1
40
10
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.3572-07.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.3572-07.2008</a>
Pages
80–90
Issue
1
Volume
28
Dublin Core
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Title
A name given to the resource
Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-01
Subject
The topic of the resource
Animals; Acoustic Stimulation/methods; Neural Inhibition/drug effects/*physiology; *Sound; Excitatory Amino Acid Antagonists/pharmacology; Action Potentials/drug effects/physiology; Auditory Pathways/*physiology; Glycine Agents/pharmacology; Glycine/*physiology; Chiroptera/physiology; Drug Interactions; GABA Agents/pharmacology; Inferior Colliculi/cytology/drug effects/*physiology; Iontophoresis/methods; Neurons/drug effects/physiology/radiation effects; Piperazines/pharmacology; Dose-Response Relationship; Receptors; Radiation; GABA/physiology; N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
Creator
An entity primarily responsible for making the resource
Sanchez Jason Tait; Gans Donald; Wenstrup Jeffrey J
Description
An account of the resource
In the mustached bat's inferior colliculus (IC), combination-sensitive neurons display time-sensitive facilitatory interactions between inputs tuned to distinct spectral elements in sonar or social vocalizations. Here we compare roles of ionotropic receptors to glutamate (iGluRs), glycine (GlyRs), and GABA (GABA(A)Rs) in facilitatory combination-sensitive interactions. Facilitatory responses to 36 single IC neurons were recorded before, during, and after local application of antagonists to these receptors. The NMDA receptor antagonist CPP [(+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid], alone (n = 14) or combined with AMPA receptor antagonist NBQX (n = 22), significantly reduced or eliminated responses to best frequency (BF) sounds across a broad range of sound levels, but did not eliminate combination-sensitive facilitation. In a subset of neurons, GABA(A)R blockers bicuculline or gabazine were applied in addition to iGluR blockers. GABA(A)R blockers did not "uncover" residual iGluR-mediated excitation, and only rarely eliminated facilitation. In nearly all neurons for which the GlyR antagonist strychnine was applied in addition to iGluR blockade (22 of 23 neurons, with or without GABA(A)R blockade), facilitatory interactions were eliminated. Thus, neither glutamate nor GABA neurotransmission are required for facilitatory combination-sensitive interactions in IC. Instead, facilitation may depend entirely on glycinergic inputs that are presumed to be inhibitory. We propose that glycinergic inputs tuned to two distinct spectral elements in vocal signals each activate postinhibitory rebound excitation. When rebound excitations from two spectral elements coincide, the neuron discharges. Excitation from glutamatergic inputs, tuned to the BF of the neuron, is superimposed onto this facilitatory interaction, presumably mediating responses to a broader range of acoustic signals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.3572-07.2008" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.3572-07.2008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sound
2008
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Auditory Pathways/*physiology
Chiroptera/physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dose-Response Relationship
Drug Interactions
Excitatory Amino Acid Antagonists/pharmacology
GABA Agents/pharmacology
GABA/physiology
Gans Donald
Glycine Agents/pharmacology
Glycine/*physiology
Inferior Colliculi/cytology/drug effects/*physiology
Iontophoresis/methods
N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/physiology/radiation effects
Piperazines/pharmacology
Radiation
Receptors
Sanchez Jason Tait
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.2894-06.2007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.2894-06.2007</a>
Pages
1954–1963
Issue
8
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contribution of NMDA and AMPA receptors to temporal patterning of auditory responses in the inferior colliculus.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
Animals; Chiroptera/*physiology; Neurons/physiology; Action Potentials/drug effects; Excitatory Amino Acid Antagonists/pharmacology; Quinoxalines/pharmacology; Inferior Colliculi/cytology/drug effects/*physiology; Piperazines/pharmacology; *Acoustic Stimulation; Reaction Time/drug effects/*physiology; N-Methyl-D-Aspartate/*physiology; Receptors; AMPA/*physiology
