1
40
7
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1161/CIRCULATIONAHA.116.024826" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/CIRCULATIONAHA.116.024826</a>
Pages
1240–1252
Issue
13
Volume
135
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling.
Publisher
An entity responsible for making the resource available
Circulation
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
Adenosine Triphosphate – Metabolism; Adenosine Triphosphate/*metabolism; Animal Studies; Animals; contrast echocardiography; Equipment and Supplies; Hemodynamics; Humans; Inbred C57BL; Male; Mice; microbubbles; Microbubbles; microcirculation; Muscle; Neurotransmitter Agents – Metabolism; perfusion; Purinergic Agents/*metabolism; Signal Transduction; Skeletal – Blood Supply; Skeletal/*blood supply; Ultrasonography – Methods; Ultrasonography/*methods
Creator
An entity primarily responsible for making the resource
Belcik J Todd; Davidson Brian P; Xie Aris; Wu Melinda D; Yadava Mrinal; Qi Yue; Liang Sherry; Chon Chae Ryung; Ammi Azzdine Y; Field Joshua; Harmann Leanne; Chilian William M; Linden Joel; Lindner Jonathan R
Description
An account of the resource
BACKGROUND: Augmentation of tissue blood flow by therapeutic ultrasound is thought to rely on convective shear. Microbubble contrast agents that undergo ultrasound-mediated cavitation markedly amplify these effects. We hypothesized that purinergic signaling is responsible for shear-dependent increases in muscle perfusion during therapeutic cavitation. METHODS: Unilateral exposure of the proximal hindlimb of mice (with or without ischemia produced by iliac ligation) to therapeutic ultrasound (1.3 MHz, mechanical index 1.3) was performed for 10 minutes after intravenous injection of 2x10(8) lipid microbubbles. Microvascular perfusion was evaluated by low-power contrast ultrasound perfusion imaging. In vivo muscle ATP release and in vitro ATP release from endothelial cells or erythrocytes were assessed by a luciferin-luciferase assay. Purinergic signaling pathways were assessed by studying interventions that (1) accelerated ATP degradation; (2) inhibited P2Y receptors, adenosine receptors, or KATP channels; or (3) inhibited downstream signaling pathways involving endothelial nitric oxide synthase or prostanoid production (indomethacin). Augmentation in muscle perfusion by ultrasound cavitation was assessed in a proof-of-concept clinical trial in 12 subjects with stable sickle cell disease. RESULTS: Therapeutic ultrasound cavitation increased muscle perfusion by 7-fold in normal mice, reversed tissue ischemia for up to 24 hours in the murine model of peripheral artery disease, and doubled muscle perfusion in patients with sickle cell disease. Augmentation in flow extended well beyond the region of ultrasound exposure. Ultrasound cavitation produced an approximately 40-fold focal and sustained increase in ATP, the source of which included both endothelial cells and erythrocytes. Inhibitory studies indicated that ATP was a critical mediator of flow augmentation that acts primarily through either P2Y receptors or adenosine produced by ectonucleotidase activity. Combined indomethacin and inhibition of endothelial nitric oxide synthase abolished the effects of therapeutic ultrasound, indicating downstream signaling through both nitric oxide and prostaglandins. CONCLUSIONS: Therapeutic ultrasound using microbubble cavitation to increase muscle perfusion relies on shear-dependent increases in ATP, which can act through a diverse portfolio of purinergic signaling pathways. These events can reverse hindlimb ischemia in mice for \textgreater24 hours and increase muscle blood flow in patients with sickle cell disease. CLINICAL TRIAL REGISTRATION: URL: http://clinicaltrials.gov. Unique identifier: NCT01566890.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1161/CIRCULATIONAHA.116.024826" target="_blank" rel="noreferrer noopener">10.1161/CIRCULATIONAHA.116.024826</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Adenosine Triphosphate – Metabolism
Adenosine Triphosphate/*metabolism
Ammi Azzdine Y
Animal Studies
Animals
Belcik J Todd
Chilian William M
Chon Chae Ryung
Circulation
contrast echocardiography
Davidson Brian P
Department of Integrative Medical Sciences
Equipment and Supplies
Field Joshua
Harmann Leanne
Hemodynamics
Humans
Inbred C57BL
Liang Sherry
Linden Joel
Lindner Jonathan R
Male
Mice
Microbubbles
Microcirculation
Muscle
NEOMED College of Medicine
Neurotransmitter Agents – Metabolism
Perfusion
Purinergic Agents/*metabolism
Qi Yue
Signal Transduction
Skeletal – Blood Supply
Skeletal/*blood supply
Ultrasonography – Methods
Ultrasonography/*methods
Wu Melinda D
Xie Aris
Yadava Mrinal
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/RUQ.0b013e3181b4f9cf" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/RUQ.0b013e3181b4f9cf</a>
Pages
171–173
Issue
4
Volume
25
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contrast-enhanced ultrasound detection and treatment guidance in a renal transplant patient with renal cell carcinoma.
