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Text
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URL Address
<a href="http://doi.org/10.1152/ajplung.00124.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00124.2005</a>
Pages
L478–484
Issue
3
Volume
290
Dublin Core
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Title
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Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.
Publisher
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American journal of physiology. Lung cellular and molecular physiology
Date
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2006
2006-03
Subject
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*Gestational Age; *Hernias; Absorption; Amiloride/pharmacology; Animals; Body Fluids/*metabolism; Congenital; Diaphragmatic; Diaphragmatic/*metabolism; Epinephrine/metabolism; Epithelial Sodium Channels; Female; Fetal Organ Maturity; Fetus/*metabolism; Hernia; Male; Newborn; Phenyl Ethers/administration & dosage; Pregnancy; Propranolol/pharmacology; Rats; Respiratory System Abnormalities; Sodium Channels/metabolism; Sodium-Potassium-Exchanging ATPase/metabolism; Sprague-Dawley
Creator
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Folkesson Hans G; Chapin Cheryl J; Beard LaMonta L; Ertsey Robert; Matthay Michael A; Kitterman Joseph A
Description
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We hypothesized that congenital diaphragmatic hernia (CDH) may decrease distal air space fluid absorption due to immaturity of alveolar epithelial cells from a loss of the normal epithelial Na+ transport, as assessed by amiloride and epithelial Na+ channel (ENaC) and Na-K-ATPase expression, as well as failure to respond to endogenous epinephrine as assessed by propranolol. Timed-pregnant dams were gavage fed 100 mg of nitrofen at 9.5-day gestation to induce CDH in the fetuses, and distal air space fluid absorption experiments were carried out on
Identifier
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<a href="http://doi.org/10.1152/ajplung.00124.2005" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00124.2005</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gestational Age
*Hernias
2006
Absorption
American journal of physiology. Lung cellular and molecular physiology
Amiloride/pharmacology
Animals
Beard LaMonta L
Body Fluids/*metabolism
Chapin Cheryl J
Congenital
Diaphragmatic
Diaphragmatic/*metabolism
Epinephrine/metabolism
Epithelial Sodium Channels
Ertsey Robert
Female
Fetal Organ Maturity
Fetus/*metabolism
Folkesson Hans G
Hernia
Kitterman Joseph A
Male
Matthay Michael A
Newborn
Phenyl Ethers/administration & dosage
Pregnancy
Propranolol/pharmacology
Rats
Respiratory System Abnormalities
Sodium Channels/metabolism
Sodium-Potassium-Exchanging ATPase/metabolism
Sprague-Dawley