1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1016/0006-8993(94)91335-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(94)91335-8</a>
Pages
353–356
Issue
2
Volume
647
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Spermine depresses NMDA, K/AMPA and GABAA-mediated synaptic transmission in the rat hippocampal slice preparation.
Publisher
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Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-06
Subject
The topic of the resource
AMPA/antagonists & inhibitors; Animals; Calcium Channels/drug effects; Evoked Potentials/drug effects; Excitatory Amino Acid Antagonists/*pharmacology; GABA-A Receptor Antagonists; Hippocampus/drug effects/*physiology; In Vitro Techniques; N-Methyl-D-Aspartate/antagonists & inhibitors; Rats; Receptors; Spermine/*pharmacology; Synapses/drug effects/*physiology; Synaptic Transmission/*drug effects
Creator
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DiScenna P G; Ferchmin P A; Eterovic V A; Teyler T J
Description
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The effects of spermine, an endogenous polyamine, were examined in area CA1 of the rat hippocampal slice preparation. Spermine, at low millimolar concentrations, rapidly and potently depressed NMDA and K/AMPA-mediated population EPSPs, and GABA-mediated monosynaptic population IPSPs. These effects contrast with its well-known potentiation of NMDA currents at lower concentrations. Our results raise the possibility that the large intracellular stores of spermine that are released after various neural insults could act as an endogenous neuroprotective mechanism by limiting excessive calcium entry.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(94)91335-8" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(94)91335-8</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
AMPA/antagonists & inhibitors
Animals
Brain research
Calcium Channels/drug effects
DiScenna P G
Eterovic V A
Evoked Potentials/drug effects
Excitatory Amino Acid Antagonists/*pharmacology
Ferchmin P A
GABA-A Receptor Antagonists
Hippocampus/drug effects/*physiology
In Vitro Techniques
N-Methyl-D-Aspartate/antagonists & inhibitors
Rats
Receptors
Spermine/*pharmacology
Synapses/drug effects/*physiology
Synaptic Transmission/*drug effects
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)00568-b" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)00568-b</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
189-196
Issue
2
Volume
689
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spermine Increases Paired-pulse Facilitation In Area Ca1 Of Hippocampus In A Calcium-dependent Manner
Publisher
An entity responsible for making the resource available
Brain Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-08
Subject
The topic of the resource
activation; binding; ca1; ca2+ channel; channels; field potential; hippocampal slice; in-vitro; ischemia; Neurosciences & Neurology; ornithine decarboxylase; paired-pulse facilitation; polyamine; polyamines; pyramidal cells; rat-brain; slices; spermine
Creator
An entity primarily responsible for making the resource
Ferchmin P A; Eterovic V A; Rivera E M; Teyler T J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(95)00568-b" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)00568-b</a>
Format
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Journal Article or Conference Abstract Publication
1995
activation
Binding
Brain research
ca1
ca2+ channel
channels
Eterovic V A
Ferchmin P A
field potential
hippocampal slice
in-vitro
ischemia
Neurosciences & Neurology
ornithine decarboxylase
paired-pulse facilitation
polyamine
polyamines
pyramidal cells
rat-brain
Rivera E M
slices
spermine
Teyler T J