Creator
An entity primarily responsible for making the resource
Sanchez Jason Tait; Gans Donald; Wenstrup Jeffrey J
Description
An account of the resource
Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory stimuli. We compared contributions of glutamatergic NMDARs and AMPA receptors (AMPARs) to auditory responses in the inferior colliculus (IC) of awake, adult mustached bats. We examined the magnitude and temporal pattern of responses to tonal signals in single units before, during, and after local micro-iontophoretic application of selective antagonists to AMPARs [NBQX (1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide)] and NMDARs [CPP ((+/-)3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid)]. Combined blockade of AMPARs and NMDARs eliminated excitatory responses in nearly all neurons, whereas separate blockade of each receptor was quantitatively similar, causing substantial (\textgreater 50%) spike reductions in approximately 75% of units. The major result was that effects of receptor blockade were most closely related to the first-spike latency of a unit. Thus, AMPAR blockade substantially reduced spikes in all short-latency units (\textless 12 ms) but never in long-latency units (\textgreater or = 12 ms). NMDAR blockade had variable effects on short-latency units but reduced spikes substantially for all long-latency units. There were no distinct contributions of AMPARs and NMDARs to early and late elements of responses. Thus, AMPAR blockade reduced early (onset) spikes somewhat more effectively than NMDAR blockade in short-latency units, but NMDAR blockade reduced onset spikes more effectively in long-latency units. AMPAR and NMDAR blockade were equally effective in reducing later elements of sustained responses in short-latency units, whereas NMDAR blockade was much more effective in long-latency units. These results indicate that NMDARs play multiple roles for signal processing in adult IC neurons.
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<a href="http://doi.org/10.1523/JNEUROSCI.2894-06.2007" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.2894-06.2007</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Acoustic Stimulation
2007
Action Potentials/drug effects
AMPA/*physiology
Animals
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Excitatory Amino Acid Antagonists/pharmacology
Gans Donald
Inferior Colliculi/cytology/drug effects/*physiology
N-Methyl-D-Aspartate/*physiology
NEOMED College of Medicine
Neurons/physiology
Piperazines/pharmacology
Quinoxalines/pharmacology
Reaction Time/drug effects/*physiology
Receptors
Sanchez Jason Tait
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0202-13.2013</a>
Pages
15964–15977
Issue
40
Volume
33
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
Animals; Chick Embryo; Synaptic Transmission/drug effects/*physiology; Excitatory Amino Acid Antagonists/pharmacology; Amino Acids/pharmacology; Cochlear Nucleus/drug effects/metabolism; Cyclopropanes/pharmacology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; GABAergic Neurons/drug effects/*metabolism; Glycine/analogs & derivatives/pharmacology; Inhibitory Postsynaptic Potentials/drug effects/physiology; Long-Term Synaptic Depression/drug effects/*physiology; Neural Inhibition/drug effects/physiology; Synapses/drug effects/*metabolism; Xanthenes/pharmacology; Receptors; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
Creator
An entity primarily responsible for making the resource
Tang Zheng-Quan; Liu Yu-Wei; Shi Wei; Dinh Emilie Hoang; Hamlet William R; Curry Rebecca J; Lu Yong
Description
An account of the resource
Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory synapses. Here we report that pharmacological or synaptic activation of group II mGluRs (mGluR II) induces LTD at GABAergic synapses without affecting the excitatory glutamatergic transmission in neurons of the chicken cochlear nucleus. Coefficient of variation and failure rate analysis suggested that the LTD was expressed presynaptically. The LTD requires presynaptic spike activity, but does not require the activation of NMDA receptors. The classic cAMP-dependent protein kinase A signaling is involved in the transduction pathway. Remarkably, blocking mGluR II increased spontaneous GABA release, indicating the presence of tonic activation of mGluR II by ambient glutamate. Furthermore, synaptically released glutamate induced by electrical stimulations that concurrently activated both the glutamatergic and GABAergic pathways resulted in significant and constant suppression of GABA release at various stimulus frequencies (3.3, 100, and 300 Hz). Strikingly, low-frequency stimulation (1 Hz, 15 min) of the glutamatergic synapses induced heterosynaptic LTD of GABAergic transmission, and the LTD was blocked by mGluR II antagonist, indicating that synaptic activation of mGluR II induced the LTD. This novel form of long-term plasticity in the avian auditory brainstem may play a role in the development as well as in temporal processing in the sound localization circuit.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.0202-13.2013" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0202-13.2013</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Amino Acids/pharmacology
Animals
Chick Embryo
Cochlear Nucleus/drug effects/metabolism
Curry Rebecca J
Cyclopropanes/pharmacology
Department of Anatomy & Neurobiology
Dinh Emilie Hoang
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
GABAergic Neurons/drug effects/*metabolism
Glycine/analogs & derivatives/pharmacology
Hamlet William R
Inhibitory Postsynaptic Potentials/drug effects/physiology
Liu Yu-Wei
Long-Term Synaptic Depression/drug effects/*physiology
Lu Yong
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Receptors
Shi Wei
Synapses/drug effects/*metabolism
Synaptic Transmission/drug effects/*physiology
Tang Zheng-Quan
The Journal of neuroscience : the official journal of the Society for Neuroscience
Xanthenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.2001.86.3.1289</a>
Pages
1289–1296
Issue
3
Volume
86
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Electrical stimuli patterned after the theta-rhythm induce multiple forms of LTP.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-09
Subject
The topic of the resource
*Theta Rhythm; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Calcium Channel Blockers/pharmacology; Calcium Channels/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/physiology; Long-Evans; Long-Term Potentiation/drug effects/*physiology; Male; N-Methyl-D-Aspartate/physiology; N-Methylaspartate/pharmacology; Neuronal Plasticity/drug effects/*physiology; Nifedipine/pharmacology; Organ Culture Techniques; Rats; Receptors
Creator
An entity primarily responsible for making the resource
Morgan S L; Teyler T J
Description
An account of the resource
The induction of long-term potentiation (LTP) by high-frequency stimulation is considered an acceptable model for the study of learning and memory. In area CA1 calcium influx through N-methyl-D-aspartate receptors (NMDARs; nmdaLTP) and/or
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.2001.86.3.1289" target="_blank" rel="noreferrer noopener">10.1152/jn.2001.86.3.1289</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Theta Rhythm
2-Amino-5-phosphonovalerate/pharmacology
2001
Animals
Calcium Channel Blockers/pharmacology
Calcium Channels/physiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/physiology
Journal of neurophysiology
Long-Evans
Long-Term Potentiation/drug effects/*physiology
Male
Morgan S L
N-Methyl-D-Aspartate/physiology
N-Methylaspartate/pharmacology
Neuronal Plasticity/drug effects/*physiology
Nifedipine/pharmacology
Organ Culture Techniques
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00883.2006</a>
Pages
1018–1029
Issue
2
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Amino Acids/pharmacology; Animals; Chickens/*physiology; Cochlear Nucleus/*cytology/*physiology; Electric Stimulation; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/physiology; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; GABA-B/physiology; gamma-Aminobutyric Acid/*physiology; Glycine/analogs & derivatives/pharmacology; In Vitro Techniques; Kinetics; Membrane Potentials/drug effects; Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology; Models; Neurological; Neurons/*physiology; Patch-Clamp Techniques; Receptors; Resorcinols/pharmacology; Synapses/physiology; Synaptic Transmission/*physiology; Xanthenes/pharmacology
Creator
An entity primarily responsible for making the resource
Lu Yong
