1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/molecules201219853" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/molecules201219853</a>
Pages
22315–22328
Issue
12
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.
Publisher
An entity responsible for making the resource available
Molecules (Basel, Switzerland)
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-12
Subject
The topic of the resource
Female; Animals; Cell Proliferation/drug effects; Rats; DMBA; Punicaceae/*chemistry; Down-Regulation/drug effects; Estrogen Receptor alpha/metabolism; Anticarcinogenic Agents/*pharmacology; beta Catenin/*metabolism; beta-catenin; Breast Neoplasms/*drug therapy/metabolism; Chemoprevention/methods; cyclin D1; estrogen receptors; mammary tumorigenesis; pomegranate (Punica granatum L.); Wnt Proteins/*metabolism; Wnt Signaling Pathway/*drug effects; Sprague-Dawley; Receptors; 10-Dimethyl-1; 9; Cell Transformation; 2-benzanthracene/pharmacology; Estrogen/*metabolism; Neoplastic/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Mandal Animesh; Bishayee Anupam
Description
An account of the resource
A pomegranate emulsion (PE), containing various bioactive phytochemicals, has recently been found to exert substantial chemopreventive effect against 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis in rats via antiproliferative and proapoptotic actions. Nevertheless, the underlying mechanisms of action are not completely understood. The present study was designed to investigate the effects of PE treatment on intratumor expression of estrogen receptor (ER)-alpha, ER-beta,beta-catenin and cyclin D1 during DMBA rat mammary carcinogenesis. Mammary tumor sections were harvested from a chemopreventive study in which PE (0.2, 1.0 and 5.0 g/kg) exhibited inhibition of mammary tumorigenesis in a dose-response manner. The expressions of ER-alpha,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/molecules201219853" target="_blank" rel="noreferrer noopener">10.3390/molecules201219853</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
10-Dimethyl-1
2-benzanthracene/pharmacology
2015
9
Animals
Anticarcinogenic Agents/*pharmacology
beta Catenin/*metabolism
beta-catenin
Bishayee Anupam
Breast Neoplasms/*drug therapy/metabolism
Cell Proliferation/drug effects
Cell Transformation
Chemoprevention/methods
Cyclin D1
DMBA
Down-Regulation/drug effects
Estrogen Receptor alpha/metabolism
estrogen receptors
Estrogen/*metabolism
Female
mammary tumorigenesis
Mandal Animesh
Molecules (Basel, Switzerland)
Neoplastic/drug effects/metabolism
pomegranate (Punica granatum L.)
Punicaceae/*chemistry
Rats
Receptors
Sprague-Dawley
Wnt Proteins/*metabolism
Wnt Signaling Pathway/*drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1194/jlr.M069013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1194/jlr.M069013</a>
Pages
1541–1551
Issue
8
Volume
57
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Publisher
An entity responsible for making the resource available
Journal of lipid research
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-08
Subject
The topic of the resource
*estrogen; *estrogen receptor alpha; *lipid and lipoprotein metabolism; *small heterodimer partner; *triglycerides; *very low density lipoprotein; Animals; Cholesterol Ester Transfer Proteins/*physiology; Estrogen Receptor alpha/metabolism; Estrogens/physiology; Female; Inbred C57BL; Lipid Metabolism; Liver/*metabolism; Metabolic Networks and Pathways; Mice; Oxidation-Reduction; Transgenic; Triglycerides/biosynthesis/*blood
Creator
An entity primarily responsible for making the resource
Palmisano Brian T; Le Thao D; Zhu Lin; Lee Yoon-Kwang; Stafford John M
Description
An account of the resource
Elevated plasma TGs increase risk of cardiovascular disease in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood. Here we explore the role of cholesteryl ester transfer protein (CETP) in the regulation of TG metabolism in female mice, which naturally lack CETP. In transgenic CETP females, acute estrogen treatment raised plasma TGs 50%, increased TG production, and increased expression of genes involved in VLDL synthesis, but not in nontransgenic littermate females. In CETP females, estrogen enhanced expression of small heterodimer partner (SHP), a nuclear receptor regulating VLDL production. Deletion of liver SHP prevented increases in TG production and expression of genes involved in VLDL synthesis in CETP mice with estrogen treatment. We also examined whether CETP expression had effects on TG metabolism independent of estrogen treatment. CETP increased liver beta-oxidation and reduced liver TG content by 60%. Liver estrogen receptor alpha (ERalpha) was required for CETP expression to enhance beta-oxidation and reduce liver TG content. Thus, CETP alters at least two networks governing TG metabolism, one involving SHP to increase VLDL-TG production in response to estrogen, and another involving ERalpha to enhance beta-oxidation and lower liver TG content. These findings demonstrate a novel role for CETP in estrogen-mediated increases in TG production and a broader role for CETP in TG metabolism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1194/jlr.M069013" target="_blank" rel="noreferrer noopener">10.1194/jlr.M069013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*estrogen
*estrogen receptor alpha
*lipid and lipoprotein metabolism
*small heterodimer partner
*triglycerides
*very low density lipoprotein
2016
Animals
Cholesterol Ester Transfer Proteins/*physiology
Department of Integrative Medical Sciences
Estrogen Receptor alpha/metabolism
Estrogens/physiology
Female
Inbred C57BL
Journal of lipid research
Le Thao D
Lee Yoon-Kwang
Lipid Metabolism
Liver/*metabolism
Metabolic Networks and Pathways
Mice
NEOMED College of Medicine
Oxidation-Reduction
Palmisano Brian T
Stafford John M
Transgenic
Triglycerides/biosynthesis/*blood
Zhu Lin
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00441-005-1114-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00441-005-1114-8</a>
Pages
35–44
Issue
1
Volume
321
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
P2X receptors in the rat uterine cervix, lumbosacral dorsal root ganglia, and spinal cord during pregnancy.
