1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0040-8166(95)80017-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0040-8166(95)80017-4</a>
Pages
149–157
Issue
2
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ultrastructural changes of female Syrian hamster cystic duct epithelium as a result of sex steroid treatment.
Publisher
An entity responsible for making the resource available
Tissue & cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-04
Subject
The topic of the resource
Animals; Cell Nucleus/drug effects/ultrastructure; Combination; Cricetinae; Cystic Duct/*drug effects/*ultrastructure; Drug Therapy; Epithelium/drug effects/ultrastructure; Estrogens/*pharmacology; Female; Gallbladder/drug effects/ultrastructure; Medroxyprogesterone/*pharmacology; Mesocricetus
Creator
An entity primarily responsible for making the resource
Gilloteaux J; Karkare S; Kelly T R
Description
An account of the resource
In view of the lack of sufficient data regarding the morphology of the cystic duct and the extensive focus on the gallbladder, a preliminary examination of the cystic duct response to female sex steroid treatment was conducted to follow up a detailed ultrastructural study of the gallbladder epithelial response to a similar treatment. As observed in the gallbladder epithelium, the cystic duct epithelial cells of nulliparous Syrian hamsters demonstrate morphologic changes in response to female sex steroid treatment. Control (C) cystic duct epithelial cells are covered by short microvilli and each cell appears to exhibit a single vestigial cilium. Estrogen (E)- and estrogen + medroxyprogesterone (E + MP)-treatments induce differential duct cell morphologic changes. These changes are the result of steroid treatments in the significant decreasing sequence E \textgreater E + MP \textgreater C for nuclear volume, indentations and perinuclear lysosomal/lipofuscin bodies. Moreover E + MP-treatment results in larger cytoplasmic volume and more sloughing of apical cell excrescences than following E treatment. It is suggested that, similar to that in the gallbladder, the action of progestin is paramount in favoring cytoplasmic morphological changes in the cystic duct which, along with the alteration of mucus, cell sloughing, decreased bile acids and motility could also participate in the gallstone nucleation process as they are brought into the gallbladder with the incoming bile flow.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0040-8166(95)80017-4" target="_blank" rel="noreferrer noopener">10.1016/s0040-8166(95)80017-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Cell Nucleus/drug effects/ultrastructure
Combination
Cricetinae
Cystic Duct/*drug effects/*ultrastructure
Drug Therapy
Epithelium/drug effects/ultrastructure
Estrogens/*pharmacology
Female
Gallbladder/drug effects/ultrastructure
Gilloteaux J
Karkare S
Kelly T R
Medroxyprogesterone/*pharmacology
Mesocricetus
Tissue & cell
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0040-8166(92)90022-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0040-8166(92)90022-y</a>
Pages
869–878
Issue
6
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Female sex steroid induced epithelial changes in the gallbladder of the ovariectomized Syrian hamster.
Publisher
An entity responsible for making the resource available
Tissue & cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1905-06
Subject
The topic of the resource
Animals; Cholesterol; Cricetinae; Dietary/*administration & dosage; Electron; Epithelium/drug effects/ultrastructure; Estrogens/*adverse effects; Female; Gallbladder/*drug effects/ultrastructure; Mesocricetus; Microscopy; Ovariectomy; Ovary/*physiology; Progesterone/*adverse effects; Scanning
Creator
An entity primarily responsible for making the resource
Gilloteaux J; Karkare S; Ko W; Kelly T R
Description
An account of the resource
Ovariectomized Syrian hamsters treated by female sex steroids during a 1-month period show gallbladder surface epithelial changes in the fundic area consistent with apical bulging and decapitations of the epithelial cells. These events were detected in the infundibulum and the fundic or body regions of estrogen- and estrogen+progesterone-treated hamsters. In control hamsters, these events were restricted to the region in the vicinity of the bile duct. Following steroid treatment, intraluminal deposits detected resembled Ca-bilirubinate deposits described in previous studies while decapitations are similar to endometrial epithelium changes associated with hormonal physiological changes or treatments. Moreover some small electron-dense deposits are comparable to those found in human cholesterol gallstones. This report indicates that, besides an alteration in bile composition, cell fragments originating from the surface epithelium of the bile duct and/or of the gallbladder mucosal epithelium could participate in gallstone nucleation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0040-8166(92)90022-y" target="_blank" rel="noreferrer noopener">10.1016/0040-8166(92)90022-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Cholesterol
Cricetinae
Dietary/*administration & dosage
Electron
Epithelium/drug effects/ultrastructure
Estrogens/*adverse effects
Female
Gallbladder/*drug effects/ultrastructure
Gilloteaux J
Karkare S
Kelly T R
Ko W
Mesocricetus
Microscopy
Ovariectomy
Ovary/*physiology
Progesterone/*adverse effects
Scanning
Tissue & cell
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
53–74
Issue
1
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gallstones induced by sex steroids in the female Syrian hamster: duration effects.
