1
40
9
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
337–355
Issue
2
Volume
21
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lipids, atherosclerosis, and the postmenopausal woman. A clinical perspective.
Publisher
An entity responsible for making the resource available
Obstetrics and gynecology clinics of North America
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-06
Subject
The topic of the resource
Female; Humans; Risk Factors; Estrogens/*pharmacology; *Arteriosclerosis/etiology/prevention & control; *Estrogen Replacement Therapy; *Postmenopause/physiology; Lipids/physiology; Lipoproteins/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Shewmon D A
Description
An account of the resource
Gynecologists are often responsible for the primary care of postmenopausal women. In this role, they become responsible for the assessment and subsequent management issues surrounding the prevention of atherosclerotic disease. The effects of estrogen upon the physiology of lipoproteins can be simplified to include an increased flux of apo B-100 particles out of and then back into the liver, an inhibition of hepatic lipase activity, and an apparent decrease in the hepatic secretion of lipoprotein(a) particles. In clinical practice, the lipoprotein picture is best thought of as one of a group of risk factors that need to be assessed and modified as needed, based upon the overall estimation of risk. The only caveat to this approach is that one should consider patients with proven heart disease for more aggressive therapy (to achieve an LDL cholesterol of less than 100 mg/dL), as long as there is no overriding morbidity from other causes.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Arteriosclerosis/etiology/prevention & control
*Estrogen Replacement Therapy
*Postmenopause/physiology
1994
Estrogens/*pharmacology
Female
Humans
Lipids/physiology
Lipoproteins/drug effects/*physiology
Obstetrics and gynecology clinics of North America
Risk Factors
Shewmon D A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
36–42
Issue
6
Volume
3
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease.
Publisher
An entity responsible for making the resource available
The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-10
Subject
The topic of the resource
Female; Humans; Male; Sex Factors; Sex Distribution; Estrogens/*pharmacology; Dopamine/metabolism; Postmenopause; Corpus Striatum/pathology/*physiopathology; Neurotoxins/*antagonists & inhibitors; Parkinson Disease/metabolism/pathology/*physiopathology; Substantia Nigra/pathology/*physiopathology; Animal; Disease Models
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
This article describes the progression of steps followed to demonstrate a gender difference associated with Parkinson's disease (PD) and to gain an understanding of the basis, mechanisms, and implications of this gender specificity. First, a review of the literature on PD shows a greater incidence in men. Next, data are presented from a series of laboratory studies in animal models of PD that suggest a basis for this gender difference: estrogen appears to act as a neuroprotectant of the striatal dopaminergic system. One mechanism for this effect may be that estrogen inhibits the uptake of neurotoxins capable of producing degeneration within dopaminergic neurons. Finally, some of the potential neurologic implications of manipulating estrogen in premenopausal and postmenopausal women are considered.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Animal
Corpus Striatum/pathology/*physiopathology
Disease Models
Dluzen D E
Dopamine/metabolism
Estrogens/*pharmacology
Female
Humans
Male
McDermott J L
Neurotoxins/*antagonists & inhibitors
Parkinson Disease/metabolism/pathology/*physiopathology
Postmenopause
Sex Distribution
Sex Factors
Substantia Nigra/pathology/*physiopathology
The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1385/endo:21:1:67" target="_blank" rel="noreferrer noopener">http://doi.org/10.1385/endo:21:1:67</a>
Pages
67–75
Issue
1
Volume
21
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen as neuroprotectant of nigrostriatal dopaminergic system: laboratory and clinical studies.