Description
An account of the resource
GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic glutamate receptors (mGluRs) with whole cell recordings in brain slice preparations. I found that tACPD, a nonspecific mGluR agonist, exerted dose-dependent suppression on evoked inhibitory postsynaptic currents (eIPSCs) in NM neurons. At concentrations of 100 or 200 microM, tACPD increased the failure rate of GABAergic transmission. Agonists for group I (3,5-DHPG, 200 microM), group II (DCG-IV, 2 microM), and group III (L-AP4, 10 microM) mGluRs produced a significant reduction in the amplitude of eIPSCs and a significant increase in failure rate, indicating the involvement of multiple mGluRs in this modulation. The frequency, but not the amplitude, of miniature IPSCs (mIPSCs) was decreased significantly by 3,5-DHPG or DCG-IV. Neither frequency nor amplitude of mIPSCs was affected by L-AP4. mGluR antagonists LY341495 (20 microM) plus CPPG (10 microM) significantly increased the amplitude of eIPSCs, indicating that endogenous mGluR activity suppresses GABA release to NM neurons. Furthermore, blockage of mGluRs increased GABA-evoked discharges recorded under physiological Cl(-) concentrations, whereas tACPD (100 microM) eliminated them. The results indicate that mGluRs play important roles in achieving balanced excitation and inhibition in NM and preserving fidelity of temporal information encoded by NM neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00883.2006" target="_blank" rel="noreferrer noopener">10.1152/jn.00883.2006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2-Amino-5-phosphonovalerate/pharmacology
2007
Amino Acids/pharmacology
Animals
Chickens/*physiology
Cochlear Nucleus/*cytology/*physiology
Department of Anatomy & Neurobiology
Electric Stimulation
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/physiology
GABA-B Receptor Agonists
GABA-B Receptor Antagonists
GABA-B/physiology
gamma-Aminobutyric Acid/*physiology
Glycine/analogs & derivatives/pharmacology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lu Yong
Membrane Potentials/drug effects
Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology
Models
NEOMED College of Medicine
Neurological
Neurons/*physiology
Patch-Clamp Techniques
Receptors
Resorcinols/pharmacology
Synapses/physiology
Synaptic Transmission/*physiology
Xanthenes/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00657.2016</a>
Pages
2550–2563
Issue
6
Volume
116
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-type calcium channels refine the neural population code of sound level.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-12
Subject
The topic of the resource
*auditory midbrain; *dynamic range; *inferior colliculus; *level tuning; *local circuits; *rate-level functions; *Sound; 4-Aminopyridine/analogs & derivatives/pharmacology; Acoustic Stimulation; Action Potentials/drug effects/*physiology; Amifampridine; Animals; Biophysical Phenomena/drug effects; Calcium Channel Blockers/pharmacology; Calcium Channels; Calcium/metabolism; Excitatory Amino Acid Antagonists/pharmacology; In Vitro Techniques; Inbred CBA; Inferior Colliculi/*cytology; L-Type/*metabolism; Mice; Neurons/*physiology; Nimodipine/pharmacology; omega-Conotoxin GVIA/pharmacology; Potassium Channel Blockers/pharmacology; Quinoxalines/pharmacology; Wakefulness
Creator
An entity primarily responsible for making the resource
Grimsley Calum Alex; Green David Brian; Sivaramakrishnan Shobhana
Description
An account of the resource
The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (CaL: CaV1.1-1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of CaL to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. CaL is a high-threshold current and comprises approximately 50% of the total calcium current in ICC neurons. In vivo, CaL activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, CaL boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, CaL either suppresses or enhances firing at sound levels that evoke maximum firing. CaL multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">10.1152/jn.00657.2016</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*auditory midbrain
*dynamic range
*Inferior colliculus
*level tuning
*local circuits
*rate-level functions
*Sound
2016
4-Aminopyridine/analogs & derivatives/pharmacology
Acoustic Stimulation
Action Potentials/drug effects/*physiology