Publisher
An entity responsible for making the resource available
Journal of submicroscopic cytology and pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
Female; Time Factors; Animals; Body Weight; Lipids/blood; Organ Size; Cricetinae; Mesocricetus; Epithelium/drug effects/ultrastructure; Cholelithiasis/*chemically induced; Estradiol/*toxicity; Gallbladder/*drug effects/pathology; Medroxyprogesterone/*toxicity; Microscopy; Electron
Creator
An entity primarily responsible for making the resource
Karkare S; Gilloteaux J
Description
An account of the resource
Scanning (SEM), and transmission (TEM) electron microscopy were used and correlated to morphologically characterize changes induced in the gallbladder epithelium of female Syrian hamster in response to treatments with estradiol (E) alone, and estradiol with medroxyprogesterone (E + MP). Compared with control (C), the E- and E + MP-treated groups demonstrated alterations in the serum lipid profile as well as significantly decreased body weights. The liver with gallbladder weights, as well as the uterus weights, were significantly increased. Two-month E and E + MP treatment groups exhibited increased number of anionically charged apical granules, and luminal mucoid elements. Contrastingly, the three-month treatment groups demonstrated larger and more gallstone-like deposits as compared to the C and two-month E and E + MP groups. This report presents a comprehensive overview of our previous and current data, including that of other investigators in relation to the various factors and parameters involved in the cholelithiatic process.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Body Weight
Cholelithiasis/*chemically induced
Cricetinae
Electron
Epithelium/drug effects/ultrastructure
Estradiol/*toxicity
Female
Gallbladder/*drug effects/pathology
Gilloteaux J
Journal of submicroscopic cytology and pathology
Karkare S
Lipids/blood
Medroxyprogesterone/*toxicity
Mesocricetus
Microscopy
Organ Size
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
35–52
Issue
1
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Morphological aspects of female Syrian hamster gallbladder induced by one-month sex steroid treatment.
Publisher
An entity responsible for making the resource available
Journal of submicroscopic cytology and pathology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
Female; Animals; Body Weight; Lipids/blood; Organ Size; Cricetinae; Mesocricetus; Epithelium/drug effects/ultrastructure; Estradiol/*toxicity; Medroxyprogesterone/*toxicity; Gallbladder/*drug effects/metabolism/ultrastructure; Microscopy; Electron; Scanning
Creator
An entity primarily responsible for making the resource
Karkare S; Kelly T R; Gilloteaux J
Description
An account of the resource
Light (LM), transmission (TEM), and scanning (SEM) electron microscopy were used to characterize morphological changes induced in the gallbladder epithelium of female Syrian hamsters in response to one-month estradiol alone (E) and estradiol with medroxyprogesterone (E + MP) treatments. TEM data were correlated with the SEM observations. Compared with control (C), E- and E + MP-treated hamsters showed significant decreases in body weight, while the liver and gallbladder, and uterus weights increased. Moreover, E treatment induced some subcellular changes (microvilli, nucleus, mitochondria, RER, glycogen, abundant apical granules). The E + MP treatment appeared to exacerbate these similar changes and, in addition, induced apical excrescences and cell shedding. Both E and E + MP gallbladders showed luminal micelles, cellular debris and crystalliths associated with mucus. Simultaneously, an increased acidification of the mucoid content of the apical granules was noticed.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Body Weight
Cricetinae
Electron
Epithelium/drug effects/ultrastructure
Estradiol/*toxicity
Female
Gallbladder/*drug effects/metabolism/ultrastructure
Gilloteaux J
Journal of submicroscopic cytology and pathology
Karkare S
Kelly T R
Lipids/blood
Medroxyprogesterone/*toxicity
Mesocricetus
Microscopy
Organ Size
Scanning