Publisher
An entity responsible for making the resource available
Endocrine
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-06
Subject
The topic of the resource
Humans; Sex Characteristics; Estrogens/*pharmacology; *Neuroprotective Agents; Basal Ganglia Diseases/prevention & control; Dopamine/*physiology; Neostriatum/cytology/drug effects/*physiology; Parkinson Disease/pathology/prevention & control; Substantia Nigra/cytology/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen Dean; Horstink Martin
Description
An account of the resource
In this review, we relate both laboratory and clinical evidence associated with the capacity for estrogen to function as a modulator of nigrostriatal dopaminergic pathology. To accomplish this goal, we have divided this review into three parts. In Part 1, we provide a brief historical perspective of studies that have laid the groundwork for demonstrating the existence of hormonal- nigrostriatal interactions. In Part 2, we focus specifically on laboratory data that show the ability and conditions by which estrogen may function as a neuroprotectant of the nigrostriatal dopaminergic system. Finally, in Part 3, we review the clinical literature related to this issue as a means for consideration of estrogen as a modulator, neuroprotectant, and therapy for Parkinson disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1385/endo:21:1:67" target="_blank" rel="noreferrer noopener">10.1385/endo:21:1:67</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Neuroprotective Agents
2003
Basal Ganglia Diseases/prevention & control
Dluzen Dean
Dopamine/*physiology
Endocrine
Estrogens/*pharmacology
Horstink Martin
Humans
Neostriatum/cytology/drug effects/*physiology
Parkinson Disease/pathology/prevention & control
Sex Characteristics
Substantia Nigra/cytology/drug effects/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1369.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1369.025</a>
Pages
282–294
Volume
1074
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen, testosterone, and methamphetamine toxicity.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-08
Subject
The topic of the resource
Animals; Corpus Striatum/drug effects/metabolism; Dopamine Agents/*administration & dosage/toxicity; Drug Interactions; Estrogens/*pharmacology; Female; Male; Methamphetamine/*administration & dosage/toxicity; Mice; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen Dean E; McDermott Janet L
Description
An account of the resource
The gonadal steroid hormone, estrogen, can diminish the degree of striatal dopamine depletion resulting from methamphetamine. In this article, we describe the conditions of this estrogen neuroprotection as well as the potential for estrogen and testosterone to enhance methamphetamine-induced neurodegeneration of the nigrostriatal dopaminergic system. When administered prior to a neurotoxic regimen of methamphetamine, estrogen significantly decreases the amount of striatal dopamine depletion in intact or gonadectomized female, but not male, mice. This capacity for estrogen to function as a neuroprotectant can occur quite rapidly, at 30 min prior to methamphetamine administration, and with relatively low doses of estrogen (1 microg estradiol benzoate). Estrogen remains an effective neuroprotectant in neonatally gonadectomized female mice treated with testosterone, but not in female mice that were gonadectomized prior to puberty. Nor does estrogen demonstrate any beneficial effects when administered after methamphetamine. Recent data have indicated some conditions where gonadal steroids can increase the extent of striatal neurodegeneration in response to methamphetamine. Specifically, when some existing perturbation is present in the nigrostriatal dopaminergic system, treatment with estrogen enhances the extent of striatal dopamine depletion to methamphetamine. Similarly, increased striatal dopamine depletion to methamphetamine is observed in gonadectomized male mice treated with testosterone.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1369.025" target="_blank" rel="noreferrer noopener">10.1196/annals.1369.025</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Animals
Annals of the New York Academy of Sciences
Corpus Striatum/drug effects/metabolism
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Drug Interactions
Estrogens/*pharmacology
Female
Male
McDermott Janet L
Methamphetamine/*administration & dosage/toxicity
Mice
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079710</a>
Pages
305–316
Issue
6
Volume
79
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects; Animals; Behavior; Brain Chemistry/drug effects; Dopamine/*metabolism; Dose-Response Relationship; Drug; Drug Interactions; Estrogen Antagonists/pharmacology; Estrogens/*pharmacology; Female; Methamphetamine/*toxicity; Mice; Movement/drug effects; Neostriatum/*drug effects/physiology; Neurotoxins/*toxicity; Organ Size/drug effects; Ovariectomy/methods; Stereotyped Behavior/drug effects; Substantia Nigra/drug effects/physiology; Tamoxifen/*pharmacology; Uterus
Creator
An entity primarily responsible for making the resource
Mickley Katherine R; Dluzen Dean E
Description
An account of the resource