Amifampridine
Animals
Biophysical Phenomena/drug effects
Calcium Channel Blockers/pharmacology
Calcium Channels
Calcium/metabolism
Excitatory Amino Acid Antagonists/pharmacology
Green David Brian
Grimsley Calum Alex
In Vitro Techniques
Inbred CBA
Inferior Colliculi/*cytology
Journal of neurophysiology
L-Type/*metabolism
Mice
Neurons/*physiology
Nimodipine/pharmacology
omega-Conotoxin GVIA/pharmacology
Potassium Channel Blockers/pharmacology
Quinoxalines/pharmacology
Sivaramakrishnan Shobhana
Wakefulness
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.pbb.2009.10.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.pbb.2009.10.002</a>
Pages
410–415
Issue
3
Volume
94
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-01
Subject
The topic of the resource
Animals; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Guinea Pigs; Locomotion/*drug effects; Mice; Nicotine/*pharmacology; Phencyclidine/*pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Simmons Mark A; Werkheiser Jennifer L; Hudzik Thomas J
Description
An account of the resource
Behavioral assays of the responses to psychomotor stimulants can be used to model certain aspects of CNS pathologies such as psychosis and addiction. However, species-dependent differences in the effects of neuromodulators in these assays can confound the interpretation of the results. The goal of this study was to determine the utility of the guinea pig as a model for assessing the behavioral actions of nicotinic receptor agonists and NMDA receptor antagonists. In the present study, the locomotor activity of adult male guinea pigs was measured, prior to and following an acute injection of nicotine, MK-801 or phencyclidine. Each animal received a single dose of the drug. Nicotine produced a dose-dependent increase in activity with an ED(50) of 1.5mg/kg. Phencyclidine also increased activity, with an ED(50) of 3.4 mg/kg. Nicotine produced increases in locomotion in all individual subjects tested, whereas at the maximally-effective dose of phencyclidine, only a fraction of the animals had locomotor activation. There was no change in activity in response to a single dose of MK-801 (0.5mg/kg). Haloperidol had a significant inhibitory effect on locomotor activity independent of the stimulant administered. Thus, both phencyclidine and nicotine are psychomotor stimulants when given to guinea pigs, although the intensity of the response and the potencies of these drugs are lower than in mice or rats under otherwise similar conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.pbb.2009.10.002" target="_blank" rel="noreferrer noopener">10.1016/j.pbb.2009.10.002</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Animals
Dizocilpine Maleate/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Guinea Pigs
Hudzik Thomas J
Locomotion/*drug effects
Mice
Nicotine/*pharmacology
Pharmacology, biochemistry, and behavior
Phencyclidine/*pharmacology
Rats
Simmons Mark A
Werkheiser Jennifer L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2008.08.037" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2008.08.037</a>
Pages
987–994
Issue
4
Volume
156
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
Animals; Autoradiography/methods; Dose-Response Relationship; Drug; Drug Interactions; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/radiation effects; Guinea Pigs; In Vitro Techniques; Iodine Isotopes/pharmacokinetics; Male; Membrane Potentials/drug effects/physiology/radiation effects; Neurokinin B/analogs & derivatives/pharmacokinetics; Neurokinin-3/agonists/antagonists & inhibitors/*metabolism; Patch-Clamp Techniques; Peptide Fragments/pharmacology; Prefrontal Cortex/*cytology; Protein Binding/drug effects; Pyramidal Cells/drug effects/*metabolism; Quinolines/pharmacology; Quinoxalines/pharmacology; Receptors; Substance P/analogs & derivatives/pharmacology; Valine/analogs & derivatives/pharmacology
Creator
An entity primarily responsible for making the resource
Simmons M A; Sobotka-Briner C D; Medd A M
Description
An account of the resource