Publisher
An entity responsible for making the resource available
Ultrasound quarterly
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
*Fluorocarbons; Aged; Angiography; Biopsy; Carcinoma; Catheter Ablation; Catheter Ablation/*methods; Computer-Assisted/methods; Contrast Media; Equipment and Supplies; Humans; Kidney Neoplasms/*diagnostic imaging/*surgery; Magnetic Resonance Imaging; Male; Renal Cell – Diagnosis; Renal Cell – Epidemiology; Renal Cell/*diagnostic imaging/*surgery; Surgery; Tomography; Treatment Outcome; Ultrasonography; Ultrasonography/*methods
Creator
An entity primarily responsible for making the resource
Sanchez Kimberly; Barr Richard G
Description
An account of the resource
Contrast-enhanced ultrasonography (CEUS) is an imaging modality that shows promise in the detection and characterization of renal masses, as well as treatment through CEUS-guided percutaneous radiofrequency ablation. These techniques may be especially valuable in challenging patients who cannot tolerate traditional contrast agents, such as those with diminished renal function, and those who cannot tolerate more invasive surgical treatment. The following case report details an incidence of renal cell carcinoma in a renal transplant patient whose tumor was diagnosed with CEU and successfully treated with CEUS-guided percutaneous RFA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/RUQ.0b013e3181b4f9cf" target="_blank" rel="noreferrer noopener">10.1097/RUQ.0b013e3181b4f9cf</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Fluorocarbons
2009
Aged
Angiography
Barr Richard G
Biopsy
Carcinoma
Catheter Ablation
Catheter Ablation/*methods
Computer-Assisted/methods
Contrast Media
Equipment and Supplies
Humans
Kidney Neoplasms/*diagnostic imaging/*surgery
Magnetic Resonance Imaging
Male
Renal Cell – Diagnosis
Renal Cell – Epidemiology
Renal Cell/*diagnostic imaging/*surgery
Sanchez Kimberly
Surgery
Tomography
Treatment Outcome
Ultrasonography
Ultrasonography/*methods
Ultrasound quarterly
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.5811/westjem.2013.12.18855" target="_blank" rel="noreferrer noopener">http://doi.org/10.5811/westjem.2013.12.18855</a>
Pages
199–204
Issue
2
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Improving bariatric patient transport and care with simulation.