In the present experiment we evaluated the dose-response effects of estrogen (estradiol benzoate; EB) and tamoxifen (TMX) in modulating the acute behavioral and chronic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system in ovariectomized (OVX) mice. EB over a range of doses from 1-40 microg resulted in a neuroprotective effect upon the NSDA system as defined by both a preservation of striatal dopamine (DA) concentrations and a decrease in DOPAC/DA ratios. Interestingly, the neuroprotective effect of the 1-microg EB dose occurred in the absence of any statistically significant effect upon the bioassay parameter of uterine weight. With the exception of an increase in stereotypy time as a response to the 40-microg dose, EB at any of the doses tested failed to alter any acute behavioral responses evoked by MA. In response to TMX, a statistically significant NSDA neuroprotectant response was obtained for DOPAC/DA ratios, but not DA concentrations, to doses ranging from 12.5 to 500 microg. No statistically significant effects upon uterine weights were obtained for any of the doses of TMX tested. Behaviorally, TMX at 500 microg had the effect of increasing the amount of time spent in the center of the cage. Taken together these results demonstrate: (1) EB and TMX at relatively low doses can exert a neuroprotective effect against MA; (2) these neuroprotective effects of EB and TMX can occur in the absence of an effect upon the bioassay parameter–uterine weights; (3) the parameter of DOPAC/DA ratio may indicate a more sensitive index of NSDA neuroprotection, and (4) modulatory effects of EB and TMX upon acute behavioral responses of the NSDA system to MA can be distinguished from their neuroprotective actions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">10.1159/000079710</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects
Animals
Behavior
Brain Chemistry/drug effects
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Drug Interactions
Estrogen Antagonists/pharmacology
Estrogens/*pharmacology
Female
Methamphetamine/*toxicity
Mice
Mickley Katherine R
Movement/drug effects
Neostriatum/*drug effects/physiology
Neuroendocrinology
Neurotoxins/*toxicity
Organ Size/drug effects
Ovariectomy/methods
Stereotyped Behavior/drug effects
Substantia Nigra/drug effects/physiology
Tamoxifen/*pharmacology
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0196-9781(03)00120-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(03)00120-7</a>
Pages
761–771
Issue
5
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-05
Subject
The topic of the resource
Afferent/metabolism; Animals; Cervix Uteri/cytology/*metabolism; Down-Regulation; Estradiol/*analogs & derivatives/pharmacology; Estrogen/antagonists & inhibitors; Estrogens/*pharmacology; Female; Fulvestrant; Ganglia; Immunohistochemistry; In Situ Hybridization; Messenger/genetics/metabolism; Neurons; Postpartum Period; Pregnancy/*metabolism; Radioimmunoassay; Rats; Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spinal Cord/cytology/*metabolism; Spinal/cytology/*metabolism; Sprague-Dawley; Substance P/*biosynthesis/genetics/metabolism; Up-Regulation
Creator
An entity primarily responsible for making the resource
Mowa C N; Usip S; Storey-Workley M; Amann R; Papka R
Description
An account of the resource
Prior to parturition the non-pliable uterine cervix undergoes a ripening process ("softens" and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence for a role for sensory neurons and their contained neuropeptides is emerging. Moreover, an apparent increase in neuropeptide immunoreactive nerves occurs in the cervix during pregnancy, maternal serum estrogen levels rise at term and uterine cervix-related L6-S1 dorsal root ganglia (DRG) sensory neurons express estrogen receptor (ER) and neuropeptides. Thus, we sought to test the hypothesis that the neuropeptide substance P (SP) changes biosynthesis and release over pregnancy, that estrogen, acting via the ER pathway, increases synthesis of SP in DRG, and that SP is utilized in cervical ripening at late pregnancy. Using immunohistochemistry, in situ hybridization, reverse transcriptase-polymerase chain reaction (RT-PCR) and radioimmunoassay (RIA), we investigated coexpression of ER-alpha/beta and SP; differential expression of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0196-9781(03)00120-7" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(03)00120-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Afferent/metabolism
Amann R
Animals
Cervix Uteri/cytology/*metabolism
Department of Anatomy & Neurobiology
Down-Regulation
Estradiol/*analogs & derivatives/pharmacology
Estrogen/antagonists & inhibitors
Estrogens/*pharmacology
Female
Fulvestrant
Ganglia
Immunohistochemistry
In Situ Hybridization
Messenger/genetics/metabolism
Mowa C N
NEOMED College of Medicine
Neurons
Papka R
Peptides
Postpartum Period
Pregnancy/*metabolism
Radioimmunoassay
Rats
Receptors
Reverse Transcriptase Polymerase Chain Reaction
RNA
Spinal Cord/cytology/*metabolism
Spinal/cytology/*metabolism
Sprague-Dawley
Storey-Workley M
Substance P/*biosynthesis/genetics/metabolism
Up-Regulation
Usip S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0040-8166(95)80017-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0040-8166(95)80017-4</a>
Pages
149–157
Issue
2
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ultrastructural changes of female Syrian hamster cystic duct epithelium as a result of sex steroid treatment.