The NK(3) subtype of tachykinin receptor has been implicated as a modulator of synaptic transmission in several brain regions, including the cerebral cortex. The localization and expression of NK(3) receptors within the brain vary from species to species. In addition, the pharmacology of NK(3) receptor-specific antagonists shows significant species variability. Among commonly used animal models, the pharmacology of the guinea-pig NK(3) receptor most closely resembles that of the human NK(3) receptor. Here, we provide anatomical localization studies, receptor binding studies, and studies of the electrophysiological effects of NK(3) receptor ligands of guinea-pig cortex using two commercially available ligands, the NK(3) receptor peptide analog agonist senktide, and the quinolinecarboxamide NK(3) receptor antagonist SB-222,200. Saturation binding studies with membranes isolated from guinea-pig cerebral cortex showed saturable binding consistent with a single high affinity site. Autoradiographic studies revealed dense specific binding in layers II/III and layer V of the cerebral cortex. For electrophysiological studies, brain slices were prepared from prefrontal cortex of 3- to 14-day-old guinea pigs. Whole cell recordings were made from layer V pyramidal neurons. In current clamp mode with a K(+)-containing pipette solution, senktide depolarized the pyramidal neurons and led to repetitive firing of action potentials. In voltage clamp mode with a Cs(+)-containing pipette solution, senktide application produced an inward current and a concentration-dependent enhancement of the amplitude and the frequency of spontaneous excitatory postsynaptic potentials. The glutamatergic nature of these events was demonstrated by block by glutamate receptor antagonists. The effects of senktide were blocked by SB-222,200, an NK(3) receptor antagonist. Taken together, these results are consistent with a functional role for NK(3) receptors located on neurons in the cerebral cortex. In layer V pyramidal neurons of the medial prefrontal cortex, activation of the NK(3) receptor system plays an excitatory role in modulating synaptic transmission.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2008.08.037" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2008.08.037</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Animals
Autoradiography/methods
Dose-Response Relationship
Drug
Drug Interactions
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/radiation effects
Guinea Pigs
In Vitro Techniques
Iodine Isotopes/pharmacokinetics
Male
Medd A M
Membrane Potentials/drug effects/physiology/radiation effects
Neurokinin B/analogs & derivatives/pharmacokinetics
Neurokinin-3/agonists/antagonists & inhibitors/*metabolism
Neuroscience
Patch-Clamp Techniques
Peptide Fragments/pharmacology
Prefrontal Cortex/*cytology
Protein Binding/drug effects
Pyramidal Cells/drug effects/*metabolism
Quinolines/pharmacology
Quinoxalines/pharmacology
Receptors
Simmons M A
Sobotka-Briner C D
Substance P/analogs & derivatives/pharmacology
Valine/analogs & derivatives/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2011.01.075" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2011.01.075</a>
Pages
145–149
Issue
3
Volume
492
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
mGluRs modulate neuronal firing in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/drug effects/*physiology; Animals; Auditory Perception/drug effects/physiology; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Glutamic Acid/physiology; Inbred CBA; Inferior Colliculi/drug effects/metabolism/*physiology; Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology; Mice; Neural Inhibition/drug effects/physiology; Neurons/drug effects/*physiology; Perceptual Masking/physiology; Receptors; Synaptic Transmission/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
The mechanisms underlying sound-evoked suppression of neuronal firing in the auditory system are poorly understood. To explore these mechanisms in the inferior colliculus (IC), agonists and antagonists targeting different groups of metabotropic glutamate receptors (mGluRs) were applied iontophoretically to IC neurons in awake mice. We found that a group I-specific mGluR agonist predominantly increased neuronal firing in 52% of neurons, whereas group I antagonist had the opposite effect in 51% of neurons. A group II specific agonist showed no effect on neuronal firing but an antagonist increased firing rate in 48% of neurons. Neither a group III-specific mGluR agonist nor an antagonist had an effect on neuronal firing in the IC. We also found that sound stimuli triggered suppression of spontaneous firing in 70% of IC neurons. This suppression was reversibly blocked by group I mGluR antagonists. There is a possible link between this suppression and two perceptual phenomena: forward masking and "residual inhibition," the brief reduction/elimination of tinnitus following an appropriate masking sound.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2011.01.075" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2011.01.075</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Acoustic Stimulation/methods