Publisher
An entity responsible for making the resource available
The western journal of emergency medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-03
Subject
The topic of the resource
Humans; United States; Educational Measurement; Education; Emergency Medicine; Obesity/*therapy; Patient Care; Airway Management; Allied Health Personnel/*education; Cardiopulmonary Resuscitation/education; Manikins; Transportation of Patients/*methods/standards; Catheterization; Human; Simulations; Analysis of Covariance; Trauma; Medical; Models; Infusions; Educational; Intraosseous/methods; Peripheral/methods; Technology; Equipment and Supplies; Bariatric Patients; Control Group; Firefighters; Obesity – Surgery; Transportation of Patients – Methods; Airway Management – Education; Emergency Medical Technicians – Education; Health Knowledge – Evaluation
Creator
An entity primarily responsible for making the resource
Gable Brad D; Gardner Aimee K; Celik Dan H; Bhalla Mary Colleen; Ahmed Rami A
Description
An account of the resource
INTRODUCTION: Obesity is prevalent in the United States. Obese patients have physiologic differences from non-obese individuals. Not only does transport and maintenance of these patients require use of specialized equipment, but it also requires a distinct skill set and knowledge base. To date, there is no literature investigating simulation as a model for educating pre-hospital providers in the care of bariatric patients. The purpose of this study was to determine if a
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.5811/westjem.2013.12.18855" target="_blank" rel="noreferrer noopener">10.5811/westjem.2013.12.18855</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Ahmed Rami A
Airway Management
Airway Management – Education
Allied Health Personnel/*education
Analysis of Covariance
Bariatric Patients
Bhalla Mary Colleen
Cardiopulmonary Resuscitation/education
Catheterization
Celik Dan H
Control Group
Department of Emergency Medicine
Education
Educational
Educational Measurement
Emergency Medical Technicians – Education
Emergency Medicine
Equipment and Supplies
Firefighters
Gable Brad D
Gardner Aimee K
Health Knowledge – Evaluation
Human
Humans
Infusions
Intraosseous/methods
Manikins
Medical
Models
NEOMED College of Medicine
Obesity – Surgery
Obesity/*therapy
Patient Care
Peripheral/methods
Simulations
Technology
The western journal of emergency medicine
Transportation of Patients – Methods
Transportation of Patients/*methods/standards
trauma
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
20–21
Issue
5
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Is middleware the right medicine?
Publisher
An entity responsible for making the resource available
Health Management Technology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-05
Subject
The topic of the resource
Access to Information; Software; Equipment and Supplies; Electronic Data Interchange; Clinical Information Systems; Health Level 7; Hospital Information Systems; Organizational Structure; Systems Integration
Creator
An entity primarily responsible for making the resource
Voltz Donald; Thanh Tran
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Access to Information
Clinical Information Systems
Electronic Data Interchange
Equipment and Supplies
Health Level 7
Health Management Technology
Hospital Information Systems
Organizational Structure
Software
Systems Integration
Thanh Tran
Voltz Donald
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/RUQ.0b013e3181dc7ce4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/RUQ.0b013e3181dc7ce4</a>
Pages
61–66
Issue
2
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Real-time ultrasound elasticity of the breast: initial clinical results.
Publisher
An entity responsible for making the resource available
Ultrasound quarterly
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
*Elasticity Imaging Techniques; *Image Processing; Adult; Aged; Biopsy; Breast; Breast – Pathology; Breast Diseases/diagnostic imaging/pathology; Breast Neoplasms – Diagnosis; Breast Neoplasms/*diagnostic imaging/*pathology; Computer-Assisted; Data Analysis Software; Diagnosis; Differential; Elasticity; Equipment and Supplies; Female; Humans; Immunohistochemistry; Mammary/*methods; Middle Aged; Needle; Ohio; Sensitivity and Specificity; Ultrasonography