Publisher
An entity responsible for making the resource available
Tissue & cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-04
Subject
The topic of the resource
Animals; Cell Nucleus/drug effects/ultrastructure; Combination; Cricetinae; Cystic Duct/*drug effects/*ultrastructure; Drug Therapy; Epithelium/drug effects/ultrastructure; Estrogens/*pharmacology; Female; Gallbladder/drug effects/ultrastructure; Medroxyprogesterone/*pharmacology; Mesocricetus
Creator
An entity primarily responsible for making the resource
Gilloteaux J; Karkare S; Kelly T R
Description
An account of the resource
In view of the lack of sufficient data regarding the morphology of the cystic duct and the extensive focus on the gallbladder, a preliminary examination of the cystic duct response to female sex steroid treatment was conducted to follow up a detailed ultrastructural study of the gallbladder epithelial response to a similar treatment. As observed in the gallbladder epithelium, the cystic duct epithelial cells of nulliparous Syrian hamsters demonstrate morphologic changes in response to female sex steroid treatment. Control (C) cystic duct epithelial cells are covered by short microvilli and each cell appears to exhibit a single vestigial cilium. Estrogen (E)- and estrogen + medroxyprogesterone (E + MP)-treatments induce differential duct cell morphologic changes. These changes are the result of steroid treatments in the significant decreasing sequence E \textgreater E + MP \textgreater C for nuclear volume, indentations and perinuclear lysosomal/lipofuscin bodies. Moreover E + MP-treatment results in larger cytoplasmic volume and more sloughing of apical cell excrescences than following E treatment. It is suggested that, similar to that in the gallbladder, the action of progestin is paramount in favoring cytoplasmic morphological changes in the cystic duct which, along with the alteration of mucus, cell sloughing, decreased bile acids and motility could also participate in the gallstone nucleation process as they are brought into the gallbladder with the incoming bile flow.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0040-8166(95)80017-4" target="_blank" rel="noreferrer noopener">10.1016/s0040-8166(95)80017-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Cell Nucleus/drug effects/ultrastructure
Combination
Cricetinae
Cystic Duct/*drug effects/*ultrastructure
Drug Therapy
Epithelium/drug effects/ultrastructure
Estrogens/*pharmacology
Female
Gallbladder/drug effects/ultrastructure
Gilloteaux J
Karkare S
Kelly T R
Medroxyprogesterone/*pharmacology
Mesocricetus
Tissue & cell
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02329-5</a>
Pages
95–104
Issue
1
Volume
868
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-06
Subject
The topic of the resource
*Sex Characteristics; 1-Methyl-4-phenylpyridinium/*toxicity; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Estrogens/*pharmacology; Extracellular Space/metabolism; Female; Herbicides/*toxicity; Male; Microdialysis; Nerve Degeneration/chemically induced/metabolism; Parkinson Disease; Rats; Secondary/chemically induced/metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Dluzen D E
Description
An account of the resource
The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta estradiol) and subjected to microdialysis 6 days later. After baseline DA release was determined, 5 mM MPP(+) was infused through the microdialysis probe for one 20-min interval. Perfusion resumed with normal medium for the duration of the experiment. A significant attenuation of MPP(+)-induced DA release was obtained in estrogen-treated females. One week later, striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned and non-lesioned striata of each animal. MPP(+) infusion significantly decreased striatal DA concentrations, however, there was no effect of estrogen treatment on striatal DA depletion. This experiment was repeated using orchidectomized male rats treated with 0, 0.1, or 5 mg estradiol. In contrast to the females, no differences in MPP(+)-induced DA release were seen among these males, and there was no significant effect of the varying estrogen treatments on striatal DA or DOPAC concentrations. These results demonstrate that in vivo estrogen treatment attenuates MPP(+)-induced striatal DA release in gonadectomized female, but not male, rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02329-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1-Methyl-4-phenylpyridinium/*toxicity
