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Text
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URL Address
<a href="http://doi.org/10.1096/fj.201601045R" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fj.201601045R</a>
Pages
1556–1570
Issue
4
Volume
31
Dublin Core
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Title
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Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae-induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation.
Publisher
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Date
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2017
2017-04
Subject
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*Airway Remodeling; *fibronectin; *myofibroblasts; *PAI-1; *PI3K; *TGF-beta1; Adult; Animals; Asthma/etiology/genetics/*metabolism/pathology; Cells; Cultured; Dermatophagoides farinae/immunology; Extracellular Matrix/*metabolism/pathology; Fibroblasts/metabolism; Fibronectins/*metabolism; Humans; Inbred C57BL; Male; Mice; Phosphatidylinositol 3-Kinases/metabolism; Plasminogen Activator Inhibitor 1/metabolism; Transforming Growth Factor beta/metabolism; TRPV Cation Channels/genetics/*metabolism
Creator
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Gombedza Farai; Kondeti Vinay; Al-Azzam Nosayba; Koppes Stephanie; Duah Ernest; Patil Prachi; Hexter Madison; Phillips Daniel; Thodeti Charles K; Paruchuri Sailaja
Description
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Contributions of mechanical signals to airway remodeling during asthma are poorly understood. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, has been implicated in cardiac and pulmonary fibrosis; however, its role in asthma remains elusive. Employing a Dermatophagoides farinae-induced asthma model, we report here that TRPV4-knockout mice were protected from D. farinae-induced airway remodeling. Furthermore, lung fibroblasts that were isolated from TRPV4-knockout mice showed diminished differentiation potential compared with wild-type mice. Fibroblasts from asthmatic lung exhibited increased TRPV4 activity and enhanced differentiation potential compared with normal human lung fibroblasts. Of interest, TGF-beta1 treatment enhanced TRPV4 activation in a
Identifier
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<a href="http://doi.org/10.1096/fj.201601045R" target="_blank" rel="noreferrer noopener">10.1096/fj.201601045R</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Airway Remodeling
*fibronectin
*myofibroblasts
*PAI-1
*PI3K
*TGF-beta1
2017
Adult
Al-Azzam Nosayba
Animals
Asthma/etiology/genetics/*metabolism/pathology
Cells
Cultured
Department of Integrative Medical Sciences
Dermatophagoides farinae/immunology
Duah Ernest
Extracellular Matrix/*metabolism/pathology
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fibroblasts/metabolism
Fibronectins/*metabolism
Gombedza Farai
Hexter Madison
Humans
Inbred C57BL
Kondeti Vinay
Koppes Stephanie
Male
Mice
NEOMED College of Medicine
Paruchuri Sailaja
Patil Prachi
Phillips Daniel
Phosphatidylinositol 3-Kinases/metabolism
Plasminogen Activator Inhibitor 1/metabolism
Thodeti Charles K
Transforming Growth Factor beta/metabolism
TRPV Cation Channels/genetics/*metabolism