Creator
An entity primarily responsible for making the resource
Barr Richard G
Description
An account of the resource
PURPOSE: To determine the sensitivity and specificity of a real-time elasticity imaging (EI) ultrasound (US) system in the characterization of breast lesions as benign or malignant. METHODS: A total of 208 patients with 251 lesions were scheduled to undergo a US-guided breast biopsy for a mass identified on B-mode US, and each received a real-time elasticity image of the lesion before the biopsy. The lesion size measurements were obtained, and the EI/B-mode size ratio was obtained. The pathology report was obtained and correlated with the EI/B-mode ratio. An EI/B-mode ratio equal to or greater than 1 was considered malignant lesion, whereas EI/B-mode ratios of less than 1 were considered benign. Sensitivity, specificity, positive predictive values, and negative predictive values were calculated. RESULTS: Of the 251 lesions biopsied, 197 were pathologically benign, and 54 were malignant. Of the 54 malignant lesions, all had an EI/B-mode ratio equal to or greater than 1. Of the 197 benign lesions, 187 had an EI/B-mode ratio of less than 1. Ten benign lesions had an EI/B-mode ratio of greater than 1. The benign lesions that had an EI/B-mode ratio of greater than 1 were lesions with dense fibrosis, and in addition, a characteristic artifact was identified, which was visualized in all simple and complex cysts. The results correspond with a sensitivity of 100%, specificity of 95%, a positive predictive value of 84%, and a negative predictive value of 100%. CONCLUSIONS: Initial results of a real-time EI system for characterization of breast lesions suggest this technique can provide significant new diagnostic information. As a result, this information may significantly improve the ability to select patients for breast biopsy, resulting in a reduction in the number of benign breast biopsies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/RUQ.0b013e3181dc7ce4" target="_blank" rel="noreferrer noopener">10.1097/RUQ.0b013e3181dc7ce4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Elasticity Imaging Techniques
*Image Processing
2010
Adult
Aged
Barr Richard G
Biopsy
breast
Breast – Pathology
Breast Diseases/diagnostic imaging/pathology
Breast Neoplasms – Diagnosis
Breast Neoplasms/*diagnostic imaging/*pathology
Computer-Assisted
Data Analysis Software
Diagnosis
Differential
Elasticity
Equipment and Supplies
Female
Humans
Immunohistochemistry
Mammary/*methods
Middle Aged
Needle
Ohio
Sensitivity and Specificity
Ultrasonography
Ultrasound quarterly
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/RUQ.0b013e318249f594" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/RUQ.0b013e318249f594</a>
Pages
13–20
Issue
1
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Shear wave ultrasound elastography of the prostate: initial results.
Publisher
An entity responsible for making the resource available
Ultrasound quarterly
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-03
Subject
The topic of the resource
*Endosonography; Aged; Biopsy; Biopsy – Methods; Diagnosis; Differential; Elasticity; Elasticity Imaging Techniques/*methods; Equipment and Supplies; Follow-Up Studies; Health Screening; Human; Humans; Magnetic Resonance Imaging; Male; Middle Age; Middle Aged; Ohio; Predictive Value of Tests; Prospective Studies; Prostate – Analysis; Prostate – Anatomy and Histology; Prostate-Specific Antigen – Blood; Prostate/*diagnostic imaging/pathology; Prostatic Hypertrophy; Prostatic Neoplasms – Diagnosis; Prostatic Neoplasms – Pathology; Prostatic Neoplasms/*diagnostic imaging/pathology; Rectum; ROC Curve; Sensitivity and Specificity; Spectrum Analysis; Ultrasonography – Methods
Creator
An entity primarily responsible for making the resource
Barr Richard G; Memo Richard; Schaub Carl R
Description
An account of the resource