2000
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Corpus Striatum/*metabolism
Disshon K A
Dluzen D E
Dopamine/*metabolism
Estrogens/*pharmacology
Extracellular Space/metabolism
Female
Herbicides/*toxicity
Male
Microdialysis
Nerve Degeneration/chemically induced/metabolism
Parkinson Disease
Rats
Secondary/chemically induced/metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0040-8166(93)90006-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0040-8166(93)90006-7</a>
Pages
527–536
Issue
4
Volume
25
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cytometric study of the female Syrian hamster gallbladder epithelium following sex steroid administration.
Publisher
An entity responsible for making the resource available
Tissue & cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-08
Subject
The topic of the resource
Animals; Cell Count; Cholelithiasis/*chemically induced/pathology; Cricetinae; Cytoplasm/drug effects; Drug Administration Schedule; Epithelial Cells; Epithelium/drug effects; Estrogens/*pharmacology; Female; Gallbladder/cytology/*drug effects; Mesocricetus; Progesterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Adamiec-Beyga E; Karkare S; Kelly T R; Gilloteaux J
Description
An account of the resource
This report is a cytometric study of the female Syrian hamster gallbladder epithelium following 1-, 2-, and 3-month administration of female sex steroids. Nulliparous, multiparous, young, old and pregnant hamsters were used in this study. A 1 month treatment with estrogen alone significantly increases the nuclear volume of the gallbladder epithelial cells, while E + P treatment significantly affects the nuclear volume only after a 2 month treatment. On the other hand, E + P and P treatments significantly increase the cell volumes as compared to the E-treated groups, this effect is most striking following the 1 month period. Prolonged sex steroid treatment (2 and 3 month) does not appear to influence the gallbladder epithelial cell and nuclear volumes as dramatically as that observed following the 1 month treatment. The nulliparous, progesterone-treated hamsters appear to have a greater cytoplasmic volume than the multiparous group and this is substantiated by the bulging apices and the luminal cellular excrescences observed with scanning and transmission electron microscopy. These observations are similar to those reported in ovariectomized hamsters (Gilloteaux et al., 1992). Further, the gallbladder epithelial cells and nuclei of the older female hamsters demonstrate an accentuated response to a 1 month sex steroid treatment as compared to the younger hamsters for the same treatment duration. These results enable us to hypothesize that changes induced by a short term sex steroid treatment participate in the gallstone nucleation process, while longer duration of the treatments contribute to progressive enlargement and accumulation of gallbladder calculi.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0040-8166(93)90006-7" target="_blank" rel="noreferrer noopener">10.1016/0040-8166(93)90006-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Adamiec-Beyga E
Animals
Cell Count
Cholelithiasis/*chemically induced/pathology
Cricetinae
Cytoplasm/drug effects
Drug Administration Schedule
Epithelial Cells
Epithelium/drug effects
Estrogens/*pharmacology
Female
Gallbladder/cytology/*drug effects
Gilloteaux J
Karkare S
Kelly T R
Mesocricetus
Progesterone/*pharmacology
Tissue & cell