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Text
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URL Address
<a href="http://doi.org/10.1016/0014-5793(91)80390-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-5793(91)80390-o</a>
Pages
188–190
Issue
1
Volume
281
Dublin Core
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Title
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Stabilization of clathrin coated vesicles by amantadine, tromantadine and other hydrophobic amines.
Publisher
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FEBS letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-04
Subject
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Animals; Swine; Structure-Activity Relationship; Kinetics; Amantadine/*analogs & derivatives/*pharmacology; Amines/*pharmacology; Brain/metabolism; Clathrin/*metabolism; Cell-Membrane/drug effects/*metabolism; Coated Pits
Creator
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Phonphok Y; Rosenthal K S
Description
An account of the resource
Amantadine and related compounds stabilized the structure of purified pig brain clathrin coated vesicles (CCV) at biologically relevant concentrations. Incubation of purified CCV for 30 min at 25 degrees C or 37 degrees C caused the release of clathrin, as determined by a centrifugation assay, and a reduction in the number of coated vesicles, by electron microscopy. Amantadine (10 mM), tromantadine (1 mM), amidine D295 (cyclohexylcarboximidamide-(N-benzyl)hydrochloride (10 mM), chloroquine (0.1 mM) and monodansylcadaverine (10 mM) significantly reduced the extent of dissociation.
Identifier
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<a href="http://doi.org/10.1016/0014-5793(91)80390-o" target="_blank" rel="noreferrer noopener">10.1016/0014-5793(91)80390-o</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Amantadine/*analogs & derivatives/*pharmacology
Amines/*pharmacology
Animals
Brain/metabolism
Cell-Membrane/drug effects/*metabolism
Clathrin/*metabolism
Coated Pits
FEBS letters
Kinetics
Phonphok Y
Rosenthal K S
Structure-Activity Relationship
Swine