PURPOSE: This prospective study was to evaluate shear wave elastography (SWE) in the detection of prostate cancer (PC). METHODS: Patients scheduled for a transrectal ultrasound (TRUS) biopsy of the prostate because of elevated prostate-specific antigen levels or abnormal digital rectal examination result underwent a standard TRUS and SWE. A second TRUS examination and sextant biopsy by a second physician blinded to SWE results was then performed. Pathologic result was reviewed, and sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated. RESULTS: A total of 53 patients (318 sextants) participated in the study. Mean age was 64.2 years (range, 53-79 years). A total of 26 foci of PC were detected in 11 patients (20.7%). On the basis of the receiver operating characteristic curve, a value of 37 kPa was used as the cutoff between benign and malignant. This produced a sensitivity of 96.2% (25/26), a specificity of 96.2% (281/292), a PPV of 69.4% (25/36), and an NPV of 99.6% (281/282). Six (55%) of 11 false-positive samples were secondary to benign calcifications. The Young modulus of PC ranged from 30 to 110 kPa (mean [SD], 58.0 [20.7] kPa). At the patient level, if a cutoff of 40 kPa was used, all PCs would have been detected, and the positive biopsy rate would be 11 (50%) of 22 compared to 11 (20.8%) of 53 without SWE–a 140% increase in the positive biopsy rate. CONCLUSIONS: Shear wave elastography has a high sensitivity, specificity, PPV, and NPV for the detection of PC. With a high PPV, patients with elevated prostate-specific antigen levels or abnormal results in the digital rectal examination and negative SWE may not require biopsy. This could significantly reduce the negative biopsy rate in PC detection.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/RUQ.0b013e318249f594" target="_blank" rel="noreferrer noopener">10.1097/RUQ.0b013e318249f594</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Endosonography
2012
Aged
Barr Richard G
Biopsy
Biopsy – Methods
Diagnosis
Differential
Elasticity
Elasticity Imaging Techniques/*methods
Equipment and Supplies
Follow-Up Studies
Health Screening
Human
Humans
Magnetic Resonance Imaging
Male
Memo Richard
Middle Age
Middle Aged
Ohio
Predictive Value of Tests
Prospective Studies
Prostate – Analysis
Prostate – Anatomy and Histology
Prostate-Specific Antigen – Blood
Prostate/*diagnostic imaging/pathology
Prostatic Hypertrophy
Prostatic Neoplasms – Diagnosis
Prostatic Neoplasms – Pathology
Prostatic Neoplasms/*diagnostic imaging/pathology
Rectum
ROC Curve
Schaub Carl R
Sensitivity and Specificity
Spectrum Analysis
Ultrasonography – Methods
Ultrasound quarterly
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1097/RUQ.0b013e3181b789aa" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/RUQ.0b013e3181b789aa</a>
Pages
141–144
Issue
3
Volume
25
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Speed of sound imaging: improved image quality in breast sonography.
Publisher
An entity responsible for making the resource available
Ultrasound quarterly
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
*Artifacts; Breast Diseases – Classification; Breast Diseases – Diagnosis; Continuing (Credit); Education; Equipment and Supplies; Female; Funding Source; Human; Humans; Image Enhancement/*methods; Mammary/*methods; Middle Aged; Observer Variation; Quality of Health Care; Reproducibility of Results; Sensitivity and Specificity; Ultrasonography; Ultrasonography – Methods
Creator
An entity primarily responsible for making the resource
Barr Richard G; Rim Alice; Graham Ruffin; Berg Wendie; Grajo Joseph R
Description
An account of the resource
PURPOSE: The purpose of this study was to evaluate blindly breast ultrasound images corrected for the speed of sound in breast tissue compared with conventional images. MATERIALS AND METHODS: In this study, 409 images from 153 patients were obtained on an Antares Ultrasound system. The system was modified to process the radiofrequency data with the standard 1540 m/s as the speed of sound and at a corrected speed of sound for breast tissue. An offline
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1097/RUQ.0b013e3181b789aa" target="_blank" rel="noreferrer noopener">10.1097/RUQ.0b013e3181b789aa</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Artifacts
2009
Barr Richard G
Berg Wendie
Breast Diseases – Classification
Breast Diseases – Diagnosis
Continuing (Credit)
Education
Equipment and Supplies
Female
Funding Source
Graham Ruffin
Grajo Joseph R
Human
Humans
Image Enhancement/*methods
Mammary/*methods
Middle Aged
Observer Variation
Quality of Health Care
Reproducibility of Results
Rim Alice
Sensitivity and Specificity
Ultrasonography
Ultrasonography – Methods
Ultrasound quarterly