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Text
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<a href="http://doi.org/10.1152/jappl.1999.87.2.611" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1999.87.2.611</a>
Pages
611–618
Issue
2
Volume
87
Dublin Core
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Title
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Effect of epinephrine on alveolar liquid clearance in the rat.
Publisher
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Journal of applied physiology (Bethesda, Md. : 1985)
Date
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1999
1999-08
Subject
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Adrenergic; Adrenergic beta-Agonists/*pharmacology; Amiloride/pharmacology; Animals; beta/metabolism; Bronchoalveolar Lavage Fluid/chemistry; Epinephrine/blood/*pharmacology; Male; Norepinephrine/blood; Propranolol/pharmacology; Pulmonary Alveoli/*drug effects; Rats; Receptors; Serum Albumin/metabolism; Sprague-Dawley; Time Factors
Creator
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Charron P D; Fawley J P; Maron M B
Description
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Endogenous epinephrine has been found to increase alveolar liquid clearance (ALC) in several pulmonary edema models. In this study, we infused epinephrine intravenously for 1 h in anesthetized rats to produce plasma epinephrine concentrations commonly observed in this species under stressful conditions and measured ALC by mass balance. Epinephrine increased ALC from 31.5 +/- 3.2 to 48.9 +/- 1.1 (SE)% of the instilled volume (P \textless 0.05). The increased ALC was prevented by either propranolol or amiloride. To determine whether ALC returns to normal after plasma epinephrine concentration normalizes, we measured ALC 2 h after stopping an initial 1-h epinephrine infusion and found ALC to be at baseline values. Finally, to determine whether desensitization of the liquid clearance response occurs, we evaluated the effects of both repeated 1-h infusions and a continuous 4-h infusion of epinephrine on ALC and found no reduction in ALC under either condition. We conclude that epinephrine increases ALC by stimulating beta-adrenoceptors and sodium transport, that the increase is reversible once plasma epinephrine concentration normalizes, and that desensitization of the ALC response does not appear to occur after 4 h of continuous epinephrine exposure.
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<a href="http://doi.org/10.1152/jappl.1999.87.2.611" target="_blank" rel="noreferrer noopener">10.1152/jappl.1999.87.2.611</a>
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1999
Adrenergic
Adrenergic beta-Agonists/*pharmacology
Amiloride/pharmacology
Animals
beta/metabolism
Bronchoalveolar Lavage Fluid/chemistry
Charron P D
Epinephrine/blood/*pharmacology
Fawley J P
Journal of applied physiology (Bethesda, Md. : 1985)
Male
Maron M B
Norepinephrine/blood
Propranolol/pharmacology
Pulmonary Alveoli/*drug effects
Rats
Receptors
Serum Albumin/metabolism
Sprague-Dawley
Time Factors