochord, *Phenotypic screen, *Somites, *Zebrafish, 2017, Aljammal Rowaa, Animals, Antineoplastic Agents/chemistry/pharmacology, Antitumor/methods, Benzoic Acid/chemistry/pharmacology, Bergeron Sadie A, Bioorganic & medicinal chemistry letters, Chen Wei-Chi, Death-Associated Protein Kinases/metabolism, Department of Integrative Medical Sciences, Drug Discovery/*methods, Drug Screening Assays, Embryo, Enzyme Activation/drug effects, Enzyme Activators/*chemistry/*pharmacology, Gaasch Briah L, Geldenhuys Werner J, Hazlehurst Lori A, Mullins Jackie E, NEOMED College of Medicine, Neoplasms/drug therapy/enzymology, Nonmammalian/*drug effects/enzymology, Protein Kinase Inhibitors/*chemistry/*pharmacology, Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Yun June, Zebrafish Proteins/antagonists & inhibitors/metabolism, Zebrafish/*embryology
A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.
Tags: *Monoamine Oxidase/chemistry/metabolism, 2012, Benzofurans/chemistry/pharmacology, Bioorganic & medicinal chemistry letters, Carroll Richard T, Enzyme Activation/drug effects, Flavonoids/chemistry/pharmacology, Funk Max O, Geldenhuys Werner J, Humans, Inhibitory Concentration 50, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/*chemistry/*pharmacology, Protein Binding/drug effects, Small Molecule Libraries, Structure-Activity Relationship, Van der Schyf Cornelis J
A plant lignan, 3'-O-methyl-nordihydroguaiaretic acid, suppresses papillomavirus E6 protein function, stabilizes p53 protein, and induces apoptosis in cervical tumor cells.
Tags: 2007, Allen Kristi L, Apoptosis Regulatory Proteins/metabolism, Apoptosis/*drug effects, Awad Keytam S, bcl-2-Associated X Protein/metabolism, Caspase 3/metabolism, Caspase 9/metabolism, Cultured/drug effects, DeLucia Angelo L, Department of Integrative Medical Sciences, Enzyme Activation/drug effects, Female, Genetic, Humans, Luciferases, Lynch William P, Masoprocol/*analogs & derivatives/therapeutic use, Molecular carcinogenesis, NEOMED College of Medicine, Oncogene Proteins, Plants/chemistry, Proto-Oncogene Proteins/metabolism, Repressor Proteins/*metabolism, Transcription, Tschantz Deidra R, Tumor Cells, Tumor Suppressor Protein p53/genetics/*metabolism, Uterine Cervical Neoplasms/*drug therapy/metabolism/pathology, Viral/*metabolism
Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat alpha 1- and alpha 2-macroglobulins.
Tags: 1998, alpha-Macroglobulins/administration & dosage/*pharmacology, Animals, Cells, Choline O-Acetyltransferase/*antagonists & inhibitors, Corpus Striatum/drug effects/*enzymology/metabolism, Cultured, Dluzen D E, Dopamine Antagonists/*pharmacology, Dopamine/analysis/*metabolism, Enzyme Activation/drug effects, Hu Y Q, Injections, Intraventricular, Journal of neuroscience research, Koo P H, Liebl D J, Male, Neurons/drug effects/*enzymology/metabolism, Rats, Serotonin/pharmacology, Sprague-Dawley, Stereotaxic Techniques