Publisher
An entity responsible for making the resource available
Cell and tissue research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-07
Subject
The topic of the resource
Animals; Blotting; Cervix Uteri/*metabolism; Estrogen Receptor alpha/metabolism; Female; Frozen Sections; Ganglia; Immunohistochemistry; Lumbosacral Region; Pregnancy; Purinergic P2/*metabolism; Purinergic P2X; Rats; Receptors; Spinal Cord/cytology/*metabolism; Spinal/cytology/*metabolism; Sprague-Dawley; Western
Creator
An entity primarily responsible for making the resource
Papka Raymond E; Hafemeister Jen; Storey-Workley Megan
Description
An account of the resource
ATP, an intracellular energy source, is released from cells during tissue stress, damage, or inflammation. The P2X subtype of the ATP receptor is expressed in rat dorsal root ganglion (DRG) cells, spinal cord dorsal horn, and axons in peripheral tissues. ATP binding to P2X receptors on nociceptors generates signals that can be interpreted as pain from damaged tissue. We have hypothesized that tissue stress or damage in the uterine cervix during late pregnancy and parturition can lead to ATP release and sensory signaling via P2X receptors. Consequently, we have examined sensory pathways from the cervix in nonpregnant and pregnant rats for the presence of purinoceptors. Antiserum against the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00441-005-1114-8" target="_blank" rel="noreferrer noopener">10.1007/s00441-005-1114-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Animals
Blotting
Cell and tissue research
Cervix Uteri/*metabolism
Estrogen Receptor alpha/metabolism
Female
Frozen Sections
Ganglia
Hafemeister Jen
Immunohistochemistry
Lumbosacral Region
Papka Raymond E
Pregnancy
Purinergic P2/*metabolism
Purinergic P2X
Rats
Receptors
Spinal Cord/cytology/*metabolism
Spinal/cytology/*metabolism
Sprague-Dawley
Storey-Workley Megan
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.20690" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.20690</a>
Pages
875–889
Issue
6
Volume
82
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activation and circuitry of uterine-cervix-related neurons in the lumbosacral dorsal root ganglia and spinal cord at parturition.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-12
Subject
The topic of the resource
Analysis of Variance; Animals; Blotting; Cell Count/methods; Cervix Uteri/*cytology; Cyclic AMP Response Element-Binding Protein/metabolism; Estrogen Receptor alpha/metabolism; Female; Ganglia; Gene Expression Regulation/physiology; Immunohistochemistry/methods; Lumbosacral Region; Models; Nerve Net/cytology/*physiology; Neurological; Neurons/classification/*physiology; Oncogene Proteins v-fos/metabolism; Parturition/*physiology; Pregnancy; Rats; Spinal Cord/*cytology; Spinal/*cytology; Sprague-Dawley; Stilbamidines/metabolism; Time Factors; Western/methods
Creator
An entity primarily responsible for making the resource
Puder B A; Papka R E
Description
An account of the resource
Stimulation of the uterine cervix at parturition activates neural circuits involving primary sensory nerves and supraspinally projecting neurons of the lumbosacral spinal cord, resulting in output of hypothalamic neurohormones. Dorsal root ganglia (DRG) and spinal neurons of these circuits are not well-characterized. The objectives of this study were to detail the activation of DRG and spinal neurons of the L6/S1 levels that are stimulated at late pregnancy, verify hypothalamic projections of activated spinal neurons, and determine whether activated neurons express estrogen receptor-alpha (ERalpha). Expression of phosphorylated cyclic-AMP response element-binding protein (PCREB) and Fos immunohistochemistry were used to "mark" activated DRG and spinal neurons, respectively. Retrograde tracing identified uterine-cervix-related and spinohypothalamic neurons. Baseline PCREB expression in the DRG increased during pregnancy and peaked during the last trimester. Some PCREB-expressing neurons contained retrograde tracer identifying them as cervix-related neurons. Fos-expressing neurons were few in spinal cords of nonpregnant and day 22 pregnant rats but were numerous in parturient animals. Some Fos-expressing neurons located in the dorsal half of the spinal cord contained retrograde tracer identifying them as spinohypothalamic neurons. Some DRG neurons expressing PCREB also expressed ERalpha, and some spinal neurons activated at parturition projected axons to the hypothalamus and expressed ERalpha. These results indicate that DRG and spinal cord neurons are activated at parturition; that those in the spinal cord are present in areas involved in autonomic and sensory processing; that some spinal neurons project axons to the hypothalamus, ostensibly part of a neuroendocrine reflex; and that sensory and spinal neurons can respond to estrogens. Moreover, some activated sensory neurons may be involved in the animal's perception of labor pain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.20690" target="_blank" rel="noreferrer noopener">10.1002/jnr.20690</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Analysis of Variance
Animals
Blotting
Cell Count/methods
Cervix Uteri/*cytology
Cyclic AMP Response Element-Binding Protein/metabolism
Estrogen Receptor alpha/metabolism
Female
Ganglia
Gene Expression Regulation/physiology
Immunohistochemistry/methods
Journal of neuroscience research
Lumbosacral Region
Models
Nerve Net/cytology/*physiology
Neurological
Neurons/classification/*physiology
Oncogene Proteins v-fos/metabolism
Papka R E
Parturition/*physiology
Pregnancy
Puder B A
Rats
Spinal Cord/*cytology
Spinal/*cytology
Sprague-Dawley
Stilbamidines/metabolism
Time Factors
Western/methods