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<a href="http://doi.org/10.1007/s00429-017-1599-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00429-017-1599-4</a>
Pages
1923–1936
Issue
4
Volume
223
Dublin Core
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Title
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GABAergic and non-GABAergic projections to the superior colliculus from the auditory brainstem.
Publisher
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Brain structure & function
Date
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2018
2018-05
Subject
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Animals; Attention; Auditory Pathways/*physiology; Avoidance behavior; Brain Mapping; Escape; Female; Fluorescent Dyes/metabolism; Functional Laterality; GABAergic Neurons/*physiology; Glutamate Decarboxylase/*metabolism; Guinea Pigs; Inferior colliculus; Inhibition; Male; Nitric Oxide Synthase/metabolism; Nucleus of the brachium of the inferior colliculus; Orienting; Superior Colliculi/*cytology
Creator
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Mellott Jeffrey G; Beebe Nichole L; Schofield Brett R
Description
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The superior colliculus (SC) contains an auditory space map that is shaped by projections from several subcortical auditory nuclei. Both GABAergic (inhibitory) and excitatory cells contribute to these inputs, but there are contradictory reports regarding the sources of these inputs. We used retrograde tracing techniques in guinea pigs to identify cells in the auditory brainstem that project to the SC. We combined retrograde tracing with immunohistochemistry for glutamic acid decarboxylase (GAD) to identify putative GABAergic cells that participate in this pathway. Following a tracer injection in the SC, the nucleus of the brachium of the inferior colliculus (NBIC) contained the most labeled cells, followed by the inferior colliculus (IC). Smaller populations were observed in the sagulum, paralemniscal area, periolivary nuclei and ventrolateral tegmental nucleus. Overall, only 10% of the retrogradely labeled cells were GAD immunopositive. The presumptive inhibitory cells were observed in the NBIC, IC, superior paraolivary nucleus, sagulum and paralemniscal area. We conclude that the guinea pig SC receives input from a diverse set of auditory brainstem nuclei, some of which provide GABAergic input. These diverse origins of input to the SC likely represent a variety of functions. Inputs from the NBIC and IC likely provide spatial information for guiding orienting behaviors. Inputs from subcollicular nuclei are less likely to provide spatial information; rather, they may provide a shorter route for auditory information to reach the SC, and could generate avoidance or escape responses to an external threat.
Identifier
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<a href="http://doi.org/10.1007/s00429-017-1599-4" target="_blank" rel="noreferrer noopener">10.1007/s00429-017-1599-4</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animals
Attention
Auditory Pathways/*physiology
Avoidance behavior
Beebe Nichole L
Brain Mapping
Brain structure & function
Department of Anatomy & Neurobiology
Escape
Female
Fluorescent Dyes/metabolism
Functional Laterality
GABAergic Neurons/*physiology
Glutamate Decarboxylase/*metabolism
Guinea Pigs
inferior colliculus
inhibition
Male
Mellott Jeffrey G
NEOMED College of Medicine
Nitric Oxide Synthase/metabolism
Nucleus of the brachium of the inferior colliculus
Orienting
Schofield Brett R
Superior Colliculi/*cytology