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40
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Text
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URL Address
<a href="http://doi.org/10.1002/jcp.25020" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcp.25020</a>
Pages
72–83
Issue
1
Volume
231
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.
Publisher
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Journal of cellular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-01
Subject
The topic of the resource
Animals; Bone and Bones/*metabolism; Bone Density/physiology; Bone Remodeling/genetics/*physiology; Bone Resorption/metabolism; Cell Differentiation/genetics/*physiology; Eye Proteins/genetics/*metabolism; Membrane Glycoproteins/genetics/*metabolism; Mice; Osteoblasts/*cytology; Osteoclasts/*cytology; Osteogenesis/genetics; Protein-Serine-Threonine Kinases/metabolism; Receptor; Receptors; Transforming Growth Factor beta/metabolism; Transforming Growth Factor-beta Type I; Transgenic
Creator
An entity primarily responsible for making the resource
Frara Nagat; Abdelmagid Samir M; Sondag Gregory R; Moussa Fouad M; Yingling Vanessa R; Owen Thomas A; Popoff Steven N; Barbe Mary F; Safadi Fayez F
Description
An account of the resource
Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA and protein expression increase during active bone regeneration post-fracture, and primary rat osteoblasts show increased OA expression during differentiation in vitro. To further examine OA/gpnmb as an osteoinductive agent, we characterized the skeletal phenotype of transgenic mouse overexpressing OA/gpnmb under the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jcp.25020" target="_blank" rel="noreferrer noopener">10.1002/jcp.25020</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Abdelmagid Samir M
Animals
Barbe Mary F
Bone and Bones/*metabolism
Bone Density/physiology
Bone Remodeling/genetics/*physiology
Bone Resorption/metabolism
Cell Differentiation/genetics/*physiology
Department of Anatomy & Neurobiology
Eye Proteins/genetics/*metabolism
Frara Nagat
Journal of cellular physiology
Membrane Glycoproteins/genetics/*metabolism
Mice
Moussa Fouad M
NEOMED College of Medicine
Osteoblasts/*cytology
Osteoclasts/*cytology
Osteogenesis/genetics
Owen Thomas A
Popoff Steven N
Protein-Serine-Threonine Kinases/metabolism
Receptor
Receptors
Safadi Fayez F
Sondag Gregory R
Transforming Growth Factor beta/metabolism
Transforming Growth Factor-beta Type I
Transgenic
Yingling Vanessa R
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jcb.25394" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jcb.25394</a>
Pages
1511–1521
Issue
7
Volume
117
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Macrophage-Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44-Dependent Mechanism.
Publisher
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Journal of cellular biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-07
Subject
The topic of the resource
*CD44; *M2 MACROPHAGES; *MSC; *OA/GPNMB; Animals; Cell Movement/*physiology; Cell Proliferation/*physiology; Cell Survival/physiology; Eye Proteins/genetics/*metabolism; Hyaluronan Receptors/genetics/*metabolism; Knockout; Macrophages/cytology/*metabolism; MAP Kinase Signaling System/physiology; Membrane Glycoproteins/genetics/*metabolism; Mesenchymal Stem Cells/cytology/*metabolism; Mice
Creator
An entity primarily responsible for making the resource
Yu Bing; Sondag Gregory R; Malcuit Christopher; Kim Min-Ho; Safadi Fayez F
Description
An account of the resource
Although MSCs have been widely recognized to have therapeutic potential in the repair of injured or diseased tissues, it remains unclear how functional activities of mesenchymal stem cells (MSCs) are influenced by the surrounding inflammatory milieu at the site of tissue injury. Macrophages constitute an essential component of innate immunity and have been shown to exhibit a phenotypic plasticity in response to various stimuli, which play a central role in both acute inflammation and wound repair. Osteoactivin (OA)/Glycoprotein non-metastatic melanoma protein B (GPNMB), a transmembrane glycoprotein that plays a role in cell differentiation, survival, and angiogenesis. The objective of this study was to investigate the potential role of OA/GPNMB in macrophage-induced MSC function. We found that reparative M2 macrophages express significantly greater levels of OA/GPNMB than pro-inflammatory M1 macrophages. Furthermore, using loss of function and rescue studies, we demonstrated that M2 macrophages-secreted OA/GPNMB positively regulates the viability, proliferation, and migration of MSCs. More importantly, we demonstrated that OA/GPNMB acts through ERK and AKT signaling pathways in MSCs via CD44, to induce these effects. Taken together, our results provide pivotal insight into the mechanism by which OA/GPNMB contributes to the tissue reparative phenotype of M2 macrophages and positively regulates functional activities of MSCs. J. Cell. Biochem. 117:
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jcb.25394" target="_blank" rel="noreferrer noopener">10.1002/jcb.25394</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*CD44
*M2 MACROPHAGES
*MSC
*OA/GPNMB
2016
Animals
Cell Movement/*physiology
Cell Proliferation/*physiology
Cell Survival/physiology
Department of Anatomy & Neurobiology
Eye Proteins/genetics/*metabolism
Hyaluronan Receptors/genetics/*metabolism
Journal of cellular biochemistry
Kim Min-Ho
Knockout
Macrophages/cytology/*metabolism
Malcuit Christopher
MAP Kinase Signaling System/physiology
Membrane Glycoproteins/genetics/*metabolism
Mesenchymal Stem Cells/cytology/*metabolism
Mice
NEOMED College of Medicine
Safadi Fayez F
Sondag Gregory R
Yu Bing