Action Potentials/drug effects/*physiology
Animals
Auditory Perception/drug effects/physiology
Department of Anatomy & Neurobiology
Excitatory Amino Acid Agonists/pharmacology
Excitatory Amino Acid Antagonists/pharmacology
Galazyuk A V
Glutamic Acid/physiology
Inbred CBA
Inferior Colliculi/drug effects/metabolism/*physiology
Metabotropic Glutamate/agonists/antagonists & inhibitors/*physiology
Mice
NEOMED College of Medicine
Neural Inhibition/drug effects/physiology
Neurons/drug effects/*physiology
Neuroscience letters
Perceptual Masking/physiology
Receptors
Synaptic Transmission/drug effects/physiology
Voytenko S V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.21225" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.21225</a>
Pages
1318–1335
Issue
6
Volume
85
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-05
Subject
The topic of the resource
Animals; Cervix Uteri/*innervation; Excitatory Amino Acid Antagonists/pharmacology; Female; Ganglia; Gene Expression Regulation/drug effects/*physiology; Glutamates/*metabolism; Lumbosacral Region; Messenger/biosynthesis; Metabotropic Glutamate 5; Metabotropic Glutamate/*metabolism; Neurons/drug effects; Oncogene Proteins v-fos/metabolism; Parturition/*metabolism; Pregnancy/*metabolism; Pyridines/pharmacology; Rats; Receptor; Receptors; Reverse Transcriptase Polymerase Chain Reaction/methods; RNA; Spinal Cord/drug effects/*physiology; Spinal/cytology; Sprague-Dawley; Vesicular Glutamate Transport Protein 1/metabolism
Creator
An entity primarily responsible for making the resource
Ghosh Chaitali; Storey-Workley Megan; Usip Sharon; Hafemeister Jen; Miller Kenneth E; Papka Raymond E
Description
An account of the resource
Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g., glutamate, an excitatory neurotransmitter involved in sensory and nociceptive processing, have not been characterized. To determine if glutamate is involved in innervation of the cervix, rats were examined for markers of glutamatergic neurons in the L6-S1 spinal cord, DRG and cervix. Metabotropic glutamate receptors mGluR5 in the spinal dorsal horn and their expression over pregnancy were examined in pregnant rats and pregnant rats treated continuously with an antagonist of mGluR5, 2-methyl-6-(phenylethynyl) pyridine (MPEP). Rats were allowed to deliver pups to determine if the antagonist altered the expression of an early response gene protein, Fos, in the L6-S1 cord. Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns. Expression of mGluR5 receptors increased over pregnancy. Fos-positive neurons were present among mGluR5-immunoreactivity in the spinal dorsal horn. Parturition-induced Fos-positive neurons in the spinal cords were abundant in control rats, but were reduced by 70% in MPEP-treated animals. These results suggest that glutamate is likely involved in the transmission of sensory signals, possibly pain, from the cervix to the spinal cord at parturition.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.21225" target="_blank" rel="noreferrer noopener">10.1002/jnr.21225</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Animals
Cervix Uteri/*innervation
Department of Anatomy & Neurobiology
Excitatory Amino Acid Antagonists/pharmacology
Female
Ganglia
Gene Expression Regulation/drug effects/*physiology
Ghosh Chaitali
Glutamates/*metabolism
Hafemeister Jen
Journal of neuroscience research
Lumbosacral Region
Messenger/biosynthesis
Metabotropic Glutamate 5
Metabotropic Glutamate/*metabolism
Miller Kenneth E
NEOMED College of Medicine
Neurons/drug effects
Oncogene Proteins v-fos/metabolism
Papka Raymond E
Parturition/*metabolism
Pregnancy/*metabolism
Pyridines/pharmacology
Rats
Receptor
Receptors
Reverse Transcriptase Polymerase Chain Reaction/methods
RNA
Spinal Cord/drug effects/*physiology
Spinal/cytology
Sprague-Dawley
Storey-Workley Megan
Usip Sharon
Vesicular Glutamate Transport Protein 1/metabolism