1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0202-13.2013</a>
Pages
15964–15977
Issue
40
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
Animals; Chick Embryo; Synaptic Transmission/drug effects/*physiology; Excitatory Amino Acid Antagonists/pharmacology; Amino Acids/pharmacology; Cochlear Nucleus/drug effects/metabolism; Cyclopropanes/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; GABAergic Neurons/drug effects/*metabolism; Glycine/analogs & derivatives/pharmacology; Inhibitory Postsynaptic Potentials/drug effects/physiology; Long-Term Synaptic Depression/drug effects/*physiology; Neural Inhibition/drug effects/physiology; Synapses/drug effects/*metabolism; Xanthenes/pharmacology; Receptors; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
Creator
An entity primarily responsible for making the resource
Tang Zheng-Quan; Liu Yu-Wei; Shi Wei; Dinh Emilie Hoang; Hamlet William R; Curry Rebecca J; Lu Yong
Description
An account of the resource
Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory synapses. Here we report that pharmacological or synaptic activation of group II mGluRs (mGluR II) induces LTD at GABAergic synapses without affecting the excitatory glutamatergic transmission in neurons of the chicken cochlear nucleus. Coefficient of variation and failure rate analysis suggested that the LTD was expressed presynaptically. The LTD requires presynaptic spike activity, but does not require the activation of NMDA receptors. The classic cAMP-dependent protein kinase A signaling is involved in the transduction pathway. Remarkably, blocking mGluR II increased spontaneous GABA release, indicating the presence of tonic activation of mGluR II by ambient glutamate. Furthermore, synaptically released glutamate induced by electrical stimulations that concurrently activated both the glutamatergic and GABAergic pathways resulted in significant and constant suppression of GABA release at various stimulus frequencies (3.3, 100, and 300 Hz). Strikingly, low-frequency stimulation (1 Hz, 15 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LTD was blocked by mGluR II antagonist, indicating that synaptic activation of mGluR II induced the LTD. This novel form of long-term plasticity in the avian auditory brainstem may play a role in the development as well as in temporal processing in the sound localization circuit.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0202-13.2013</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Amino Acids/pharmacology
Animals
Chick Embryo
Cochlear Nucleus/drug effects/metabolism
Curry Rebecca J
Cyclopropanes/pharmacology
Department of Anatomy & Neurobiology
Dinh Emilie Hoang
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
GABAergic Neurons/drug effects/*metabolism
Glycine/analogs & derivatives/pharmacology
Hamlet William R
Inhibitory Postsynaptic Potentials/drug effects/physiology
Liu Yu-Wei
Long-Term Synaptic Depression/drug effects/*physiology
Lu Yong
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Receptors
Shi Wei
Synapses/drug effects/*metabolism
Synaptic Transmission/drug effects/*physiology
Tang Zheng-Quan
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xanthenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.2001.86.3.1289</a>
Pages
1289–1296
Issue
3
Volume
86
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Electrical stimuli patterned after the theta-rhythm induce multiple forms of LTP.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-09
Subject
The topic of the resource
*Theta Rhythm; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Calcium Channel Blockers/pharmacology; Calcium Channels/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; Long-Evans; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/physiology; N-Methylaspartate/pharmacology; Neuronal Plasticity/drug effects/*physiology; Nifedipine/pharmacology; Organ Culture Techniques; Rats; Receptors
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
The induction of long-term potentiation (LTP) by high-frequency stimulation is considered an acceptable model for the study of learning and memory. In area CA1 calcium influx through N-methyl-D-aspartate receptors (NMDARs; nmdaLTP) and/or
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">10.1152/jn.2001.86.3.1289</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Theta Rhythm
2-Amino-5-phosphonovalerate/pharmacology
2001
Animals
Calcium Channel Blockers/pharmacology
Calcium Channels/physiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/drug effects/*physiology
Male
Morgan S L
N-Methyl-D-Aspartate/physiology
N-Methylaspartate/pharmacology
Neuronal Plasticity/drug effects/*physiology
Nifedipine/pharmacology
Organ Culture Techniques
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2011.01.075" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2011.01.075</a>
Pages
145–149
Issue
3
Volume
492
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
mGluRs modulate neuronal firing in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/drug effects/*physiology; Animals; Auditory Perception/drug effects/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Glutamic Acid/physiology; Inbred CBA; Inferior Colliculi/drug effects/metabolism/*physiology; Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology; Mice; Neural Inhibition/drug effects/physiology; Neurons/drug effects/*physiology; Perceptual Masking/physiology; Receptors; Synaptic Transmission/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
The mechanisms underlying sound-evoked suppression of neuronal firing in the auditory system are poorly understood. To explore these mechanisms in the inferior colliculus (IC), agonists and antagonists targeting different groups of metabotropic glutamate receptors (mGluRs) were applied iontophoretically to IC neurons in awake mice. We found that a group I-specific mGluR agonist predominantly increased neuronal firing in 52% of neurons, whereas group I antagonist had the opposite effect in 51% of neurons. A group II specific agonist showed no effect on neuronal firing but an antagonist increased firing rate in 48% of neurons. Neither a group III-specific mGluR agonist nor an antagonist had an effect on neuronal firing in the IC. We also found that sound stimuli triggered suppression of spontaneous firing in 70% of IC neurons. This suppression was reversibly blocked by group I mGluR antagonists. There is a possible link between this suppression and two perceptual phenomena: forward masking and "residual inhibition," the brief reduction/elimination of tinnitus following an appropriate masking sound.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2011.01.075" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2011.01.075</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Acoustic Stimulation/methods
Action Potentials/drug effects/*physiology
Animals
Auditory Perception/drug effects/physiology
Department of Anatomy & Neurobiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Galazyuk A V
Glutamic Acid/physiology
Inbred CBA
Inferior Colliculi/drug effects/metabolism/*physiology
Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology
Mice
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Neurons/drug effects/*physiology
Neuroscience letters
Perceptual Masking/physiology
Receptors
Synaptic Transmission/drug effects/physiology
Voytenko S V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(95)02041-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(95)02041-1</a>
Pages
39–42
Issue
1
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996
Subject
The topic of the resource
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants/*pharmacology; Calcium Channel Blockers/pharmacology; Enzyme Inhibitors/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Female; Hippocampus/*drug effects; Isoquinolines/pharmacology; Long-Term Potentiation/*drug effects; Male; Membrane Potentials/drug effects; N-Methylaspartate/pharmacology; Piperazines/pharmacology; Protein Kinase C/antagonists & inhibitors; Rats; Synapses/drug effects
Creator
An entity primarily responsible for making the resource
Lee G Y; Brown L M; Teyler T J
Description
An account of the resource
In hippocampal CA1 area, there are at least two forms of long-term potentiation (LTP): one is N-methyl-D-aspartate (NMDA) receptor-dependent LTP (NMDA LTP), which is induced with a 25 Hz tetanus and blocked by 50 microM
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(95)02041-1" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(95)02041-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
1996
Animals
Anticonvulsants/*pharmacology
Brain research bulletin
Brown L M
Calcium Channel Blockers/pharmacology
Enzyme Inhibitors/pharmacology
Excitatory Amino Acid Agonists/pharmacology
Female
Hippocampus/*drug effects
Isoquinolines/pharmacology
Lee G Y
Long-Term Potentiation/*drug effects
Male
Membrane Potentials/drug effects
N-Methylaspartate/pharmacology
Piperazines/pharmacology
Protein Kinase C/antagonists & inhibitors
Rats
Synapses/drug effects
Teyler T J